JPH1149684A - Climacteric skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin lotion suitable for climacterium remarkably expressing wrinkles, looseness, dullness, etc., by compounding a combination of several kinds of raw materials having widely been used for cosmetics, skin medicines for external uses, etc. SOLUTION: This skin lotion use contains the essence of malt and polyacrylic acid and/or its physiologically acceptable salt. The malt essence is obtained by germinating malt (especially preferably barley) and is contained in an amount of 0.01-10 wt.%. The polyacrylic acid preferably has a polymerization degree of 10-100,000 in the polyacrylic acid portion, and the polyacrylic acid and/or its salt is contained in an amount of 0.01-10 wt.%. The preparation preferably further contains a γ-oryzanol stimulating a blood circulation action and a collagen production action in addition to the essential components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin suitable for use by menopausal persons.

[0002]

2. Description of the Related Art In recent years, the average life expectancy has been remarkably prolonged, and the arrival of an aging society has been announced. In the whole society, systems and products corresponding to the aging society have been produced.
For example, slopes are installed in buildings,
Wheelchairs and the like are becoming available, and in medicine, various drugs for menopausal hormone replacement therapy are being developed. Among such measures, a particularly urgent need is to take measures against changes in the skin during menopause, mainly wrinkles and dullness. In menopause after menopause, various changes in the skin such as wrinkles, sagging, dullness, etc. appear rapidly, and in severe cases, they also bring about remarkable changes in appearance, and these are psychological stresses. This is because there are many cases where the menopause is worsened. If such changes in skin morphology and appearance can be prevented, psychological stress in menopausal disorders can be alleviated to a considerable extent, and there has been a strong demand for the development of a treatment composition having such effects. In particular, a skin external preparation that can be easily treated has been desired.

On the other hand, malt essence, polyacrylic acid and its salts, γ-oryzanol and the like are widely used in the field of external preparations for skin such as cosmetics and external preparations for skin, but they are used in combination. It was not known at all, nor was it known that the use of these in combination would provide a skin external preparation suitable for the above menopause. Furthermore, it has not been known at all that cosmetics containing such raw materials are suitable for improvement of wrinkles, sagging and dullness in menopause.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide a skin external preparation suitable for menopause, in which wrinkles, sagging, dullness, etc. are remarkably exhibited. .

[0005]

In view of this situation, the present inventors have conducted intensive studies in search of an external preparation for skin suitable for menopause in which wrinkles, sagging, dullness, etc. remarkably appear. Such action was found in a skin external preparation characterized by containing acrylic acid and / or a physiologically acceptable salt thereof, and the present invention was completed. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Changes in skin morphology and physiology during menopause As described above, skin changes significantly morphologically or physiologically during menopause. Its characteristics are wrinkles, sagging,
Various changes of the skin such as dullness suddenly appear, and in severe cases, even a remarkable change in appearance.
This is a phenomenon that appears regardless of gender, and the cause is considered to be a remarkable modulation of hormonal balance of estrogen, progesterone and androgen during menopause. These can be prevented to a large extent by hormone replacement therapy, but they are not enough to remedy wrinkles and tarmi that have occurred once.
It was not very effective against dullness.
The morphological features of such changes are that the dermal collagen fiber bundles are disrupted in the skin, the water retention capacity of collagen itself is significantly reduced, and the collagen production capacity The present inventors have found that the blood circulation, particularly blood circulation in peripheral capillaries is inhibited, and the metabolic rate is reduced.

(2) Essence of malt used in the present invention The essence of malt of the present invention is an essence of malt obtained by germinating wheat, and any of wheat, barley and oat may be used. Although possible, barley is most preferred. The essence referred to in the present invention is malt itself, malt dried, shredded, pulverized processed product, pressed product obtained by pressing malt, malt itself or an extract extracted by adding a solvent to the processed product and its solvent. Removed products, squeezed products, extracts, extracts, solvent removal of the extract is a generic term for purified products obtained by fractionation and purification by column chromatography, liquid-liquid extraction, etc. and their solvent removal products, etc. The solvent removed is particularly preferred. The extraction may be performed according to a conventional method.
Water, alcohols such as ethanol, methanol and 1,3-butanediol, ketones such as acetone and methyl ethyl ketone, ethers such as diethyl ether and tetrahydrofuran, halogenated hydrocarbons such as methylene chloride and chloroform, acetonitrile, acrylonitrile and the like 1 to 10 times the amount of one or more selected from esters such as nitriles, ethyl acetate, methyl formate, etc., and immerse for several days at room temperature and several hours at a temperature near the boiling point. Good. Preferred among the extracts are alcohol extracts. Among them, 1,3-butanediol, glycerin,
Polyhydric alcohol extracts such as propylene glycol and polyethylene glycol are particularly preferred. The preferred content of these malt essences in the present invention is 0.01 to 10% by weight, more preferably 0.05 to 7% by weight, and even more preferably 0.1 to 10% by weight, based on the total amount of the external preparation for skin.
1 to 5% by weight. (Production Example 1) To 1 kg of malt of barley was added 5 l of 1,3-butanediol, and the mixture was heated and stirred at 80 ° C for 3 hours, cooled and filtered to remove insolubles, thereby obtaining malt essence 1. (Production Example 2) Ethanol 2 was obtained by adding 5 l of ethanol to 1 kg of barley malt, heating under reflux and filtering to remove insolubles, and distilling under reduced pressure. (Production Example 3) To 1 kg of malt of wheat was added 5 l of ethanol, and the mixture was heated under reflux and filtered to remove insolubles. (Production Example 4) To 1 kg of malt of oats was added 5 l of ethanol, and the mixture was heated under reflux and filtered to remove insolubles.

