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JPS5754157A - L-argininal derivative and its preparation - Google Patents

L-argininal derivative and its preparation

Info

Publication number
JPS5754157A
JPS5754157A JP55129097A JP12909780A JPS5754157A JP S5754157 A JPS5754157 A JP S5754157A JP 55129097 A JP55129097 A JP 55129097A JP 12909780 A JP12909780 A JP 12909780A JP S5754157 A JPS5754157 A JP S5754157A
Authority
JP
Japan
Prior art keywords
formula
argininal
leucyl
drug
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55129097A
Other languages
English (en)
Other versions
JPH02342B2 (ja
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyanagi
Shinichi Ishii
Tetsuyuki Saino
Tetsuya Someno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP55129097A priority Critical patent/JPS5754157A/ja
Priority to US06/300,443 priority patent/US4401594A/en
Priority to GB8128012A priority patent/GB2086380B/en
Priority to FR8117674A priority patent/FR2490632B1/fr
Priority to CA000386220A priority patent/CA1183130A/en
Priority to IT49318/81A priority patent/IT1171538B/it
Priority to DE19813137280 priority patent/DE3137280A1/de
Publication of JPS5754157A publication Critical patent/JPS5754157A/ja
Publication of JPH02342B2 publication Critical patent/JPH02342B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP55129097A 1980-09-19 1980-09-19 L-argininal derivative and its preparation Granted JPS5754157A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP55129097A JPS5754157A (en) 1980-09-19 1980-09-19 L-argininal derivative and its preparation
US06/300,443 US4401594A (en) 1980-09-19 1981-09-08 L-Argininal derivatives and a method of manufacturing the same
GB8128012A GB2086380B (en) 1980-09-19 1981-09-16 L-argininal derivatives
FR8117674A FR2490632B1 (fr) 1980-09-19 1981-09-18 Derives de l-argininal et procede de preparation
CA000386220A CA1183130A (en) 1980-09-19 1981-09-18 L-argininal derivatives and a method of manufacturing the same
IT49318/81A IT1171538B (it) 1980-09-19 1981-09-18 Derivati di l-arginale e metodo per produrli
DE19813137280 DE3137280A1 (de) 1980-09-19 1981-09-18 L-argininalderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55129097A JPS5754157A (en) 1980-09-19 1980-09-19 L-argininal derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5754157A true JPS5754157A (en) 1982-03-31
JPH02342B2 JPH02342B2 (ja) 1990-01-08

Family

ID=15000995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55129097A Granted JPS5754157A (en) 1980-09-19 1980-09-19 L-argininal derivative and its preparation

Country Status (7)

Country Link
US (1) US4401594A (ja)
JP (1) JPS5754157A (ja)
CA (1) CA1183130A (ja)
DE (1) DE3137280A1 (ja)
FR (1) FR2490632B1 (ja)
GB (1) GB2086380B (ja)
IT (1) IT1171538B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61148275U (ja) * 1985-03-08 1986-09-12
JPH07500167A (ja) * 1991-10-14 1995-01-05 キャッシュ・エンジニアリング・リサーチ・プロプライエタリ・リミテッド 圧縮機システム用入口制御複合装置

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124233B (en) * 1982-07-19 1985-09-18 Nat Res Dev Synthetic peptides and their preparation
GB8312339D0 (en) * 1983-05-05 1983-06-08 Austen B M Peptides
IT1223604B (it) * 1987-12-24 1990-09-29 Co Pharma Corp Srl Derivati purinici ad azione farmacologica
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
JPH0813835B2 (ja) * 1990-09-05 1996-02-14 日東紡績株式会社 ピログルタミン酸残基を有するトリペプチド誘導体
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
CA2104602A1 (en) * 1991-02-22 1992-08-23 Carl N. Hodge Substituted .alpha.-aminoaldehydes and derivatives
AU2882792A (en) * 1991-10-23 1993-05-21 Procter & Gamble Company, The Tripeptide derivative anti-inflammatory agents
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
US5932733A (en) * 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5883107A (en) * 1994-06-17 1999-03-16 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5714499A (en) * 1994-06-17 1998-02-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
JPH10503176A (ja) * 1994-06-17 1998-03-24 コーバス インターナショナル， インコーポレイテッド 酵素インヒビターとしての３−アミノ−２−オキソ−１−ピペリジン酢酸誘導体
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5550262A (en) * 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
US5614649A (en) * 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5691368A (en) * 1995-01-11 1997-11-25 Hoechst Marion Roussel, Inc. Substituted oxazolidine calpain and/or cathepsin B inhibitors
DE19520792A1 (de) * 1995-06-07 1996-12-12 Bloch Wilhelm Dr Verwendung der Stickstoffmonoxidsynthese hemmenden Substanzen der Gruppe der L-Argininanaloge zur Herstellung eines Mittels zur Abschwellung entzündlich bzw. allergisch angeschwollener Nasenschleimhaut und der Hemmung entzündlich und allergisch bedingter Nasensekretion
US6214800B1 (en) 1995-10-25 2001-04-10 Senju Pharmaceutical Co., Ltd. Angiogenesis inhibitor
ES2193615T3 (es) 1995-10-25 2003-11-01 Senju Pharma Co .nhibidor de la angiogenesis.
CA2217550A1 (en) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
WO1999026920A1 (en) * 1997-11-26 1999-06-03 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii)
US6204384B1 (en) 1997-11-26 2001-03-20 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941418A (ja) * 1972-08-29 1974-04-18

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268212A (en) * 1968-04-19 1972-03-22 Zaidan Hojin Biseibutsu Tripeptide derivatives
GB1292846A (en) * 1968-11-21 1972-10-11 Zaidan Hojin Biseibutsu A process for the synthesis of leupeptins and their analogues
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941418A (ja) * 1972-08-29 1974-04-18

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61148275U (ja) * 1985-03-08 1986-09-12
JPH0314144Y2 (ja) * 1985-03-08 1991-03-29
JPH07500167A (ja) * 1991-10-14 1995-01-05 キャッシュ・エンジニアリング・リサーチ・プロプライエタリ・リミテッド 圧縮機システム用入口制御複合装置

Also Published As

Publication number Publication date
FR2490632A1 (fr) 1982-03-26
DE3137280A1 (de) 1982-06-03
CA1183130A (en) 1985-02-26
GB2086380B (en) 1984-05-31
GB2086380A (en) 1982-05-12
US4401594A (en) 1983-08-30
FR2490632B1 (fr) 1986-12-12
JPH02342B2 (ja) 1990-01-08
IT1171538B (it) 1987-06-10
IT8149318A0 (it) 1981-09-18

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