JPH08243158A - Liquid-tight sealing method and blood purifying device - Google Patents

Abstract

PURPOSE: To make it possible to extremely easily and liquid-tightly seal a casing body which is formed by fixing hollow fiber bundles with sealants and a cap member from each other by mounting this cap member at the aperture at one end of the casing body and annularly sealing the end face of a cylindrical body for the casing body, the outer region of the hollow fiber bundles and the cap member with adhesives. CONSTITUTION: This blood purifying device 1a has the casing body 2, the cap member 3 and the adhesives 4. The casing body 2 has the cylindrical body 5 for the casing body, the hollow fiber bundles 7 consisting of plural hollow fiber membranes 6 housed within the cylindrical body 5 for the casing body and a sealing part 9 for fixing the hollow fiber bundles 7 in the aperture 8 at the end of the cylindrical body 5 for the casing body. The cylindrical body 5 for the casing body is a cylindrical body having apertures at both ends. The outer peripheral surfaces of the apertures 8 at both ends thereof have cap member mounting parts 10 having external thread parts for mounting the cap member 3. An annular groove 15 is formed in the region on the outer side of the region where the hollow fiber bundles 7 exist so as to enclose the region where the bundles exist. The adhesive 4 is packed into this hollow groove 15.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid-tight sealing method and a blood purification apparatus, and more particularly, it is possible to extremely easily and liquid-tightly seal between a casing body and a lid member of the blood purification apparatus. The present invention relates to a liquid-tight sealing method and a blood purification device which is extremely easy to manufacture and does not generate residual blood inside.

[0002]

2. Description of the Related Art Conventionally, a casing body having a hollow fiber bundle and a lid member attached to an end portion of the casing body and having a blood inlet / outlet port are provided. In the blood purifier, the seal between the casing body and the lid member is such that a seal ring is interposed between the casing body and the lid member when the lid member is attached to the end of the casing body. It was common to do so.

However, since the seal ring made of silicone which is widely used as the seal ring is highly reliable but expensive, it is one of the reasons why the manufacturing cost of the blood purifier cannot be reduced. It was

As a sealing method that does not use such a seal ring, a method of ultrasonically welding a casing body and a lid member has been put into practical use. This method is a method of ultrasonically fusing an end portion of a casing body cylinder and a lid member attached to the end portion of the casing body.

However, according to this method, since sealing is performed considerably outside the region where the hollow fiber bundle is open on the end face of the casing body, residual blood is present in the region outside the region where the hollow fiber bundle is open. There was a problem that was generated.

As a method of preventing such residual blood, an annular convex portion is provided on the inner side surface of the lid member facing the casing body, and the annular convex portion is brought into contact with the end surface of the sealing material, and the cylindrical body for the casing body is provided. There has been proposed a method of ultrasonically bonding the end portion of the and the lid member.

However, according to this method, it is necessary to bring the end surface of the sealing material in which the hollow fiber bundle opens and the annular convex portion of the lid member into contact with each other without a gap, and the sealing in which the hollow fiber bundle opens. There is a problem that extremely high precision is required for cutting when forming the end face of the material, and it is not possible to cope with it with conventional equipment. Further, in some cases, there is a problem that a gap is formed between the end surface of the sealing material and the annular convex portion of the lid member, and blood coagulation occurs in this gap.

The present invention has been completed based on such circumstances. That is, an object of the present invention is to solve the above problems. An object of the present invention is to provide a liquid-tight sealing method that can extremely easily and liquid-tightly seal between a casing body and a lid member of a blood purification device. Another object of the present invention is to provide a blood purification device that is extremely easy to manufacture and does not generate residual blood inside.

