JPH11199457A - Water-soluble or water-swelling polymer having dispersibility and production of tooth paste containing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition useful for tooth paste by including a granular water-soluble and water-swelling polymer partially aggregated by a specific amount of polyol treatment. SOLUTION: This composition is obtained by including a granular water-soluble or water-swelling polymer at least partially aggregated by treatment of at least one kind of polyol in an amount of >=10 wt.% based on total weight of the composition. The composition is preferably dispersed in a solvent substantially fast than untreated water-soluble or water-swelling polymer without producing polymer mass. The treatment of polyol is preferably carried out by spraying a liquid polyol into water-soluble or water-swelling polymer particles in a fluidized bed and drying these particles simultaneously with spraying. The water-soluble or water-swelling polymer is polysaccharide, preferably cellulose ether, carrageenan, guar gum, guar derivative or pectin.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition comprising a water-soluble or water-swellable polymer, agglomerated by treatment with a polyol, and to the use of said composition in the manufacture of a toothpaste.

[0002]

BACKGROUND OF THE INVENTION Toothpaste formulations generally include a dentally acceptable abrasive, a humectant, water, and a water-soluble polymer that acts as a component thickener and binder. Flavors, sweeteners,
Various other components such as preservatives, fluorides and the like can also be used at low levels. Glycerol and sorbitol (usually as an aqueous solution) are the most commonly used humectants for toothpastes, and can also contain polyethylene glycol or propylene glycol, depending on the properties desired for the product. Two types of toothpaste are widely manufactured:
1) creamy or opaque; 2) transparent or translucent gel.

The most commonly used thickeners or binders for toothpastes are carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC),
Silica and magnesium aluminum silicate. Carrageenan, xanthan, and polyacrylates are also used, but with a much smaller range.

[0004]

In the process of making toothpastes, the incorporation of a dry, water-soluble binder polymer into a composition often presents difficulties, however, when the dry polymer is added or dispersed in an aqueous system. Is likely to be generated. This increases the time required for homogeneous hydration or dispersion of the binder polymer. Accordingly, there is a need in the industry for a method of formulating a water-soluble binder polymer that results in a lump-free product, rapid viscosity development, and reduced batch preparation time, and facilitates binder handling.

[0005] Japanese Patent Application No. 73036167B discloses that
(1) (a) glycerol or alcohol coating, or (b) treatment of (a) followed by starch paste, shellac, gelatin and agar coating, or (c) a mixture of the substance of (a) and the substance of (b) Carboxymethylcellulose, alginic acid, polyacrylic acid, or a salt thereof, which has been treated by coating; (2) an alkali carbonate optionally treated by the method of (a), (b), and (c);
Disclosed are compositions comprising an alkali salt of bicarbonate, phosphate, polyphosphate or EDTA; and optionally (3) glucose, sugar, fructose, maltose, mannitol, and common salts. When water is added to the composition, it rapidly wets and disperses, and a solution of alginic acid, polyacrylic acid, or carboxymethylcellulose is rapidly obtained.

Japanese Patent Application No. 72044335B discloses that
The solubility of the water-soluble polymer can be
Alternatively, it is taught to improve by coating with an emulsion aid. Water-soluble polymers include methylcellulose, CMC, polyvinyl alcohol, alginic acid, polyacrylic acid or salts thereof, and polyacrylamide. Polyhydric alcohols include sorbitol, mannitol, and inositol, and sugars include glucose, sucrose, and lactose. The coating substance is used in an amount of 0.5 to 10% by weight, preferably 3 to 5% by weight, based on the polymer.

[0007] Guckenberg (Guckenberg)
U.S. Pat. No. 3,850,838 to E. et al. discloses a process for preparing alcohol-insoluble hydrocolloids in the form of readily dispersible and soluble agglomerates, the process comprising combining the hydrocolloid with both water and alcohol. In combination with a soluble carbohydrate binder, and a hydroalcoholic solvent for carbohydrates, granulating the resulting mixture, and then drying the resulting agglomerated granules.

None of the above patents teaches the use of polyol-aggregated water-soluble or water-swellable polymers in toothpaste compositions.

[0009]

SUMMARY OF THE INVENTION The present invention is directed to a composition comprising a particulate water-soluble or water-swellable polymer at least partially agglomerated by treatment with at least one polyol. The polyol is at a level greater than about 10% by weight based on the total weight of the composition;
It relates to the above composition. The composition disperses in the solvent substantially faster than the corresponding untreated water-soluble or water-swellable polymer without forming a lump of polymer.