(3) The polyacrylic acid used in the present invention and / or a physiologically acceptable salt thereof The polyacrylic acid portion of the polyacrylic acid and / or a physiologically acceptable salt thereof used in the present invention includes: The polymerization degree is preferably from 10 to 100,000, and these are already commercially available, and can be produced according to a conventional method such as a solution polymerization method. Examples of these physiologically acceptable salts include alkali metal salts such as potassium and sodium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, basic amino acid salts such as lysine and arginine, and triethanolamine. And organic amine salts such as triethylamine. The preferred content of polyacrylic acid and / or a physiologically acceptable salt thereof in the external preparation for skin of the present invention is 0.01 to 10% by weight, more preferably 0.05 to 7% by weight. ,
More preferably, it is 0.1 to 5% by weight.

(4) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the above malt essence and polyacrylic acid and / or a physiologically acceptable salt thereof. The characteristic action of the external preparation for skin of the present invention is to promote blood circulation, promote collagen production, and improve wrinkles, sagging and dullness. In particular, it works effectively against such phenomena that occur after menopause. As the skin external preparation of the present invention, a lotion,
Preferred examples include cosmetics such as emulsions, creams, foundations and packs, and external skin pharmaceutical compositions such as ointments, creams, solutions and patches. The most preferred form is a cosmetic that can be used every day. This is because the skin external preparation of the present invention is excellent in safety. The external preparation for skin of the present invention particularly preferably contains γ-oryzanol, which promotes blood circulation promoting action and collagen producing action, in addition to these essential components. The preferred content of γ-oryzanol is 0.001 to 1% by weight, more preferably 0.005 to 0.5% by weight, and still more preferably 0.01 to 0.1% by weight. Other components preferably contained in the external preparation for skin of the present invention include, for example, salts of hyaluronic acid, salts of polysulfated polysaccharides, salts of sulfated polysaccharides, lecithin, phosphatidylethanolamine, phosphatidylinositol, methacryloyl. Oxyethyl phosphorylcholine is a monomer or one of the monomers
It is preferable to contain a substance having an excellent action of maintaining moisture retention, such as a phospholipid such as a polymer or a copolymer. The preferred content of these moisturizing substances is 0.1 to 2
0% by weight, more preferably 0.2 to 10% by weight, still more preferably 0.5 to 5% by weight. In addition to these components, the external preparation for skin of the present invention can contain optional components usually used in external preparations for skin. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, Stearic acid, fatty acids such as oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants,
Examples include cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, dyes, and powders. It should be noted here that since the skin function is deteriorated in the climacteric period, it is particularly preferable to use a surfactant having high skin irritation such as a surfactant as much as possible. Therefore, it is preferable to use a hydrophilic surfactant having low skin irritation without using a raw material having high skin irritation such as an anionic surfactant. As such a surfactant, a nonionic surfactant is preferable, and polyoxyethylene polyoxypropylene alkyl ether is preferably used as a hydrophilic surfactant. Further, glycerin is preferably contained as a polyhydric alcohol, and the content is also 10 to 25% by weight, more preferably 15 to 20% by weight.
It is particularly preferable to contain a large amount by weight.

[0010]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to examples, but it goes without saying that the present invention is not limited only to these examples.