[0009]

In order to solve the above-mentioned problems, the invention according to claim 1 is characterized in that the hollow-fiber bundle has a cutting opening end face of the hollow-fiber bundle with a sealant for a casing main body. A lid member having a blood outlet is attached to the one end opening of the casing body fixed to the one end opening of the body, and the end face of the casing body cylinder and / or the seal formed by the sealant 3. A liquid-tight sealing method, wherein an outer region of the hollow fiber bundle and an outer region of the hollow fiber bundle are annularly sealed with an adhesive, and the invention according to claim 2 provides the hollow fiber bundle. A casing body in which a hollow fiber bundle is fixed to an opening at one end of a casing body cylinder with a sealant so as to have a cutting opening end face, and a blood outlet port, and an end of the casing body cylinder body A lid member attached to the part,
The inner surface of the lid member facing the casing body, the end surface of the casing body cylinder and / or the end surface of the sealing portion formed by the sealant, and the non-existing region of the hollow fiber membrane are annularly formed. A blood purification apparatus comprising: an adhesive formed by adhering the formed adhesive surface; and the invention according to claim 3, wherein the hollow fiber bundle is opened in the cutting opening end face of the hollow fiber bundle. A casing body in which an annular groove formed on the outer surface of the hollow fiber bundle, which is the end face of the sealing portion fixed to the one end opening of the casing body cylinder with a sealing agent, is filled with an adhesive. A hollow fiber membrane, which has a blood outlet and is attached to an end of the casing body, and which is the end face of the casing body cylinder and / or the end face of the sealing portion with the adhesive. A ring-shaped adhesive surface is attached to the area. And a lid member adhered with an adhesive. The invention according to claim 4 provides a hollow fiber bundle in which the cutting opening end face of the hollow fiber bundle is opened. A casing body having a sealing portion fixed to one end opening of the casing body cylinder with a sealant, a blood outlet port, and attached to the end portion of the casing body, and annular on the inner surface. A ring-shaped adhesive applied to the end surface of the casing main body cylinder and / or the end surface of the sealing portion, which is a region in which the hollow fiber membrane is not present, and a lid member that is adhered to the end surface. It is a blood purification device characterized by.

The present invention will be described in detail below.

(Casing body) In the casing body in the method or apparatus of the present invention, the hollow fiber bundle is fixed to the opening at one end of the casing body cylinder with a sealant so as to have a cutting opening end face of the hollow fiber bundle. Become.

That is, the casing body according to the present invention includes a casing body cylinder having an opening at one end, a hollow fiber bundle housed in the casing body cylinder, and the hollow fiber bundle for the casing body. The tubular body has a sealing portion fixed to the one end opening portion with a sealing agent so as to have a cutting opening end face.

The casing body cylinder is not particularly limited as long as it can accommodate a hollow fiber bundle inside and has an opening at one end to which a lid member described later can be attached. The tubular body for the casing main body, which has been used in the blood purification apparatus of (1), can be preferably used, which is conventionally known per se. However,
Usually, a suitable casing body cylinder is a cylinder having openings at both ends.

The material forming the casing body cylinder is not particularly limited, but in relation to the sealant for fixing the hollow fiber membrane to the end opening, for example, polycarbonate, polystyrene, acrylonitrile and styrene are used. And a copolymer, polymethylmethacrylate, ABS resin, AB resin and the like are preferable. However, the material forming the casing body cylinder is not limited to the above examples, and other ordinary polymer materials and metal materials can be appropriately adopted.

The hollow fiber membrane constituting the bundle of hollow fibers is not limited by the characteristics such as material and shape,
For example, as the material, cellulose, cellulose diacetate, cellulose triacetate, etc., cellulose derivatives such as cellulose ethers, polyamide-based derivatives,
Examples thereof include polyester derivatives, methacrylic or acrylic polymers such as polymethylmethacrylate, polyvinyl chloride polymers such as polyvinyl chloride, polyurethane, and polyolefins such as polyethylene and polypropylene. The outer diameter of the hollow fiber membrane is usually about 10 to 600 μm.

