JPH08217668A - Laminated material for application medicine and application agent using the same - Google Patents
Laminated material for application medicine and application agent using the sameInfo
- Publication number
- JPH08217668A JPH08217668A JP5207595A JP5207595A JPH08217668A JP H08217668 A JPH08217668 A JP H08217668A JP 5207595 A JP5207595 A JP 5207595A JP 5207595 A JP5207595 A JP 5207595A JP H08217668 A JPH08217668 A JP H08217668A
- Authority
- JP
- Japan
- Prior art keywords
- patch
- moisture
- laminated material
- film
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、貼付薬を塗布する積層
材及びその積層材を用いた貼付剤に関するものである。
また、本積層材は、消炎鎮痛剤、傷ガードフィルム、絆
創膏用フィルム、プロテクトフィルム等の皮膚貼着用基
材として使用するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a laminated material for applying a patch and a patch using the laminated material.
Moreover, this laminated material is used as a skin adhering substrate such as an anti-inflammatory analgesic, a wound guard film, a bandage film, and a protect film.
【０００２】[0002]
【従来の技術】従来貼付剤は、不織布やプラスチックフ
ィルム等の基材に貼付薬を塗布したものが多く使用され
ている。そして、貼付薬は消炎剤等の薬剤と粘着剤から
なり、粘着剤によって皮膚に粘着されるようになってい
る。2. Description of the Related Art Conventional patches are often used in which patches are applied to a base material such as a non-woven fabric or a plastic film. The patch is composed of a drug such as an anti-inflammatory agent and an adhesive, which is adhered to the skin by the adhesive.
【０００３】[0003]
【発明が解決しようとする課題】不織布を貼付薬用基材
として使用した場合、不織布はドレープ性がよく、貼付
剤の基材への接着が良好であるが、不織布単層では透湿
性及びガス透過性が大きく、薬剤中の薬効成分が不織布
を通して外気中に揮散するため、患部への薬効成分の吸
収が減少し、貼付剤として十分な効果を発揮できないと
いう問題があった。When a non-woven fabric is used as a medicated patch substrate, the non-woven fabric has good drapeability and good adhesiveness of the patch to the substrate, but a non-woven fabric single layer has moisture permeability and gas permeability. Since the medicinal component in the drug is volatilized into the outside air through the nonwoven fabric, absorption of the medicinal component in the affected area is reduced, and there is a problem that the patch cannot exert a sufficient effect.
【０００４】また、貼付薬用基材としてプラスチックフ
ィルムを用いた場合、薬効成分の外気への揮散は防止で
きるが、水蒸気透過性が不織布に比較して非常に小さい
ため、長時間貼付剤を貼付していると、貼着部分の皮膚
がむれて不快感を感じるようになる。場合によっては、
カブレ等の皮膚の疾患につながることがある。又、プラ
スチックフィルムは貼付薬の接着が不織布に比較して弱
いという問題もある。本発明は、不織布と透湿性のよい
プラスチックフィルムを積層した積層材を用いることに
より、従来の問題点を解決し、優れた貼付薬用積層材を
提供し、更にその積層材を用いて、貼着感の良い貼付剤
を得ることを目的とする。Further, when a plastic film is used as a medicated patch base, it is possible to prevent volatilization of the medicinal component to the outside air, but since the water vapor permeability is much smaller than that of the non-woven fabric, the patch is applied for a long time. If you do, you will feel discomfort due to the skin on the applied part peeling off. In some cases,
May cause skin problems such as rash. Further, the plastic film also has a problem that the adhesion of the patch is weaker than that of the non-woven fabric. The present invention solves the conventional problems by using a laminated material obtained by laminating a non-woven fabric and a plastic film having good moisture permeability, and provides an excellent adhesive medicated laminated material. The purpose is to obtain a pleasing patch.
