JPH01146816A - Skin cleaning agent composition and production thereof - Google Patents

Abstract

PURPOSE:To obtain a creamy skin cleaning agent composition, by blending an alkali metallic salt of N-acyl acidic amino acid with a polyvalent metallic salt of N-acyl acidic amino acid and an N-acyl acidic amino acid in a specific blending ratio. CONSTITUTION:30-65wt.% at least one of an alkali metallic salt and an organic amine salt of an N-acyl acidic amino acid is blended with 5-40wt.% polyvalent metallic salt of N-acyl acidic amino acid and 15-40wt.% N-acyl acidic amino acid. The blend is optionally mixed with an emulsifying agent, wetting agent or dispersion stability and dissolved under heating at 50-100 deg.C to give the aimed substance. The skin cleaning agent has low irritation to the skin and excellent washing properties, rapidly removes sliminess, has improved high- temperature viscosity stability, shape retention is suitably usable for person with skin sensitivity or patient of skin disease. The skin cleaning agent has no change in feeling in use and in appearance even in summer and in the torrid zone and causes no change in quality.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention provides a cream-like skin cleanser that is less irritating to the skin, has good rinsability, and has excellent viscosity stability at high temperatures and cream-like shape retention. The present invention relates to a drug composition and a method for producing the same.

BACKGROUND OF THE INVENTION Cleaning agents based on N-acyl acidic amino acid surfactants are known, and because they are less irritating to the skin and have excellent cleaning power, they can be used not only for squeezing, but also for squeezing. It is also widely used by people with skin sensitivities and patients with skin diseases.

In this way, the N-acyl acidic amino acid surfactant is
Although it has a mild effect on the skin and is safe to use, the foam is not creamy enough to provide a smooth feeling of use, and when rinsed, it leaves a sticky feeling or leaves a sticky feeling. It has the disadvantage that it cannot be used.

In order to improve the drawbacks of such N-acyl acidic amino acid surfactants, amphoteric surfactants have been added (JP-A-48-56205, JP-A-18-56708).
(Japanese Patent Application Laid-Open No. 1983-1987), with lecithin added
410), those to which alkyl phosphate ester salts are added (JP-A-54-120610), cationic polysaccharides (JP-A-55-65298), and higher fatty acids. (Unexamined Japanese Patent Publication No. 56-1069
No. 99) and the like have been proposed, but even with these, the feel of the foam is only slightly improved, but satisfactory results have not been obtained in terms of rinsability.

On the other hand, some commercially available products contain a large amount of fatty acid alkali salts to improve the foam feel and rinsability. The inherent hypoallergenic properties of surfactants are inevitably impaired.

Furthermore, recently, a skin cleansing agent has been proposed in which a part of the monovalent metal salt of the N-acyl acidic amino acid is changed to a polyvalent metal salt, thereby improving the feeling of use.

This product still has the problem of rinsability mentioned above, and its solubility is highly dependent on temperature, so
When placed at a relatively high ambient temperature, the solubility of the N-acylamino acid surfactant contained therein changes, resulting in a decrease in the viscosity stability and shape retention of the detergent composition in cream form. be.

Problems to be Solved by the Invention The present invention aims to improve the rinsability and high temperature properties of conventional cream skin cleansers containing N-acyl acidic amino acid salts without sacrificing their hypoallergenic properties and good feeling of use. This was done with the aim of improving the viscosity stability and shape retention of.

Means for Solving the Problems The present inventors have developed a method that has low irritation to the skin, can quickly remove slimy skin during rinsing, and can be used in high temperatures in summer, in tropical and subtropical regions. In order to develop a creamy skin cleansing agent that exhibits excellent viscosity stability and shape retention, we have conducted intensive research to develop a creamy skin cleansing agent that exhibits excellent viscosity stability and shape retention. This objective is achieved by creating a cream composition containing a surfactant in which a polyvalent metal salt of 1, and an N-acyl acidic amino acid are mixed in a particular ratio. The product is an alkali salt of an N-acyl acidic amino acid or an organic compound in an aqueous medium containing the ingredients necessary for cream formation. It was discovered that it can be easily produced by dissolving an amine salt, adding a required amount of a water-soluble polyvalent metal compound and an organic acid thereto, and causing the reaction. Based on this knowledge, the present invention was accomplished.

That is, the present invention provides (a) 30 to 65% by weight of at least one component selected from alkali metal salts and organic amine salts of N-acyl acidic amino acids, (b) polyvalent N-acyl acidic amino acids. (c) At least one component selected from metal salts (5 to 40% by weight) and (c) at least one component selected from N-acyl acidic amino acids (1)
A creamy skin cleansing composition characterized by containing an N-acyl acidic amino acid mixture of 5 to 40% by weight based on the total amount of the composition, and this composition as an ingredient necessary for cream formation. A required amount of at least one compound selected from an alkali metal salt and an organic amine salt of an N-acyl acidic amino acid is dissolved in an aqueous medium containing a required amount of ftQ water-soluble polyvalent metal compound and an organic amine salt. This provides a method for producing by adding an acid and causing a heating reaction while stirring.

The N- constituting the anion moiety of the salt of component (a) and component ('b) in the N-acyl acidic amino acid mixture of the present invention
The acyl acidic amino acids and the N-acyl acidic amino acids used as component (C) may be the same as those conventionally used as the main ingredients of hypoallergenic skin cleansers, and may be arbitrarily selected from these. can. Such amino acids include acidic amino acids, that is, amino acids having one amino group and two or more carboxyl groups, such as glutamic acid, aspartic acid, cystic acid, and homocystic acid, where the amino group nitrogen atom has 8 carbon atoms. ~24
compounds substituted with long-chain acyl groups such as lauroyl, valmitoyl, myristoyl, oleoyl, cocoyl, etc., such as N-lauroylglutamic acid, N-myristoylglutamic acid, N-balmitoylglutamic acid, N-stearoylglutamic acid, N
-Lauroyl cystic acid, N-myristoyl aspartic acid, N-lauroyl cystic acid, N-balmitoyl homocystic acid, etc. can be mentioned.

As the component (α) of the present invention, alkali metal salts and organic amine salts of these N-acyl acidic amino acids are used, and these alkali metal salts include sodium salts, potassium salts, lithium salts, etc. Salts include lower alkylamine salts, alkanolamine salts, basic amino acid salts, and the like. These alkali metal salts and organic amine salts may be used alone or as a mixture of two or more.

In addition, as component (b), polyvalent metal salts of these N-acyl acidic amino acids are used, and these polyvalent metal salts include beryllium salts, magnesium salts, calcium salts, barium salts, zinc salts, and aluminum salts. Includes salt, etc.

These polyvalent metal salts may be used alone or as a mixture of two or more.

Next, the N-acyl acidic amino acid mixture in the composition of the present invention contains (a) component 30 to 65% by weight, and (b) component 5 to 40% by weight.
It is necessary to have a composition ratio of 15 to 40% by weight of component (C). If this (a) component exceeds 65% by weight, the slime will not disappear quickly during rinsing, and the shape retention at high temperatures will decrease.
If the content of a) component is less than 30% by weight, a detergent with low skin irritation cannot be obtained.

In addition, if the amount of component (b) or component (C) exceeds 40% by weight, the detergency and foaming power will decrease, and if component (b)
If the weight of component (C) is less than 15% by weight, the viscosity stability and shape retention at high temperatures will not be improved.

The attached drawing shows the composition of the N-acyl acidic amino acid mixture of the present invention using a triangular diagram with the above-mentioned components (a) to (C) as the vertices.
Point A [: (a) -65,0, (b) = 5.0,
(c)-30,0], point B ((a)-65,0,(
b) −20,0, (c) −15,0], point C [
(a) -45,0, (b) -40,0, (c) -15
, 0], D point (: (a) - 30, 0, (b) =
40.0. (c) −30,0], K point [(a)
-30,0, (b) -30,0, (c) -40,0,
], F point C(a)-55,O,(b)-5,0,
(c) -40,0].