The sealant is not particularly limited as long as the hollow fiber bundle can be fixed to the casing body cylinder, and is itself used for fixing the hollow fiber bundle in the conventional blood purification apparatus. Conventionally known sealing agents can be suitably adopted. Specifically, for example, a curable polymer composition such as polyurethane resin, silicone resin, or epoxy resin can be preferably used. Among these, polyurethane resins and epoxy resins can be particularly preferably used because of their relationship with the adhesives described below. Adopting these as a sealant, as an adhesive to be described later,
A polyurethane-based adhesive, an epoxy-based adhesive, or the like with less resin sink after curing can be preferably used, and there are advantages such as extremely excellent sealing properties and adhesive properties.

With this sealant, the hollow fiber membrane is fixed so as to have a cutting opening end face of the hollow fiber bundle at the one end opening of the casing body cylinder. In other words, the end surface of the sealing portion formed by the sealant is exposed at the one end opening of the casing body cylinder, and the end portion of each hollow fiber in the hollow fiber bundle is open at the end surface of the sealing portion. Thus, the hollow fiber bundle is fixed to the one end opening of the casing body cylinder in a state where the cut opening end surface of the hollow fiber bundle and the end surface of the sealing portion are flush with each other.

The method of fixing the hollow fiber bundle so as to have the cut opening end face is not particularly limited as long as it can be fixed in such a state as a result, and for example, one end opening portion of the casing main body cylinder is made by a sealant. After fixing the hollow fiber bundle to the above, the encapsulant may be cut together with the hollow fiber bundle at a predetermined position to expose and form the cutting opening end face of the hollow fiber bundle.

By fixing the hollow fiber bundle with a sealant, the end face of the casing body cylinder and / or the end face of the seal portion formed with the sealant is formed at the one end opening of the casing body. To be done. As its mode,
The end surface of the casing body tubular body and the end surface of the sealing portion may be flush with each other, or the end surface of the sealing portion may slightly project from the end surface of the casing body tubular body, or the sealing The agent may cover the end surface of the casing body cylinder so that only the end surface of the sealant is formed on the surface.

(Lid Member and Attachment thereof) The lid member in the present invention is attached to the opening portion at one end or both ends of the casing body cylinder. The lid member in this invention is
An end opening of the casing body tubular body, which has a blood outlet and an inner surface facing the end surface of the casing body tubular body and / or the end surface of the sealing portion formed by the sealant. It is formed so that it can be attached to.

The blood lead-out port introduces blood into or draws out from the space where the cutting opening end face of the hollow fiber bundle fixed by the sealant is opened. The position at which this blood outlet port is provided in the lid member is not particularly limited as long as blood can be introduced or led out, but it is preferably provided at the center of the inner surface of the lid member.

There is no particular limitation on the method of attaching the lid member to the end opening of the casing body cylinder, as long as it is attachable, and for example, the outer peripheral surface of the end opening of the casing body cylinder is used. There may be a method of screwing a lid member having a male screw portion formed on the inner peripheral surface thereof with a male screw portion, or at the end opening portion of the casing main body cylinder having no screw portion. Alternatively, a method of simply fitting a lid member having no screw portion may be used. Particularly preferred is a method in which the male screw portion and the female screw portion are screwed together. According to this method, it is possible to particularly easily and surely perform sealing with an adhesive described later.

(Sealing or Adhesion) In the liquid-tight sealing method of the present invention, the end surface of the casing body tubular body and / or the end surface of the casing body tubular body which is formed at the opening at one end or both ends of the casing body tubular body. The end surface of the sealant and the lid member are annularly bonded with an adhesive in an area outside the area where the cutting opening end surface of the hollow fiber bundle is present (hereinafter, also referred to as “outer area”). To seal.

In the method of the present invention, as a method of sealing in an annular shape with an adhesive, the adhesive after adhesion surrounds the existing region, and the end surface of the casing body cylinder and / or the sealing member. There is no particular limitation as long as it exists on the end surface of the stop.

As such a sealing or bonding method, for example, the end surface of the casing body cylinder and / or
Or, after applying an adhesive to the end surface of the sealing portion and so as to surround the existing region, a method of mounting the lid member, and applying an annular adhesive to the inner surface of the lid member. In addition, a method of attaching this to the casing body cylinder can be mentioned.