【０００５】[0005]
【課題を解決するための手段】従来の問題点の解決を図
るため、貼付薬用基材を次のような構成とした。該基材
が、透湿性フィルムと不織布を部分接着により積層した
ことを特徴とする貼付薬用積層材とした。また、その積
層材の透湿性フィルムが、４８０〜９６００ｇ／ｍ2 ・
２４ｈの透湿度を有する貼付薬用積層材とした。更に、
上記基材に消炎鎮痛剤等の貼付薬を塗布して貼付剤を構
成して、従来の問題点の解決を図った。Means for Solving the Problems In order to solve the conventional problems, the patch base material has the following constitution. The substrate was a laminated material for medicated patches, wherein a moisture-permeable film and a nonwoven fabric were laminated by partial adhesion. In addition, the moisture permeable film of the laminated material is 480 to 9600 g / m 2 ·
It was a laminated material for a medicated patch having a moisture permeability of 24 h. Furthermore,
An adhesive patch such as an anti-inflammatory analgesic was applied to the above base material to form an adhesive patch to solve the conventional problems.
【０００６】尚、透湿度は、ＪＩＳ Ｚ ０２０８の試
験方法に準拠して、４０℃、９０％ＲＨの条件で試料を
測定したときの透湿量を示すもので、試料の厚さは特に
限定しないものとする。即ち、本発明に使用する透湿性
フィルムは、厚さに関係なく４８０〜９６００ｇ／ｍ2
・２４ｈの透湿量が必要であることを意味する。The water vapor transmission rate indicates the amount of water vapor transmission when the sample is measured under the conditions of 40 ° C. and 90% RH in accordance with the test method of JIS Z 0208, and the thickness of the sample is particularly limited. I will not do it. That is, the moisture permeable film used in the present invention has a thickness of 480 to 9600 g / m 2 regardless of the thickness.
-It means that a moisture permeability of 24 h is required.
【０００７】貼付薬用基材として、不織布と透湿性のよ
いプラスチックフィルムを部分接着により積層した積層
材を用いることにより、薬効成分の外気への揮散を抑制
し、且つ水蒸気透過量をコントロールすることができる
ので、貼付薬として十分な効果を発揮し、しかもむれ等
の従来の問題を解消することができた。即ち、貼付薬と
の接着性がよく、柔軟性があり透湿性の大きい不織布に
貼付薬を塗布し、貼付剤としての従来の特徴を生かし、
水蒸気透過量の大きいプラスチックフィルムを不織布の
上に部分接着することにより、問題点の薬効成分の外部
への揮散を防止した。By using a laminated material in which a non-woven fabric and a plastic film having good moisture permeability are laminated by partial adhesion as a medicated patch substrate, it is possible to suppress volatilization of the medicinal component to the outside air and control the amount of water vapor permeation. As a result, it was possible to exert a sufficient effect as a patch and to solve the conventional problems such as swelling. That is, the adhesiveness is good with the adhesive patch, the adhesive patch is applied to a non-woven fabric having flexibility and large moisture permeability, and the conventional characteristics of the adhesive patch are utilized,
By partially adhering a plastic film with a high water vapor transmission rate onto the non-woven fabric, the problematic medicinal component was prevented from evaporating to the outside.
【０００８】透湿性のフィルムとしては、微細無機フィ
ラーを混練したポリオレフィン樹脂でフィルムを作製
し、更に二軸延伸法により均一な微細孔を付与した微多
孔フィルム、及びプラスチックフィルムに透湿性を付与
するために、熱による孔空け加工を施したフィルムが好
適である。As the moisture permeable film, a film is prepared from a polyolefin resin in which a fine inorganic filler is kneaded, and further, a microporous film having uniform fine pores by a biaxial stretching method and a plastic film are provided with moisture permeability. For this reason, a film that has been perforated by heat is suitable.
【０００９】従って、本発明の積層材の不織布側に、従
来と同様に薬剤を塗布すれば、製造上の問題もなく貼付
剤を製造することができ、また、この貼付剤を患部に貼
着したとき、従来と同様な貼着感が得られ、貼付剤とし
ての問題点は生じない。しかも、不織布の上に積層され
た透湿性のフィルムにより、薬効成分の揮散は大幅に抑
制され、且つ水蒸気の揮散はコントロールできるので、
基材にプラスチックフィルムを使用したときの問題点を
大幅に改善することができた。Therefore, if the non-woven fabric side of the laminated material of the present invention is coated with a drug in the same manner as in the past, a patch can be produced without problems in production, and this patch is attached to an affected area. When this is done, the same sticking feeling as in the past can be obtained, and the problem as a patch does not occur. Moreover, since the moisture-permeable film laminated on the non-woven fabric, the volatilization of the medicinal component is significantly suppressed, and the volatilization of water vapor can be controlled,
The problems when using a plastic film as the substrate could be greatly improved.
