JPS5914843A - Portable sugar level measuring apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to a portable blood glucose level measuring device.

Conventional blood sugar level measurement involves first collecting the patient's blood with a syringe, then separating the serum from this blood or using whole blood as a blood sample.
This was done by sampling a certain amount of each specimen and supplying it to a measuring device. However, it is necessary to frequently check white sugar levels during the treatment of diabetic coma patients, during surgery for diabetic patients, and during childbirth, and the above methods require labor and are difficult to operate, making it difficult to respond quickly. There was also a problem. For this reason, it consists of a blood sugar level detection section equipped with a blood sugar level measurement electrode and a calculation section that calculates the blood sugar level based on the output signal of the blood sugar level test 3-peak section, and these are built into a single housing. A so-called veradryoid type blood glucose level measuring device has been proposed.

However, the conventional blood glucose level detection unit @C' has a drawback that the blood glucose level measuring electrode and the calculation unit are relatively large, so the entire device becomes large and can only be used with Bedzyte. Furthermore, since conventional devices measure blood glucose levels by diluting blood collected from a patient, blood collection places a heavy burden on the patient and cannot be used continuously for a long period of time.

An object of the present invention is to provide a portable blood glucose level measuring device that can be carried and used, does not require blood sampling for blood glucose level measurement, and can be used continuously for a long period of time.

The portable blood glucose level measuring device according to the first invention includes a blood glucose level measuring electrode that is inserted into a 5-4 unit, and includes a blood glucose level detecting section and a microcomputer, and is configured to detect the blood glucose level based on the output signal of the blood glucose level detecting section. and a calculation section that calculates the blood sugar level.
The device is characterized in that a portion including a blood sugar level detection section and a calculation section is configured to be worn on the body. In addition,
In this specification, the term RPi worn on the body is used.
is used to include both cases where it is attached directly to the body and cases where it is attached to clothing.

According to the first invention, since the blood sugar level detection section is equipped with a blood sugar level measuring electrode that is inserted into the body, there is no need to collect blood for blood sugar level measurement, and the burden on the patient is reduced. Can be used continuously for a period of time. In addition, it is possible to use a blood glucose level measuring electrode inserted into the body and a microcomputer, so that it can be carried and used because the blood glucose level detection unit and calculation unit can be made smaller. As a result,
The patient can move freely.

The portable blood glucose level i1+1 device according to the second invention uses a blood glucose level detection section equipped with a blood glucose level measurement electrode inserted into the body and a combicoater to detect blood sugar levels based on the output signal of the blood sugar level detection section. It consists of a calculation section that calculates the value, a blood sugar level display that displays the performance result, and a section that includes a white sugar level detection section;
The calculation unit and the part including the blood sugar level display are separated from each other, the part including the blood sugar level detection unit is worn on the body, and the output signal of the blood sugar level detection unit is wirelessly transmitted to the calculation unit. It is characterized by the fact that it is

According to the second invention, in addition to the same effects as the first invention,
The following effects can be expected. That is, the part containing the blood sugar level detection section and the part containing the calculation part and blood sugar level display are separated from each other, the part containing the white sugar level detection part is worn on the body, and the part containing the white sugar level detection part is attached to the body, and the part containing the calculation part and the blood sugar level display is separated from each other. Since it is not necessary to carry the part containing the patient, the part to be carried can be further miniaturized, making it easier to carry and allowing the patient to move more freely. In addition, a large-capacity computer is used on the platform where the parts including the calculation unit and blood sugar level display are not carried, and highly accurate calculations are performed, and the calculation unit is shared by multiple portable glycan measuring devices. These can also be managed centrally.

The present invention will be described in detail below with reference to the drawings.

1 to 4 show a first embodiment of the present invention, and this portable face sugar level measuring device, as shown in FIGS. 7-1 and 2, It is composed of a value detection section (1), a calculation section (2), a liquid crystal blood sugar level display (3), and an alarm buzzer (4), and the entire body is shaped like a wristwatch. The blood sugar level detection unit (1) consists of a blood sugar level measurement electrode (5) that measures white sugar levels using polarography and a polar autograph electric circuit (6), and the calculation unit (2) includes:
It consists of an AD converter (7) and a microcomputer (8).

