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JPS5714574A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5714574A
JPS5714574A JP8807180A JP8807180A JPS5714574A JP S5714574 A JPS5714574 A JP S5714574A JP 8807180 A JP8807180 A JP 8807180A JP 8807180 A JP8807180 A JP 8807180A JP S5714574 A JPS5714574 A JP S5714574A
Authority
JP
Japan
Prior art keywords
carbostyril
action
formula
agent
carbostyril derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8807180A
Other languages
Japanese (ja)
Other versions
JPS648623B2 (en
Inventor
Takao Nishi
Fujio Tafusa
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP8807180A priority Critical patent/JPS5714574A/en
Publication of JPS5714574A publication Critical patent/JPS5714574A/en
Publication of JPS648623B2 publication Critical patent/JPS648623B2/ja
Granted legal-status Critical Current

Links

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  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyril derivative of formula I(R1 is lower alkyl; R2 is cycloalkyl or pyridyl; A is lower alkylene; the carbon -carbon bond between the 3- and 4-positions in the carbostyril skeleton represents single or double bond).
EXAMPLE: 6-[3-(N-Methyl-N-cyclohexylcarbonylamino)propoxy]carbostyril.
USE: A preventing agent and remedy for thrombosis, phosphodiesterase inhibitor, antiulcer agent, hypotensive agent, cardiotonic agent, etc., having inhibitory action on blood platelet agglutination, inhibitory action on phosphodiesterase, antiulcer action, cardiotonic action, anti-inflammatory action, etc.
PROCESS: A carbostyril derivative of formula II is reacted with a compound of formula III to give a reaction product, which is then reacted with an alkylamine. The resultant carbostyril derivative is further reacted with an acifd chloride to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8807180A 1980-06-27 1980-06-27 Carbostyril derivative Granted JPS5714574A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8807180A JPS5714574A (en) 1980-06-27 1980-06-27 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8807180A JPS5714574A (en) 1980-06-27 1980-06-27 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5714574A true JPS5714574A (en) 1982-01-25
JPS648623B2 JPS648623B2 (en) 1989-02-14

Family

ID=13932613

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8807180A Granted JPS5714574A (en) 1980-06-27 1980-06-27 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5714574A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
WO1993004042A1 (en) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5310989A (en) * 1976-06-08 1978-01-31 Monosolar Inc Method of producing electrochemically semiconductor photovoltaic cell and photovoltaic generator
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5310989A (en) * 1976-06-08 1978-01-31 Monosolar Inc Method of producing electrochemically semiconductor photovoltaic cell and photovoltaic generator
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
EP0531548A1 (en) * 1991-04-03 1993-03-17 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
US5401754A (en) * 1991-04-03 1995-03-28 Otsuka Pharmaceutical Company, Limited Agent for treating thrombosis and phosphodiesterase inhibitor
EP0647447A1 (en) * 1991-04-03 1995-04-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as phosphodiesterase inhibitors
EP0531548B1 (en) * 1991-04-03 1995-09-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
US5532253A (en) * 1991-04-03 1996-07-02 Otsuka Pharmaceutical Company, Limited Agent for treating thrombosis and phosphodiesterase inhibitor
WO1993004042A1 (en) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
US5658926A (en) * 1991-08-23 1997-08-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent

Also Published As

Publication number Publication date
JPS648623B2 (en) 1989-02-14

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