JPH10108899A - Liquid agent for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enhance safety for eyes while producing excellent sterilizing effect by constituting with a main ingredient of water containing specified amounts of polyhexamethylenebiguanide, and nonionic isotonic agent. SOLUTION: A liquid agent for contact lenses comprises water as a main ingredient containing 0.1ppm-10ppm of polyhexamethylenebiguanide, and nonionic isotonic agent, with the nonionic isotonic agent being contained by a ratio providing an osmotic pressure within a range of equivalent weight of 0.3-1.2% by weight/volume of sodium chloride. As the nonionic isotonic agent is used; glycerin, propylene glycol, polyethylene glycol of an average molecular weight of 100-400, or their combination. In a preferable embodiment, glycerin is contained by 1.0-4.1% by weight/volume, propylene glycol 0.7-2.9% by weight/ volume, and polyethylene glycol by 1.7-6.7% by weight/volume.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement in a liquid preparation for contact lenses, and more particularly to a liquid preparation for contact lenses which exhibits an excellent sterilizing effect and is sufficiently safe for eyes.

[0002]

BACKGROUND ART Conventionally, contact lenses have generally been
They are classified into non-hydrous contact lenses and hydrous contact lenses, and are roughly divided into hard contact lenses and soft contact lenses. And
Regarding any of those contact lenses, when worn, a stain derived from tears, such as protein or eye oil, may adhere to the contact lens, and when such a stain is attached, This leads to deterioration of wearing feeling, deterioration of visual acuity, and eye disorders such as conjunctival hyperemia.

[0003] In order to wear such contact lenses safely and comfortably, it is necessary to perform a cleaning operation on the contact lenses when the contact lenses are removed from the eyes during daily handling. Becomes Also, in addition to such a washing operation, in order to prevent contamination of microorganisms such as bacteria and fungi on the contact lens during storage, the contact lens removed from the eyes is subjected to a disinfection treatment, and further, Until wearing, it is necessary to store the contact lens in an appropriate solution.

Therefore, such operations of cleaning, disinfecting, and preserving contact lenses are indispensable operations for safely wearing contact lenses.

However, cleaning, disinfecting, and preserving operations for these contact lenses are complicated, and moreover, cleaning and disinfecting solutions,
Several types of liquids, such as preservatives, must be prepared, and the labor and cost involved in using and maintaining contact lenses place a heavy burden on contact lens users.

[0006] In order to solve the above problems, a versatile contact lens solution which can perform the processing (cleaning, disinfection, storage) necessary for maintaining the contact lens with one type of solution today. However, it has been marketed overseas and in Japan. In other words, these contact lens solutions are prepared by adding a surfactant or a bactericide to a preservative solution.
The contact lens can be cleaned, disinfected, and stored.

[0007] In such a liquid preparation for contact lenses, as a bactericide component added thereto, polyhexamethylene biguanide (P) as a high-molecular chemical substance is used.
HMB) is widely used because it has characteristics such as bactericidal properties and harmlessness that are particularly useful as compared with other bactericide components. However, PHMB used as a bactericide is highly toxic at a high concentration, irritates the mucous membranes of the eye, and may cause inflammation. At the time of addition, studies have been made to obtain higher bactericidal efficacy with a lower content.

For example, in Japanese Patent Application Laid-Open No. 6-321715, PHMB is used as a solution for disinfecting and preserving contact lenses which has a high level of antibacterial activity and has low toxicity to the eyes. It has been proposed to use PHM as a disinfecting composition for contact lenses that has excellent disinfecting properties and has substantially no irritation.
It has been proposed to use B with a Tris buffer.
However, the bactericidal efficacy of these contact lens solutions has not been sufficient.

[0009]

The present invention has been made in view of the above circumstances, and an object of the present invention is to use a lower concentration of PHMB as a bactericide to reduce eye safety. Another object of the present invention is to provide a contact lens solution which can exhibit excellent bactericidal efficacy at the same time.

[0010]

The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, using polyhexamethylene biguanide (PHMB) as a bactericidal component, and further adding a nonionic tonicity agent. When used in combination, the PHMB
Antimicrobial activity is enhanced by the disinfectant (PHM
The present inventors have found that a sufficient disinfecting action can be exerted even when the amount of B) added is much lower than in the prior art, and have completed the present invention.

