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JPS5626847A - Preparation of substituted salicylic acid derivative - Google Patents

Preparation of substituted salicylic acid derivative

Info

Publication number
JPS5626847A
JPS5626847A JP10228479A JP10228479A JPS5626847A JP S5626847 A JPS5626847 A JP S5626847A JP 10228479 A JP10228479 A JP 10228479A JP 10228479 A JP10228479 A JP 10228479A JP S5626847 A JPS5626847 A JP S5626847A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
acid derivative
salicylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10228479A
Other languages
Japanese (ja)
Inventor
Sei Kondo
Kiyohide Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP10228479A priority Critical patent/JPS5626847A/en
Publication of JPS5626847A publication Critical patent/JPS5626847A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound, useful for anti-inflammatory and analgesic agents, efficiently and without danger of explosion, by removing sulfinic acid from an unsaturated ketoester derivative formed by the dehydrogenation of a compound as a raw material which is obtained from a benzyl sulfone derivative.
CONSTITUTION: The titled compound of formula I is obtained by removing sulfinic acid from a compound of formula V (X1 and X2 are Hs, or halogens; R is alkyl; Ar is aryl). The compound of formula V is obtained by dehydrogenation of a compound of formula IV, which is obtained by the rection of a compound of formula II with a compound of the formula CH2=CHCO2R in the presence of a base ( e.g. sodium methoxide or C2H5ONa), in the presence of a dehydrogenat ing agent (e.g. a high-energy quinone or Pd).
EFFECT: The reaction is carried out safely, since diazonium salts are not used. Isolation of the compound of formula III as an intermediate can improve the yield of the compound of formula IV.
COPYRIGHT: (C)1981,JPO&Japio
JP10228479A 1979-08-13 1979-08-13 Preparation of substituted salicylic acid derivative Pending JPS5626847A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10228479A JPS5626847A (en) 1979-08-13 1979-08-13 Preparation of substituted salicylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10228479A JPS5626847A (en) 1979-08-13 1979-08-13 Preparation of substituted salicylic acid derivative

Publications (1)

Publication Number Publication Date
JPS5626847A true JPS5626847A (en) 1981-03-16

Family

ID=14323302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10228479A Pending JPS5626847A (en) 1979-08-13 1979-08-13 Preparation of substituted salicylic acid derivative

Country Status (1)

Country Link
JP (1) JPS5626847A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984663B2 (en) 2001-08-21 2006-01-10 Merck Sharp & Dohme Limited Cyclohexyl sulphones
US7101895B2 (en) 2002-10-04 2006-09-05 Merck Sharp & Dohme Limited Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
US7411004B2 (en) 2001-04-05 2008-08-12 Merck Sharp & Dohme Ltd. Sulphones which modulate the action of gamma secretase
US7595344B2 (en) 2001-04-05 2009-09-29 Merck Sharp & Dohme Limited Sulphones which modulate the action of gamma secretase

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411004B2 (en) 2001-04-05 2008-08-12 Merck Sharp & Dohme Ltd. Sulphones which modulate the action of gamma secretase
US7595344B2 (en) 2001-04-05 2009-09-29 Merck Sharp & Dohme Limited Sulphones which modulate the action of gamma secretase
US7598386B2 (en) 2001-04-05 2009-10-06 Merck Sharp & Dohme Limited Sulphones which modulate the action of gamma-secretase
US6984663B2 (en) 2001-08-21 2006-01-10 Merck Sharp & Dohme Limited Cyclohexyl sulphones
US7304094B2 (en) 2001-08-21 2007-12-04 Merck Sharp + Dohme Cyclohexyl sulphones
US7101895B2 (en) 2002-10-04 2006-09-05 Merck Sharp & Dohme Limited Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

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