As a mode of applying the adhesive, an annular concave portion or an annular groove is formed on the outer surface of the hollow fiber bundle on the end face of the sealing portion, and the adhesive is filled therein. It may be.

The sealing with the annular adhesive is performed at the same time as mounting the lid member on the casing body cylinder body, that is, mounting the lid member on the casing body cylinder body. A desirable mode is one in which the curing of the adhesive is completed almost at the same time as the above, and the sealing is completed. However, the mounting and the bonding may be performed by independent operations. Further, after the mounting and the bonding, another process such as ultrasonic welding may be performed.

The adhesive in the present invention is not particularly limited as long as it can bond the lid member and the end surface of the casing body cylinder and / or the end surface of the sealing portion. For example, a urethane-based adhesive, Epoxy adhesives and the like can be preferably used. Among these, the type with less resin sink mark after curing is particularly preferable.

The adhesive in the present invention may be the same composition as the above-mentioned sealant or a completely different kind of composition. Preferably, the same composition as the sealant is adopted. When an adhesive that is the same type of composition as the sealing agent is adopted, the sealing portion and the adhesive are well adapted to each other, so that the end surface of the casing body cylinder and / or the end surface of the sealing portion and the A very good seal is achieved with the lid member. Further, there is an advantage that it is possible to reduce the kinds of materials with which blood comes into contact and the antithrombotic property is improved. In this case, even if the composition is not completely the same as the composition of the sealing agent, the components may be common to some extent.

The adhesion in the present invention may be performed after the sealing agent is completely cured, or may be performed before the sealing agent is completely cured. In particular, it is preferable to perform the adhesion before the sealant is completely cured, because the sealant and the adhesive are well compatible with each other and extremely excellent sealing is achieved.

The blood purification apparatus of the present invention is similar to the method of the present invention in that the end surface of the casing body cylinder and / or
Alternatively, it can be manufactured by adhering the end surface of the sealing portion formed of the sealing agent and the lid member with the adhesive.

[0032]

According to the liquid-tight sealing method of the present invention, without using an expensive seal ring such as a silicone ring,
By the extremely simple operation of mounting the lid member on the casing body, the end opening of the casing body cylinder and the lid member can be liquid-tightly sealed.

Further, according to the liquid-tight sealing method of the present invention, since sealing is performed in the end face of the casing main body cylinder and / or in the end face of the sealing portion in the vicinity of the region where the hollow fiber bundle exists, Occurrence of residual blood is prevented in the region where the hollow fiber bundle is absent on the end face of the casing body cylinder and / or the end face of the sealing portion.

In the blood purification apparatus of the present invention, the region where the hollow fiber bundle is absent and the lid member on the end face of the casing body cylinder and / or the end face of the sealing portion are annularly sealed with an adhesive. Therefore, good liquid tightness is maintained without using a seal ring. Further, since the end face of the casing body cylinder and / or the end face of the sealing portion and the inner side face of the lid member are fixed by the adhesive, the lid member is not easily detached.

Further, since the sealing is made in the end face of the casing body cylinder and / or the end face of the sealing portion in the vicinity of the region where the hollow fiber bundle exists, the end face of the casing body cylinder and / or Alternatively, generation of residual blood on the end surface of the sealant is prevented.

[0036]

EXAMPLES The present invention will be described in detail below with reference to examples.

(Embodiment 1) FIG. 1 is a sectional view schematically showing the vicinity of one end opening of a casing body cylinder in a blood purification apparatus according to an embodiment of the present invention. FIG. 1 shows one end of this blood purification device. This blood purification device 1 a has a casing body 2, a lid member 3, and an adhesive 4.

The casing body 2 includes the casing body cylinder 5, a hollow fiber bundle 7 composed of a plurality of hollow fiber membranes 6 accommodated in the casing body cylinder 5, and the hollow fiber bundle 7. And a sealing portion 9 for fixing the above at the end opening 8 of the casing body tubular body 5.