[0011] That is, the present invention relates to a liquid lens for contact lenses, which comprises 0.1 pp.
m to 10 ppm of PHMB and further contain a nonionic tonicity agent, wherein the nonionic tonicity agent has a penetration within the range of 0.3 to 1.2 w / v% sodium chloride equivalent. The gist of the present invention is that of a contact lens solution that is contained at a rate of applying pressure.

[0012] In the contact lens solution according to the present invention, the antibacterial activity of PHMB as a bactericide is enhanced by the combined use with a nonionic tonicity agent. From the viewpoint that the concentration of PHMB required to exhibit the same bactericidal effect as that of a lens solution can be suppressed to a lower level, P is advantageously used.
The amount of HMB to be added can be reduced, so that the safety for eyes can be further enhanced.

Further, in such a contact lens solution, the predetermined nonionic tonicity agent is 0.3 to
The osmotic pressure of the contact lens solution is 97 to 387 mOsm by being contained at a ratio giving an osmotic pressure in the range of 1.2 w / v% sodium chloride equivalent.
, So that there is no irritation to the eyes.

In the contact lens solution according to the present invention, glycerin, propylene glycol, polyethylene glycol having an average molecular weight of 100 to 400, or a polyethylene glycol having an average molecular weight of 100 to 400 is preferably used as the nonionic tonicity agent. A combination will be used.

According to a preferred embodiment of the liquid preparation for contact lenses according to the present invention, glycerin as the nonionic tonicity agent is contained at a ratio of 1.0 to 4.1 w / v%. Propylene glycol as the nonionic tonicity agent is contained at a ratio of 0.7 to 2.9 w / v%, and polyethylene glycol as the nonionic tonicity agent is 1.7 to 2.9 w / v%. 6.7w /
v%. In such a concentration range, by adding and blending glycerin, propylene glycol, or polyethylene glycol, respectively, the osmotic pressure of the contact lens solution according to the present invention is advantageously 0.3 to 1.2 w / v. % Sodium chloride equivalent can be adjusted.

Further, according to another preferred embodiment of the present invention, the contact lens solution according to the present invention further contains at least one of a buffer and a cleaning agent. By further containing a buffer, the pH of the contact lens solution is 6.0 to 6.0.
It is adjusted to 8.0 so that there is no irritation to the eyes. In addition, as such a buffer, a borate buffer,
A citrate buffer, a glycine buffer, or a tris (trishydroxyaminomethane) buffer will be preferably used. Further, by further containing the cleaning agent, the effect of removing dirt such as eye grease adhered to the contact lens can be further improved.

In the present invention, as such a detergent, particularly, the general formula: HO- (CH ₂ —CH ₂ —
_{O) x - (CH 2 -CH} (CH 3) -O) y - (CH 2
—CH ₂ —O) _x —H (where x represents an integer of 50 to 150, and y represents an integer of 20 to 80), comprising a polyoxyethylene-polyoxypropylene glycol copolymer. Using a nonionic surfactant,
It is preferred. By adding a polyoxyethylene-polyoxypropylene glycol copolymer, which is such a nonionic surfactant, as a cleaning agent, adsorption of itself to a contact lens can be suppressed, and PHM can be suppressed.
An excellent cleaning effect can be expected without lowering the bactericidal efficacy of B, and the addition of B exerts characteristics such as little influence of toxicity.

The gist of the present invention also relates to a method for disinfecting a contact lens, which comprises disinfecting a contact lens by immersing the contact lens in the solution using the contact lens solution as described above. However, according to the method of the present invention, even if the disinfection treatment by immersion in the contact lens solution is performed for a long time, since the concentration of the bactericide added to the contact lens solution is suppressed to a low level, The disinfectant adsorbed on the surface of the contact lens does not cause injuries such as inflammation in the eyes, and the contact lens can be disinfected safely.

[0019]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In short, the present invention is intended to exert an extra bactericidal effect by containing PHMB and a nonionic tonicity agent in water mainly. In addition, the present invention provides a useful contact lens solution which can more easily perform a disinfection treatment of a contact lens by utilizing such an excessive sterilizing effect.

