JPS58124711A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To provide a skin cosmetic such as lotion, etc., containing specific amounts of levulinic acid and/or its salt, capable of promoting the turn-over rate of the corneal layer of the skin (rate of skin regeneration), and making a fair skin. CONSTITUTION:The objective skin cosmetic such as lotion, cream, milky lotion, pack, etc. contains levulinic acid and/or its salt, e.g. ammonium salt, alkali metal salt, alkaline earth metal salt, alkanolamine salt, etc. in an amount of 0.05-0.7wt%, preferably 0.1-0.5wt% based on the sum of the cosmetic components. The levulinic acid contained in the cosmetic is stable and absorbed in the skin with time to activate the skin cells, promote the function of the skin and accelerate the regeneration of the skin. By the combined effect with the other components in the cosmetic, it improves the healthy state of the skin, promotes the beautification, and remarkably improves the fineness, tenseness and gloss of the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin cosmetic that promotes the turnover rate of the stratum corneum (skin regeneration rate) and has a beautifying effect on the skin.

Conventionally, levulinic acid and its salts have been used as the most representative compounds for resin additives, erasing agents, pharmaceuticals, industrial chemicals,
Used as a fragrance intermediate. In addition, due to the solubility of levulinic acid or Shisonotei, it is used as a compounding ingredient in depilatory agents (#11A Kaikai 52-79055), and as a compounding ingredient in hair rinses (4I patent application publication 54-404) due to its electrostatic effect.
14).

However, the previously known literature does not disclose the beautifying effect of salts on the skin.In general, with aging, the ability to regenerate epidermal cells weakens and the cells themselves atrophy. It is known that skin texture, firmness, luster, etc. are lost.The turnover rate t (skin regeneration rate*) of the stratum corneum is 14 for women in their 20s.
Approximately 16 days, 15 to 18 days for women in their 40s, and 16 to 20 days for women in their 60s, and moderate promotion of turnover rate prevents the skin from softening due to Ichisanban, and improves the skin itself. It is said to prevent skin aging and maintain good skin texture, radiance, and luster.

The present inventors promoted the turnover rate (skin regeneration rate) of the carrion layer with regard to physiological effects on the human body,
As we age, the ability to regenerate epidermal cells weakens and the cells themselves atrophy, preventing the skin from losing its firmness, preventing aging and improving the skin's fine, moisturized color and luster. So-called beautifying effect on the skin that makes the skin smooth ^
The present invention has been completed based on the discovery that the present invention can be carried out in the same way.

The object of the present invention is to provide a novel skin cosmetic having the above-mentioned excellent beautifying effect on the skin.

That is, the present invention uses levulinic acid and /l or its salts at α05 to α7? based on the total amount of prescription ingredients. It is a skin cosmetic product characterized by a high content by weight.

Examples of the salts of levulinic acid in Kajiki include: 1. Alkanol acine salts such as ammonium salts and triethanolamine salts; alkali metal salts such as sodium salts and potassium salts;
Examples include alkaline earth metal salts such as calcium salts and magnesium salts.

The content (blended amount) of levulinic acid and its salts in the present invention is α05 to 170% by weight, preferably α1 to α5% by weight, based on the total amount of prescription ingredients of the skin cosmetic. If α0505% by weight is too low, it will not promote proper skin regeneration of the stratum corneum, and the above-mentioned beautifying effect on the skin will not be achieved. Because it generates agglomerated particles (so-called puffiness), it comes off during use and does not blend well with the skin during stretching.

Furthermore, the effect of accelerating the skin regeneration rate of the stratum corneum is also reduced, so the chemical effect on the skin is weakened.

The cosmetics of the present invention can be prepared by adding levulinic acid or its salts directly to skin cosmetics, such as cosmetic creams and emulsions, or by dissolving them in advance in their aqueous phases, or by adding levulinic acid or its salts to skin cosmetics, such as cosmetic creams and emulsions, or by dissolving them in advance in their aqueous phases. By adding and blending pre-dissolved salts, emulsifying, mixing and dispersing, salts are stable and absorbed into the skin over time.
Activates cells, takes care of skin functions, promotes the turnover rate of the skin's stratum corneum (skin regeneration rate), and furthermore, works in conjunction with other ingredients coexisting in cosmetics to create a remarkable state of skin health. Other effects that improve skin appearance and enhance beautification may vary depending on the type of skin cosmetic, etc., and details of these will be described later.