【００１０】[0010]
【作用】本発明によれば、貼付薬用基材として、透湿性
フィルムと不織布を部分接着により積層した積層材を用
い、その積層材の透湿性フィルムの透湿度を４８０〜９
６００ｇ／ｍ2 ・２４ｈとすることにより、貼付剤の薬
効成分の揮散は大幅に抑制され、貼付薬として十分な効
果を発揮させるこができる。更に、前記積層材を使用し
て作製した貼付剤は、患部に貼着したときも、貼着感は
良好で、且つプラスチックフィルムを使用したときのむ
れ等の問題も解消することができる。According to the present invention, a laminated material in which a moisture permeable film and a non-woven fabric are laminated by partial adhesion is used as a patch medicated substrate, and the moisture permeability of the laminated material is 480 to 9
By setting the amount to 600 g / m 2 · 24 h, the volatilization of the medicinal component of the patch can be significantly suppressed, and a sufficient effect as a patch can be exhibited. Further, the patch prepared by using the above-mentioned laminated material has a good feeling of sticking even when it is stuck to an affected area, and can solve problems such as unevenness when a plastic film is used.
【００１１】[0011]
【実施例】以下、実施例に基づいて、図面を参照にしな
がら本発明を詳細に説明する。図１は本発明の貼付剤の
一例を示す模式断面図であり、図２は本発明の貼付薬用
積層材の一例を示す模式断面図である。図３は本発明の
積層材で、不織布と透湿性フィルムを接着剤で部分接着
したときの模式平面図であり、図４はその積層材の模式
断面図である。The present invention will be described in detail below with reference to the drawings based on the embodiments. FIG. 1 is a schematic cross-sectional view showing an example of the patch of the present invention, and FIG. 2 is a schematic cross-sectional view showing an example of the adhesive patch laminate of the present invention. FIG. 3 is a schematic plan view of the laminated material of the present invention in which a nonwoven fabric and a moisture-permeable film are partially bonded with an adhesive, and FIG. 4 is a schematic cross-sectional view of the laminated material.
【００１２】本発明の貼付薬用積層材は、図２に示すよ
うに、基本的には不織布４と透湿性フィルム３から構成
され、不織布４と透湿性フィルム３は接着剤５等により
部分接着されている。また、、不織布４と透湿性フィル
ム３がポリエチレンやポリプロピレン等の同じ材質の場
合は、部分的にヒートシールして積層材とすることがあ
る。そして、透湿度が４８０〜９６００ｇ／ｍ2 ・２４
ｈの範囲の透湿性フィルムを選定することにより、積層
材全体の透湿度をコントロールする。不織布と透湿性フ
ィルムを部分接着し、接着部分の面積を小さくすること
により、積層材の透湿度は透湿性フィルムの透湿度と略
同じにすることができる。部分接着については、皮膚の
ムレ、カブレ防止の観点から、ドット状或いは線状に接
着部分を設けることが望ましい。更に、関節等の動きの
激しい部位に貼着する場合、層間剥離の防止の観点から
前記ドット及び線に、密度の疎密の部分を設けたり、ド
ットの大小や線の太さに変化をつけてもよい。またこれ
らに限らず任意の位置に設けても構わない。As shown in FIG. 2, the adhesive patch laminate of the present invention basically comprises a non-woven fabric 4 and a moisture permeable film 3, and the non-woven fabric 4 and the moisture permeable film 3 are partially bonded by an adhesive 5 or the like. ing. When the nonwoven fabric 4 and the moisture permeable film 3 are made of the same material such as polyethylene or polypropylene, they may be partially heat-sealed to form a laminated material. And the water vapor transmission rate is 480-9600g / m 2 · 24
By selecting a moisture-permeable film in the range of h, the moisture permeability of the entire laminated material is controlled. By partially bonding the non-woven fabric and the moisture permeable film and reducing the area of the bonded portion, the moisture permeability of the laminated material can be made substantially the same as the moisture permeability of the moisture permeable film. Regarding partial adhesion, it is desirable to provide the adhesive part in a dot shape or a linear shape from the viewpoint of preventing stuffiness and rash of the skin. In addition, when sticking to areas with strong movement such as joints, from the viewpoint of preventing delamination, the dots and lines should be provided with sparse and dense parts, or the size of dots and the thickness of lines should be changed. Good. Further, it is not limited to these and may be provided at any position.