The fungicide PHMB used in the present invention is represented by the following formula 1:

Embedded image (However, n = 2 to 50), and various known materials belonging to the category are appropriately selected and used, and are usually supplied as different mixtures of n. Therefore, such a mixture is used as it is. Further, the use concentration range is 0.1 to 10 ppm, preferably 0.2 to 10 ppm.
To 3.0 ppm, more preferably 0.2 to 1.0 ppm
When used in the range, a particularly effective bactericidal effect is exhibited. The concentration of PHMB is 0.1%.
If the concentration is lower than 1 ppm, a sufficient bactericidal effect cannot be obtained for the intended contact lens,
Also, if it is higher than 10 ppm, there is a possibility that it may have a bad influence on the human body due to adsorption to the contact lens surface or the like.

The bactericide containing PHMB is already commercially available. For example, “Cosmocil CQ” is commercially available from ICI, UK as a solution containing 20% of the bactericide. Can suitably use such commercially available products.

As the nonionic tonicity agent to be combined with PHMB as described above, various conventionally known ones can be used. For example, glycerin, propylene glycol, glycols such as polyethylene glycol, and glucose, sucrose, sorbitol, sugar alcohols such as mannitol and the like can be mentioned, if it is highly safe for the purpose of the present invention, Any of them can be used, and from them, they can be used alone or in appropriate combination. The amount of the nonionic tonicity agent to be added is 0.3 to 1.
It must be in a range that gives an osmotic pressure of 2 w / v% sodium chloride equivalent, preferably 0.5 to 0.9 w / v%
It will be the range which gives the osmotic pressure of sodium chloride equivalent.

In particular, as such a nonionic tonicity agent, preferably, glycerin, propylene glycol and polyethylene glycol having an average molecular weight of 100 to 400 can be mentioned. They are used in appropriate combinations. When the molecular weight of the polyethylene glycol exceeds 400, the viscosity becomes too high in order to obtain a desired osmotic pressure, so that it is inappropriate to add the solution to the solution.

In order to achieve the above-mentioned osmotic pressure with the above-mentioned nonionic tonicity agent, glycerin must be contained in an amount of 1.0 to 1.0.
It is contained at a ratio of 4.1 w / v%, and preferably at a ratio of 1.7 to 3.1 w / v%. Propylene glycol is contained at a ratio of 0.7 to 2.9 w / v%, preferably at a ratio of 1.2 to 2.2 w / v%. Furthermore, polyethylene glycol is 1.7
To 6.7 w / v%, preferably 2.8 to 5.0 w / v%. However, for any of the nonionic tonicity agents, outside the above concentration range, it will greatly deviate from the physiological osmotic pressure region, and as a result, it will irritate the eyes. It is.

In the contact lens solution according to the present invention, the pH value is preferably adjusted to the range of 6.0 to 8.0, more preferably 6.5 to 7.5. Is adjusted to the range. The pH
This is because when the value is lower than 6.0 or higher than 8.0, there is a risk of irritating the eye or causing a disorder.

In order to maintain the pH of such a contact lens solution effectively and in a safe range for the eyes, at least one kind of buffer is generally added. The agent is appropriately selected from various conventionally known agents and used. Specific examples include a borate buffer, a citrate buffer, a glycine buffer, a tris (trishydroxyaminomethane) buffer, a phosphate buffer, and a carbonate buffer. This is because these buffers are particularly safe for the eyes and can reduce the effect on contact lenses. The amount of the buffer is generally about 0.1 to 1.2 w / v%, preferably 0.2 to 0.8 w / v%. This is because if the concentration of the buffer is too low, the intended buffering capacity cannot be sufficiently exhibited.
Does not mean that the stability of
Conversely, safety may be adversely affected such as eye irritation.

In the liquid preparation for contact lenses according to the present invention, a predetermined surfactant is advantageously added or contained in order to further improve the effect of removing dirt such as eye grease adhered to the contact lens. It will be. As the surfactant, any conventionally known surfactant can be used as long as it has high safety to living bodies and does not affect the contact lens material. In addition, since anionic surfactants and amphoteric surfactants are considered to be unfavorable from the viewpoint of safety because adsorption of the surfactants on contact lenses is recognized, particularly in the present invention, nonionic surfactants and amphoteric surfactants are used. Surfactant is preferably used, for example, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycol fatty acid ester,
Examples thereof include polyoxyethylene alkylamine. Such nonionic surfactants themselves
Since it is not adsorbed to contact lenses, it has no effect on the contact lens material, it can be expected to have an excellent cleaning effect without lowering the sterilizing effect of PHMB, and there is little effect of toxicity due to its addition. It has the following characteristics.

