JPS5839613A - Dentrifrice composition - Google Patents

Abstract

PURPOSE:To provide a dentrifrice composition having excellent antibacterial activity against Fusobacterium nucleatum, and useful for the prevention of oral odor and periodontosis, by using extract of sage and/or rosemarry in combination with sodium alkylsulfate. CONSTITUTION:A dentrifrice composition is obtained by adding (A) the extract of sage and/or extract of rosemarry and (B) preferably 8-18C alkylsulfuric acid sodium salt, e.g. sodium caprylsulfate, especially sodium laurylsulfate, to a dentrifrice composition such as toothpaste, moistened tooth powder, tooth powder, liquid dentrifrice, etc. The amounts of the components (A) and (B) are preferably 0.0005-5wt%, especially 0.005-2wt% and preferably 0.1-5wt%, especially 0.5-3wt% of the whole composition, respectively. The above components exhibit synergistic excellent antibacterial effect against Fusobacterium nucleatum which is a pathogenic bacterium of oral odor and periodontosis, at low dose, and give the objective dentrifrice composition having high safety.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention can be used in combination with Koryu-diO extract and/or rosemary 0 extract and sodium alkyl sulfate,
7. A toothpaste composition that exhibits good antibacterial activity against Zopacterium nucleatum.

There are various O bacteria in the oral cavity, among which 7 Δacterium fistulae (haoba@t*rIm)
mmmcl@atm) 111 indole, hydrogen sulfide,
It produces mercaptan, etc., and has traditionally been used to inhibit the growth of 7. To prevent bad breath, 1
9. Effective in preventing periodontal disease.

Conventionally, sodium alkyl sulfate has been shown to have antibacterial properties against D*iiK and other bacteria as well as surfactant action, but its antibacterial action against Δactericum nucleitae has been demonstrated in the experimental examples described below. As shown in the figure, there is no high price.

In view of these circumstances, the present inventors have conducted intensive research on active ingredients for toothpaste that have a high anti-1 action against Fusibacterium nucleatum, and have found that they have been found to be effective against Fusibacterium nucleatum using various plants as natural additives. sage extract,
n-z! As a result of selecting extracts of Z. nuculatum and using them singly or in combination with sodium alkyl sulfate, they exhibited synergistic antibacterial activity that was specific and excellent against Zopactericum nucleatum even in small amounts. For this reason, the present inventors discovered that blending extracts of sage, a-tq sori, and sodium alkyl sulfate into toothpaste compositions is effective in preventing bad breath and periodontal disease, leading to the present invention. *This will be explained in detail below.

The present invention applies to toothpaste, moist toothpaste, powdered toothpaste, liquid trout paste, etc.
Sage extract and/or rosemary O in the polishing composition
It is a blend of extract and Fium alkyl sulfate.

In this case, the raw materials used to obtain extracts of sage and rosemary include sage and rosemary O powder; residues obtained by extracting oil from these by steam distillation and other essential oil extraction residues; or sage and rosemary O powder; Dama 9-t
Ethyl ether, ethylene! Lower alcohols such as rotoid, geocan, acetone, methanol in ethanol,
Ethyl acetate,! ■ Oleoresin obtained by extraction with polar solvents such as birendaricoll, glycerin, water, etc.) and the extraction residue; An oleoresin obtained by extraction with a nonpolar solvent such as oleoresin, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, penzene, etc. and its extraction residue is used. When obtaining extracts of sage and um. In the present invention, this extract can be used as it is, but this extract can be used as is. A steam distillation residue obtained by steam distillation treatment, a product obtained by treating this extract or the steam distillation residue with an adsorbent such as activated carbon, diatomaceous earth, or acid clay, and a product obtained by treating the extract with an adsorbent and then steam distillation. The residue obtained by the treatment can be suitably used as an extract of tomo sage and bursmary. Note that a known method can be used as the extraction method, such as digesting dry powder of sage or rosemilli in a solvent. In this case, the solvent is preferably an organic solvent, and an organic solvent extract obtained by extracting sage or rosemary with an organic solvent is more effective.