Furthermore, regarding skin irritation caused by levulin or T salts used in the present invention, results were obtained according to the Draize method described below.
Both the animal skin irritation score and the human skin irritation score were 0, indicating no irritation.

[Drsiiz@, 7. H, Asgocration
of Food and Drug offioiml
so the units at%@a
Appraisal of the E
kf@%7 ofOhsmicals in Foo
ds Drug and C<m*%1oa, 46
(195?)TaX&s, 5tate Depar
tment of Health, Augustin
] Hereinafter, various skin cosmetics of the present invention will be explained in detail.

(1) Loshirons The present invention includes, for example, Enscent Lotion, Skin Conditioning Lotion, Astringent Lotion, After Shape Lotion 7, Calamine Lotion, Makeup Transparent Lotion, Nutritional Essence, Tontan Loshi Proverbs, and I-Lukiirosi 1. The blending amount of various salts such as salts should be α05% to [1
7% by weight, preferably FA, (LIX~(LS) promotes the turnover rate of the skin's stratum corneum, has an affinity for the skin (Hadakura Jigo) like Arashikokura, and makes the skin shiny and smooth. can give.

The amount of alcohol added is at most 20% of the total amount of prescription ingredients.
% by weight, preferably from tO to 10% by weight.

Other ingredients that are blended include fragrance 1 coloring agent.

In addition to the antiseptic side, an astringent, a skin nutrient, an anti-inflammatory pigment, an ultraviolet absorber, a solubilizer (the above-mentioned emulsifier), a humectant, and a PH adjuster are added to the side as necessary.

The above-mentioned carapon lotion, make-up transparent lotion ■
Pigments (e.g., yellow iron oxide, red iron sulfide, black iron oxide, talc, titanium oxide,
Kaolin, etc.) are blended.

The amount of pigment blended is at most 10% by weight, preferably 1% by weight of α5-7.

The rosin soda obtained by the present invention is extremely stable without forming precipitates, discoloration, or odor even when stored for a long period of time, does not irritate the skin, provides nutrition to the skin, has a smooth texture, and has a good texture.
The effects of levcin and/or its salts are quite different, as it gives firmness and spreads well on the skin.

(21 Cream-like or emulsion-like skin cosmetics The present invention provides 1)
For example, pine surge cream, cleansing cream,
Skin cream, Nantan cream, foundation 1 cream.

It is applied to creamy or emulsion-like skin cosmetics such as liquid makeup base, milky lotion, etc.

The amount of Il of L/7' phosphoric acid and/or its salts in cream-like or emulsion-like cosmetics is α05-α70% by weight, preferably Q, 1, based on the total amount of prescription ingredients.
~(L5% by weight.

In the cosmetic composition of the present invention, for example, Replic acid and/or its salts are dissolved in the aqueous phase component along with water-soluble components such as preservatives and emulsifiers.

% of the aqueous phase component (about 70℃) of the kernels melted (about 70℃)
It is manufactured by mixing and emulsifying oil phase components (oil-based substances, etc.) with stirring.

As the emulsifier, surfactants (non-ionic and anionic surfactants) and surface-active substances such as pectin, karaya gum, and locust bean gum are used.

The amount of the emulsifier is usually 10% based on the total amount of prescription ingredients.
It is within the range of 5 to 5% by weight.

Oily substances include hydrocarbons and animal fats and oils.

Known and commonly used oily substances for skin cosmetics such as vegetable oils, waxes, and ester oils may be used. The amount incorporated is usually 5 to 90% by weight based on the total amount of prescription ingredients.

Other ingredients included are fragrances and preservatives.

In addition to pigments, skin nutrients, moisturizers, PH1 as necessary
Ill conditioners, ultraviolet light inhibitors, etc. can be added.