Further, among such nonionic surfactants, in the present invention, since the safety is particularly high, the general formula: HO- (CH ₂ -CH ₂ -O) _x- (CH
_{2 -CH (CH 3) -O)} y - (CH 2 -CH 2 -O)
_x- H (where x is an integer of 50 to 150, y is 2
A nonionic surfactant comprising a polyoxyethylene-polyoxypropylene glycol copolymer represented by the following formula (indicating an integer of 0 to 80) is most preferably used. In addition, in this general formula, when x and y are integers less than the above range, the molecular weight becomes low, so that adsorption to a contact lens is concerned, and when it is an integer exceeding the above range, high viscosity results. This is because it becomes difficult to handle.

As the polyoxyethylene-polyoxypropylene glycol copolymer represented by the above general formula, the following are already commercially available, and in the present invention, They can be suitably used. Specifically, polyoxyethylene [42]
Polyoxypropylene [67] glycol (Pluronic P123; manufactured by Asahi Denka Kogyo KK), polyoxyethylene [54] polyoxypropylene [39] glycol (Pluronic P85; manufactured by Asahi Denka Kogyo KK), polyoxyethylene [160] Polyoxypropylene [3
0] glycol (Pluronic F68; manufactured by BASF), polyoxyethylene [196] polyoxypropylene [67] glycol (Pluronic F127; BA)
SF Co., Ltd.).

The amount of the nonionic surfactant added is generally about 0.1 to 1.0 w / v%, preferably 0.2 to 0.6 w / v%. More preferably, the content is 0.2 to 0.4 w / v%. If the amount of addition is less than 0.1 w / v%, the obtained cleaning effect will be insufficient, and
This is because the cleaning effect does not change even if it exceeds / v%.

Further, other additives include a chelating agent, a thickening agent, a protein removing agent, etc., which are safe for living bodies and have an adverse effect on the material of the contact lens. If not provided, any conventionally known ones can be used, and they can be included in the contact lens solution as needed.

In particular, in the contact lens solution of the present invention, it is preferable to include a metal chelating agent in order to prevent metal ions such as calcium in tears from adsorbing to the soft contact lens. As such a metal chelating agent, sodium edetate, nitrilotriacetic acid, tripolyphosphoric acid and the like will be used. In particular, these chelating agents were selected because of their low toxicity and high safety to the eyes. In addition, the addition amount of such a metal chelating agent is generally about 0.005 to 0.10 w / v%,
Preferably, it is added at a ratio of 0.01 to 0.05 w / v%. If the amount is small, sufficient effect cannot be expected, and if the amount is large, the effect of the chelating agent is not further enhanced.

Further, each of the additional components as described above has a final osmotic pressure of 20 parts of the resulting contact lens solution.
So as to have a physiological osmotic pressure in the range of 0 to 400 mOsm,
The addition amount is adjusted. That is, by finally adjusting the osmotic pressure to the above range, no irritation to the eyes is caused when the liquid preparation is used.

When the contact lens is to be cleaned using the contact lens solution according to the present invention obtained as described above, the following procedure is specifically used. . That is, first, several drops of the contact lens solution according to the present invention are dropped on the contact lens removed from the eyes, and then the contact lens is rubbed with a finger for several tens of seconds, and rinsed. Then, the contact lens is immersed in an appropriate container filled with the contact lens solution for 30 minutes or more, preferably 2 hours or more, to perform storage and disinfection. When the contact lens is worn again, the contact lens is taken out of the solution and worn. However, since the present solution is safe for the eyes, the contact lens is physiologically worn when worn. Since there is no need for rinsing with a saline solution or the like, it is possible to take out the contact lens immersed in the liquid preparation and directly wear it on the eye. That is, if the contact lens solution according to the present invention is used,
This solution 1 for cleaning, storage and disinfection of contact lenses
Since it can be performed with a book, and furthermore, rinsing at the time of wearing is not required, care of the contact lens can be performed extremely easily.

