JPS5777646A - Preparation of hydroxamic acid - Google Patents
Preparation of hydroxamic acidInfo
- Publication number
- JPS5777646A JPS5777646A JP15229280A JP15229280A JPS5777646A JP S5777646 A JPS5777646 A JP S5777646A JP 15229280 A JP15229280 A JP 15229280A JP 15229280 A JP15229280 A JP 15229280A JP S5777646 A JPS5777646 A JP S5777646A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxylamine
- water
- halide
- solvent
- room temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled substance useful as a color reaction testing reagent, precipitate forming reagent, medicine, agricultural chemical, etc. in high yield by an easy operation, by reacting a carboxylic acid halide with hydroxylamine in water as a solvent at room temperature.
CONSTITUTION: A carboxylic acid halide of formulaI(R is alkyl, aryl or aralkyl; X is halogen) is reacted with hydroxylamine in water as a solvent at room temperature to give hydroxamic acid of formula II. In case the hydroxylamine is used in the form of a salt, e.g. hydrochloride or sulfate, an equivalent amount of a basic substance, e.g. NaOH or Na2CO3, is simultaneously used.
EFFECT: No removing and separating operation is required due to the metallic halide as a by-product dissolved in water, and the metallic halide will not be contained in the aimed substance. No trouble, e.g. danger, of fire in the absence of an organic solvent used.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15229280A JPS5777646A (en) | 1980-10-31 | 1980-10-31 | Preparation of hydroxamic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15229280A JPS5777646A (en) | 1980-10-31 | 1980-10-31 | Preparation of hydroxamic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5777646A true JPS5777646A (en) | 1982-05-15 |
Family
ID=15537333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15229280A Pending JPS5777646A (en) | 1980-10-31 | 1980-10-31 | Preparation of hydroxamic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5777646A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4534911A (en) * | 1982-12-13 | 1985-08-13 | Continental Pharma, Inc. | Method for the preparation of p-butoxyphenylacetyl-hydroxamic acid in the finely divided state and a composition containing this acid |
| JP2007269732A (en) * | 2006-03-31 | 2007-10-18 | Asahi Kasei Fainkemu Kk | Method for producing bishydroxamic acid |
| US7465719B2 (en) | 2003-01-17 | 2008-12-16 | Topotarget Uk Limited | Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors |
| CN103896810A (en) * | 2014-04-04 | 2014-07-02 | 湖南迪诺制药有限公司 | Synthesis method of bufexamac |
-
1980
- 1980-10-31 JP JP15229280A patent/JPS5777646A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4534911A (en) * | 1982-12-13 | 1985-08-13 | Continental Pharma, Inc. | Method for the preparation of p-butoxyphenylacetyl-hydroxamic acid in the finely divided state and a composition containing this acid |
| US7465719B2 (en) | 2003-01-17 | 2008-12-16 | Topotarget Uk Limited | Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors |
| JP2007269732A (en) * | 2006-03-31 | 2007-10-18 | Asahi Kasei Fainkemu Kk | Method for producing bishydroxamic acid |
| CN103896810A (en) * | 2014-04-04 | 2014-07-02 | 湖南迪诺制药有限公司 | Synthesis method of bufexamac |
| CN103896810B (en) * | 2014-04-04 | 2015-09-16 | 湖南迪诺制药有限公司 | The synthetic method of bufexamac |
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