JPS5773000A - Production of olean-1-2ene-3beta,30-diol - Google Patents
Production of olean-1-2ene-3beta,30-diolInfo
- Publication number
- JPS5773000A JPS5773000A JP14841280A JP14841280A JPS5773000A JP S5773000 A JPS5773000 A JP S5773000A JP 14841280 A JP14841280 A JP 14841280A JP 14841280 A JP14841280 A JP 14841280A JP S5773000 A JPS5773000 A JP S5773000A
- Authority
- JP
- Japan
- Prior art keywords
- olean
- ene
- acid
- triol
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: Glycyrrhetinic acid (olean-12-ene-11-oxo-3β-ol-30-oic acid) is reduced and the product is subjected to catalystic hydrogenation to produce the titled compound used as an anti-inflammatory or antiallergic with industrial advantage.
CONSTITUTION: Glycyrrhetinic acid of formulaI(olean-12-ene-11-oxo-3β-ol-30-oic acid) is reduced, (A) straight by use of bis (2-methoxyethoxy)aluminum sodium hydride, (B) by methyl esterification of glycyrrhitinic acid with a diazomthane solution before the reduction with sodium aluminum hydride to prepare a triol of formula II (olean-12-ene-3β-11ξ,30-triol). The product is subjected to catalytic reduction in the presence of Pd/C catalyst to produce the objective compound of formula III.
EFFECT: The objective compound is obtained in high yield by no use of expensive platinum catalyst.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14841280A JPS5773000A (en) | 1980-10-24 | 1980-10-24 | Production of olean-1-2ene-3beta,30-diol |
| DE19813111522 DE3111522A1 (en) | 1980-04-01 | 1981-03-24 | MEDICINE WITH ANTIULCUS EFFECT, ANTI-INFLAMMATORY AND ANTIALLERGIC EFFECT |
| US06/248,222 US4374284A (en) | 1980-04-01 | 1981-03-27 | Antiulcer, antiinflammatory, and antiallergic agent comprising as the main ingredient olean-12-ene-3β, 30-diol which is devoid of side effects of glycyrrhetinic acid and a new process for preparation of olean-12-ene-3β, 30-diol |
| IT819373A IT1167857B (en) | 1980-04-01 | 1981-03-31 | ANTI-ULCER, ANTI-INFLAMMATORY AND ANTI-ALLERGIC AGENT INCLUDING AS MAIN INGREDIENT OLEAN-12-ENE-3BETA, 30-DIOL AND PREPARATION OF IT |
| GB8110193A GB2075835B (en) | 1980-04-01 | 1981-04-01 | A pharmacological composition comprising and olean-12-ene 3 30 diol or an ester thereof and a process for preparing said compound |
| GB08324020A GB2134525B (en) | 1980-04-01 | 1983-09-07 | Preparation of olean-12-ene-3b 30-diol and esters thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14841280A JPS5773000A (en) | 1980-10-24 | 1980-10-24 | Production of olean-1-2ene-3beta,30-diol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5773000A true JPS5773000A (en) | 1982-05-07 |
| JPS6118536B2 JPS6118536B2 (en) | 1986-05-13 |
Family
ID=15452207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14841280A Granted JPS5773000A (en) | 1980-04-01 | 1980-10-24 | Production of olean-1-2ene-3beta,30-diol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5773000A (en) |
-
1980
- 1980-10-24 JP JP14841280A patent/JPS5773000A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6118536B2 (en) | 1986-05-13 |
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