#i ingredient is blended into the liquid makeup base and foundation cream. The blending amount of the pigment is the same as in the case of the above-mentioned Roshi pigments.

As mentioned above, the cream or emulsion skin cosmetic of the present invention is extremely stable, without causing discoloration or odor during the formation of aggregated particles in the precipitate, even when stored for a long period of time.
When used, it comes off easily and spreads well on the skin, providing nourishment and nourishment to the skin.
It has four excellent properties such as emulsion stability, viscosity (hardness) stability, and appearance, as well as giving good eeling feel (smooth feel), pleasant luster, and firmness. The effect is remarkable.

:5) Pack agent The amount of salts in the film-type pack agent and wipe-off pack according to the present invention is α05 to 070% by weight based on the total amount of prescription ingredients.
Preferably, α1 is in the range of 15% by weight.

Film agents that can be used in pack agents include, for example, polyvinyl alcohol, polyacrylic acid)-/, INIIRI
Sivinylbo 9mer in 11 carbo.

Carboxymethyl heptalulose, polyvinylpyrrolidone,
Examples include sodium alginate, pectin, zentin, natural rubber latex, synthetic rubber latex, and vegum. The blending amount of the coating agent is α01 to 15% by weight, preferably α05 to 10% by weight, based on the total amount of prescription ingredients as a dry product.
Weight%. The amount of alcohol blended is at most 20% by weight.
, preferably 5 to 10% by weight.

Commonly used ingredients that can be incorporated into the pack agent of the present invention include perfumes, preservatives, dyes, pigments, humectants, solubilizers, pH adjusters, oily substances, cosmetic medicinal ingredients, and the like.

The pack agent obtained by the present invention is stable without producing aggregates or sediments, discoloration, odor, or viscosity reduction even after long-term storage, and can be easily and uniformly applied and peeled off during use. At the same time, it gives a moderate feeling of firmness, and after peeling off the film, it can give a moist feel and gloss to the skin.

Examples will be described below.

The parts shown in the examples mean parts by weight, and the percentages shown in the examples mean parts by weight.

1 & The skin stratum corneum turnover rate was measured according to the method of Jikin Shichinin et al. described below.
Skin stratum corneum protein staining was performed on the facial skin of 20 people using a 4x4 square of fluorescent dye dansyl-lide.
Afterwards, apply a large skin cosmetic containing levulinic acid and/or its salts twice a day (morning and evening), and as it changes over the course of the day, it will change over time.
or@acene* 8taining Jschni
que For ikilmtl, Jurnovo
r of th@Hmars 8tratum Oor
naum; Br1tiahJournal of
Edited by D@rmtolo, 1974909) Example 1 (
Skin conditioning lotion) 10 parts ethanol, 5s1 glycerin, 1 polyoxyethylene lauryl ether (ZOR, O,) (solubilizer) 1
5 parts, methylparaben [LI part, fragrance α05 parts, water B&
55 parts and α5 parts of each of the following levulinic acids or salts thereof to prepare 1 kb of the skin conditioning lotion of the present invention in a conventional manner. For comparison, a skin toning lotion containing levulinic acid and salt 11 was prepared. ? Table 1 shows the results of examining the quality characteristics and sensory characteristics of these skin lotions.

The levulinic acid and its salts used in Example 1 and their symbols are as follows. c Same as below. To levulinic acid and its salts; levulinic acid B; levulinic acid triethanolamine O1;
Ammonium Levulinate D; Sodium Levulinate 1 Table Example 2 Other than changing the amount of levulinic acid as shown in Table 2,
11 A skin conditioning lotion #l# was prepared in the same manner as in Example 1 of the present invention.

Table 2 shows the results of examining the quality characteristics, sensory characteristics, and stratum corneum turnover rate of these skin lotions.

Example 5 A skin lotion was prepared with the amount of sodium levulinate shown in Table 5.

The quality characteristics, organoleptic properties, and stratum corneum turnover rate of the obtained skin conditioning lotion were the same as those of the skin conditioning lotion of Example 2, as shown in Table 3.