[0010] Another aspect of the present invention is an improved method of making a toothpaste composition comprising at least one dry water-soluble or water-swellable polymer, wherein the improvement is dry water-soluble or water-swellable. Instead of the polymer, it relates to a process as described above, comprising using a particulate water-soluble or water-swellable polymer at least partially agglomerated by treatment with a polyol. A particulate water-soluble or water-swellable polymer that has been at least partially agglomerated by treatment with a polyol is substantially more soluble than the corresponding untreated water-soluble or water-swellable polymer without forming a lump of polymer. Hydrate quickly to water or water-containing solvents.

[0011] The composition of the present invention comprises a particulate water-soluble or water-swellable polymer, at least partially agglomerated by treatment with at least one polyol, wherein the polyol comprises the total weight of the composition. At levels greater than about 10% by weight, based on Agglomeration is defined here as the aggregation of individual particles which results in an increase in the size of the particulate matter.

[0012] Natural or synthetic water-soluble or water-swellable polymers can be used to prepare the compositions of the present invention. Preferred water-soluble or water-swellable polymers are polysaccharides. Useful polysaccharides include cellulose ethers, guar, guar derivatives, carob gum, syllium, gum arabic, guttie gum, karaya gum, tragacanth gum, carrageenan, agar, algin, xanthan, hard glucan, dextran, pectin, starch, chitin, and Includes, but is not limited to, chitosan.

Preferred polysaccharides are cellulose ethers,
Carrageenan, guar, guar derivatives, and pectin.

The cellulose ether used in the present invention includes hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), water-soluble ethyl hydroxyethyl cellulose (EHEC), carboxymethyl cellulose (CMC), carboxymethyl hydroxyethyl cellulose (CMHEC), Hydroxypropyl hydroxyethyl cellulose (HPHEC), methyl cellulose (MC), methyl hydroxypropyl cellulose (MHPC), methyl hydroxyethyl cellulose (M
HEC), carboxymethyl methylcellulose (CMM)
C), hydrophobically modified carboxymethylcellulose (HMC
MC), hydrophobically modified hydroxyethyl cellulose (HM
HEC), hydrophobically modified hydroxypropylcellulose (HMHPC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), hydrophobically modified carboxymethylhydroxyethylcellulose (HMCMHEC), hydrophobically modified hydroxypropylhydroxyethylcellulose (HMHPHEC), hydrophobic Modified methylcellulose (HMMC), hydrophobically modified methylhydroxypropylcellulose (HMMHPC), hydrophobically modified methylhydroxyethylcellulose (HMMHEC), hydrophobically modified carboxymethylmethylcellulose (HMMCMC), cationic hydroxyethylcellulose (cationic HEC) ),
And cationic hydrophobically modified hydroxyethyl cellulose (cationic HMHEC). Preferred cellulose ethers are carboxymethyl cellulose and hydroxyethyl cellulose.

Guar derivatives used in the present invention include carboxymethyl guar (CM guar), hydroxyethyl guar (HE guar), hydroxypropyl guar (HP guar), carboxymethyl hydroxypropyl guar (CMHP guar), Ionic guar, hydrophobically modified guar (HM guar), hydrophobically modified carboxymethyl guar (HMCM guar), hydrophobically modified hydroxyethyl guar (HMHE guar), hydrophobically modified hydroxypropyl guar (HMHP guar), cation Includes hydrophobically modified hydroxypropyl guar (cationic HMHP guar), hydrophobically modified carboxymethyl hydroxypropyl guar (HMCMHP guar), and hydrophobically modified cationic guar (HM cationic guar).

The more preferred polysaccharides used in preparing the compositions of the present invention are carboxymethylcellulose, carrageenan and pectin, or mixtures thereof. Most preferred is carboxymethylcellulose.

The polyols used to aggregate the water-soluble or water-swellable polymers include sugars, sugar alcohols,
Glycerol, polyethylene glycol, propylene,
And mixtures thereof, but are not limited thereto.

Typical sugars are sucrose, glucose, lactose, fructose, and xylose, or mixtures thereof. Typical sugar alcohols are sorbitol, inositol, mannitol, galactidol, arabitol, ribitol, xylitol, and mixtures thereof.

Preferred polyols for use in the present invention are sorbitol and polyethylene glycol, or mixtures thereof. The molecular weight of the polyethylene glycol used in the present invention is not critical. Polyethylene glycol is preferably from about 200 to about 5,000.
000, more preferably from about 600 to about 25,000.
0, most preferably from about 1,000 to about 10,000
Having a molecular weight of

In the compositions of the present invention, the polyol used for agglomeration is at a level greater than about 10% by weight, based on the total weight of the composition. The maximum level of polyol is preferably about 90% by weight, more preferably about 50% by weight, and most preferably about 30% by weight.

The agglomerated composition is prepared by spraying the particulate polymer with a liquid polyol. The polyol may be in a molten state or a solution state, and is preferably an aqueous solution. In a preferred method, a molten polyol or polyol solution is sprayed onto particles of a water-soluble or water-swellable polymer in a fluidized bed, while simultaneously drying the particles if the polyol is in solution. Commercially available fluidized bed spray units can be used for this operation.

The agglomerated compositions of the present invention hydrate or disperse in water or water-containing solvents substantially faster than the corresponding untreated water-soluble or water-swellable polymers without forming a lump of polymer. I do. The rate of hydration or dispersion is determined by the Haake Visco Tester.
ter) 501, which is the torque (force) required to maintain rotation of the sensor in solution at a regulated speed (400 rpm) as the polymer hydrates and thickens. ) Measure the amount. The hydration time is a final viscosity of 9
The final viscosity is taken as the minutes required to achieve 5%, and the final viscosity is the average of the last 20 minutes of viscosity in a 2 hour test.

In this work, the hydration in water was determined to be 55 ° C. For example, under the above conditions, untreated carboxymethylcellulose immediately clumps and takes about 15 minutes to reach 95% viscosity, while carboxymethylcellulose aggregated by treatment with 20% by weight sorbitol or 20% by weight polyethylene glycol. Immediately produced some clumps, which quickly dispersed and dissolved in less than 1 minute.

An additional advantage of these compositions is that agglomeration serves to reduce the amount of dusting that occurs when handling untreated polymers.

The toothpaste of the present invention comprises an abrasive, a humectant,
And a water-soluble polymer. Humectants are used in toothpastes, particularly at the nozzle end of tubes where the toothpaste has long contact with air, to retain moisture. The water-soluble polymer acts as a thickener and binder for the components.
Various other ingredients such as flavors, sweeteners, preservatives, detergents, anticalculus, antiplaque, and fluoride are also available at low levels.

The dental abrasives used in the toothpastes of the present invention are typically silica and insoluble inorganic salts. Preferred inorganic salts are calcium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, calcium sulfate, insoluble sodium metaphosphate, hydrated aluminum oxide, and magnesium carbonate, and phosphoric acid. Silica and silica xerogels are particularly useful for translucent or transparent toothpastes.

Typical humectants used in the toothpastes of the present invention include glycerol, sorbitol, propylene glycol, or mixtures thereof, which are mixed with a suitable humectant vehicle, such as water.

In the toothpaste of the present invention, the aggregated water-soluble or water-swellable polymer is present in an amount of about 0.5 to about 90% by weight, based on the total weight of the aggregated water-soluble or water-swellable polymer. At a level of. Preferred levels are from about 2 to about 50% by weight,
A more preferred level is from about 10 to about 30% by weight.

For the preparation of the toothpaste according to the invention, the water-soluble or water-swellable polymer agglomerated by treatment with the polyol comprises: a) a humectant or a mixture of humectants;
b) humectant vehicle, most typically water; c) salt,
Stirred with flavor, colorant, surfactant; and d) abrasive to obtain a complete toothpaste formulation. In a preferred preparation method, the aggregated water-soluble polymer is
Directly added to the mixture of humectant and humectant vehicle,
Stir until the polymer particles are sufficiently dissolved or swelled, then the salt is added, followed by the abrasive. The abrasive is added after the salt has completely dissolved. The mixture is agitated until the abrasive particles are moistened, then the flavor is added, followed by the surfactant.

The present invention is illustrated by the following examples, which are intended to be illustrative, but not limiting. All percentages, parts, etc. are by weight unless otherwise indicated.

