JPS5740492A - Novel 2-phenylimidazo 2,1-b benzothiazole derivative - Google Patents
Novel 2-phenylimidazo 2,1-b benzothiazole derivativeInfo
- Publication number
- JPS5740492A JPS5740492A JP55115610A JP11561080A JPS5740492A JP S5740492 A JPS5740492 A JP S5740492A JP 55115610 A JP55115610 A JP 55115610A JP 11561080 A JP11561080 A JP 11561080A JP S5740492 A JPS5740492 A JP S5740492A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- agent
- halogen
- nitroso
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- RBQGKSWYSQGVDV-UHFFFAOYSA-N imidazo[2,1-b][1,3]benzothiazole Chemical compound C1=CC=C2N3C=CN=C3SC2=C1 RBQGKSWYSQGVDV-UHFFFAOYSA-N 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- GKCLFRIPYBZAML-UHFFFAOYSA-N nitroso thiocyanate Chemical compound O=NSC#N GKCLFRIPYBZAML-UHFFFAOYSA-N 0.000 abstract 1
- -1 nitroso, carboxy Chemical group 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled derivative of formula I (R<1>, R<2> and R<3> are H, halogen, OH, nitro, nitroso, carboxy, etc.; R<4>, R<5> and R<6> are H, halogen, OH, nitro, nitroso, thiocyanate, etc.; the dotted line represents the presence or absence of double bond) and a salt thereof. EXAMPLE:7-Hydroxy-2-(p-methoxyphenyl)imidazo[2,1-b]benzothiazole. USE:Useful as an immunological regulator, antiallergic agent, antiasthmatic agent, antirheumatic agent, anticancer agent, remedy for autoimmune diseases, and rejection inhibitor in organ transplantation or skin grafting. PROCESS:A compound of formula II [A is carbonyl or formula III (X is halogen)] is cyclized to give the compound of formula I. The reaction is carried out in a solvent, e.g. methanol, if necessary in the presence of a base.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55115610A JPS5740492A (en) | 1980-08-22 | 1980-08-22 | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55115610A JPS5740492A (en) | 1980-08-22 | 1980-08-22 | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5740492A true JPS5740492A (en) | 1982-03-06 |
| JPH0138791B2 JPH0138791B2 (en) | 1989-08-16 |
Family
ID=14666900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55115610A Granted JPS5740492A (en) | 1980-08-22 | 1980-08-22 | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5740492A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6479162A (en) * | 1987-06-17 | 1989-03-24 | Eisai Co Ltd | Benzothiazole derivative |
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
| WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
| EP0816366A4 (en) * | 1995-03-13 | 1998-07-08 | Nikken Chemicals Co Ltd | IMIDAZOTHIAZOL COMPOUNDS |
| US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6248672A (en) * | 1985-06-18 | 1987-03-03 | ビオガル ジヨジセルジヤ−ル | Thiazolinedicarboxylic acid derivative |
| JPS6320237A (en) * | 1986-07-11 | 1988-01-27 | Kubota Ltd | Driving device for hydraulic pump of vehicle |
| JPS6320236A (en) * | 1986-07-11 | 1988-01-27 | Daihatsu Motor Co Ltd | Control device for two/four wheel drive changeover mechanism |
-
1980
- 1980-08-22 JP JP55115610A patent/JPS5740492A/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6248672A (en) * | 1985-06-18 | 1987-03-03 | ビオガル ジヨジセルジヤ−ル | Thiazolinedicarboxylic acid derivative |
| JPS6320237A (en) * | 1986-07-11 | 1988-01-27 | Kubota Ltd | Driving device for hydraulic pump of vehicle |
| JPS6320236A (en) * | 1986-07-11 | 1988-01-27 | Daihatsu Motor Co Ltd | Control device for two/four wheel drive changeover mechanism |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6479162A (en) * | 1987-06-17 | 1989-03-24 | Eisai Co Ltd | Benzothiazole derivative |
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
| EP0816366A4 (en) * | 1995-03-13 | 1998-07-08 | Nikken Chemicals Co Ltd | IMIDAZOTHIAZOL COMPOUNDS |
| US5919799A (en) * | 1995-03-13 | 1999-07-06 | Nikken Chemicals Co., Ltd. | Imidazothiazole compound |
| WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
| US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8129374B2 (en) | 2006-03-17 | 2012-03-06 | Ambit Bioscience Corporation | Method of using imidazolothiazole compounds for the treatment of disease |
| US8557810B2 (en) | 2006-03-17 | 2013-10-15 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8921546B2 (en) | 2006-03-17 | 2014-12-30 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
| US9585892B2 (en) | 2007-09-19 | 2017-03-07 | Ambit Biosciences | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0138791B2 (en) | 1989-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |