JPS57156456A - Preparation of 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3- diene and its derivative - Google Patents
Preparation of 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3- diene and its derivativeInfo
- Publication number
- JPS57156456A JPS57156456A JP4163081A JP4163081A JPS57156456A JP S57156456 A JPS57156456 A JP S57156456A JP 4163081 A JP4163081 A JP 4163081A JP 4163081 A JP4163081 A JP 4163081A JP S57156456 A JPS57156456 A JP S57156456A
- Authority
- JP
- Japan
- Prior art keywords
- butenonitrile
- methyl
- trimethyl
- formula
- cyanocyclohexa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a synthetic raw material of pesticides, pharmaceuticals, etc., in high yield and selectivity, by reacting 3- methyl-3-butenonitrile with 3-methyl-2-butenonitrile in the presence of a base of alkali metal amide.
CONSTITUTION: 3-Methyl-3-butenonitrile of formulaIis made to react with 3- methyl-2-butenonitrile of formula II in the presence of an alkali metal amide base (e.g. lithium diethylamide) to afford 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3-diene, which is converted to 3,5,5-trimethyl-6-cyano-cyclohexa-2-enone of formula IV by hydrolysis. The reaction is preferably carried out by metallizing with alkali metal amide in an ether solvent (e.g. THF), and reacting with the compound of formula II at ≤50°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4163081A JPS57156456A (en) | 1981-03-24 | 1981-03-24 | Preparation of 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3- diene and its derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4163081A JPS57156456A (en) | 1981-03-24 | 1981-03-24 | Preparation of 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3- diene and its derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57156456A true JPS57156456A (en) | 1982-09-27 |
| JPS619304B2 JPS619304B2 (en) | 1986-03-22 |
Family
ID=12613644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4163081A Granted JPS57156456A (en) | 1981-03-24 | 1981-03-24 | Preparation of 1,5,5-trimethyl-3-amino-4-cyanocyclohexa-1,3- diene and its derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57156456A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11753687B2 (en) | 2008-05-14 | 2023-09-12 | Dermtech, Inc. | Diagnosis of melanoma and solar lentigo by nucleic acid analysis |
| US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS639004U (en) * | 1986-07-05 | 1988-01-21 |
-
1981
- 1981-03-24 JP JP4163081A patent/JPS57156456A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11753687B2 (en) | 2008-05-14 | 2023-09-12 | Dermtech, Inc. | Diagnosis of melanoma and solar lentigo by nucleic acid analysis |
| US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS619304B2 (en) | 1986-03-22 |
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