The type of contact lens to which the contact lens solution according to the present invention is applied is not limited to any particular type.
Soft contact lenses classified as all such as low water content, high water content, etc., and hard contact lenses can be targeted, and the material and the like of the contact lens are not questioned when applying the contact lens liquid according to the present invention. Absent.

[0036]

EXAMPLES In order to clarify the present invention more specifically, some examples of the present invention will be shown below.
It goes without saying that the present invention is not subject to any restrictions by the description of such embodiments. In addition, the present invention may be variously modified based on the knowledge of those skilled in the art, in addition to the following examples, in addition to the description in the above-described embodiments, without departing from the spirit of the present invention. It should be understood that changes, modifications, improvements and the like can be made. The percentages in the following examples are all shown as w / v%.

Example 1 The following experiment was conducted to examine the bactericidal efficacy of the contact lens solution according to the present invention. First, the following Tables 1-4
The liquid compositions for contact lenses according to Inventive Examples 1 to 12 and Comparative Examples 1 to 4 were respectively prepared so as to have the component compositions of As a disinfectant, polyhexamethylene biguanide (PHMB) (Cosmocil CQ; manufactured by ICI) is used, and as a detergent, a polyoxyethylene-polyoxypropylene glycol copolymer of a nonionic surfactant is used. Polyoxyethylene [196] polyoxypropylene [67] glycol (Pluronic F1
27; manufactured by BASF). As the nonionic tonicity agent, propylene glycol (PG), glycerin, or polyethylene glycol (PEG200) having an average molecular weight of 200 was used.

Next, two types of medium, glucose peptone agar medium and tryptic soy agar medium, were prepared respectively. In addition, glucose peptone agar medium is a commercially available glucose peptone agar medium for sterility test (manufactured by Eiken Chemical Co., Ltd.)
And 28.5 g of agar powder for bacterial culture (15 g of Wako Pure Chemical Industries, Ltd.) were dissolved by adding 1000 mL of distilled water and then subjected to high-pressure steam sterilization at 121 ° C. for 20 minutes. ,Obtained. The tryptic soy agar is dissolved in 40.0 g of a commercially available tryptic soy agar (manufactured by Eiken Chemical Co., Ltd.) by adding 1000 mL of distilled water and then subjected to high-pressure steam sterilization at 121 ° C. for 20 minutes. As a result, it was obtained.

Then, 9.9 mL of each of the contact lens solutions obtained above was placed in a test tube, and Staphylococcus aureus ATCC 6538 (Sa: Staphylococcus aureus) was added thereto.
), E. coli (Ec: Eschrichia coli ATCC 8739),
Serratia marcescens (Sm: Serratia marcescens
ATCC 13880), Candida albicans (Ca: Candid)
aalbicans ATCC 10231 or the 10 ^8-1 of)
0.1 mL of a bacterial solution containing ⁰⁹ cfu / mL was added and stirred, and finally each bacterial suspension containing a bacterial count of 10 ⁶ to 10 ⁷ cfu / mL was prepared. Then, after leaving them at 23 ° C. for 4 hours, 1 mL of such a bacterial suspension was taken out, and those containing Candida albicans were used with 20 mL of glucose-peptone agar medium, and S. aureus, E. coli or Serratia. Those containing Marce sense
Using 17 mL of tryptic soy agar medium, the viable cell count in 1 mL of the sample was measured by a plate dilution method. And
After calculating the number of viable bacteria in 1 mL of the treatment solution from the number of viable bacteria, the number of reduced bacteria converted to logarithm was calculated according to the following formula. Number of reduced bacteria [logarithmic conversion] = LOG {(viable count in 1 mL of bacterial suspension immediately after preparation)-(viable count in 1 mL of bacterial suspension after treatment)}

The results are shown in Tables 5 to 7 below. In the plate dilution method, a sample was used at a concentration that does not inhibit the growth of each test sample.