The casing body cylinder 5 is a cylinder having openings at both ends, and a lid member mounting portion 10 having a male screw portion for mounting the lid member 3 on the outer peripheral surface of the opening 8 at both ends. Have. In the figure, 11 is a dialysate inlet / outlet pipe for introducing or leading dialysate or the like into the space formed by the inner peripheral surface of the casing body cylinder 5 and the outer peripheral surface of the hollow fiber membrane 6. .

Both ends of the hollow fiber bundle 7 are sealed at the both ends of the casing body tubular body 5 at the openings 8 at both ends.
It is fixed by.

The sealing portion 9 has an end surface 13 formed flush with the end surface 12 of the casing body tubular body 5 inside the end surface 12 of the casing body tubular body 5. A cut opening end surface 14 of the hollow fiber bundle 7 is provided on the surface 13.

In this embodiment, the sealing end face 13 having such cutting opening end face 14 was formed as follows. That is, the hollow fiber bundles 7 are housed so that both ends of the hollow fiber bundles 7 project slightly outward from the end surface 12 of the casing body tubular body 5, and the hollow fiber bundles 7 are housed in the one end opening 8 of the casing body tubular body 5. After fixing the hollow fiber bundle 7 with a sealant, a sealing portion 9 formed by the sealant is attached to the hollow fiber bundle 7 on a surface corresponding to the end surface 12 of the casing body tubular body 5. It was formed by cutting with.

FIG. 2 is a perspective view showing an opening at one end of the casing body cylinder 5. In FIG. 2, the alternate long and two short dashes line L
A region where the cutting opening end face 14 on the sealing end face 13 is surrounded by is a region where the hollow fiber bundle exists, and is an outside of this region and an end of the casing body tubular body 5. The area inside the outer circumference of the portion is the outside area of the hollow fiber bundle 7.

In this embodiment, the sealing end face 13
An annular groove 15 for filling the adhesive 4 is formed in the. That is, the annular groove 15 is formed in a region outside the existing region of the hollow fiber bundle 7 so as to surround the existing region. FIG. 2 shows a state in which the adhesive 4 is filled in the concave groove 15, but the lid member 3 is not attached to the end portion of the casing body tubular body 5 yet. In addition,
The male screw portion for mounting the lid member 3 in the lid member mounting portion 10 is not shown in FIG.

The lid member 3 has a blood outlet port 16, a mounting portion 17 for mounting in the end opening of the casing body tubular body 5, an end surface of the casing body tubular body 5 and / or the above. Inner surface 18 facing the end surface 13 of the sealing portion
Have and.

The blood outlet 16 has the inner surface 18
Is formed in the center of the.

The mounting portion 17 has a function of mounting the lid member 3 in the opening portion of the casing body tubular body 5, and a screw portion formed in the lid member mounting portion 10 of the casing body tubular body 5. A female screw portion that can be screwed into the inner peripheral surface is provided.
The lid member 3 in this embodiment is mounted by being screwed into the lid member mounting portion 10 of the casing body tubular body 5.

The inner side surface 18 of the lid member 3 has a diameter substantially equal to the average of the inner diameter and the outer diameter of the annular groove 15 formed in the sealing end surface 13 so as to surround the central axis of the lid member 3. An annular protrusion 19 is formed. The tip of the annular protrusion 19 is sharpened. This annular protrusion 1
When the lid member 3 is attached to the end opening 8 of the casing body cylindrical body 5, the ridge line formed at the tip of the lid member 3 is filled in the annular groove 15 formed in the sealing end surface 15 for adhesion. It is formed so as to be in contact with or buried in the agent 4.
In particular, the annular protrusion 19 is formed so that the tip of the annular protrusion 19 is inserted into the annular groove 15 in a state where the lid member 3 is attached to the end of the casing body cylinder 5. Preferably. If formed in this way, more reliable sealing or liquid-tight sealing is achieved, and since the lid member 3 and the casing body cylinder 5 are particularly strongly adhered to each other, the lid is particularly long-term. Inconveniences such as loosening of the member 3 can be prevented.

