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JPS5463024A - 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use - Google Patents

3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use

Info

Publication number
JPS5463024A
JPS5463024A JP12933777A JP12933777A JPS5463024A JP S5463024 A JPS5463024 A JP S5463024A JP 12933777 A JP12933777 A JP 12933777A JP 12933777 A JP12933777 A JP 12933777A JP S5463024 A JPS5463024 A JP S5463024A
Authority
JP
Japan
Prior art keywords
formula
hydroxyamino
formyl
compound
protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12933777A
Other languages
Japanese (ja)
Inventor
Takashi Kamiya
Shinji Hashimoto
Keiji Henmi
Shuichi Takeno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP12933777A priority Critical patent/JPS5463024A/en
Publication of JPS5463024A publication Critical patent/JPS5463024A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:3-(N-Formyl-N-hydroxyamino)-2(R)-hydroxypropylphonic acid of formula I and its salts.
USE: A preventive and a remedy for bacterially infected diseases.
PROCESS: For example, diethyl 2(R), 3-dihydroxyprophylphosphonate is made to react with a reaction reagnet of formula R2SO3H (R2=alkyl or aryl), e.g. p-toluene sulphonic acid chloride, or its reactive derivative. The reaction product obtained is then made to react with an OH-protecting agent and a compound of formula II (R3-4 are protecting proup of hydroxy and amino groups), e.g. N,O-bis (trimethylsilyl) acetamide to give a compound of formula III (R5=H or hdroxy protecting goup), which is successively subjected to the hydrolysis and the formylation to afford the objective compound.
COPYRIGHT: (C)1979,JPO&Japio
JP12933777A 1977-10-27 1977-10-27 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use Pending JPS5463024A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12933777A JPS5463024A (en) 1977-10-27 1977-10-27 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12933777A JPS5463024A (en) 1977-10-27 1977-10-27 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use

Publications (1)

Publication Number Publication Date
JPS5463024A true JPS5463024A (en) 1979-05-21

Family

ID=15007103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12933777A Pending JPS5463024A (en) 1977-10-27 1977-10-27 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use

Country Status (1)

Country Link
JP (1) JPS5463024A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332729A (en) * 1992-05-08 1994-07-26 Ciba-Geigy Corporation N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
WO2010014943A2 (en) * 2008-08-01 2010-02-04 Bioxiness Pharmaceutics, Inc. Methionine analogs and methods of using same
JP2015536928A (en) * 2012-10-29 2015-12-24 ラボラトワール ビオディム Novel antibacterial compounds and their biomedical applications

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332729A (en) * 1992-05-08 1994-07-26 Ciba-Geigy Corporation N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
US5424441A (en) * 1992-05-08 1995-06-13 Ciba-Geigy Corporation N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids
WO2010014943A2 (en) * 2008-08-01 2010-02-04 Bioxiness Pharmaceutics, Inc. Methionine analogs and methods of using same
WO2010014943A3 (en) * 2008-08-01 2011-01-13 Bioxiness Pharmaceutics, Inc. Methionine analogs and methods of using same
US8580859B2 (en) 2008-08-01 2013-11-12 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same
US9695119B2 (en) 2008-08-01 2017-07-04 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same
JP2015536928A (en) * 2012-10-29 2015-12-24 ラボラトワール ビオディム Novel antibacterial compounds and their biomedical applications

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