JPH029561B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a novel collagen-containing cosmetic lotion. More specifically, the present invention relates to a collagen-containing cosmetic lotion whose soluble natural collagen does not undergo denaturation, aggregation, or precipitation even after long-term storage, and which causes low skin irritation when applied. Soluble natural collagen is obtained by directly extracting the connective tissue of the skin of young animals or animal fetuses, and is unaltered natural collagen having no intermolecular or intramolecular crosslinks. Conventionally, in the physiological aging process of the skin, unchanged soluble collagen in the connective tissue of the dermis changes to insoluble collagen with the generation of intermolecular and intramolecular cross-links, and the content of insoluble collagen increases, resulting in a decrease in skin elasticity. It is said that there is a decrease in wettability and an increase in wrinkles. This soluble natural collagen is used as a skin protective agent (Special Publication No. 1983-1983) based on the idea that it penetrates the skin and prevents the loss of soluble collagen in connective tissues, or replenishes soluble collagen to increase its elasticity and prevent wrinkles. 8384). In recent years, research on soluble collagen has progressed, and as its structure and properties have become clearer, the above concept has been questioned.In fact, soluble natural collagen has begun to attract attention for its excellent water-retaining effect, and cosmetic creams that utilize this water-retaining effect have been developed. Currently, some cosmetic emulsions and lotions are being studied. However, in water-based cosmetics such as cosmetic lotions, if soluble natural collagen is simply mixed into various cosmetics, problems such as decreased solubility, hydrolysis, and aggregation and precipitation over time will occur, making it extremely unstable. . On the other hand, natural collagen gelatinized by heat denaturation and low-molecular peptides decomposed by acid or alkali treatment are easily soluble in water and do not decrease in solubility or aggregate and precipitate over time, so these aqueous solutions are difficult to compare. It is stable. Furthermore, atelocollagen, which is obtained by selectively digesting and removing telopeptides present at the end portions of natural collagen molecules using proteolytic enzymes, is similarly easily soluble in water, making it easy to obtain stable lotions (Japanese Patent Application Laid-open No. 110336-1982). ). Unlike these low-molecular-weight polypeptides and enzyme-treated atelocollagen, soluble natural collagen does not have sufficient solubility in water-based cosmetics such as lotions, and collagen fiber molecules are arranged regularly and aggregate and precipitate over time. Easy to occur. For example, the isoelectric point of soluble natural collagen is the PH value
5.8, easily coagulates and precipitates in weakly acidic areas,
In addition, when alcohol is used, collagen is denatured and promotes aggregation and precipitation, while surfactants such as cationic or anionic surfactants form complexes with collagen or cause denaturation of collagen molecules, resulting in turbidity. It is difficult to put it to practical use because it causes aggregation over time. Therefore, it can be said that it has been virtually impossible to formulate a collagen-containing cosmetic lotion with high commercial value. The present invention has been made to solve the above-mentioned problems in cosmetic lotions, and has finally been completed as a result of intensive research aimed at creating a cosmetic lotion that is superior to the conventional cosmetic lotions. The present invention provides a stable collagen-containing cosmetic lotion comprising 0.5-2% by weight of any one or more of sodium chloride, potassium chloride or sodium citrate as a solubilization stabilizer;
and 3-10% by weight of one or more of glucose, sorbitol or mannitol
0.3-3% by weight of soluble natural (untreated) collagen with a molecular weight of approximately 300,000 in 75-95% by weight of water containing
This is a stable collagen-containing cosmetic lotion characterized by containing 0.1 to 5% by weight of an aqueous suspension of collagen, and when applied to the skin, it provides appropriate moisture to the stratum corneum of the skin and makes the skin smooth. , the purpose of which is to give strength. One of the objects of the present invention is to solve the above-mentioned problems and to stabilize soluble natural collagen in cosmetic systems. The cosmetic lotion of the present invention refers to ordinary skin conditioning and nourishing lotions, as well as astringent lotions, wiping lotions, shape lotions, body lotions, liquid packs, and the like. The collagen applied to the present invention is soluble natural (unprocessed) collagen with a molecular weight of about 300,000. Normally, soluble natural collagen is obtained by directly extracting connective tissues such as the skin, bones, and tendons of young animals or animal fetuses, and has no intermolecular or intramolecular crosslinks. It is not broken down by enzymes. The nature of the soluble natural (unprocessed) collagen applied to the present invention is a thin milky opaque liquid, which is an aqueous suspension extracted with a weak acid (PH3.0-5.0). The aqueous suspension contains 0.3-3% by weight of soluble natural collagen. The solubilizing stabilizers applied to the present invention include neutral salts such as sodium chloride, potassium chloride, and sodium citrate as salts, and monosaccharides such as glucose, sorbitol, and mannitol as sugars. preferable. These neutral salts or monosaccharides may be used alone or in combination of two or more. For solubilization and stabilization of collagen, it is essential to use both salts and sugars in combination, and the preferred concentration is 0.5 to 2% by weight of salts and 3 to 10% by weight of sugars. Salts of 2% or more and sugars of 10% or more are highly irritating to the skin, become sticky and feel uncomfortable to use;
If 0.5% or less and sugars are less than 3%, the solubilization and stabilization of collagen is insufficient, so salts of 0.5 to 0.5% of the total weight
2% by weight and 3 to 10% by weight of sugars. At the above concentrations, these salts or saccharides used to solubilize and stabilize natural collagen can be expected to have a favorable moisturizing effect on the skin when the cosmetic lotion of the present invention is applied to the skin. In the present invention, three essential components are the above-mentioned collagen, a solubilization stabilizer consisting of salts, and saccharides, plus water, and it is an essential condition that salts and saccharides are used in combination at the above-mentioned weight percentage as the solubilization stabilizer. And it is necessary to maintain the PH range between 4 and 10. A pH of 4 or below and a pH of 10 or above is unfavorable in terms of the feeling of use and irritation when applied to the skin, while a pH of 10 or above is optimal because collagen gelatinizes or becomes lower in molecular weight due to hydrolysis, losing the effectiveness of soluble natural collagen. is PH
A range of 5 to 9 is preferable. As a pH adjuster, it is effective to use phosphoric acid-based carbonic acid-based inorganic acids and their alkali salts, and organic acids such as citric acid, succinate-tartaric acid, and malic acid, and their alkali salts in an amount of about 1% or less based on the total weight. be. This cosmetic lotion may contain other main cosmetic ingredients such as humectants, alcohols, surfactants, ultraviolet absorbers, various medicinal ingredients, and chelating agents. Moisturizers include urea, amino acids, peptides, lactate,
It is possible to use PCA salts, glycerin, etc. Alcohols such as ethyl alcohol and isopropyl alcohol can be used in amounts up to about 10% by weight, taking into account denaturation, aggregation, and precipitation of collagen over time, and irritation to the skin. Avoid using cationic surfactants and anionic surfactants because they form complexes with collagen or cause denaturation of collagen molecules, causing turbidity and aggregation over time, resulting in poor stability in the system. Should. Ether type nonionic activators and ester type nonionic activators can be used, but ether type nonionic activators are particularly good, and their use is preferably 3% by weight or less. As the ultraviolet absorber, it is preferable to use urocanic acid type, benzophenone type or benzoic acid type in the range of 0.01 to 2.00% by weight. Medicinal ingredients include anti-inflammatory agents such as glycyrrhetinic acid and its derivatives, glycyrrhetinic acid and its derivative allantoin, vitamins such as vitamin E and vitamin _B2 derivatives,
It is also possible to use blood circulation enhancers such as γ-oryzanol. It goes without saying that in the present invention, cosmetic raw materials such as fragrances, preservatives, pigments, thickeners, etc., may be used as necessary in ordinary cosmetic lotions. Next, the manufacturing method of the present invention will be described. Oil-soluble cosmetic ingredients (medicinal ingredients, ultraviolet absorbers, surfactants, fragrances, etc.) are dissolved in alcohol in advance, and water-soluble cosmetic ingredients (solubilization stabilizers, PH adjustment agents, etc.) are dissolved in alcohol. gradually add (heat if necessary) water in which the ingredients (medicinal ingredients, preservatives, ultraviolet absorbers, etc.) have been dissolved (heated if necessary), and mix and dissolve completely.
The optimal method is to then add soluble natural (unprocessed) collagen at a temperature below 40°C to obtain a cosmetic lotion. Soluble natural collagen needs to be added at a temperature below 40℃ to prevent denaturation due to heat, and contact with cosmetic ingredients, especially alcohol, that can cause denaturation and aggregation by direct contact with collagen should be avoided as much as possible. Therefore, as mentioned above, it is important to add collagen at the final stage to obtain a stable cosmetic lotion. The cosmetic lotion of the present invention obtained as described above achieves long-term stabilization of the soluble natural (untreated) collagen system with a molecular weight of approximately 300,000, and effectively utilizes the excellent water-retaining effect of soluble natural collagen. It gives the stratum corneum a moisturizing feeling (moisture) that cannot be obtained with conventional cosmetic lotions using only moisturizers, blends well with the skin, smoothes the skin, and gives firmness. be. Next, examples of the cosmetic lotion of the present invention will be shown. The blending ratio is expressed in weight percent. Example 1 Aqueous suspension containing 0.3% by weight of soluble natural collagen in lotion 0.5 Glucose 5.0 Sodium chloride 0.8 Sodium carbonate 0.02 Preservative 0.1 Fragrance (water soluble) Trace amount of water 93.58 Example 2 Aqueous suspension containing 3% by weight of soluble natural collagen in nutritional lotion Suspension 2.0 Glucose 3.0 Sorbitol 2.0 Sodium chloride 0.8 De-α-tocopherol acetate 0.1 Ethyl alcohol 7.0 1.3-butylene glycol 2.0 Sodium carbonate 0.2 Preservative 0.05 Flavor Trace water 82.85 Example 3 Astringent lotion Contains 0.3% by weight of soluble natural collagen Aqueous suspension 0.1 Glucose 3.0 Urea 2.0 Potassium chloride 0.5 Ethyl alcohol 10.0 Glycerin 1.0 Citric acid 0.01 Sodium hydrogen phosphate 0.1 Urocanic acid 0.05 Preservative 0.05 Fragrance Trace water 83.19 Example 4 Skin conditioning lotion Soluble natural collagen 2% by weight Aqueous suspension containing 1.0 Sorbitol 6.0 Urea 2.0 Nasylium chloride 0.5 Dipotassium glycyrrhizinate 0.1 Ethyl alcohol 5.0 Polyoxyethylene hydrogenated castor oil 0.3 Succinic acid 0.01 Sodium succinate 0.15 p-amino acid benzoic acid 1.0 Preservative 0.1 Flavor Trace water 83.84 Implemented Example 5 Aftershave lotion Aqueous suspension containing 0.3% by weight of soluble natural collagen 0.5 Sodium citrate 0.5 Mannitol 5.0 Isopropyl alcohol 10.0 Polyoxyethylene hydrogenated castor oil 0.4 Propylene glycol 3.0 Tartaric acid 0.1 Menthol 0.01 Preservative 0.05 Fragrance Trace water 80.44 Example 6 Liquid pack Aqueous suspension containing 3.0% by weight of soluble natural collagen 5.0 Glucose 6.0 Polyethylene glycol 3.0 Sodium chloride 1.0 Stearyl glycyrrhenate 0.05 Polyoxyethylene oleyl ether 0.3 Polyvinyl alcohol 5.0 Ethyl alcohol 5.0 Glycerin 1.0 Preservative 0.1 Flavor Trace amount Water 74.55 Next, the aging of the cosmetic lotion according to the present invention will be described. Explanation of the table The table shows the change over time of the cosmetic lotion according to the present invention, and the cosmetic lotion of the same formulation without the solubilizing stabilizer used in the present invention (the cosmetic lotion of the present invention except that only the solubilizing stabilizer was removed). ) compared with the change over time. Table 1, Table 2, Table 3, Table 4, Table 5 and Table 6 represent Example 1,
2 shows changes over time in the appearance and properties of cosmetic lotions Nos. 2, 3, 4, 5 and 6. In the table, the symbols - to - represent changes in the appearance and properties of the cosmetic lotion depending on the degree of collagen denaturation. − No change ± Slight collagen aggregation + Collagen aggregation Collagen aggregation precipitate.

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[Table] Room temperature ±
±＋
45℃±
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Claims (1)

[Claims] 1. A stable collagen-containing cosmetic lotion containing 0.5-2% by weight of any one or more of sodium chloride, potassium chloride or sodium citrate as a solubilization stabilizer, and glucose, sorbitol or An aqueous suspension of 0.3-3% by weight of soluble natural (untreated) collagen having a molecular weight of approximately 300,000 in 75-95% by weight of water containing 3-10% by weight of any one or more of mannitol. A stable collagen-containing cosmetic lotion characterized by containing 5% by weight. 2. A stable collagen-containing cosmetic lotion according to claim 1, which contains a drug. 3. The stable collagen-containing cosmetic lotion according to claim 1, which contains alcohol. 4. A stable collagen-containing cosmetic lotion according to claim 1, which contains 0.01-2.00% by weight of an ultraviolet absorber.