Comparative Example A skin lotion was prepared in the same manner as in Example 1, except that glyoxyl or acetone dicarboxylic acid was used instead of lupulic acid.

The appearance and K odor of the obtained skin conditioning lotion were the same as those of the skin conditioning lotion of Example 1. Both the glyoxyl skin toning lotion and the acetone dicarboxylic acid skin toning lotion had sensory properties that made the texture finer in 1/20 people, and improved luster in 1/720 people. The girth has come out, but 0 people/
There were 20 people. The stratum corneum turnover rate is 1 line 5±
At 1.0, the turnover rate of the stratum corneum was not promoted, and no beautifying effect on the skin was observed.

Example 4 Astringent lotion An astringent lotion of the present invention consisting of 2 parts of levulinic acid α, 1 part of estradiol α, 15 parts of ethanol, 05 parts of fragrance α, 84°8 parts of water and 1 appropriate amount of pigment was prepared in the usual way. Manufactured. For comparison, an astringent lotion #JI4JIll was prepared by replacing Repli/#2 with citric acid. Quality characteristics of these astringent lotions.

The results of the investigation of sensory characteristics and stratum corneum turnover rate are shown in Table 4.

Table 4 Example 5 (After Shape Low Scene) Ethanol 5
0 parts, fragrance α 1 part, isoglubil methylphenol α 0
1 part, polyethylene dari: z-+2 (10zs, igsilon amino 7'a acid α 1 part, appropriate amount of dye, water 67.5
A part and a replin blow scene were prepared according to a conventional method. For comparison, a skin conditioning lotion without the addition of levulinic acid or its salts was also prepared.

After Shape Law Sheen containing levulinic acid or its salts (B, O, D, K) and After Shape Law Sheen without the addition of levulinic acid look strangely the same after 2 months of sunlight irradiation as they did immediately after manufacture.

Smell: Even after 2 months at 445℃, there was no strange odor and the condition was good.
In terms of organoleptic properties and turnover rate of the stratum corneum, the aftershave bread containing levulinic acid or its salt* (AIBIOID) was good, whereas the aftershave bread without the addition of levulinic acid was unfavorable.

50 parts of polyoxyethylene lauryl ether, squalane tag, cetyl alcohol tag.

Each skin cream (0/W
ll) was prepared according to the method described above. For comparison, a skin cream without the addition of levulinic acid or its salts was also prepared.

1) Quality characteristics Levulinic acid and its salts 1ii1 (A*B*'
*' *Both the skin cream in II) and the skin cream without the addition of levulinic acid, the appearance remains the same white cream after 2 months of sunlight exposure as immediately after manufacture, and the odor remains at 45℃2.
Even after heating, it is in good condition with no strange odor, and the hardness (50℃) is 45.
It was 7 after heating at 2 degrees Celsius, and 8 immediately after production, showing no change and being stable. U) Sensory characteristics Levulinic acid and its salts @ (A I ” t ' e
Ωsan E)'s skin cream weighs 1g68 < JIIL
K * Gives skin shine, firmness, but does not give skin cream without levulinic acid.

1ii) Stratum corneum turnover rate Levulinic acid and its salts (A, B, O, D.

As shown in Table 6, the skin cream E) promotes the stratum corneum I-operation speed, but the skin cream containing no additives does not.

Example 7 Each skin cream was prepared in the same manner as in Example 6 of the present invention except that the concentration of levulinic acid O was changed as in No. 79.

The quality characteristics, sensory characteristics, and stratum corneum turnover rate of each skin cream were investigated and the results are shown in Table 11117.

Example 8 Skin creams were prepared in the same manner as in Example 7, except that levulinic acid was replaced with triethanolamine levulinate, and the quality characteristics, sensory characteristics, and stratum corneum turnover rate of each skin cream obtained were as follows. As shown in Table 8, the skin creams in Example 7 were the same.

Polyvinyl alcohol 11071+, 50 parts of ethanol, ethylene sorbitan fatty acid ester IIL
Part s, 05 parts of fragrance α, methyl noxpene [1111, 8i 9 parts of water and each of the following levulinic acid and its salts Ii [L5
A transparent film layer was prepared consisting of: For comparison, a pack without the addition of levulinic acid or its salts was also prepared.