[0041]

[0042]

[0043]

[0044] * THAM: Trishydroxyaminomethane

[0045]

[0046]

[0047]

As is apparent from the results of Tables 5 to 7, when any buffer of borate buffer, citrate buffer, glycine buffer, or Tris buffer was added to the buffer. Even when a non-ionic tonicity agent is employed, when the contact lens solutions according to Examples 1 to 12 of the present invention are used, an excellent bactericidal effect is obtained against any bacteria. ing. On the other hand, when the contact lens solutions according to Comparative Examples 1 to 4 employing sodium chloride as an ionic tonicity agent were used, a sufficient bactericidal effect was not obtained, and in particular, bacteria (Sa) , Ec, and Sm). That is, in the contact lens solution according to the present invention, PHM
It is considered that the combination of B bactericide with a nonionic tonicity agent exerts the bactericidal efficacy of such bactericide in an additive manner.

Example 2 Using the contact lens liquid according to the present invention, "I
According to "SO9363-1", safety evaluation was performed by performing a cytotoxicity test as follows.

First, Example 1 of the present invention used in Example 1 above
And contact lens solutions according to Comparative Examples 5 to 7, which were prepared so as to have the component compositions shown in Table 8 below, as test liquids.
One soft contact lens in each test solution (5 mL) (Menicon Soft MA; manufactured by Menicon Corporation)
Were immersed at room temperature for 24 hours to prepare them as test lenses. Here, with respect to the cleaning agents used in the contact lens solutions according to Comparative Examples 5 to 7, BL-9 was used.
EX is polyoxyethylene (9) lauryl ether (Nikko Chemicals), R-1020 is polyoxyethylene nonylphenylformaldehyde condensate (Nikko Chemicals), and NP-10 is polyoxyethylene (10). Nonyl phenyl ether (Nikko Chemicals).

On the other hand, L-929 cells cultured in a CO ₂ incubator at 37 ° C. for 3 days were peeled off from the flask using a trypsin / EDTA solution, and the cells were cultured at about 2 × 10 ⁵ cells / mL using a MEM Darbecos medium. A cell suspension was used. This cell suspension was transferred to a 60 mm × 15
Then, 4.5 mL of the mixture was seeded on a Petri dish of 2 mm in diameter and cultured again in a CO ₂ incubator at 37 ° C for 24 hours. Thereafter, the old medium was discarded, and the agar medium for the overlay was 4.5 m.
After confirming that the solution had flowed L and was solidified, a neutral red solution was further added, and the mixture was cultured in a CO ₂ incubator at 37 ° C. for 30 minutes, and then the excess neutral red solution was discarded. Then, the above-mentioned test lens is placed thereon, and the lens is placed in a CO ₂ incubator at 37 ° C. for ₂ hours.
After culturing for 4 hours, toxicity was evaluated according to the following method.

The toxicity was evaluated by observing the size of the discoloration zone due to dead cells and the degree of lysis of the cells located immediately below the lens.
In addition, the case where cell melting was observed was evaluated as positive, and the case where neutral red discoloration and cell melting were not observed was evaluated as negative. The size of the bleaching zone was observed with the naked eye, and the degree of cell melting was observed using an inverted microscope. The results are shown in Table 9 below.

[0053]

[0054] +: Positive-: Negative

As a result, no fading or melting of cells was observed in any of the liquid preparations for contact lenses according to Examples 1 to 12 of the present invention. Was not recognized, and it was confirmed that the product was highly safe for the eyes. vice versa,
The liquid preparations for contact lenses according to Comparative Examples 5 to 7 showed positive results, indicating toxicity to cells. Therefore,
It can be seen that a nonionic surfactant, particularly a polyoxyethylene-polyoxypropylene glycol copolymer, is preferably used as the detergent contained in the contact lens solution according to the present invention.

Example 3 The liquid preparations for contact lenses according to Examples 1 to 12 of the present invention prepared in Example 1 were prepared as test liquids, and these test liquids were tested for cleaning effect as follows. Was performed.