Bonding in this embodiment is performed by using the annular groove 1
5 is filled with the adhesive 4 and before the adhesive 4 is cured, the lid member mounting portion 1 of the casing body cylinder 5
This is done by mounting the lid member 3 on the 0. That is, when the lid member 3 is attached to the opening portion of the casing body tubular body 5, the tip of the annular protrusion 19 formed on the inner side surface 18 of the lid member 3 has the annular groove 15 of the sealing end surface 14. It contacts or is buried in the adhesive 4 filled therein. Then, by curing the adhesive 4 in this state, the sealing end surface 14 and the inner side surface 18 of the lid member 3 are bonded.

In this state, the adhesive 4 bonds the lid member and the non-existing region with the bonding surface formed in an annular shape.

The mounting of the lid member 3 on the casing body cylinder 5 and the adhesion of the outer end region of the hollow fiber bundle on the sealing end face 13 to the lid member in this embodiment are performed by the liquid-tight seal of the present invention. It is also an example of a method. (Embodiment 2) FIG. 3 is a sectional view showing the outline of a blood purification apparatus according to another embodiment of the present invention.

The casing main body 2 in this blood purification apparatus 1b is the same as that of the first embodiment in that the annular concave groove is not formed in the end surface 13 of the sealing portion formed by the sealing agent.
It is different from the casing body in the blood purification apparatus shown in FIG.

The lid member 3 in this embodiment has a mounting portion 17 for mounting in the blood outlet 16 and the opening of the casing body tubular body 5, and the end surface 12 and / or the end surface 12 of the casing body tubular body 5. And an inner side surface 18 facing the end surface 13 of the sealing portion.

Also in the second embodiment, the mounting portion 17 of the lid member has a female screw portion on the inner peripheral surface, and the male screw portion formed on the lid member mounting portion 10 of the casing body cylinder 5 has a female screw portion. It is mounted on the casing body cylinder 5 by screwing.

In the vicinity of the outer circumference of the inner side surface 18 of the lid member 3, two annular protrusions 20 are formed concentrically with each other so as to surround the central axis thereof. The outer annular protrusion 20a located on the outer side has a flat portion 21 at the tip.
And the tip of the inner annular protruding portion 20b located inside is sharply formed. The outer protruding portion 20a is provided on the end surface 12 of the casing body cylinder 5 with the tip flat surface portion 2a.
1 is fixed in a state of being in contact with it, while the inner projecting portion 20b is fixed in a state of having its tip in contact with or in proximity to the region where the hollow fiber membrane is absent in the sealing end face 13.

The fixing is performed by mounting the lid member 3 on the casing body cylinder 5 and adhering it with an adhesive 4 described later.

In the second embodiment, the lid member 3 and the casing body cylinder 5 and / or the end surface 13 of the sealing portion are adhered to each other by the outer protruding portion 20a and the inner protruding portion 20.
By filling the annular groove 22 formed with b with the adhesive 4 in a heaped state, and while the adhesive 4 is not cured, the lid member 3 is attached to the casing body cylinder 5 at the end opening. Has been done. Due to this adhesion, the end surface 12 of the casing body cylinder and / or the end surface 13 of the sealing portion is
The outer region of the hollow fiber bundle and the lid member 3 are sealed with the adhesive 4 formed in a ring shape.

The attachment of the lid member 3 to the casing body cylinder 5 and the adhesion between the outer region of the hollow fiber bundle of the sealing end surface 13 and the lid member 3 in this embodiment are performed by the liquid-tightness of the present invention. It is also an example of the sealing method. (Embodiment 3) The liquid-tight sealing method according to the present invention is shown in FIG.
It is also possible to carry out in the manner as shown in,
The blood purification device in the present invention may be a device as shown in FIG.