【００１３】即ち、貼付剤に使用される不織布の透湿度
は透湿性フィルムに比較して数倍も大きいので、不織布
に透湿性フィルムを積層した場合、積層材の透湿度は透
湿性フィルムの透湿度によって規制される。更に、部分
接着された透湿性フィルムの透湿度は接着面積によって
影響されるが、部分接着して接着面積を５％以下にすれ
ば、積層材の透湿度は透湿性フィルムの透湿度の９５％
以上有することになる。従って、透湿性フィルムの透湿
度を４８０〜９６００ｇ／ｍ2 ・２４ｈの範囲から選定
すれば、積層材の透湿度を別に規定しなくとも、実用上
特に問題は生じない。しかし、透湿度の範囲を厳密に規
定する必要がある場合は、積層材の透湿度を測定して、
適合する範囲になるように透湿性フィルムを選定する必
要がある。That is, since the moisture permeability of the non-woven fabric used for the patch is several times higher than that of the moisture-permeable film, when the moisture-permeable film is laminated on the nonwoven fabric, the moisture permeability of the laminated material is the same as that of the moisture-permeable film. Regulated by humidity. Furthermore, the moisture permeability of the partially bonded moisture-permeable film is affected by the adhesive area, but if the partial adhesive is used to reduce the adhesive area to 5% or less, the moisture permeability of the laminated material is 95% of that of the moisture-permeable film.
You have the above. Therefore, if the moisture permeability of the moisture permeable film is selected from the range of 480 to 9600 g / m 2 · 24 h, there is no particular problem in practice even if the moisture permeability of the laminated material is not specified separately. However, if it is necessary to strictly specify the range of moisture permeability, measure the moisture permeability of the laminated material,
It is necessary to select a moisture-permeable film so that it will be in a suitable range.
【００１４】従って、本発明の貼付薬用基材は、透湿度
が４８０〜９６００ｇ／ｍ2 ・２４ｈの範囲内にあり、
薬効成分の揮散と皮膚からの水蒸気の透過量が適度のバ
ランスを保ち、貼付剤としてその薬効を十分に発揮する
ことになる。透湿度が４８０ｇ／ｍ2 ・２４ｈ以下で
は、貼着部の皮膚がむれて不快感を感じ、場合によって
は皮膚に疾患を生じることもある。透湿度が９６００ｇ
／ｍ2 ・２４ｈ以上では、薬効成分が基材を通して外部
に揮散し、貼付剤としてその薬効を十分に発揮すること
ができなくなる。Therefore, the patch base material of the present invention has a water vapor transmission rate in the range of 480 to 9600 g / m 2 · 24 h,
A proper balance is maintained between the volatilization of the medicinal component and the amount of water vapor permeation through the skin, and the medicinal effect as a patch is sufficiently exerted. If the moisture vapor transmission rate is 480 g / m 2 · 24 h or less, the skin of the adhered part may be peeled and discomfort may occur, and in some cases, skin may be damaged. Water vapor transmission rate is 9600g
If it is / m 2 · 24 h or more, the medicinal component volatilizes to the outside through the base material, and the medicinal effect as a patch cannot be sufficiently exerted.
【００１５】本発明の貼付薬用基材に用いる不織布とし
ては、ポリエチレン、ポリプロピレン、ポリエステル、
ナイロン、ポリウレタン、レーヨン、ポリアクリロニト
リル等の不織布が使用できる。Nonwoven fabrics used for the medicated patch base of the present invention include polyethylene, polypropylene, polyester,
Nonwoven fabrics such as nylon, polyurethane, rayon and polyacrylonitrile can be used.