The blood glucose level measuring electrode (5) measures the glucose temperature in the blood using the current generated when hydrogen peroxide produced from glucose is electrolyzed using glucose oxidase as a catalyst. As shown in , the platinum electrode (@electrode) (9) and the silver electrode (cathode) (
10). Electrode reaction part 9 of platinum electrode (9)
- 8 - The parts other than the tip part (11) as a lead wire connection part and the rear end part as a lead wire connection part are insulated with glass (12), and the platinum electrode (9) has a silver electrode (10 ) is passed through a welded stainless steel cylinder (13). The tips of the platinum electrode (9) and the cylinder (13) are made by welding the tip of glass (12) as an insulating material to the inner surface of the tip of the cylinder (13), and the rear ends of both ( The plastic stopper (14) is connected to the platinum electrode (9) and the cylinder (1
3) are fixed by fitting and covering the rear ends of the parts. Then, on the surface of the platinum electrode tip (11), a cellulose acetate membrane (15) as a hydrogen peroxide permeable hydrophilic semipermeable membrane is laminated, and on the upper surface of the cellulose acetate membrane (15), an immobilized glucose oxidase membrane ( 16) are laminated, and further a polyurethane membrane (17) as a hydrophilic semipermeable membrane having glucose, oxygen, and hydrogen peroxide permeability of 10 - is laminated on the upper surface thereof. The rear ends of the platinum electrode (9) and the cylinder (13) are connected to insulated lead wires (18) and (19), respectively. The blood glucose level measuring electrode (5) is attached to the distal end of the indwelling catheter (20) and inserted into a blood vessel or subcutaneously. The signals from the electrodes (5) are then guided through the catheter (20) to the polarographic electrical circuit (6). The polarography electric circuit (6) has the function of applying a constant voltage to both electrodes (9) and (10), measuring and amplifying the current generated during hydrogen peroxide electrolysis, and converting the amplified output signal into Based on this, the blood glucose concentration # degree, that is, the blood sugar level is determined.

Using this electrode (5), a glucose tolerance test was conducted on dog blood, and the results are shown in FIG. This measured value was in good agreement with the measured value by the currently commonly used lji quasi-measurement method. In FIG. 4, the horizontal axis shows time and the vertical axis shows voltage, and between T1 and T2 G; tlo
omq/d11 between 2 and 3 is 2ooI1g/d/, 1
300 m a / d / (7) standard wow between 3 and 14
However, between 14 and 15, physiological saline was passed, and between 15 and 16, dog normal blood was passed, and at T6 and T7, 50%
50 cc of glucose aqueous solution is injected intravenously into the dog's thigh.

Moreover, as a result of basic tests, this electrode (5)
In the VitrO system, it is stable for more than 24 hours, linearity is observed in the response to glucose concentrations of 0 to 5ooIl1g/dl, the response time is quick on the order of seconds, and it is stable in the temperature range of 36 to 42 ° C. in
It has been confirmed in in vivo animal experiments that highly reliable measurement results such as good responsiveness to 11-glucose loading and insulin hypoglycemia can be obtained.

The material of each part constituting the blood glucose level measuring electrode (5) is not limited to those mentioned above and can be changed as appropriate, but noble metals such as platinum and gold are preferable as the anode material, and silver, silver, and the like as the cathode material. Silver chloride is preferable, glass, plastic, etc. are preferable as the insulating material, and hydrogen peroxide permeable hydrophilic semipermeable membranes include cellulose (mono, di, or tri) acetate, cellulose propionate, and cellulose butyrate. Preferred are cellulose derivatives such as , and porous glass or plastic is preferred as the carrier for immobilizing glucose oxidase. In addition, hydrophilic semipermeable membrane-13 permeable to glucose, oxygen, and hydrogen peroxide.
It is desirable that a blood coagulation inhibitor such as heparin be added to the electrode surface to prevent blood coagulation from forming on the electrode surface.