[0031]

Examples Examples 1-14 show the preparation and testing of carrageenan and carboxymethylcellulose, aggregated by treatment with polyethylene glycol or sorbitol. Carrageenan was GENU® (available from Hercules, Wilmington, Del.). Carboxymethyl cellulose is CM
C7MF or CMC 7MXF (available from Hercules, Wilmington, Del.).

The polymer was prepared in a Glatt fluid bed processor (Model GPCG-5) top spray unit to a final polyol level of about 20% by weight, polyethylene glycol, PEG 4600 and 1450 (Union Carbide, Carbowax, Inc.). (Registered trademark) 4600 and 1450) (25,
33, and 50%). The polymer also has 7
10% and 2% by application of 0% sorbitol aqueous solution
Treated with sorbitol at the 0% level.

In practice, all polyol solutions were heated to 50 ° C. and metered with a calibration pump and scale. The Glatt fluid bed processor was preheated for all tests. Schlick 94
Five nozzles were utilized with a 30/3 second filter shaking cycle, which was slowed down to 2 minutes / 3 seconds after increasing particle size. The atomizing air pressure was set at 2 bar. All products were dried to about 6-8% moisture and then cooled to 30-34 ° C. The batch size was 3 kg.

The agglomerated sample and untreated control were FL1
The dispersibility and hydration / dissolution properties in deionized water at 55 ° C. were evaluated using a Haake VT501 viscometer with a 0 sensor. This instrument measures the amount of torque (force) required to maintain rotation of the sensor in solution at a regulated speed (400 rpm) as the polymer hydrates and thickens. The data is then mathematically converted to viscosity (cps) by a computer.

The hydration time reported in Table 1 is the time required to reach 95% viscosity, assuming 100% of the viscosity for the last 20 minutes of the 2 hour test. The viscosity of each sample is
Tested at 2% concentration based on total solution weight. No modification was made to the amount of polyol or moisture in the sample.

Examples 1-8 and Comparative Example A These examples illustrate the aggregation of carrageenan by treatment with sorbitol and polyethylene glycol.
The data is shown in Table 1. Comparative Example A is to show the hydration time of untreated carrageenan.

[0037]

[Table 1]

Examples 9 to 14 and Comparative Example B and
Fine C These examples illustrate agglomeration of carboxymethyl cellulose by treatment with sorbitol and polyethylene glycol. The data is shown in Table 2. Comparative Examples B and C are to show the hydration time of untreated carboxymethylcellulose.

The data show that the hydration time of carboxymethylcellulose is substantially reduced at a level of 10% or more by aggregation with sorbitol or polyethylene glycol.

[0040]

[Table 2]

Examples 15 and 16 and Comparative Example
D and E These examples illustrate toothpaste formulations utilizing carboxymethylcellulose agglomerated by treatment with sorbitol or polyethylene glycol. The comparative example shows the formulation of the control composition using untreated carboxymethylcellulose.

Examples 15 and 16 show 9% sorbitol and 16% polyethylene glycol (PE
G 1450) describes the preparation of a toothpaste at room temperature using carboxymethylcellulose CMC 7MF agglomerated by treatment with G.1450). Comparative Examples D and E are C
MC 7MF shows a similar formulation untreated. The ingredients and ingredient levels for each formulation are listed in Table 3.

[0043]

[Table 3]

Glycerol-free formulation (Examples 15 and 1)
6 and Comparative Example E), the following procedure was used: Tetrasodium pyrophosphate (0.42 parts), sodium saccharin (0.20 parts), sodium monofluorophosphate (0.76 parts), and sodium benzoate (0.50 parts) were mixed with stirring with 6.25 parts. Added to water and dissolved by heating to about 60 ° C.

2. Carboxymethyl cellulose (1.1
Sorbitol solution (35.43) in a beaker.
And stirred for 15 minutes or until fully dispersed. Then, 8.79 parts of water was added, and the resulting mixture was stirred for 15 to 30 minutes to confirm that the polymer was completely hydrated (gel-free). The warm salt solution from step 1 was then added with stirring, which continued for 15 minutes or until homogenization (no lumps or gels). The mixture was then transferred to a Ross double planetary mixer.

3. Dicalcium phosphate dihydrate (DCP)
(45.00 parts) was added to the mixer and mixing was continued for 10 minutes to completely wet the DCP. The mixer was then opened and the beater and bowl sides scraped off. The mixer was then closed, a vacuum applied, and mixing continued at high speed for 20 minutes or until the mixture was smooth.

4. Sodium lauryl sulfate (1.00
Part) was then added and mixing continued at low speed for 5 minutes without vacuum. The flavor (0.55 parts) was then added and mixing continued at low speed for 2 minutes. The mixer was then opened and the beater and bowl sides scraped off. The mixer was then closed, a vacuum applied and mixing continued at medium speed for 15 minutes. The mixer was then turned off, the vacuum was discontinued, and the toothpaste was packed.

For Comparative Example D utilizing glycerol, the procedure was essentially the same as above, except that carboxymethylcellulose was dispersed in glycerol with stirring in step 2. Stirring was continued for 5 minutes or until the carboxymethylcellulose was well dispersed. The sorbitol solution was then added and stirring continued for another 10 minutes. Water (14.36 parts) was added and stirring was continued for 15-30 minutes to ensure that the polymer was completely hydrated (gel-free). Add warm salt solution and stir for 1
Continued for 5 minutes or until homogenization (no lumps or gels).
The mixture was then transferred to a Ross mixer for the remaining steps.

In Examples 15 and 16, it was observed that the agglomerated carboxymethylcellulose was very easily dispersed in the aqueous sorbitol solution. Hydration of the polymer appeared to have started within about 3-4 minutes and progressed slowly until the addition of water and salt solution. No carboxymethylcellulose mass was observed.

In Comparative Example D, untreated carboxymethylcellulose was readily dispersed in anhydrous glycerol without lumps. However, in Comparative Example E, the untreated carboxymethylcellulose was dispersed in the sorbitol solution only at a very high stirring speed. Hydration of the polymer appeared to have commenced within 1-2 minutes. Some lumps of carboxymethylcellulose were observed in the sorbitol / salt solution.

Examples 17 and 18 and Comparative Example
F and G These examples illustrate a toothpaste formulation utilizing carboxymethylcellulose agglomerated by treatment with sorbitol or polyethylene glycol at 55 ° C. The comparative example shows the formulation of the control composition using untreated carboxymethylcellulose.

Examples 17 and 18 were 9% sorbitol and 16% polyethylene glycol (PE
G 1450) describes the preparation of a toothpaste at room temperature using carboxymethylcellulose CMC 7MF agglomerated by treatment with G.1450). Comparative Examples F and G are C
A similar formulation is shown where MC 7MF is untreated. The ingredients and ingredient levels for each formulation are listed in Table 4.

[0053]

[Table 4]

Glycerol-free formulation (Examples 17 and 1)
8 and Comparative Example G), the following procedure was used: Tetrasodium pyrophosphate (0.42 parts), sodium saccharin (0.20 parts), sodium monofluorophosphate (0.76 parts), and sodium benzoate (0.50 parts) were mixed with stirring with 6.25 parts. Added to water and dissolved by heating to about 60 ° C.

2. The sorbitol solution (35.43 parts) was heated to 55 ° C, then carboxymethylcellulose (1.00 parts) was added with stirring and stirring continued for 15 minutes or until sufficient dispersion was achieved. Then 5
Water (8.89 parts) heated to 5 ° C. was added, and the mixture was stirred for 15 minutes.
Continued for ３０30 minutes to ensure complete hydration of the polymer (no gel). The warm salt solution from step 1 was then added with stirring, which continued for 15 minutes or until homogenization (no lumps or gels). The mixture was then transferred to a Ross double planetary mixer.

3. Dicalcium phosphate dihydrate (DCP)
(45.00 parts) was added to the mixer and mixing was continued for 10 minutes to completely wet the DCP. The mixer was then opened and the beater and bowl sides scraped off. The mixer was then closed, a vacuum applied, and mixing continued at high speed for 20 minutes or until the mixture was smooth.

4. Sodium lauryl sulfate (1.00
Part) was then added and mixing continued at low speed for 5 minutes without vacuum. The flavor (0.55 parts) was then added and mixing continued at low speed for 2 minutes. The mixer was then opened and the beater and bowl sides scraped off. The mixer was then closed, a vacuum applied and mixing continued at medium speed for 15 minutes. The mixer was then turned off, the vacuum was discontinued, and the toothpaste was packed.

The procedure of Comparative Example F differs from that described above only in step 2. The carboxymethylcellulose was dispersed in the glycerol with stirring at 55 ° C., and the stirring was continued for 5 minutes or until sufficient dispersion was achieved. The sorbitol solution was then added and stirring continued for another 10 minutes. 55 ° C water is then added with stirring for 15-30 minutes to ensure complete hydration (gel-free), then the warm salt solution from step 1 is added with stirring and stirring is continued for 15 minutes.
Or continued to homogenization (no lumps or gels). The mixture was then transferred to a Ross double planetary mixer.

In Examples 17 and 18 and Comparative Example F, the carboxymethylcellulose material was found to disperse easily and evenly into hot sorbitol without lumps. Hydration of the polymer began after 1-2 minutes and progressed rapidly after the addition of water and salt solution. The resulting gel phase was very smooth and the resulting paste was a smooth cream. In contrast, in Comparative Example G, it was not possible to achieve a smooth dispersion of untreated carboxymethylcellulose. Even at high stirring speeds, severe lumps of polymer were inevitable.

Example 19 This example illustrates the preparation of a toothpaste containing carrageenan agglomerated by treatment with 20% sorbitol.

Ingredients Glycerol 22 parts Carrageenan (aggregated by treatment with 20% sorbitol 0.96) Sodium benzoate 0.50 Sodium saccharin 0.2 Tetrasodium pyrophosphate 0.25 Sodium monofluorophosphate 0.76 Deionized water 21. 28 dicalcium phosphate 51.75 sodium lauryl sulfate 1.50 peppermint oil 0.80

Procedure A dry blend of sodium saccharin, sodium benzoate, aggregated carrageenan, sodium monofluorophosphate, tetrasodium pyrophosphate is mixed with glycerol,
Stir for 5 minutes. Then water was added and the resulting mixture was heated to 66-71 ° C for 15 minutes. The weight was then returned to the original weight by the addition of distilled water. The mixture was transferred to a Hobart mixer, dicalcium phosphate was added, and the resulting mixture was stirred at a mixer speed of 1 for 2 minutes. The mixer was turned off, the bowl and blades scraped off, and mixing was resumed at speed 2 for 10 minutes.

The paste was transferred to a vacuum deaerator and added while mixing sodium lauryl sulfate and flavor oil, then the mixture was degassed at 0.98 bar for 5 minutes. The resulting toothpaste was then packed into tubes for storage.

During this preparation, the dispersion of aggregated carrageenan
Occurred rapidly without the formation of lumps.

It is to be understood that the examples provided are not to be construed as limiting the invention, but are presented to illustrate some of the specific embodiments of the invention. Various modifications and variations of the present invention may be made without departing from the scope of the appended claims.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Jashawant J. Modi 19707, Delaware, USA, Hockesin, Bella Vista, Rafael Road 57

Claims (37)

[Claims] 1. A composition comprising a particulate water-soluble or water-swellable polymer, at least partially agglomerated by treatment with at least one polyol, wherein the polyol comprises a total weight of the composition. Such a composition, wherein the composition is at a level of greater than about 10% by weight; 2. The composition according to claim 1, wherein the composition disperses in the solvent substantially faster than the untreated water-soluble or water-swellable polymer without forming a mass of the polymer. A composition as described. 3. The process of claim 1, wherein the treatment comprises spraying the at least one polyol in liquid form onto particles of a water-soluble or water-swellable polymer in a fluidized bed while simultaneously drying the particles. Composition. 4. The composition according to claim 1, wherein said water-soluble or water-swellable polymer is at least one polysaccharide. 5. The polysaccharide is a cellulose ether, guar, guar derivative, locust bean gum, syllium, gum arabic, guttie gum, karaya gum, tragacanth gum, carrageenan, agar, algin, xanthan, hard glucan, dextran, pectin, starch, chitin The composition according to claim 4, wherein the composition is at least one selected from the group consisting of: and chitosan. 6. The polysaccharide may be hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HP
C), water-soluble ethyl hydroxyethyl cellulose (EH
EC), carboxymethylcellulose (CMC), carboxymethylhydroxyethylcellulose (CMHE)
C), hydroxypropylhydroxyethylcellulose (HPHEC), methylcellulose (MC), methylhydroxypropylcellulose (MHPC), methylhydroxyethylcellulose (MHEC), carboxymethylmethylcellulose (CMMC), hydrophobically modified carboxymethylcellulose (HMCMC), hydrophobic Modified hydroxyethyl cellulose (HMHEC), hydrophobic modified hydroxypropyl cellulose (HMHPC), hydrophobic modified ethyl hydroxyethyl cellulose (HMEHEC),
Hydrophobic modified carboxymethyl hydroxyethyl cellulose (HMMHHEC), hydrophobic modified hydroxypropyl hydroxyethyl cellulose (HMHPHEC), hydrophobic modified methyl cellulose (HMMC), hydrophobic modified methyl hydroxypropyl cellulose (HMMHPC), hydrophobic modified methyl Hydroxyethyl cellulose (HMMH
EC), hydrophobically modified carboxymethyl methylcellulose (HMMCMC), cationic hydroxyethylcellulose (cationic HEC), and at least one cellulose selected from the group consisting of cationic hydrophobically modified hydroxyethylcellulose (cationic HMHEC) 5. The composition according to claim 4, which is an ether. 7. The method according to claim 7, wherein the polysaccharide is carboxymethyl guar (C
M guar), hydroxyethyl guar (HE guar),
Hydroxypropyl guar (HP guar), carboxymethyl hydroxypropyl guar (CMHP guar),
Cationic guar, hydrophobically modified guar (HM guar), hydrophobically modified carboxymethyl guar (HMCM guar),
Hydrophobic modified hydroxyethyl guar (HMHE guar), hydrophobic modified hydroxypropyl guar (HMHP guar)
Guar), cationic hydrophobically modified hydroxypropyl guar (cationic HMHP guar), hydrophobically modified carboxymethyl hydroxypropyl guar (HMCMHP guar), and hydrophobically modified cationic guar (HM cationic guar) 5. The composition of claim 4, which is at least one guar derivative selected from the group consisting of: 8. The composition according to claim 4, wherein said polysaccharide is carboxymethylcellulose. 9. The composition according to claim 4, wherein said polysaccharide is carrageenan. 10. The composition according to claim 4, wherein said polysaccharide is a mixture of carboxymethylcellulose and carrageenan. 11. The method according to claim 11, wherein the polyol is a sugar, a sugar alcohol,
The composition of claim 1, wherein the composition is selected from the group consisting of glycerol, polyethylene glycol, propylene glycol, and mixtures thereof. 12. The method according to claim 12, wherein the polyol is selected from the group consisting of sorbitol, inositol, mannitol, galactidol, arabirol, ribitol, xylitol, sucrose, glucose, lactose, fructose, xylose, glycerol, polyethylene glycol, propylene glycol, and mixtures thereof. Selected,
The composition according to claim 1. 13. The composition according to claim 1, wherein the polyol is selected from the group consisting of sorbitol, polyethylene glycol and mixtures thereof. 14. The composition of claim 1, wherein the maximum level of the polyol is about 90% by weight based on the total weight of the composition. 15. The composition of claim 14, wherein the maximum level of the polyol is about 50% by weight, based on the total weight of the composition.
A composition according to claim 1. 16. The composition of claim 15, wherein the maximum level of the polyol is about 30% by weight, based on the total weight of the composition.
A composition according to claim 1. 17. The water-soluble or water-swellable polymer,