In the end opening 8 of the casing body tubular body 5 in the third embodiment, the sealing portion 9 covers the end surface 12 of the casing body tubular body 5 so that the sealing portion 9 is sealed.
Only the sealing end face 13 of is exposed on the surface.

The lid member 3 according to the third embodiment is attached to a blood outlet (not shown) and an opening 17 of the casing 5 for the casing body, and an inner portion facing the sealing end surface 13. And a side surface 18.

In the vicinity of the inner peripheral surface of the mounting portion 17 on the inner side surface 18, an annular shape having a diameter larger than the inner diameter of the casing body tubular body 5 and smaller than the outer diameter of the casing body tubular body 5. The protrusion 24 is formed.

In this embodiment, the annular protrusion 2
The adhesive 4 is annularly loaded into the space formed between the inner peripheral surface of the mounting portion 17 and the upper end portion of the inner peripheral surface of the mounting portion 17. The filling amount of the adhesive 4 is not particularly limited, but when the lid member 3 is mounted on the casing body cylinder 5, the annular protruding portion 24, the inner peripheral surface of the mounting portion 17, and the sealing end surface. It is desirable that the space surrounded by 12 be filled with the adhesive agent with almost no space.

Also in the third embodiment, the lid member 3 has the female screw portion 23 on the inner peripheral surface of the mounting portion 17, and the male screw portion formed on the lid member mounting portion 10 of the casing body cylinder 5. It is mounted on the casing body cylinder 5 by being screwed into.

By this mounting, adhesion between the non-existing region of the hollow fiber bundle on the sealing end surface 13 and the inner side surface 18 of the lid member is achieved. At the same time, a liquid-tight seal is formed between them.

Some of the embodiments of the present invention have been described above. The present invention is not limited to the above embodiment. To summarize the above examples, (1) the end face of the sealing part formed by fixing the hollow fiber bundle to the one end opening of the casing body cylinder with a sealant in the state where the cutting end face of the hollow fiber bundle is opened. The outer region of the hollow fiber bundle or the opening end surface of the casing body cylinder and the inner side surface of the lid member are circularly bonded with an adhesive, or (2) the hollow fiber bundle The end face of the sealing portion formed by fixing the hollow fiber bundle to the one end opening of the casing body cylinder with the sealant in the state where the end face of the cutting opening is open, and the region outside the hollow fiber bundle or the casing body. An annular groove is formed on the open end surface of the casing for use in the casing, and the adhesive filled in the annular groove is used to cover the end face of the sealing portion and the region outside the hollow fiber bundle or the casing body casing and the lid member. The inner surface of the adhesive, or (3)
A region outside the hollow fiber bundle, which is an end face of a sealing portion formed by fixing the hollow fiber bundle to the opening at one end of the casing body cylinder with a sealant in a state where the cutting opening end face of the hollow fiber bundle is open. Alternatively, it is important that the opening end surface of the casing body cylinder and the inner side surface of the lid member are bonded with an adhesive agent filled in an annular groove provided on the inner side surface of the lid member.

[0066]

According to the present invention, it is possible to provide a liquid-tight sealing method capable of extremely easily and liquid-tightly sealing between a casing body and a lid member of a blood purification device.

According to the present invention, it is possible to provide a liquid-tight sealing method which can maintain sufficient liquid-tightness without using a seal ring and can achieve sealing by an extremely simple operation. it can.

Further, the liquid-tight sealing method of the present invention has the following advantages. That is, in the conventional blood purification apparatus, in order to reliably maintain the coupling between the casing body cylinder and the lid member for a long period of time, after the casing body cylinder and the lid member are mounted, the casing body cylinder While the operation of adhering the tubular body and the lid member was required, the liquid-tight sealing method of the present invention can be very easily liquid-tightly sealed, and the end surface of the casing main body tubular body And / or the end face of the encapsulant and the inner side face of the lid member can be adhesively fixed to each other, which is an advantage that a bonding operation as a separate step in the related art becomes unnecessary.