In addition, in the present invention, even if one type obtained by the above-mentioned method is used as the sage, guan-zumary O extract, two
The amount of extracts of t*, sage, and rose 1 li to be added to the toothpaste composition is from total OQ, 0005- (same below weight-1) to S capsule, It is preferable to set it as o, oos to 2-.

The sodium alkyl sulfate used in the present invention preferably has an alkyl group having 8 to 18 carbon atoms, and examples thereof include p1 sodium cagril sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium Δlumityl sulfate, etc. Particularly preferred is sodium lauryl sulfate.
In addition, it is desirable that the amount added to the dentifrice composition be 0.1 to 0.5 to 3% of the total amount.

As the V40-relaxation component of the present invention, an appropriate component depending on the type of toothpaste composition is used. For example, in the case of toothpaste O, dicalcium phosphate dihydrate and anhydride, calcium carbonate, / Abrasives such as acid caruncum, Il calcium sulfate, non-sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate F, arsenium hydroxide, aluminum oxide, resin, etc. (appropriate amount, usually 20
~60LIk), Cal I#xymethylcellulose, hydroxyethylcellulose, algin [J[, force? “Binders” such as Danan, A2PFM, polyvinyl alcohol, etc.
In addition to thickening agents (10 to 70%) such as ethylene glycol, sorbitol, glycerin, and glopylene glycol (10 to 70%), and (if necessary) sodium alkyl sulfate, Sodium dodecylbenzenesulfonate, hydrated coconut fatty acid monodaliceride monosodium sulfate, sodium lauryl sulfoacetate, sodium N-2 uroyldercosine, N-acyl glutamate, lauryl diethanolamide,
A blowing agent (0 to 5-) such as No. 11 fatty acid ester is blended.

In addition, % (essential oils such as Δ-2 and Spaunt, fragrance materials such as L-menthol, Calin, Oilnol, Anethole, etc.) , dalycyrrhitene, perifrutin, p-methoxycinna?, quaarte and dorsomatin, and other sweeteners and preservatives are mixed with water and produced according to a conventional method.

In addition, in the present invention, in addition to the extracts of lily, sage, and rosemary, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexicine or its salt, sorbic acid, alexicin, hinokitiol, cetylviridinium coolide, alkyl Glycine, alkyldiaminoethylglycine salt, 7lantoin, -17itsuka! Gastric acid, Door 4 quinamic acid, azulene, Vitashi 1, sodium monofluorophosphate, sodium fluoride, stannous heptadide, water-soluble 14 or 2 phosphate, quaternary ammonium compound, Active ingredients such as sodium chloride can also be blended.

Therefore, the dentifrice composition according to the present invention uses sage extract and/or rosemary extract together with Fium alkyl sulfate, so that they act synergistically to improve the 7zoΔ It exhibits an excellent antibacterial effect against Tatherium nucleatum, and is therefore effective in preventing bad breath and periodontal disease caused by this bacterium.

(9) The dentifrice composition of the present invention contains a highly safe plant extract as an active ingredient, and is highly effective even when blended with a relatively low weave, so the amount to be blended can be reduced. Therefore, it is highly safe to use.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

Dry sage powder 100. (Add 300 d of methanol to 1 ml and reflux for 1 hour on a water bath at 70 to 80°C with a cooling tube attached. Next, the methanol fraction is separated by furnace, fresh methanol is added to the residue, and the same reflux is repeated twice. Perform the extraction operation a total of 3 times.

The methanol extracts were collectively concentrated under reduced pressure to obtain a dark green paste of 27.4N.

Danku, 3011 rosemary dry powder and 11 methanol
Add 50117 and reflux for 1 hour on a 70-80°C water bath with a cooling tube attached.9. The following procedure was carried out in the same manner as in the case of sage to obtain a dark greenish-brown solid 7.3I.

