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JPS56104864A - Pyrrolidine derivative - Google Patents

Pyrrolidine derivative

Info

Publication number
JPS56104864A
JPS56104864A JP748180A JP748180A JPS56104864A JP S56104864 A JPS56104864 A JP S56104864A JP 748180 A JP748180 A JP 748180A JP 748180 A JP748180 A JP 748180A JP S56104864 A JPS56104864 A JP S56104864A
Authority
JP
Japan
Prior art keywords
formula
compound
alkylthio
methylene substituted
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP748180A
Other languages
Japanese (ja)
Other versions
JPS6310948B2 (en
Inventor
Fumio Shibayama
Seiichiro Yamada
Hiroyuki Kikuchi
Taiji Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP748180A priority Critical patent/JPS56104864A/en
Publication of JPS56104864A publication Critical patent/JPS56104864A/en
Publication of JPS6310948B2 publication Critical patent/JPS6310948B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Pyrrolidine derivatives of formula I (R1 is H, lower alkyl, formyl; R2 is hydroxymethylene, methylene substituted with lower alkoxy groups, methylene substituted with lower alkylthio groups, methylene substituted with aralkyl or lower alkylthio-lower-alkylthio groups, methyl disubstituted with lower alkoxy or alkylthio, sulfur-containing saturated heterocyclic group; X is O, S).
EXAMPLE: 3-(α-Methoxy-α-methylthio)methyl-2-thioxyopyrrolidine, which is named raphantin.
USE: Hypotensor and anesthetic and their synthetic intermediate.
PREPARATION: For example, a compound of formula II is brought into contact with lithium di-isopropylamide to increase the reactivity. Then, the compound of formula II is made to react with a formic ester to form a compound of formula I in which R2 is CHOH.
COPYRIGHT: (C)1981,JPO&Japio
JP748180A 1980-01-24 1980-01-24 Pyrrolidine derivative Granted JPS56104864A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP748180A JPS56104864A (en) 1980-01-24 1980-01-24 Pyrrolidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP748180A JPS56104864A (en) 1980-01-24 1980-01-24 Pyrrolidine derivative

Publications (2)

Publication Number Publication Date
JPS56104864A true JPS56104864A (en) 1981-08-20
JPS6310948B2 JPS6310948B2 (en) 1988-03-10

Family

ID=11666950

Family Applications (1)

Application Number Title Priority Date Filing Date
JP748180A Granted JPS56104864A (en) 1980-01-24 1980-01-24 Pyrrolidine derivative

Country Status (1)

Country Link
JP (1) JPS56104864A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012129A1 (en) * 1991-01-10 1992-07-23 Santen Pharmaceutical Co., Ltd. Cyclic compound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012129A1 (en) * 1991-01-10 1992-07-23 Santen Pharmaceutical Co., Ltd. Cyclic compound
US5461158A (en) * 1991-01-10 1995-10-24 Santen Pharmaceutical Co., Ltd. Substituted butaneolides and butane lactams, and pharmaceutical use thereof

Also Published As

Publication number Publication date
JPS6310948B2 (en) 1988-03-10

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