【００１６】透湿性フィルムとしては、微細無機フィラ
ーを混練したポリオレフィン樹脂を用いて成膜した後
に、二軸延伸法によりフィルムを延伸して無機フィラー
部分に微細孔を施した微多孔フィルムが多く使用され
る。また、プラスチックフィルムに透湿性を付与するた
めに、熱により孔空け加工を施した多孔質フィルムも使
用できる。更に、無孔フィルムで透湿性の大きいセロハ
ン、ポバール、ポリブタジエン系のフィルムも使用でき
る。As the moisture permeable film, a microporous film in which a film made of a polyolefin resin in which a fine inorganic filler is kneaded and then stretched by a biaxial stretching method to form fine holes in the inorganic filler portion is often used. To be done. Further, in order to impart moisture permeability to the plastic film, it is also possible to use a porous film which is perforated by heat. Furthermore, a non-porous film having high moisture permeability such as cellophane, poval, or polybutadiene film can be used.
【００１７】不織布と透湿性フィルムを積層する方法と
しては、接着剤を印刷法により透湿性フィルムにパター
ンコートして不織布を貼り合わせ、パターンコート部分
だけを接着して積層フィルムとする。接着剤のパターン
コートを不織布に行っても同じような積層材を作ること
ができる。また、不織布と透湿性フィルムがヒートシー
ル可能なフィルムの場合は、凹凸のある熱ロール又は熱
板を用いて、不織布と透湿性フィルムを部分的にヒート
シールして積層フィルムとすることもできる。又、必要
とする透湿度によっては、殆ど全面に接着剤を塗布して
も目的を達成する場合もある。特に、透湿度の大きい接
着剤を使用する場合は、接着剤の塗布面積を多くした
り、全面塗布しても目的は達成される。接着剤として
は、ウレタン系樹脂、ポリエステル系樹脂、アクリル系
樹脂等を用いた接着剤が多く使用される。As a method for laminating the non-woven fabric and the moisture permeable film, an adhesive is pattern-coated on the moisture permeable film by a printing method, the non-woven fabrics are bonded together, and only the pattern-coated portion is adhered to form a laminated film. A similar laminate can be made by pattern-coating an adhesive on a non-woven fabric. When the non-woven fabric and the moisture-permeable film are heat-sealable films, the non-woven fabric and the moisture-permeable film can be partially heat-sealed to form a laminated film by using an uneven heat roll or hot plate. Further, depending on the required moisture permeability, the purpose may be achieved even if an adhesive is applied to almost the entire surface. In particular, when an adhesive having a high water vapor permeability is used, the object can be achieved even if the area of application of the adhesive is increased or the entire surface is applied. As the adhesive agent, an adhesive agent using urethane resin, polyester resin, acrylic resin, or the like is often used.
【００１８】貼付剤の製造方法としては、従来と同様な
方法が使用できる。即ち、消炎鎮痛剤等の薬効成分及び
副剤等を溶解剤に溶解して塗工液を作り、これを前記積
層材の不織布側にコンマコート法にて塗布し、乾燥後に
薬剤面に、剥離処理を施したポリオレフィンフィルム、
ポリエステルフィルム、又は剥離紙等のライナー（保護
層）をラミネートして貼付剤を作製する。また、上記と
は逆に、剥離処理を施したポリオレフィンフィルム、ポ
リエステルフィルム、又は剥離紙等に、消炎鎮痛剤等の
塗工液を塗布し乾燥後に、積層材の不織布側をラミネー
トして貼付剤を作製することもできる。使用に際して
は、貼付剤のライナーを剥離して皮膚の患部に貼着す
る。As a method for producing the patch, the same method as the conventional one can be used. That is, a medicinal component such as an anti-inflammatory analgesic and an auxiliary agent are dissolved in a dissolving agent to prepare a coating solution, which is applied to the nonwoven fabric side of the laminated material by a comma coat method, and peeled off on the drug surface after drying. Treated polyolefin film,
A patch is prepared by laminating a polyester film or a liner (protective layer) such as release paper. Further, contrary to the above, the release agent is applied to a release-treated polyolefin film, polyester film, release paper, or the like, and after application of a coating solution such as an anti-inflammatory analgesic, the non-woven fabric side of the laminated material is laminated. Can also be produced. At the time of use, the liner of the patch is peeled off and attached to the affected area of the skin.
【００１９】貼付薬の消炎鎮痛剤としては、サリチル酸
メチル、サリチル酸グリコール、インドメタシン、ケト
プロフェン、フルルブロフェン、ｌ−メントール、ｌ−
カンフル等を主成分としたものが使用される。Examples of anti-inflammatory and analgesic agents for patches are methyl salicylate, glycol salicylate, indomethacin, ketoprofen, flurbrofen, l-menthol and l-.