Furthermore, in the composition of the present invention, it is necessary to contain the N-acyl acidic amino acid mixture having such a composition in a range of 15 to 40% by weight based on the total amount of the composition. If it is less than 40% by weight, its ability as a detergent will be reduced, and if it exceeds 40% by weight, it will be difficult to maintain a creamy state and the viscosity stability at high temperatures will be insufficient.

In addition to the N-acyl acidic amino acid mixture, the composition of the present invention may contain additives commonly used in ordinary skin cleansers, if necessary. Examples of such substances include higher fatty acids, higher alcohols,
Antilipidating agents such as higher fatty acid glycerides, glycerin,
Examples include humectants such as propylene glycol, sorbitol, and polyethylene glycol, as well as other disinfectants, anti-inflammatory agents, antioxidants, chelating agents, fragrances, and coloring agents.

Generally, in order to produce a creamy skin cleansing composition containing a mixture of N-acyl acidic amino acids, a predetermined amount of the necessary ingredients is added to an aqueous medium, dissolved by heating, and then cooled. An acidic amino acid is dissolved in an aqueous medium, and a predetermined amount of a water-soluble metal compound or an organic amine is added thereto to partially neutralize it to form a salt of an N-acyl acidic amino acid, and then necessary additives are added. A method of adding and mixing is used. Although the composition of the present invention can also be prepared using these methods, it is particularly advantageous to use the following method.

That is, ingredients necessary for cream formation, such as emulsifiers, wetting agents, dispersion stabilizers, etc., are dissolved in an aqueous medium, and then at least one selected from alkali metal salts and organic amine salts of N-acyl acidic amino acids is dissolved in the aqueous medium. After adding one type of compound, a water-soluble polyvalent metal compound and an organic acid are further added. In this case, the amount of the alkali metal salt and organic amine salt of the N-acyl acidic amino acid is determined as (a) of the composition of the present invention.
, the water-soluble polyvalent metal compound is ion-exchanged with a portion of the alkali metal salt and organic amine salt of the N-acyl acidic amino acid in an amount sufficient to supply components (b) and (C). , sufficient l to supply the necessary component (b), and the organic acid hydrolyzes a portion of the alkali metal salt and organic amine salt of the N-acyl acidic amino acid.

The amount is sufficient to supply the necessary component (C).

As the aqueous medium used at this time, purified water may be used alone, or a mixture of water and a water-miscible solvent such as alcohol such as ethyl alcohol, furoyl alcohol, or ethylene glycol may be used. Good too.

The alkali metal salt and organic amine salt of N-acyl acidic amino acid used as raw materials are arbitrarily selected from the compounds listed as examples of component (a). In addition, water-soluble polyvalent metal compounds include beryllium, magnesium,
Calcium, barium.

Zinc, aluminum halides, sulfates, carbonates,
Nitrates, hydroxides such as calcium chloride, magnesium sulfate, aluminum sulfate, zinc chloride, magnesium chloride, etc. are used. Examples of organic acids include monobasic acids such as acetic acid, lactic acid, gluconic acid, pyrrolidonecarboxylic acid, and glycine, malic acid, tartaric acid, succinic acid, adipic acid, maleic acid, fumaric acid, glutamic acid, and asparadic acid. Dibasic acids, citric acid, isocitric acid, tribasic acids such as nitrilotriacetic acid, etc. are used.

These water-soluble polyvalent metal compounds and organic acids may be used alone or as a mixture of two or more.

The composition of the present invention can be obtained by adding desired components to these necessary components, heating and dissolving the mixture at 50 to 100° C., reacting the mixture with stirring, and cooling the mixture to room temperature after the reaction is completed. The reaction time at this time is usually about 5 to 60 minutes.

In this way, a homogeneously dispersed creamy skin cleansing composition is obtained.

Effects of the Invention The composition of the present invention is less irritating to the skin, quickly removes the slimy feeling upon rinsing, and has good viscosity stability at high temperatures.
Since it is a cream-like skin cleansing agent with good shape retention, it can be suitably used for people with skin sensitivities and patients with skin diseases, and there is no change in its feel or appearance even in summer or in tropical regions. , it has the advantage of not causing a decrease in product value.

EXAMPLES Next, the present invention will be explained in more detail by way of examples. The performance and physical properties of each side were evaluated using the following method.

(1) Rinseability A sensory test was conducted using 20 women as panelists by washing their faces, and evaluations were made based on the following criteria.

◎・・・Slimy stains are easily removed by simple rinsing.

○... Slightly increasing the number of rinses will eliminate stains and slime.

Δ...The slime doesn't go away unless you rinse it out a lot.

×...Numeshi is always nice to leave.

(2) High temperature shape retention Fill a polyethylene tube with cleaning agent.

After being left in a constant temperature bath at 45° C. for 10 days, the cream was extruded from the tube and the shape of the cream was evaluated according to the following criteria.

5... The top of the extruded cream retains its original circular shape, but the surface in contact with the plate becomes flat.

4...The upper part of the extruded cream retains its circular shape, roughly in the shape of the mouth, but the contact surface with the plate has been enlarged [7].

3...The top of the extruded cream should be slightly flat,
The contact surface with the board has also been expanded.

2...The upper part of the extruded cream is even flatter and the contact surface with the plate is significantly expanded.

1...When extruded, the cream immediately spreads onto the board.

(3) High-temperature viscosity stability The detergent was left in a constant temperature bath at 45°C for 20 days, and a B-type viscometer (BH type, No. 7 rotor, 10 rpm, manufactured by Tokyo Keiki ■) was used.
The viscosity was measured and evaluated based on the following criteria.

O: When left at 45°C, the difference in viscosity between 1 day and 20 days is 200p or less.

Δ: When left at 45° C., the difference in viscosity after 1 day and after 20 days is between 200 and 400 p.

x: When left at 45°C, the difference in viscosity after 1 day and after 20 days is 400p or more.

Examples 1-4. Comparative Examples 1 to 4 Propylene glycol, polyethylene glycol (15
A predetermined amount of 00) is mixed with purified water in a beaker, and the mixture is heated and dissolved to prepare a mixture at 70°C.

Separately, a mixture (n) is prepared by placing predetermined amounts of POE (4010,) hydrogenated castor oil monostearate, glycerin monostearate, and palmitic acid in a beaker and dissolving them under heating.

Next, mixture (II) was added to mixture (1), and 70
After stirring for 10 minutes at ℃ to homogenize, the mixture is cooled to room temperature while stirring to obtain a creamy skin cleansing agent.

In this way, the total amount of the three components (a) sodium N-myristoylglutamate, (b) magnesium N-myristoylglutamate, and (c) N-myristoylglutamic acid is 20% by weight of the entire composition, propylene glycol 15% by weight, Polyethylene glycol (15
00) 10% by weight, POK (40B, O,) 3% by weight of hydrogenated castor oil monostearate, 1% by weight of glycerin monostearate and 2% by weight of palmitic acid, and the total amount is 1% by weight.
A cream skin cleansing agent containing purified water up to 0.003% was obtained. The performance of this product is shown in Table 1.

As is clear from this table, components within the range of 30 to 65% by weight of components (,), 5 to 40% by weight of component (b), and 15 to 40% by weight of component (C) have good performance and physical properties. However, those outside this range had insufficient performance or physical properties.

Examples 5 to 11 Creamy skin cleansers were prepared using the ingredients shown in Table 2. That is, after mixing N-myristoyl glutamic acid, nrubitol, and polyethylene glycol 400 with purified water and heating and dissolving it, a water-soluble divalent metal salt or its substitute and an organic acid or its salt were added and dissolved with stirring, and then the mixture CI) was prepared. Prepare.

