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JPS5653682A - Production of novel rifamycin derivative - Google Patents

Production of novel rifamycin derivative

Info

Publication number
JPS5653682A
JPS5653682A JP13051079A JP13051079A JPS5653682A JP S5653682 A JPS5653682 A JP S5653682A JP 13051079 A JP13051079 A JP 13051079A JP 13051079 A JP13051079 A JP 13051079A JP S5653682 A JPS5653682 A JP S5653682A
Authority
JP
Japan
Prior art keywords
rifamycin
formula
derivative
production
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13051079A
Other languages
Japanese (ja)
Other versions
JPS647076B2 (en
Inventor
Goro Tsukamoto
Kenzaburo Yoshida
Norio Aikawa
Masahiro Taguchi
Isamu Uchiumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP13051079A priority Critical patent/JPS5653682A/en
Publication of JPS5653682A publication Critical patent/JPS5653682A/en
Publication of JPS647076B2 publication Critical patent/JPS647076B2/ja
Granted legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (X is H, acetyl; R1 is alkyl, aralkyl, aryl; R2 is H, group originating from 3-substituted rifamycin s of formula II or its 25-O-deacetyl derivative).
EXAMPLE: 4-O-(p-Tolylsulfonyl)rifamycin SV.
USE: Antibiotic.
PREPARATION: The reaction of rifamycin S of formula II or its 25-O-deacetyl derivative or these 3-substituted derivative with a sulfinate salt of R1-SO2M (M is alkali or alkaline earth metal) such as methansulfinic acid is conducted in an inert solvent such as DMSO under near-neutral conditions to give 4-sulfonate ester derivative of Rifamycin SV of formula I. The preferable reaction temperature is room one to 50°C.
COPYRIGHT: (C)1981,JPO&Japio
JP13051079A 1979-10-09 1979-10-09 Production of novel rifamycin derivative Granted JPS5653682A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13051079A JPS5653682A (en) 1979-10-09 1979-10-09 Production of novel rifamycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13051079A JPS5653682A (en) 1979-10-09 1979-10-09 Production of novel rifamycin derivative

Publications (2)

Publication Number Publication Date
JPS5653682A true JPS5653682A (en) 1981-05-13
JPS647076B2 JPS647076B2 (en) 1989-02-07

Family

ID=15036004

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13051079A Granted JPS5653682A (en) 1979-10-09 1979-10-09 Production of novel rifamycin derivative

Country Status (1)

Country Link
JP (1) JPS5653682A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213935A2 (en) * 1985-08-29 1987-03-11 American Home Products Corporation Rifamycin derivatives for treating hepatitis
JPH0684209U (en) * 1993-04-28 1994-12-02 リンナイ株式会社 Cooker exhaust system
CN103641844A (en) * 2013-12-27 2014-03-19 漯河南街村药业集团制药有限公司 Preparation method of low content 25-deacetyl rifamycin S

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50100293A (en) * 1974-01-09 1975-08-08
JPS5123520A (en) * 1974-08-21 1976-02-25 Nisshin Oil Mills Ltd Emarushontoryono seizoho
JPS5218278A (en) * 1975-08-01 1977-02-10 Seikosha Co Ltd Automatic cutter
JPS54106500A (en) * 1978-02-06 1979-08-21 Kanebo Ltd 3-sulforifamycin and its preparation
JPS54122297A (en) * 1978-03-09 1979-09-21 Archifar Lab Chim Farm Method of manufacturing 33aminoorifamycin s and sv

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50100293A (en) * 1974-01-09 1975-08-08
JPS5123520A (en) * 1974-08-21 1976-02-25 Nisshin Oil Mills Ltd Emarushontoryono seizoho
JPS5218278A (en) * 1975-08-01 1977-02-10 Seikosha Co Ltd Automatic cutter
JPS54106500A (en) * 1978-02-06 1979-08-21 Kanebo Ltd 3-sulforifamycin and its preparation
JPS54122297A (en) * 1978-03-09 1979-09-21 Archifar Lab Chim Farm Method of manufacturing 33aminoorifamycin s and sv

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213935A2 (en) * 1985-08-29 1987-03-11 American Home Products Corporation Rifamycin derivatives for treating hepatitis
EP0213935A3 (en) * 1985-08-29 1988-10-05 American Home Products Corporation Rifamycin derivatives for treating hepatitis
JPH0684209U (en) * 1993-04-28 1994-12-02 リンナイ株式会社 Cooker exhaust system
CN103641844A (en) * 2013-12-27 2014-03-19 漯河南街村药业集团制药有限公司 Preparation method of low content 25-deacetyl rifamycin S

Also Published As

Publication number Publication date
JPS647076B2 (en) 1989-02-07

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