Those containing camphor as a main component are used.
【００２０】次に、具体的な実施例によって詳細に説明
する。 （実施例１）不織布として、坪量２０ｇ／ｍ2 、厚さ２
３０μｍのポリプロピレン系不織布を用い、透湿性フィ
ルムとして、厚さ５０μｍで透湿度４８００ｇ／ｍ2 ・
２４ｈのポリプロピレン製の微多孔フィルムを使用し
た。微多孔フィルムはポリプロピレン樹脂に平均粒径３
０μｍの炭酸カルシウム（ＣａＣＯ3 ）を２７％添加し
た複合体を用いてエクストルージョン法でフィルムを作
製し、更にそのフィルムを二軸延伸してフィルムの炭酸
カルシウム部分に微細孔を形成させ、厚さ５０μｍのフ
ィルム作製した。透湿度は二軸延伸の際の延伸度合いに
よって調整した。Next, detailed description will be made with reference to specific examples. (Example 1) Nonwoven fabric having a basis weight of 20 g / m 2 and a thickness of 2
Using a polypropylene non-woven fabric of 30 μm as a moisture permeable film with a thickness of 50 μm and a water vapor transmission rate of 4800 g / m 2 ·
A 24 h polypropylene microporous film was used. The microporous film is made of polypropylene resin and has an average particle size of 3
A film was prepared by an extrusion method using a composite having 0% of calcium carbonate (CaCO 3 ) added by 27%, and the film was biaxially stretched to form micropores in the calcium carbonate portion of the film, and the thickness was adjusted. A 50 μm film was prepared. The water vapor transmission rate was adjusted by the degree of stretching during biaxial stretching.
【００２１】次に、透湿性フィルムにウレタン系接着剤
をグラビアコート法によりパターン状にコートし、これ
に不織布を貼り合わせて乾燥し、積層材を作製した。こ
の積層材の透湿度は透湿性フィルムと殆ど同じであっ
た。Next, the moisture-permeable film was coated with a urethane-based adhesive in a pattern by the gravure coating method, and a nonwoven fabric was attached to the coated film and dried to prepare a laminated material. The moisture permeability of this laminated material was almost the same as that of the moisture permeable film.
【００２２】図１に示すように、前記積層材２の不織布
４側に下記組成の消炎鎮痛剤塗工液をコンマコート法に
て塗布し、薬剤層６を形成した。薬剤層６の乾燥後の塗
布量は５０ｇ／ｍ2 とした。この薬剤層の上に、図１に
示すように、ライナー７として剥離処理を施した厚さ２
５μｍのポリエチレンテレフタレートフィルムをラミネ
ートして貼付剤１を作製した。As shown in FIG. 1, an anti-inflammatory analgesic coating liquid having the following composition was applied to the nonwoven fabric 4 side of the laminated material 2 by a comma coat method to form a drug layer 6. The coating amount of the drug layer 6 after drying was 50 g / m 2 . As shown in FIG. 1, as a liner 7, a release layer 2 having a thickness of 2 is formed on the drug layer.
A patch 1 was prepared by laminating a 5 μm polyethylene terephthalate film.
【００２３】 ☆ 塗工液の組成 ・サリチル酸グリコール １．３重量部 ・ｌ−メントール １．０重量部 ・ｄｌ−カンフル ０．３重量部 ・ビタミンＥ酢酸エステル １．０重量部 ・ゼラチン ２２．０重量部 ・ポリビニルアルコール ５．０重量部 ・グリセリン ３０．０重量部 ・カオリン １７．０重量部 ・ポリアクリル酸ナトリウム １．０重量部 ・ポリブテン ３．０重量部 ・精製水 １８．５重量部Composition of coating liquid: glycol salicylate 1.3 parts by weight l-menthol 1.0 parts by weight dl-camphor 0.3 parts by weight vitamin E acetate 1.0 part by weight gelatin 22.0 Parts by weight-polyvinyl alcohol 5.0 parts by weight-glycerin 30.0 parts by weight-kaolin 17.0 parts by weight-sodium polyacrylate 1.0 parts by weight-polybutene 3.0 parts by weight-purified water 18.5 parts by weight
【００２４】以上のように作製した貼付剤は、透湿度が
４８００ｇ／ｍ2 ・２４ｈであり、薬効成分の揮散も少
なく、貼付剤として十分な性能を発揮することができ
た。又、皮膚に貼着したときもむれることがなく貼着感
は良好であった。The adhesive patch prepared as described above had a water vapor transmission rate of 4800 g / m 2 · 24 h, little volatilization of medicinal components, and was able to exhibit sufficient performance as an adhesive patch. Also, when it was applied to the skin, it did not get loose and the feeling of attachment was good.