Example 1 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) Lauryl ether 0.1 parts by weight Lecithin 2 parts by weight b 1, 3-butanediol 10 parts by weight Glycerin 20 parts by weight Malt essence 11 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60.8 parts by weight

Example 2 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) Lauryl ether 0.1 parts by weight Lecithin 2 parts by weight b 1, 3-butanediol 10 parts by weight Glycerin 20 parts by weight Malt essence 21 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60.8 parts by weight

Example 3 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) Lauryl ether 0.1 parts by weight Lecithin 2 parts by weight b 1, 3-butanediol 10 parts by weight Glycerin 20 parts by weight Malt essence 31 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60.8 parts by weight

Example 4 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) Lauryl ether 0.1 parts by weight Lecithin 2 parts by weight b 1, 3-butanediol 10 parts by weight Glycerin 20 parts by weight Malt essence 41 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 parts by weight Methyl paraben 0.3 parts by weight Water 60.8 parts by weight

Example 5 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) lauryl ether 0.1 parts by weight Lecithin 2 parts by weight γ-oryzanol 0.5 parts by weight b 1,3-butanediol 10 parts by weight glycerin 20 parts by weight Malt essence 1 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60.3 Parts by weight

Example 6 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) lauryl ether 0.1 parts by weight Lecithin 2 parts by weight γ-oryzanol 0.5 parts by weight b 1,3-butanediol 10 parts by weight glycerin 20 parts by weight Malt essence 11 1 part by weight Sodium polyacrylate 5 parts by weight Sodium sulfated trehalose 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60. 3 parts by weight

Example 7 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) lauryl ether 0.1 parts by weight Lecithin 2 parts by weight γ-oryzanol 1 part by weight b 1,3-butanediol 10 parts by weight glycerin 20 parts by weight Malt essence 1 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 59.8 parts by weight

Example 8 An emulsion (cosmetic) was prepared according to the following formulation. That is, (a) and (b) were each heated and dissolved at 80 ° C., (b) was gradually added to (a), emulsified, and cooled by stirring to obtain an emulsion (cosmetic). A Hazelnut oil 0.5 parts by weight Sorbitan monooleate 0.1 parts by weight POE (20) Sorbitan monooleate 0.1 parts by weight POE (34) POP (23) lauryl ether 0.1 parts by weight Phosphalidyl inositol 2 parts by weight γ-oryzanol 0.5 parts by weight b 1,3-butanediol 10 parts by weight glycerin 20 parts by weight Malt essence 1 1 part by weight Sodium polyacrylate 5 parts by weight Sodium hyaluronate 0.1 part by weight Methyl paraben 0.3 parts by weight Water 60.3 parts by weight

<Example 9> The emulsions (cosmetics) of Examples 1 to 5 were subjected to 1 month using a group of 10 female panelists with postmenopausal menopause suffering from wrinkles, sagging and dullness. A use test was carried out to examine the effect of the emulsion (cosmetic) of the present invention. In other words, they were used twice a day in the morning and evening, and a questionnaire was given to improve wrinkles, sagging, and dullness. Comparative Example 1 was obtained by replacing sodium polyacrylate of Example 1 with water, and Comparative Example 2 was obtained by replacing malt essence 1 of Example 1 with water. Further, as a control example, a product obtained by replacing the sodium polyacrylate of Example 1 with malt essence 1 with water was used. The results were evaluated as the average value of the scores of the answers (score 3: marked improvement, score 2: improved, score 1: slight improvement, score 0:
(No improvement) is shown in Table 1. From this, it is clear that all the emulsions (cosmetics) of the present invention are excellent in the action of improving wrinkles, sagging and dullness during menopause. Further, as the malt essence, barley malt essence is preferable,
It is understood that it is preferable to contain γ-oryzanol.

[0020]

[Table 1]

Example 10 According to the following formulation,
An external skin pharmaceutical composition was obtained. That is, each of (a), (b) and (c) was heated and solubilized at 80 ° C., (b) was gradually added to (a), and (c) was gradually added and emulsified, followed by stirring and cooling to obtain a skin external pharmaceutical composition. A Diethyl adipate 10 parts by weight Liquid paraffin 5 parts by weight Oleyl alcohol 1 part by weight Stearyl monoglyceride 3 parts by weight POE (20) stearyl ether 1 part by weight POE (34) POP (23) lauryl ether 0.1 part by weight γ-oryzanol 1 Parts by weight estradiol 1 part by weight lecithin 1 part by weight propylparaben 0.1 part by weight b carboxyvinyl polymer 0.2 part by weight glycerin 20 parts by weight malt essence 15 parts by weight sodium hyaluronate 0.1 part by weight water 30 parts by weight c water Potassium oxide 0.2 parts by weight Water 20.4 parts by weight

[0022]

According to the present invention, it is possible to provide an external preparation for skin which is suitable for menopause when wrinkles, sagging, dullness, etc. are remarkably exhibited.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hiromitsu Araki 2-8-16 Funatari, Itabashi-ku, Tokyo

Claims (5)

[Claims] An external preparation for skin, comprising malt essence and polyacrylic acid and / or a physiologically acceptable salt thereof. 2. The external preparation for skin according to claim 1, further comprising γ-oryzanol. 3. The external preparation for skin according to claim 1, which is used for menopause. 4. The external preparation for skin according to any one of claims 1 to 3, which is a cosmetic. 5. The method according to claim 1, which has an action of promoting blood circulation and / or an action of increasing collagen.
5. The external preparation for skin according to any one of items 4 to 4.