JPS5571701A - Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient - Google Patents
Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredientInfo
- Publication number
- JPS5571701A JPS5571701A JP14517578A JP14517578A JPS5571701A JP S5571701 A JPS5571701 A JP S5571701A JP 14517578 A JP14517578 A JP 14517578A JP 14517578 A JP14517578 A JP 14517578A JP S5571701 A JPS5571701 A JP S5571701A
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- hydrolyzate
- formic acid
- added
- immunoregulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
PURPOSE: To obtain a hydrolyzate polysaccharide useful for an immunoregulator of cancer, anticular rheumatism, etc., easily soluble in water and capable of forming an aqueous solution scarcely being gelled, by treating a polysaccharide produced by a fungus of corticiaceal with formic acid, followed by hydrolysis.
CONSTITUTION: A polysaccharide, which basidiomycete, a fungus of corticiaceae, for example, a genus of corticium, produces as a metabolic product, is treated with formic acid, and hydrolyzed. In the preparation of a hydrolyzate polysaccharide from the polysaccharide, a starting material, for example, 70W90wt% formic acid is added to the polysaccharide, and stirred at 80W100°C for from 5 minutes to one hour. Formic acid is removed under pressure, water is added to the residue and reflux under heating is continued until deformylation is over. The resulting gelatinous material is removed by centrifugation,an organic solvent is added to the supernatant liquid to precipitate deposists, which are collected. A glucan consisting of β-(1→3) bond as a backbone chain and β-(1→6) bond as a side chain is obtained.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14517578A JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14517578A JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5571701A true JPS5571701A (en) | 1980-05-30 |
Family
ID=15379159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14517578A Pending JPS5571701A (en) | 1978-11-24 | 1978-11-24 | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5571701A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02256620A (en) * | 1989-02-20 | 1990-10-17 | Taito Kk | Composition and method for enhancing effect of fish vaccine |
| WO1991003248A2 (en) * | 1989-09-08 | 1991-03-21 | Alpha Beta Technology, Inc. | Method for immune system activation |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
-
1978
- 1978-11-24 JP JP14517578A patent/JPS5571701A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02256620A (en) * | 1989-02-20 | 1990-10-17 | Taito Kk | Composition and method for enhancing effect of fish vaccine |
| US5663324A (en) * | 1989-09-08 | 1997-09-02 | Alpha-Beta Technology, Inc. | Method for producing underivatized, aqueous soluble β(1-3) glucan |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| US5532223A (en) * | 1989-09-08 | 1996-07-02 | Alpha-Beta Technology, Inc. | Use of aqueous soluble glucan preparations to stimulate platelet production |
| WO1991003248A2 (en) * | 1989-09-08 | 1991-03-21 | Alpha Beta Technology, Inc. | Method for immune system activation |
| US5849720A (en) * | 1989-09-08 | 1998-12-15 | Alpha-Beta Technology, Inc. | Enhancement of non-specific immune defenses by administration of underivatized, aqueous soluble glucans |
| US5322841A (en) * | 1989-09-08 | 1994-06-21 | Alpha-Beta Technology, Inc. | Method for producing neutral glucans for pharmaceutical applications |
| US5633369A (en) * | 1989-09-08 | 1997-05-27 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5783569A (en) * | 1992-08-21 | 1998-07-21 | Alpha-Beta Technology, Inc. | Uses for underivatized, aqueous soluble β(1-3) glucan and compositions comprising same |
| US5817643A (en) * | 1992-08-21 | 1998-10-06 | Alpha-Beta Technology, Inc. | Underivatized, aqueous soluable β(1-3) glucan, composition and method of making same |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| US7022685B2 (en) | 1998-09-25 | 2006-04-04 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
| US7566704B2 (en) | 1998-09-25 | 2009-07-28 | Biopolymer Engineering, Inc. | Very high molecular weight β-glucans |
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