【００２５】（実施例２）不織布として、坪量２０ｇ／
ｍ2 、厚さ２３０μｍのポリエチレン系不織布を用い、
透湿性フィルムとしては、厚さ５０μｍで、透湿度４８
００ｇ／ｍ2 ・２４ｈのポリエチレン製の微多孔フィル
ムを使用し、これを凹凸のある加熱ロールを用いて部分
的にヒートシールして積層フィルムを作製した。ポリエ
チレン製の微多孔フィルムは実施例１と同様にして作製
した。この積層フィルムの透湿度は透湿性フィルムと殆
ど同じであった。次に、上記積層材を用いて、積層材の
不織布側に、実施例１と同様に、消炎鎮痛剤塗工液を塗
布して貼付剤を作製した。以上のように作製した貼付剤
は、薬効成分の揮散も少なく、貼付剤として十分な性能
を発揮することができ、又、皮膚に貼着したときも、皮
膚へのフィット性も良く、むれることがなく貼着感は良
好であった。(Example 2) As a non-woven fabric, a basis weight of 20 g /
m 2 with a thickness of 230 μm polyethylene non-woven fabric,
The moisture permeable film has a thickness of 50 μm and a moisture permeability of 48.
A polyethylene microporous film of 00 g / m 2 · 24 h was used, and this was partially heat-sealed using a heating roll having irregularities to produce a laminated film. A microporous film made of polyethylene was produced in the same manner as in Example 1. The moisture permeability of this laminated film was almost the same as that of the moisture permeable film. Next, using the above laminated material, the anti-inflammatory analgesic coating liquid was applied to the nonwoven fabric side of the laminated material in the same manner as in Example 1 to prepare a patch. The patch prepared as described above has less volatilization of the medicinal component, can exhibit sufficient performance as a patch, and when it is applied to the skin, it also has a good fit to the skin and peels off. The sticking feeling was good.
【００２６】（実施例３）不織布として、坪量２０ｇ／
ｍ2 、厚さ２３０μｍのポリプロピレン系不織布を用
い、透湿性フィルムとしては、厚さ５０μｍで、透湿度
１２００ｇ／ｍ2 ・２４ｈのポリウレタンフィルムを使
用し、実施例１と同様にして積層材を作製した。上記積
層材の透湿度は透湿性フィルムと殆ど同じであった。次
に、上記積層材を用いて、積層材の不織布側に、実施例
１と同様に、消炎鎮痛剤塗工液を塗布して貼付剤を作製
した。以上のように作製した貼付剤は、薬効成分の揮散
も少なく、貼付剤として十分な性能を発揮することがで
き、又、皮膚に貼着したときも、皮膚へのフィット性も
良く、むれることがなく貼着感は良好であった。Example 3 As a non-woven fabric, the basis weight is 20 g /
A polypropylene-based nonwoven fabric having a thickness of m 2 and a thickness of 230 μm was used, and as the moisture-permeable film, a polyurethane film having a thickness of 50 μm and a water vapor permeability of 1200 g / m 2 · 24 h was used. did. The moisture permeability of the above laminated material was almost the same as that of the moisture permeable film. Next, using the above laminated material, the anti-inflammatory analgesic coating liquid was applied to the nonwoven fabric side of the laminated material in the same manner as in Example 1 to prepare a patch. The patch prepared as described above has less volatilization of the medicinal component, can exhibit sufficient performance as a patch, and when it is applied to the skin, it also has a good fit to the skin and peels off. The sticking feeling was good.