Separately myristic acid, glycerin monooleate and PO
E-cure Cured castor triisostearate is mixed and heated to dissolve to prepare a mixture [11]. Next, mixture [11] was added to mixture CD, stirred to homogenize, and then cooled to room temperature while stirring to obtain a cream-like skin cleansing agent. Table 2 shows the performance and physical properties of the sample thus obtained.

As can be seen from this table, performance and physical properties are good when the three essential components are formed within a predetermined ratio (Mu 1 and 2), but when divalent metal salts are not formed (Mu 43), the performance and physical properties are good. ,4,
7) or when no acid was formed (45, 6, 7), the performance or physical properties were poor. Furthermore, no deterioration in quality such as discoloration or odor during preparation was observed in any of these samples.

Example 12 A cream skin cleansing agent was prepared using the ingredients shown below.

Namely, sodium N-lauroylglutamate, N
- Mix sodium myristoyl glutamate, propylene glycol, and nrubitol in purified water, heat-dissolve it, add hecono-phosphoric acid and magnesium sulfate, and dissolve with stirring to prepare a mixture [1]. Separately, a mixture [I[] is prepared by mixing and heating and dissolving lauric acid, polyoxyethylene (40) hydrogenated castor oil monolaurate, coconut oil fatty acid jetanolamide, and glyceryl monostearate.

Next, mixture [11] was added to mixture [■], stirred at 70° C. for 10 minutes to homogenize, and then cooled to room temperature while stirring to obtain a creamy skin cleansing agent.

In addition, essential components (a), (b),
The ratio of (C) is (a):(b):(c)=53:
24:23.

The obtained creamy skin cleanser not only has excellent rinsability, high-temperature shape retention, and viscosity stability, but is also very easy to prepare and has no problems such as coloring or odor during preparation. Ta.

Ram 20. O
Sodium N-myristoylglutamate 5.0
Lauric acid 3.0 Coco fatty acid diethanolamide 1.0 Glyceryl monostearate 0.5 Propylene glycol 20.0 Sorbitol
8.0 Succinic acid
1.0 Magnesium Sulfate
i.

Fragrance 0
．． 3 Purified water 38.2

[Brief explanation of the drawing]

The figure is a triangular diagram showing the composition range of the N-acyl acidic amino acid mixture used in the composition of the present invention. Patent applicant Lion Corporation

Claims (1)

[Scope of Claims] 1 (a) 30 to 65% by weight of at least one component selected from alkali metal salts and organic amine salts of N-acyl acidic amino acids; (b) polyester of N-acyl acidic amino acids; At least one component selected from valent metal salts 5 to 4
Contains 15 to 40% by weight of an N-acyl acidic amino acid mixture consisting of 0% by weight and (c) 15 to 40% by weight of at least one component selected from N-acyl acidic amino acids, based on the total amount of the composition. A creamy skin cleansing composition characterized by: 2. Dissolve a required amount of at least one compound selected from alkali metal salts and organic amine salts of N-acyl acidic amino acids in an aqueous medium containing the ingredients necessary for cream formation, and add the required amount of at least one compound selected from the alkali metal salts and organic amine salts of N-acyl acidic amino acids. (a) At least one component selected from alkali metal salts and organic amine salts of N-acyl acidic amino acids, characterized in that a water-soluble polyvalent metal compound and an organic acid are added and reacted with heating while stirring. 30-65% by weight, (b) at least one component selected from polyvalent metal salts of N-acyl acidic amino acids5-
Contains 15 to 40% by weight of an N-acyl acidic amino acid mixture consisting of 40% by weight and (c) 15 to 40% by weight of at least one component selected from N-acyl acidic amino acids, based on the total amount of the composition. A method for producing a creamy skin cleansing composition.