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JPS5747488A - Improved method of producing antibiotic - Google Patents

Improved method of producing antibiotic

Info

Publication number
JPS5747488A
JPS5747488A JP12143380A JP12143380A JPS5747488A JP S5747488 A JPS5747488 A JP S5747488A JP 12143380 A JP12143380 A JP 12143380A JP 12143380 A JP12143380 A JP 12143380A JP S5747488 A JPS5747488 A JP S5747488A
Authority
JP
Japan
Prior art keywords
methyl
carboxylic acid
improved method
cephem
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12143380A
Other languages
Japanese (ja)
Other versions
JPH0123473B2 (en
Inventor
Hiroshi Gushima
Kensho Nagano
Takeshi Saito
Yoji Yamaguchi
Kenichi Suzuki
Katsuyuki Funakoshi
Toshiaki Miyoshi
Shozo Abe
Narimasa Tsunoda
Toshio Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP12143380A priority Critical patent/JPS5747488A/en
Publication of JPS5747488A publication Critical patent/JPS5747488A/en
Publication of JPH0123473B2 publication Critical patent/JPH0123473B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: The compound, which is produced, when St. oganonensis is cultured in the presence of magnesium carbonate, is treated with a D-aminoacid oxidase to produce 7β-( 4-carboxybutyramide )-3-( 1-methyl-1H-tetrazol-5-yl )thiomethyl-7α- methoxy-3-cephem-4-carboxylic acid.
CONSTITUTION: Streptomyces oganonensis is cultured in a medium containing magnesium carbonate to form 7β-(5-amino-5-carboxyvaleramide)-3-hydroxymethyl-7α- methyoxy-3-cephem-4-carboxylic acid and cell bodies having activity of D-aminoacid oxidase or its treatment product is made to act on the compound. Further, diketene, then 1-methyl-5-mercaptotetrazole are made to act on the product to produce 7β- ( 4-carboxylbutyramide )-3-( 1-methyl-1H-tetrazol-5-yl )thiomethyl-7α-methoxy-3- cepthem-4-carboxylic acid.
COPYRIGHT: (C)1982,JPO&Japio
JP12143380A 1980-09-02 1980-09-02 Improved method of producing antibiotic Granted JPS5747488A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12143380A JPS5747488A (en) 1980-09-02 1980-09-02 Improved method of producing antibiotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12143380A JPS5747488A (en) 1980-09-02 1980-09-02 Improved method of producing antibiotic

Publications (2)

Publication Number Publication Date
JPS5747488A true JPS5747488A (en) 1982-03-18
JPH0123473B2 JPH0123473B2 (en) 1989-05-02

Family

ID=14811012

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12143380A Granted JPS5747488A (en) 1980-09-02 1980-09-02 Improved method of producing antibiotic

Country Status (1)

Country Link
JP (1) JPS5747488A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59173181U (en) * 1983-05-06 1984-11-19 松下電器産業株式会社 disk jacket
JPS6298063U (en) * 1985-12-10 1987-06-22

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59173181U (en) * 1983-05-06 1984-11-19 松下電器産業株式会社 disk jacket
JPH0514367Y2 (en) * 1983-05-06 1993-04-16
JPS6298063U (en) * 1985-12-10 1987-06-22

Also Published As

Publication number Publication date
JPH0123473B2 (en) 1989-05-02

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