Other solvents were operated in the same manner as above to obtain various extracts of sage and rose w9-.

Table 1 shows the extraction results.

Summary 1 Table 1 Medium containing 0.001% of sodium alkyl sulfate, 0.01% of each extract of sage and rosemary, 0.001% of sodium alkyl sulfate and 0 of each extract of sage and rosemary Pre-cultured Zopactericum nucleatum 1436 was added to a medium containing 0.01%
Added 100 ml and under anaerobic conditions (801GN, 10'
jiH, #10%, CO,), incubated for 2 days at 37 °C, and then the extent of bacterial growth was measured at 550 m 0TI.
The results are shown in Table 3.

The medium used was Todd-Haitt medium (DIFCO Jl) containing cysteine o and oss'.

312 table 550 mrm Q absorbance No. 311 SSO
mwaOFIk Luminosity The results in Table 2.3 show that by using the extracts of sage, rosemary, and sodium alkyl sulfate in combination, these act synergistically on Δacterium nucleatum, resulting in 7zoΔacterium nucleatum. It is found that it exhibits excellent anti-corrosion ability against carbon dioxide.

Examples are shown below.

[Example 1] Toothpaste Dicalcium Phosphate Dihydrate 50% Glycerin 20 Power Dimethyl Cellulose -1.0 Flavor 1.0 Z Listyl Sodium Sulfate 1.0 Sage Methanol Extract o, I Saccharin
0.1 Sodium chloride 0.1 Plantin 0.1100, Ol [Example 2] Toothpaste dicalcicum phosphate dihydrate 50 54 Tulr) 1G glycerin
10 Cal-1? Dimethylcellulose 1.0 Flavor 1.0 Sodium lauryl sulfate 2.0 Sey80-ethanol extract 0.1 Sodium heptanofluorophosphate 0.3 Ethanol
2.0 Satukarin
0.1 Mutanase 0.1 Water
100 left, O
l [Example 3] Toothpaste calcium carbonate 5G 11 Glycerin 20 Kararnan O65 Calgaxymethyl cellulose 10 Shi, Matiho notuurate 2-O Fragrance 0.8% Sodium 2-uryl sulfate 1G Sage water extract 0.1 Su, Karin
0.1 Chlorine hydrochloride 0.005 Dextophnase 0.01 Azulene
0.1 water
Remaining 10G, O1 [Example 4] Toothpaste dicalcium phosphate dihydrate 50 Tiglycerin 20 Dimethylcellulose in Calf 2.0 Flavor 1.0 Sodium lauryl sulfate 2.0 Chlorhexidine gluconate 0.01 Su, Karin
0,1 glycyrrhizic acid
0.2 bentonite 0.5 water remaining 100.
0- [Example 5] Toothpaste Anhydrous Sili 30 - Glycerin 30 Sorbit 20 Cal? Medium dimethyl cellulose 1.0 Fragrance 1.0 Sodium quince 0.1 Sodium lauryl sulfate 2.0 Tranexamic acid 0.1 Water
Remaining 100, 〇- [Example 6] Liquid toothpaste glycerin 35.0-force 2r Nan
1.5 power! Lingsi, gar
2.0 Fragrance 0.9% Ethanol 1.0 Sodium monofluorophosphate 0.52 Sodium krylsulfate 1.5 Sage ethyl acetate extract
0.1 Oregano methanol extract 0.
Tetralhexidine monohydrochloride 0.01 water
100.0 remaining
% [Example 7] Toothpaste dicalcium phosphate dihydrate 5oon calcium carbonate 30.0glycerin
10.0 Flavoring 1.0 Saccharin 0.1 Sodium monofluorophosphate 0.1 Sodium lauryl sulfate 1.0 Ethanol extract of 4-Zumari 0.1 Dextran
0.5 water
100.016 remaining

Claims (1)

[Claims] 1. A toothpaste composition comprising a combination of sage extract and/or quatsumari extract and sodium alkyl sulfate.