According to the present invention, it is possible to provide a blood purification device in which residual blood does not occur inside and which is extremely easy to manufacture.

According to the present invention, sufficient liquid-tightness can be maintained without the use of a seal ring, the production is extremely easy, and residual blood is generated in the interior. It is possible to provide a blood purification device that solves the above.

If the same kind of composition as that used for the above-mentioned sealant is used as the adhesive used for the seal,
It is possible to reduce the types of materials with which blood comes into contact and improve antithrombotic properties.

[Brief description of drawings]

FIG. 1 is a sectional view showing an outline of a blood purification apparatus which is an embodiment of the present invention.

FIG. 2 is a schematic perspective view showing the vicinity of an end opening of a casing body cylinder in the blood purification apparatus of Example 1.

FIG. 3 is a sectional view showing the outline of a blood purification apparatus according to another embodiment of the present invention.

FIG. 4 is a sectional view showing the outline of a blood purification apparatus according to another embodiment of the present invention.

[Explanation of symbols]

1 ... Blood purification device, 2 ... Casing body, 3 ...
..Lid member, 4 ... Adhesive, 5 ... Casing body cylinder, 6 ... Hollow fiber membrane, 7 ... Hollow fiber bundle, 8 ...
・ Opening of casing body cylinder, 9 ... Sealing part, 1
0 ... Lid member mounting part, 11 ... Dialysate inlet / outlet pipe, 1
2 ... End surface of casing body cylinder body, 13 ... Sealing end surface, 14 ... Cutting opening end surface, 15 ... Annular concave portion, 16 ... Blood outlet port, 17 ... Mounting portion , 18
... Inner side surface, 19 ... Annular protrusion, 20a ... Outer protrusion, 20b ... Inner annular protrusion, 21 ... Planar portion, 22 ... Annular groove, 23 ... Female Screw part, 24 ・
..Round protrusions

Claims (4)

[Claims] 1. A blood outlet port at the one end opening of a casing main body formed by fixing the hollow fiber bundle to one end opening of a casing main body cylinder with a sealant so as to have a cut opening end face of the hollow fiber bundle. And a lid member having an end face of the casing body cylinder and / or an end face of a sealing portion formed by the sealant, the outer region of the hollow fiber bundle and the lid member are annularly bonded with an adhesive. A liquid-tight sealing method comprising: 2. A casing main body formed by fixing the hollow fiber bundle to one end opening of a casing main body cylinder with a sealant so as to have a cut opening end face of the hollow fiber bundle, and a blood outlet port, and A lid member attached to an end of the casing body tubular body, an inner surface of the lid member facing the casing body, an end surface of the casing body tubular body, and / or a sealing portion formed by the sealant. A blood purification device comprising: an end surface of the hollow fiber membrane and an area where the hollow fiber membrane is absent, and the adhesive surface is bonded by an adhesive surface formed in an annular shape. 3. An end face of a sealing portion formed by fixing the hollow fiber bundle to a one end opening of a casing body cylinder with a sealant in a state where the cutting opening end face of the hollow fiber bundle is opened. A casing body having an annular groove formed on the outside of the bundle filled with an adhesive, a blood outlet port, and attached to an end of the casing body, and the casing body cylinder body with the adhesive. And / or an end surface of the sealing portion and a region in which the hollow fiber membrane is absent, and a lid member formed by bonding an annular bonding surface with an adhesive. apparatus. 4. A casing main body having a sealing portion formed by fixing the hollow fiber bundle with a sealant to one end opening of the casing main body cylinder in a state where the cutting opening end face of the hollow fiber bundle is opened, and a blood guide. An annular adhesive that has an entrance and exit, is attached to the end of the casing body, and is applied in an annular shape on the inner side surface, and is used for the end surface of the casing body cylinder and / or the end surface of the sealing portion. A blood purification apparatus comprising: a lid member that is adhered to a region where the hollow fiber membrane does not exist.