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JPS5655355A - Preparation of alkylenediamine derivative - Google Patents

Preparation of alkylenediamine derivative

Info

Publication number
JPS5655355A
JPS5655355A JP13175279A JP13175279A JPS5655355A JP S5655355 A JPS5655355 A JP S5655355A JP 13175279 A JP13175279 A JP 13175279A JP 13175279 A JP13175279 A JP 13175279A JP S5655355 A JPS5655355 A JP S5655355A
Authority
JP
Japan
Prior art keywords
formula
protecting group
alkylenediamine
group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13175279A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Michio Watanabe
Makoto Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP13175279A priority Critical patent/JPS5655355A/en
Publication of JPS5655355A publication Critical patent/JPS5655355A/en
Pending legal-status Critical Current

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound simply in high yield and in high purity effective against bronchial asthma, etc., having bronchodilatory action, etc., by reacting a dihydroxyphenyldihydroxyethane derivative with an alkylenediamine.
CONSTITUTION: A compound shown by the formula I [R is H, lower alkyl, alalkyl, or acyl as a protecting group; Z is a group shown by the formula II (X is halogen or OH) or a group shown by the formula III] is reacted with an alkylenediamine shown by the formula IV (R1 is H, alalkyl or acyl as a protecting group; n is 4W12) in water or in the presence of an inert organic solvent(e.g., methanol, etc.) under reaction conditions to give a reaction product, which is optionally hydrolyzed to remove the protecting group or converted to an acid addition salt, to give a compound shown by the formula V or its acid addition salt. In the reaction, the presence of an acid or preferably a base can shorten the time requied for the condensation reaction or to remove the protecting group.
COPYRIGHT: (C)1981,JPO&Japio
JP13175279A 1979-10-15 1979-10-15 Preparation of alkylenediamine derivative Pending JPS5655355A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13175279A JPS5655355A (en) 1979-10-15 1979-10-15 Preparation of alkylenediamine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13175279A JPS5655355A (en) 1979-10-15 1979-10-15 Preparation of alkylenediamine derivative

Publications (1)

Publication Number Publication Date
JPS5655355A true JPS5655355A (en) 1981-05-15

Family

ID=15065353

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13175279A Pending JPS5655355A (en) 1979-10-15 1979-10-15 Preparation of alkylenediamine derivative

Country Status (1)

Country Link
JP (1) JPS5655355A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10288602B2 (en) 2013-01-08 2019-05-14 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatement
US11357757B2 (en) 2017-09-13 2022-06-14 Atrogi Ab Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia
US11427539B2 (en) 2017-09-13 2022-08-30 Atrogi Ab Beta-hydroxy heterocyclic amines and their use in the treatment of hyperglycaemia
US11648216B2 (en) 2017-09-13 2023-05-16 Atrogi Ab Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia
US11793774B2 (en) 2017-09-13 2023-10-24 Atrogi Ab Chiral beta-hydroxyethylamines and their use in the treatment of hyperglycemia
WO2023203223A1 (en) 2022-04-22 2023-10-26 Atrogi Ab Combinations of beta 2-adrenergic receptor agonists and beta 3-adrenergic receptor agonists, and medical uses thereof
WO2024184408A1 (en) 2023-03-06 2024-09-12 Atrogi Ab Combination of beta-2-adrenergic receptor agonists and glp-1 receptor agonists for use in treating hyperglycaemia

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10288602B2 (en) 2013-01-08 2019-05-14 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatement
US11357757B2 (en) 2017-09-13 2022-06-14 Atrogi Ab Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia
US11427539B2 (en) 2017-09-13 2022-08-30 Atrogi Ab Beta-hydroxy heterocyclic amines and their use in the treatment of hyperglycaemia
US11648216B2 (en) 2017-09-13 2023-05-16 Atrogi Ab Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia
US11793774B2 (en) 2017-09-13 2023-10-24 Atrogi Ab Chiral beta-hydroxyethylamines and their use in the treatment of hyperglycemia
US12036210B2 (en) 2017-09-13 2024-07-16 Atrogi Ab Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia
WO2023203223A1 (en) 2022-04-22 2023-10-26 Atrogi Ab Combinations of beta 2-adrenergic receptor agonists and beta 3-adrenergic receptor agonists, and medical uses thereof
WO2024184408A1 (en) 2023-03-06 2024-09-12 Atrogi Ab Combination of beta-2-adrenergic receptor agonists and glp-1 receptor agonists for use in treating hyperglycaemia

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