JPS5655355A - Preparation of alkylenediamine derivative - Google Patents
Preparation of alkylenediamine derivativeInfo
- Publication number
- JPS5655355A JPS5655355A JP13175279A JP13175279A JPS5655355A JP S5655355 A JPS5655355 A JP S5655355A JP 13175279 A JP13175279 A JP 13175279A JP 13175279 A JP13175279 A JP 13175279A JP S5655355 A JPS5655355 A JP S5655355A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- protecting group
- alkylenediamine
- group
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound simply in high yield and in high purity effective against bronchial asthma, etc., having bronchodilatory action, etc., by reacting a dihydroxyphenyldihydroxyethane derivative with an alkylenediamine.
CONSTITUTION: A compound shown by the formula I [R is H, lower alkyl, alalkyl, or acyl as a protecting group; Z is a group shown by the formula II (X is halogen or OH) or a group shown by the formula III] is reacted with an alkylenediamine shown by the formula IV (R1 is H, alalkyl or acyl as a protecting group; n is 4W12) in water or in the presence of an inert organic solvent(e.g., methanol, etc.) under reaction conditions to give a reaction product, which is optionally hydrolyzed to remove the protecting group or converted to an acid addition salt, to give a compound shown by the formula V or its acid addition salt. In the reaction, the presence of an acid or preferably a base can shorten the time requied for the condensation reaction or to remove the protecting group.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13175279A JPS5655355A (en) | 1979-10-15 | 1979-10-15 | Preparation of alkylenediamine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13175279A JPS5655355A (en) | 1979-10-15 | 1979-10-15 | Preparation of alkylenediamine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5655355A true JPS5655355A (en) | 1981-05-15 |
Family
ID=15065353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13175279A Pending JPS5655355A (en) | 1979-10-15 | 1979-10-15 | Preparation of alkylenediamine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5655355A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10288602B2 (en) | 2013-01-08 | 2019-05-14 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatement |
| US11357757B2 (en) | 2017-09-13 | 2022-06-14 | Atrogi Ab | Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia |
| US11427539B2 (en) | 2017-09-13 | 2022-08-30 | Atrogi Ab | Beta-hydroxy heterocyclic amines and their use in the treatment of hyperglycaemia |
| US11648216B2 (en) | 2017-09-13 | 2023-05-16 | Atrogi Ab | Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia |
| US11793774B2 (en) | 2017-09-13 | 2023-10-24 | Atrogi Ab | Chiral beta-hydroxyethylamines and their use in the treatment of hyperglycemia |
| WO2023203223A1 (en) | 2022-04-22 | 2023-10-26 | Atrogi Ab | Combinations of beta 2-adrenergic receptor agonists and beta 3-adrenergic receptor agonists, and medical uses thereof |
| WO2024184408A1 (en) | 2023-03-06 | 2024-09-12 | Atrogi Ab | Combination of beta-2-adrenergic receptor agonists and glp-1 receptor agonists for use in treating hyperglycaemia |
-
1979
- 1979-10-15 JP JP13175279A patent/JPS5655355A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10288602B2 (en) | 2013-01-08 | 2019-05-14 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatement |
| US11357757B2 (en) | 2017-09-13 | 2022-06-14 | Atrogi Ab | Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia |
| US11427539B2 (en) | 2017-09-13 | 2022-08-30 | Atrogi Ab | Beta-hydroxy heterocyclic amines and their use in the treatment of hyperglycaemia |
| US11648216B2 (en) | 2017-09-13 | 2023-05-16 | Atrogi Ab | Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia |
| US11793774B2 (en) | 2017-09-13 | 2023-10-24 | Atrogi Ab | Chiral beta-hydroxyethylamines and their use in the treatment of hyperglycemia |
| US12036210B2 (en) | 2017-09-13 | 2024-07-16 | Atrogi Ab | Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia |
| WO2023203223A1 (en) | 2022-04-22 | 2023-10-26 | Atrogi Ab | Combinations of beta 2-adrenergic receptor agonists and beta 3-adrenergic receptor agonists, and medical uses thereof |
| WO2024184408A1 (en) | 2023-03-06 | 2024-09-12 | Atrogi Ab | Combination of beta-2-adrenergic receptor agonists and glp-1 receptor agonists for use in treating hyperglycaemia |
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