JPH02205A - Perfume-containing coating agent for soft capsule - Google Patents

Abstract

PURPOSE:To obtain the subject preparation exhibiting high retention of perfume after the lapse of time and capable of keeping stable feeling to the palate the adding a polyhydric alcohol to a pullulan solution containing an oily perfume and a surfactant such as a sugar ester having high HLB. CONSTITUTION:An emulsion of a perfume is prepared by vacuum emulsification of 1pt.wt. of a perfume (e.g. menthol, peppermint oil or cinnamon oil) and 0.1-10 pts.wt. of a surfactant (e.g. sugar ester having an HLB of 15-16). The emulsion is added with a proper amount of water, mixed with pullulan (at a concentration of 8-12wt.% in the whole liquid) and then mixed with 5-30wt.% of a polyhydric alcohol (e.g. glycerol or sorbitol) to obtain the subject coating agent. When the water-content in the soft capsule is 8.0-8.5wt.% after drying, the perfume retainability in the soft capsule coating film is high and the capsule is resistant to coagulation, softening and cracking.

Description

[Detailed description of the invention] [Industrial use! ! ? ] The present invention relates to a coating agent for soft capsules, and more particularly to a coating agent for soft capsules.

[Conventional technology] So far, soft capsules that can contain fragrance have not been known; an example of coating a solid drug with pullulan was disclosed in Japanese Patent Application Laid-Open No. 1986-
It is known from the publication No. 104011.

[Problems to be Solved by the Invention] Flavoring agents are generally added to solid preparations to enhance the feeling of taking them. However, simply adding and mixing powdered or liquid fragrances will inevitably cause them to disappear over time, and it is extremely difficult to retain them, especially in the case of volatile essential oils such as menthol and cinnamon oil. .

Pullulan has an excellent oxygen permeation inhibiting effect and aroma-retaining function, and is thought to be suitable for these purposes.However, in reality, pullulan has an excellent oxygen permeation inhibiting effect and aroma-retaining function. When spray coating pullulan at a high concentration, it was difficult to form a film due to pullulan's unique stringiness. For this reason, the concentration of pullulan and the quality and quantity of additives had to be selected in order to perform spray coating without losing pullulan's ability to suppress oxygen permeation and aroma retention.

[Means for Solving the Problems] As a result of intensive research, the present inventors have developed a coating characterized in that 5 to 30% polyhydric alcohol is blended into pullulan containing a fragrance and a water-soluble pullulan derivative solution. The base material advantageously solves the above problems, namely:
The present invention was completed based on the discovery that a fragrance-retaining soft capsule that is stable over time can be obtained by applying a film to a soft capsule using a coating liquid containing a fragrance in a solution of pullulan and a water-soluble pullulan derivative.

The pullulan used in the present invention is a natural polymer in which maltotriose, which is a trimer of glucose, is repeatedly bonded through α-1,6 bonds. Further, the water-soluble pullulan derivative is a derivative synthesized using natural pullulan as a raw material and may be one that has not lost its water solubility, but preferably water-soluble pullulan ether or water-soluble pullulan ester.

The concentration of pullulan in the total liquid is 5 to 20% by weight, and 8 to 20% by weight.
The concentration of pullulan in the total liquid is 5, particularly preferably 12% by weight.
If the weight percentage is not dropped, the fragrance will disappear when the coating dries, and if it exceeds 20 weight percent, the viscosity of the film liquid will increase, making coating difficult. In particular, in spray coating, if the concentration of pullulan in the total liquid exceeds 12%, the viscosity of the coating liquid becomes high and spraying becomes difficult.

The fragrances of the present invention include menthol, peppermint oil, cinnamon bark oil,
Examples include spearmint, peppermint, harp, cinnamon, yakiniku flavor, fruit juice flavor, etc., but especially when the flavor is a volatile essential oil such as menthol, peppermint oil, cinnamon bark oil, etc., the coating agent of the present invention has aroma-retaining properties. The effect is remarkable.

Furthermore, when using oily fragrances such as the above-mentioned volatile essential oils, it is necessary to incorporate various surfactants in order to efficiently and uniformly disperse them. Among them, sugar esters with an HLB value of 11 or more are preferable, and sugar esters with an HLB value of 15 or more are preferable.
-16 sugar esters are most preferred.The blending amount of these surfactants is preferably 0.1 to 10 parts by weight per 1 part by weight of the oily fragrance. If the amount is less than 0.1 part by weight, emulsification will not be complete. Further, if 10 parts by weight or more is added, the fragrance is emulsified and retained, and there is no need to add more.

The polyhydric alcohols of the present invention include glycerin, sorbitol, mannitol, propylene glycol, and the like.

The blending amount of these polyhydric alcohols is 5 to 30% of pullulan.
% by weight is preferred, and 10 to 25% by weight is more preferred.
When a polyhydric alcohol is used in a concentration within this range, the stringiness of pullulan can be suppressed and the viscosity of the film solution suitable for spray coating can be obtained.

The coating agent of the present invention can be prepared, for example, by the following method.

That is, after mixing and stirring a fragrance into an aqueous dispersion of sugar ester, an emulsion of the fragrance is prepared by vacuum emulsification. Furthermore, after adding an appropriate amount of water and mixing pullulan, a polyhydric alcohol is added and stirred to obtain the coating agent of the present invention.

In order to coat soft capsules with the coating agent prepared in this way, conventionally known equipment such as a pan coating equipment, a fluid coating equipment, various equipment equipped with an aeration drying mechanism, a vacuum granulation equipment, etc. are used. can be done.

However, the amount of fragrance remaining over time changes depending on the moisture remaining in the coating. That is, when the moisture content in the soft capsule coating after drying is 8.0 to 8.5% by weight, the amount of fragrance remaining in the soft capsule coating is high.

Furthermore, if the water content remaining in the coating is more than 10% by weight, the capsules will aggregate and soften. On the other hand, if the water content remaining in the coating is lower than 8.0% by weight, the coating will be too hard and cracks will occur in the soft capsule. For this reason, it is preferable that the water content in the soft capsule coating after drying is 8.0 to 8.5% by weight.

[Effects of the Invention] Soft capsules coated with the coating agent of the present invention have a high residual amount of flavor over time, and can efficiently and uniformly disperse the flavor, thereby maintaining a stable feeling when taking the capsule. Furthermore, if you use an analgesic and anti-inflammatory agent as the main ingredient in the soft capsule, choose a refreshing fragrance.
There is an improvement in the feeling of taking it.

[Example] The present invention will be specifically described below with reference to Examples.

Example 1 67 g of diphenhydramine hydrochloride and 2 ml of promvalerylurea
A mixture of gelatin and glycerin (weight ratio: 10
:3) 305 g was dissolved in twice the amount of boiling water, degassed, and wrapped in a thin film stretched on a flat surface with a length of 13. Q
llm, minor axis 7.5 ms, and 1 kg of soft capsules with a single force weight of 180 m+ were placed in a doria coater manufactured by Fuji Sangyo Co., Ltd., 5 g of sugar ester 31670 was dispersed in 90 ml of 80° C. hot water, and the mixture was cooled while stirring.
I kept it at room temperature. I liquefied it with warm water d! - A menthol emulsion was obtained by stirring and emulsifying while adding 5 g of menthol.

Add 69K purified water to 20g of this menthol emulsion, and add 10g of pullulan [PI-20 manufactured by Ibara Chemical Co., Ltd.].
was dissolved, and 1 g of glycerin was further added to obtain a pullulan-menthol coating composition. Using this coating composition, coating was carried out until a coating weight of 5 μm solids per capsule was reached.

After coating, it was left to dry at 40° C. and 40% for 3 days.

Examples 2 to 7 Soft capsules were coated in the same manner as in Example 1, except that a pullulan-menthol coating composition having the formulation shown in Table 1 was used.

As a result of Table 1, it became possible to achieve a uniform film coating that did not lose its glossy appearance.

The disintegration time was 17-18 minutes, meeting diurnal standards.

Test Example 1 [Temporal Change Test] (Sample) Sample 1: 20 soft capsules obtained in Example 2 were used.

Specimen 2: As a control product, 20 soft capsules coated with a coating liquid having the following formulation were used.

(Formulation) PC-L Menthol Sugar Ester S Glycerin Purified Water 10% by weight 1! ! Amount% 70 1% by weight 1% by weight 87% by weight (Test method) Samples 1 and 2 were placed in an 8kg bottle and heated to 40°C and 75%RH.
The samples were stored for several months, and the appearance, disintegration, and menthol residual rate of each sample were measured.

(result) 1. Appearance No aggregation, softening, or deterioration of glossiness was observed.

2. Disintegrability It showed the same disintegration properties as the freshly prepared product.

3. Stability of menthol Menthol was determined by hydrogen flame gas chromatography. As shown in Table 2, the results showed that the product maintained the same stability as the product immediately after use.

Table 2

Claims (1)

[Scope of Claims] 1) A coating agent for soft capsules, characterized in that a pullulan solution containing a fragrance contains 5 to 30% by weight of polyhydric alcohol. 2) The coating agent for soft capsules according to claim 1, wherein 8 to 12% by weight of pullulan is blended into the coating base. 3) The fragrance is an oily fragrance, and for 1 part by weight of the oily fragrance,
The coating agent for soft capsules according to claim 1 or 2, which contains 0.1 to 10 parts by weight of a surfactant. 4) The coating agent for soft capsules according to claim 3, wherein the surfactant is a high HLB sugar ester.