First, as a substance giving a general lipid stain, “ISO / TC 172 / SC7 / WG 5 N3” is used.
5 "was prepared. That is, sorbitan monooleate (Arcel 80; manufactured by Wako Pure Chemical Industries, Ltd.): 6 w / v%, castor oil (manufactured by Wako Pure Chemical Industries, Ltd.): 16 w / v%, lanolin (Wako Pure Chemical Industries, Ltd.) Oleic acid (manufactured by Wako Pure Chemical Industries, Ltd.): 5 w / v%, sorbitan trioleate (Span 85; manufactured by Wako Pure Chemical Industries, Ltd.): 4 w / v%, cetyl alcohol (Wako Pure Chemical Industries, Ltd.): 2 w / v%, cholesterol (Wako Pure Chemical Industries, Ltd.): 2 w / v%, and cholesterol acetate (Wako Pure Chemical Industries, Ltd.): 30 w / v% are dissolved. And
2.5 w / v% of artificial lipid liquid homogenized by stirring
And 97.5 w / v% of physiological saline to prepare an artificial lipid solution.

Next, a soft contact lens (Menicon Soft 72; manufactured by Menicon Co., Ltd.) and a hard contact lens (Menicon Super EX; manufactured by Menicon Co., Ltd.) were prepared as test lenses. Was attached uniformly every 0.1 g to obtain an artificial lipid soiled lens. Then, the obtained artificial lipid-stained lens is picked up on the palm, and 3 drops of the test solution is applied to one side of the contact lens (6 drops per lens).
Drop) The contact lens was cleaned by dripping and rubbing with a fingertip for 30 seconds.

After the washing treatment, the appearance of the contact lens was observed. As a result, the artificial lipid stains attached to the contact lens were completely removed from both the soft contact lens and the hard contact lens.

On the other hand, when the same treatment was performed using physiological saline instead of the test solution, the artificial lipid stain attached to the contact lens was not completely removed, and a part thereof remained on the surface. Was. Therefore, when the cleaning operation was performed using the liquid preparations for contact lenses according to Examples 1 to 12, the dirt on the contact lenses could be removed very effectively.

[0061]

From the above results, the present invention provides an antibacterial agent for PHMB bactericide by adding a nonionic tonicity agent to a contact lens solution containing polyhexamethylene biguanide (PHMB) as a bactericide. The strength is enhanced, and a sufficient amount of a bactericide can be expected to provide a sufficient bactericidal effect, and a liquid for contact lenses with improved safety for eyes can be obtained.

Further, by adding a polyoxyethylene-polyoxypropylene glycol copolymer as a non-ionic surfactant as a cleaning agent, a contact lens having high detergency and high safety can be obtained. A liquid preparation can be obtained.

Claims (9)

[Claims] Claims: 1. Mainly water, 0.1 ppm to 10 pp
m polyhexamethylene biguanide,
The composition further comprises a nonionic tonicity agent, and the nonionic tonicity agent is contained at a ratio that provides an osmotic pressure in the range of 0.3 to 1.2 w / v% sodium chloride equivalent. A liquid formulation for contact lenses, characterized in that: 2. The method according to claim 1, wherein the nonionic tonicity agent is glycerin, propylene glycol or an average molecular weight of 100.
The liquid preparation for a contact lens according to claim 1, wherein the liquid preparation is a polyethylene glycol of ~ 400 or a combination thereof. 3. The method according to claim 1, wherein the glycerin is present in an amount of 1.0 to 4.1 w /
The solution for contact lenses according to claim 2, which is contained at a ratio of v%. 4. The method according to claim 1, wherein the propylene glycol is 0.7 to
The liquid preparation for contact lenses according to claim 2, which is contained at a ratio of 2.9 w / v%. 5. The method according to claim 1, wherein the polyethylene glycol is 1.7.
The liquid preparation for contact lenses according to claim 2, which is contained at a ratio of -6.7 w / v%. 6. The liquid for contact lenses according to claim 1, further comprising at least one of a buffer and a cleaning agent. 7. The contact lens solution according to claim 6, wherein the buffer is a borate buffer, a citrate buffer, a glycine buffer, or a trishydroxyaminomethane buffer. 8. The cleaning agent of the general formula: HO— (CH _{2
-CH 2 -O) x - (CH} 2 -CH (CH 3) -O) y
-(CH ₂ -CH ₂ -O) _x -H (where x is 50 to 1)
The contact lens according to claim 6, wherein the contact lens is a nonionic surfactant comprising a polyoxyethylene-polyoxypropylene glycol copolymer represented by an integer of 50 and y represents an integer of 20 to 80). Liquid. 9. A method for disinfecting a contact lens, comprising using the liquid agent for contact lenses according to claim 1 and immersing the contact lens in the liquid agent.