1) Quality characteristics Levulinic acid and its salts (A+ Be○l D4K)
Both the levulinic acid-free pack and the pack without the addition of levulinic acid (%) appear as colorless and transparent even after 2 months of sunlight irradiation, as they did immediately after production, and the odor remains good with no off-odor even after 2 months at 45°C, and the viscosity remains at 45°C. No change was observed after 2 months. 1i) Sensory properties A pack containing levulinic acid and its salts (AeBsO*D+ic) gives texture, shine, and firmness to the skin, but a pack without levulinic acid does not.

1li) Stratum corneum turnover rate Levulinic acid and its salts (A, B, C, D.

The pack E) promotes the lower rate of turnover of the stratum corneum as shown in Table 9, but the pack without levulinic acid does not.

Table 9 Example 10 Each pack was prepared in the same manner as in Example 90 of the present invention, except that the amount of levulinic acid was changed as shown in Table #110.

Table 10 shows the results of examining the quality characteristics, sensory characteristics, and stratum corneum turnover rate of each pack.

@10 Table This pack has a transparent appearance when the levulinic acid and its salts are in the above range, is stable without any noticeable decrease in viscosity, can be applied and peeled off easily and uniformly during use, and does not touch the skin after peeling off the film. It gives luster, plumpness, and texture, and promotes the turnover rate of the stratum corneum.As such, the effects of levulinic acid and its salts are remarkable. 3 Item 3 Mr. Harune Shimada, Commissioner of the Japan Patent Office 1. Indication of 1 Patent Application No. 8687 of 1986 2, Name of Invention Relationship to Case of Person Who Makes Five Amendments to Skin and Cosmetics Patent Applicant Address Sumida-ku, Tokyo Sumida 5-chome +7-4, 5-80 Tomo 1-cho, Bejima-ku, Osaka 534, Japan Patent Department, Kanebo Co., Ltd. Telephone: (06) 925-1145 4. Number of inventions increased by amendment None 5. Amendment Discussion Z Contents of amendment (1) "Agglomerated particles?" (so-called gutsu wo) described in the specification, page 4, line 15 to line 16 of the same page, is amended to "agglomerated particle (so-called gutsu wo)."

(2) 9hn an as stated in the specification, page 12, line 14
J is corrected by "Jan-・nJ.

(5) jJurno described in the specification, page 12, line 14
verJf Correct to Cturnover J.

(4) Details 1. r (zo
g・0)” is corrected to f(2LIE・O)J.

(Memei J8 book, page 19, line 5, “(B%C%D
, g) Jt-j (^, a%c, p, g) J [correct.

(6) "No salts added" stated in the specification, No. 20, No. 1 O, is corrected to "Insensitive to salts IFl'ljJ."

(7) In Table 8 on page 2S of the specification, j12.5±[15'' written in the bottom line of the vertical column of 0.5 is
．． s±α2”.

(8) In Table 10 on page 26 of the specification, it is stated in one of the test items that ``External appearance j is corrected to r appearance j.''

(9) r stated in % 12th member line 2 of the specification to line 6 of the same page
2550iJ is corrected by r2s~so JK.

(j1 described in ILIJ specification, page +2, line 7 from the bottom)
974"9J'kr197a, 90,9 JKil
l positive tb.

Claims (4)

[Claims] (1) A skin cosmetic containing 0.05 to 0.7% by weight of leplic acid and/or its salts based on the total amount of prescription ingredients. (2) Leplic acid and/or its salts are contained in an amount of 01 to 115% by weight based on the total amount of prescription ingredients. A skin cosmetic according to claim (1). (3) The skin cosmetic according to Claim No. (1) JJ, wherein the salts of leplic acid are ammonium salts, alkali metal salts, alkaline earth metal salts, and alkanolamine salts of leplic acid. (4) Skin cosmetics include Rosi soda and creams. The skin cosmetic according to claim (1), which is an emulsion or a pack agent 4.