Alternatively, glucose oxidase may be immobilized and laminated by repeatedly immersing the tip of the electrode in a glucose oxidase-containing solution and drying it. Furthermore, in order to provide flexibility to the electrode itself, a plastic tube may be used instead of the stainless steel cylinder (13). In this case, the cathode can be formed by vacuum-depositing silver on the outer surface of the plastic tube and then plating the upper surface with silver.

The programmable read-only memory (PROM) of the microcomputer (8) of the performance section (2) contains a program 14 for calculating the blood sugar level based on the output signal of the blood sugar level detection section (1). is stored.

The portable blood glucose level measuring device described above is used with the blood glucose level measuring device 1 (5) inserted into a blood vessel or subcutaneously, while being fixed to a patient's arm. Then, the blood sugar level is measured at regular intervals (for example, 1 minute) as follows.

That is, the analog signal from the electrode (5) is amplified by the polarography electric circuit (6) and then converted into a digital signal by the AD converter (7) of the calculation section (2).
This signal is sent to the micro combi coater (8). The microcomputer (8) calculates the blood sugar level based on this digital signal at regular intervals and displays this on the display (3).The microcomputer (8) also displays the blood sugar level at preset upper and lower limits. When the limit is exceeded, a buzzer (4) will sound an alarm.

5 and 6 show a second embodiment of the present invention, and this portable blood glucose level measuring device includes a blood glucose level detection section (1
), a wristwatch-shaped transmitter part (21), a calculation part (21), etc.
) and a receiving part (22) including a blood glucose indicator (3).
It is composed of.

The transmitting side part (21) includes a voltage controlled oscillator (23), a main carrier modulator (24), a wireless transmitting circuit (25), and a blood sugar level detecting section (1) similar to the first embodiment. A transmitting antenna (26) is included, and the band portion serves as the transmitting antenna (26).

The reception side part 22) includes a reception antenna (22) in addition to the calculation unit (2) and blood sugar level display (3) similar to those in the first embodiment.
7), a radio reception circuit (28), a main carrier demodulator (29), an FM11 modulation circuit (30), an alarm buzzer (4), and a keyboard (31), all of which are integrated into one small device. It is incorporated into the housing (32). The microcomputer (8) of the calculation section (2)
) stores a program for calculating the blood sugar level based on the output signal of the blood sugar level detection unit (1) that is wirelessly transmitted as described later, and the program is stored in the FROM of the micro combicoater (8). Random access memory (RA)
M) stores the parameters of the above calculation formula, measurement data, etc. Parameters of the arithmetic expression are set using the keyboard (31).

The receiving part (22) can be carried by the patient separately from the transmitting part (21), or can be installed at a nurse's station or the like. In the latter case, a combination coater with a larger capacity than in the first embodiment may be used in the calculation section to perform highly accurate 17-16- calculations, or a verse division method may be adopted. It is also possible to share the arithmetic control unit among a plurality of portable blood glucose level measuring devices and manage them all at once.

The portable blood glucose level measuring device described above measures the blood glucose level at regular intervals as follows, with the transmitting part (21) fixed to the patient's arm as in the first embodiment. .

That is, the analog signal from the electrode (5) is amplified by the polarographic electric circuit (6) and the voltage controlled oscillator (2
After the voltage-frequency conversion is performed in step 3), the main carrier modulator (24) is passed through the transmitter circuit (25) to the antenna (
26).

The signal transmitted from the transmitting part (21) is sent to the receiving circuit (28) via the antenna (27) of the receiving part (22).
After passing through the main carrier demodulator (29), the signal is input to the FM demodulation circuit (30) and converted into an analog signal proportional to the output signal of the polarography electric circuit (6). This analog signal is converted into a digital signal by the ΔD converter (7) of the arithmetic unit (2), and this signal is sent to the microphone "1:1 encoder (8).Then, the microcomputer (8) The blood sugar level is adjusted based on this signal at regular intervals.

