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JPS5547130A - Manufacture of collagen bead - Google Patents

Manufacture of collagen bead

Info

Publication number
JPS5547130A
JPS5547130A JP11946178A JP11946178A JPS5547130A JP S5547130 A JPS5547130 A JP S5547130A JP 11946178 A JP11946178 A JP 11946178A JP 11946178 A JP11946178 A JP 11946178A JP S5547130 A JPS5547130 A JP S5547130A
Authority
JP
Japan
Prior art keywords
collagen
organic solvent
liquid
globular
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11946178A
Other languages
Japanese (ja)
Other versions
JPS641169B2 (en
Inventor
Takeshi Hayade
Hisao Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippi Inc
Original Assignee
Nippi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippi Inc filed Critical Nippi Inc
Priority to JP11946178A priority Critical patent/JPS5547130A/en
Publication of JPS5547130A publication Critical patent/JPS5547130A/en
Publication of JPS641169B2 publication Critical patent/JPS641169B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Glanulating (AREA)

Abstract

PURPOSE: To manufacture collagen beads which can be suitably used as carriers for bioactive substances by the procedure in which a clooagen liquid is dropped in an organic solvent to make the collagen globular and then harden it.
CONSTITUTION: A mixture of aqueous collagen or the kile with a 3 to 30wt% liquid and aqueous dispersin of collagen fibers concentration of collagen substance sobubilized with an enzyme or an alkali is dropped in a water insoluble or non- miscible organic solvent, or ther mixture is emulsified in an organic solvent with an emulsifier, whereupon the collagen is made globular and floated in the organic solvent. Afterwards, an aldehyde compound soluble in the organic solvent used in the collagen solution is added to the globular collagen-containing liquid or an ultraviolet-ray irradiation treatment is applied to the liquid for hardening the collagen particles. Thus, the collagen beads can be manufactured and used as carriers for bioactive substances.
COPYRIGHT: (C)1980,JPO&Japio
JP11946178A 1978-09-28 1978-09-28 Manufacture of collagen bead Granted JPS5547130A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11946178A JPS5547130A (en) 1978-09-28 1978-09-28 Manufacture of collagen bead

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11946178A JPS5547130A (en) 1978-09-28 1978-09-28 Manufacture of collagen bead

Publications (2)

Publication Number Publication Date
JPS5547130A true JPS5547130A (en) 1980-04-03
JPS641169B2 JPS641169B2 (en) 1989-01-10

Family

ID=14761923

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11946178A Granted JPS5547130A (en) 1978-09-28 1978-09-28 Manufacture of collagen bead

Country Status (1)

Country Link
JP (1) JPS5547130A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164723A (en) * 1983-03-10 1984-09-17 Koken:Kk Substrate containing regenerated collagen fibril and its preparation
JPS60174725A (en) * 1984-02-22 1985-09-09 Koken:Kk Substrate containing regenerated collagen fibril and its preparation
JPH05246422A (en) * 1992-02-28 1993-09-24 Enshu Shikogyo Kk Production of waterproof corrugated board case
JPH05294753A (en) * 1992-04-23 1993-11-09 Fuji Elelctrochem Co Ltd Production of ferrite porous body
JPH06511197A (en) * 1991-12-20 1994-12-15 アライド−シグナル・インコーポレーテッド Porous crosslinked natural polymer material
JP2006291198A (en) * 2005-03-31 2006-10-26 Ethicon Inc Method for producing cross-linked collagen small sphere
JP2006340679A (en) * 2005-06-10 2006-12-21 Gunma Univ Method for producing fine particle for cell culture, fine particle for cell culture obtained from the method and method of cell culture by using the fine particle
KR100735675B1 (en) 2004-10-16 2007-07-04 유향자 The Processing Method to Improve Efficacy of Collagen by Low-Molecularization and Hydrophilicity, and Collagen Thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5019604A (en) * 1973-06-23 1975-03-01
JPS51141289A (en) * 1975-05-21 1976-12-04 Nisshin Oil Mills Ltd Artificial silkwormmfeeding stuffs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5019604A (en) * 1973-06-23 1975-03-01
JPS51141289A (en) * 1975-05-21 1976-12-04 Nisshin Oil Mills Ltd Artificial silkwormmfeeding stuffs

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164723A (en) * 1983-03-10 1984-09-17 Koken:Kk Substrate containing regenerated collagen fibril and its preparation
JPH043949B2 (en) * 1983-03-10 1992-01-24
JPS60174725A (en) * 1984-02-22 1985-09-09 Koken:Kk Substrate containing regenerated collagen fibril and its preparation
JPH06511197A (en) * 1991-12-20 1994-12-15 アライド−シグナル・インコーポレーテッド Porous crosslinked natural polymer material
JPH05246422A (en) * 1992-02-28 1993-09-24 Enshu Shikogyo Kk Production of waterproof corrugated board case
JPH05294753A (en) * 1992-04-23 1993-11-09 Fuji Elelctrochem Co Ltd Production of ferrite porous body
KR100735675B1 (en) 2004-10-16 2007-07-04 유향자 The Processing Method to Improve Efficacy of Collagen by Low-Molecularization and Hydrophilicity, and Collagen Thereof
JP2006291198A (en) * 2005-03-31 2006-10-26 Ethicon Inc Method for producing cross-linked collagen small sphere
JP2006340679A (en) * 2005-06-10 2006-12-21 Gunma Univ Method for producing fine particle for cell culture, fine particle for cell culture obtained from the method and method of cell culture by using the fine particle

Also Published As

Publication number Publication date
JPS641169B2 (en) 1989-01-10

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