At least one selected from the group consisting of carrageenan, carboxymethylcellulose, and a mixture thereof; and the polyol is at least one selected from the group consisting of sorbitol, polyethylene glycol, and a mixture thereof. 2. The composition of claim 1, wherein the maximum level is about 50% by weight based on the total weight of the composition. 18. A method of making a toothpaste composition, comprising using at least one dry water-soluble or water-swellable polymer, wherein the improvement comprises a polyol instead of a dry water-soluble or water-swellable polymer. Using a particulate water-soluble or water-swellable polymer that has been at least partially agglomerated by the treatment of. 19. The agglomerated water-soluble or water-swellable polymer can be added to water or a water-containing solvent substantially faster than an untreated water-soluble or water-swellable polymer without forming a lump of polymer. The method according to claim 18, characterized in that it is hydrated. 20. The method according to claim 18, wherein said water-soluble or water-swellable polymer is a polysaccharide. 21. The polysaccharide is a cellulose ether, guar, guar derivative, locust bean gum, syllium, gum arabic, guttie gum, karaya gum, tragacanth gum, carrageenan, agar, algin, xanthan, hard glucan, dextran, pectin, starch, chitin 21. The method according to claim 20, wherein the method is at least one selected from the group consisting of: and chitosan. 22. The polysaccharide is selected from the group consisting of hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HP).
C), water-soluble ethyl hydroxyethyl cellulose (EH
EC), carboxymethylcellulose (CMC), carboxymethylhydroxyethylcellulose (CMHE)
C), hydroxypropylhydroxyethylcellulose (HPHEC), methylcellulose (MC), methylhydroxypropylcellulose (MHPC), methylhydroxyethylcellulose (MHEC), carboxymethylmethylcellulose (CMMC), hydrophobically modified carboxymethylcellulose (HMCMC), hydrophobic Modified hydroxyethyl cellulose (HMHEC), hydrophobic modified hydroxypropyl cellulose (HMHPC), hydrophobic modified ethyl hydroxyethyl cellulose (HMEHEC),
Hydrophobic modified carboxymethyl hydroxyethyl cellulose (HMMHHEC), hydrophobic modified hydroxypropyl hydroxyethyl cellulose (HMHPHEC), hydrophobic modified methyl cellulose (HMMC), hydrophobic modified methyl hydroxypropyl cellulose (HMMHPC), hydrophobic modified methyl Hydroxyethyl cellulose (HMMH
EC), hydrophobically modified carboxymethyl methylcellulose (HMMCMC), cationic hydroxyethylcellulose (cationic HEC), and at least one cellulose selected from the group consisting of cationic hydrophobically modified hydroxyethylcellulose (cationic HMHEC) 21. The method according to claim 20, which is an ether. 23. The polysaccharide is carboxymethyl guar (CM guar), hydroxyethyl guar (HE guar), hydroxypropyl guar (HP guar), carboxymethyl hydroxypropyl guar (CMHP guar), cationic guar, hydrophobic modification Guar (HM guar), hydrophobically modified carboxymethyl guar (HMCM guar), hydrophobically modified hydroxyethyl guar (HMHE)
Guar), hydrophobically modified hydroxypropyl guar (HM
HP guar), cationic hydrophobic modified hydroxypropyl guar (cationic HMHP guar), hydrophobic modified carboxymethyl hydroxypropyl guar (HMCMHP guar), and hydrophobic modified cationic guar (HM cationic guar) 21. The method according to claim 20, which is at least one guar derivative selected from the group. 24. The method of claim 20, wherein said polysaccharide is selected from the group consisting of carboxymethylcellulose, carrageenan, pectin, and mixtures thereof. 25. The method according to claim 20, wherein said polysaccharide is carboxymethylcellulose. 26. The method of claim 2, wherein said polysaccharide is carrageenan.
The method according to 0. 27. The method of claim 20, wherein said polysaccharide is a mixture of carboxymethyl cellulose and carrageenan. 28. The polyol, wherein the polyol is a sugar, a sugar alcohol,
Glycerol, polyethylene glycol, propylene,
20. The method of claim 18, wherein the method is selected from the group consisting of: and mixtures thereof. 29. The polyol is selected from the group consisting of sorbitol, inositol, mannitol, galactidol, arabitol, ribitol, xylitol, sucrose, glucose, lactose, fructose, xylose, glycerol, polyethylene glycol, propylene glycol, and mixtures thereof. Done,
The method according to claim 18. 30. The method of claims 18 or 25-27, wherein said polyol is selected from the group consisting of sorbitol, polyethylene glycol, and mixtures thereof. 31. The at least partially agglomerated, particulate water-soluble or water-swellable polymer converts the at least one polyol in liquid form to particles of the water-soluble or water-swellable polymer in a fluidized bed. 19. The method of claim 18, wherein the method is prepared by spraying while simultaneously drying the particles. 32. The method of claim 31, wherein said polyol is an aqueous solution. 33. The polyol in an agglomerated water-soluble or water-swellable polymer comprises from about 0.5 to about 9 based on the total weight of the aggregated water-soluble or water-swellable polymer.
19. The method of claim 18, wherein the level is at 0% by weight. 34. The polyol in the agglomerated water-soluble or water-swellable polymer is at a level of about 2 to about 50% by weight, based on the total weight of the aggregated water-soluble or water-swellable polymer. 34. The method of claim 33. 35. The polyol in an agglomerated water-soluble or water-swellable polymer comprises from about 10 to about 30 based on the total weight of the aggregated water-soluble or water-swellable polymer.
35. The method of claim 34, which is at a level of weight percent. 36. Toothpaste produced by the method of claim 18 or 31. 37. Toothpaste produced by the method of claim 30.