[Brief explanation of drawings]

1 to 4 show a first embodiment of the present invention.
The figure is an overall perspective view, Figure 2 is an overall block diagram, Figure 3 is an enlarged vertical cross-sectional view of an electrode for measuring blood glucose level, and Figure 4 is a glucose tolerance test on dog blood using the electrode in Figure 3. FIGS. 5 and 6 are graphs showing the results of this process, and show the second embodiment of the present invention. FIG. 5 is an overall perspective view, and FIG.
The figure is an overall block diagram. (1)...Blood sugar level detection section, (2)...Calculation section, (3
)...Glucose level indicator, (5)...Blood sugar level measurement electrode, (8)...Microcomputer, (9)...Platinum electrode (anode), (10)...Silver electrode (cathode), (1
1)...Platinum electrode tip, (13)...Cylinder, (1
5)... Lerulose acetate crotch (hydrophilic semipermeable membrane permeable to hydrogen peroxide), (16)... Glucose oxidase membrane, (17)... Polyurethane membrane (glucose/
Hydrophilic semipermeable membrane permeable to oxygen and hydrogen peroxide), (21)
... Sending side part, (22)... Receiving side part. Patent applicant: Fujisawa Pharmaceutical Co., Ltd. Figure 1 Figure 2

Claims (5)

[Claims] (1) A blood sugar level detection unit (1) equipped with a blood sugar level measurement electrode (5) inserted into the body, and a microcomputer (8).
) and a calculation section (2) that calculates the blood sugar level based on the output signal of the blood sugar level detection section (1);
1. A portable blood glucose level measuring device characterized in that a portion including the calculating section (2) and the calculating section (2) is configured to be worn on the body. (2) A blood sugar level display (2) that displays the calculation results of the calculation unit (2) in a part that includes the blood sugar level detection unit (1) and the calculation unit (2).
3>. The portable blood glucose level measuring device according to claim 1, wherein the portable blood glucose level measuring device is provided with: (3) The blood glucose level measuring electrode (5) has an anode (9) which is insulated except for the tip part (11) as an electrode reaction part and the rear end part as a lead wire connection part, and a cylindrical cathode. (
10), the anode (9) is fixed in the cylinder (13), and a hydrophilic semipermeable membrane (15) permeable to hydrogen peroxide is placed on the surface of the tip (11) of the anode (9). An immobilized glucose oxidase membrane (16), and a hydrophilic semipermeable membrane (16) permeable to glucose, oxygen, and hydrogen peroxide.
The portable blood glucose level measuring device according to claim 1 or 2, characterized in that 7) are sequentially stacked. (4) A blood glucose level detecting unit (1) equipped with a blood glucose level measuring electrode (5) inserted into the body and a computer (8), which detects the blood glucose level based on the output signal of the blood glucose level detecting unit (1). It consists of a calculation unit (2) that performs calculations, and a blood sugar level indicator (3) that displays the calculation results, and includes a part that includes the blood sugar level detection unit <1>, a calculation unit (2), and a blood sugar level display (3) that displays the calculation results. ) are separated from each other, the part containing the blood sugar level detection unit (1) is worn on the body, and the output horn signal of the blood sugar level detection unit (1) is wirelessly transmitted to the calculation unit (2). J: A portable blood glucose level measuring device characterized by the fact that it is made of sea urchin. (5) The blood glucose level measuring electrode (5) has a cylindrical anode (9) which is insulated with -C, except for the tip part (11) as the electrode reaction part and the rear end part (11) as the lead wire connection part. The anode (9) is fixed in a cylinder (13), and a hydrophilic semipermeable membrane (15) permeable to hydrogen peroxide 11 is formed on the surface of the tip (11) of the anode (9). , then immobilized glucose oxidase flu (16), and a hydrophilic semipermeable membrane (17) that is roughly permeable to glucose, oxygen, and hydrogen peroxide are sequentially laminated. The portable blood glucose level measuring device described in 2.