【００２７】[0027]
【発明の効果】本発明によれば、貼付薬用基材として、
透湿性フィルムと不織布を部分接着により積層した積層
材を用い、その積層材の透湿性フィルムの透湿度を４８
０〜９６００ｇ／ｍ2 ・２４ｈとすることにより、貼付
剤の薬効成分の揮散は大幅に抑制されるので、貼付薬の
性能を十分に発揮させるこができる。更に、前記積層材
を使用して作製した貼付剤は、貼付薬は従来と同様に不
織布側に塗布されているので、患部に貼着したときも、
皮膚へのフィット性等は従来と変わらず貼着感は良好
で、且つプラスチックフィルムを使用したときのむれ等
の問題も解消することができる。従って、本発明によ
り、従来の問題点を大いに改善し、性能の良い貼付剤を
得ることができた。According to the present invention, as a patch base material,
Using a laminated material in which a moisture permeable film and a nonwoven fabric are laminated by partial adhesion, the moisture permeability of the laminated material is 48
When the amount is 0 to 9600 g / m 2 · 24 h, volatilization of the medicinal component of the patch is significantly suppressed, so that the performance of the patch can be fully exhibited. Furthermore, the patch prepared by using the above-mentioned laminated material, because the patch is applied to the non-woven fabric side in the same manner as in the past, even when applied to the affected area,
The fit to the skin and the like are the same as in the past and the feeling of attachment is good, and the problems such as unevenness when using a plastic film can be solved. Therefore, according to the present invention, it was possible to greatly improve the conventional problems and obtain a patch having good performance.
【図１】本発明の貼付剤の一例を示す模式断面図。FIG. 1 is a schematic sectional view showing an example of the patch of the present invention.
【図２】本発明の貼付薬用基材の一例を示す模式断面
図。FIG. 2 is a schematic cross-sectional view showing an example of the medicated patch base material of the present invention.
【図３】本発明の貼付薬用基材の部分接着を示した平面
の模式図。FIG. 3 is a schematic plan view showing partial adhesion of the medicated patch base material of the present invention.
【図４】本発明の貼付薬用基材の部分接着を示した断面
の模式図。FIG. 4 is a schematic diagram of a cross-section showing partial adhesion of the medicated patch base material of the present invention.
１ 貼付剤 ２ 貼付薬用基材 ３ 透湿性フィルム ４ 不織布 ５ 接着剤 ６ 薬剤層 ７ ライナー DESCRIPTION OF SYMBOLS 1 Patch 2 Base material for patch 3 Moisture permeable film 4 Nonwoven fabric 5 Adhesive 6 Drug layer 7 Liner
Claims (3)
が、透湿性フィルムと不織布を部分接着により積層した
ことを特徴とする貼付薬用積層材。1. A laminate for a patch, which is a base material to which a patch is applied, wherein the base material is obtained by laminating a moisture-permeable film and a non-woven fabric by partial adhesion.
〜９６００ｇ／ｍ2・２４ｈの透湿度を有することを特
徴とする請求項１に記載の貼付薬用積層材。2. The moisture permeable film of the laminated material is 480.
2. The adhesive patch laminate according to claim 1, having a water vapor transmission rate of 9600 g / m 2 · 24 h.
て、該基材が、請求項１及び請求項２に記載した積層材
であることを特徴とする貼付剤。3. A patch comprising a base material coated with a patch, wherein the base material is the laminated material according to claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5207595A JPH08217668A (en) | 1995-02-17 | 1995-02-17 | Laminated material for application medicine and application agent using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5207595A JPH08217668A (en) | 1995-02-17 | 1995-02-17 | Laminated material for application medicine and application agent using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08217668A true JPH08217668A (en) | 1996-08-27 |
Family
ID=12904707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5207595A Withdrawn JPH08217668A (en) | 1995-02-17 | 1995-02-17 | Laminated material for application medicine and application agent using the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH08217668A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058232A1 (en) * | 2002-12-26 | 2004-07-15 | Kowa Co., Ltd. | Adhesive patch |
| WO2004096536A1 (en) * | 2003-04-28 | 2004-11-11 | Kuraray Co., Ltd. | Moisture-permeable elastomer sheet |
| JP2005089469A (en) * | 2003-09-18 | 2005-04-07 | Bristol Myers Squibb Co | Adhesive structure for attaching to skin |
| US6953602B2 (en) | 1999-09-17 | 2005-10-11 | Avery Dennison Corporation | Pattern coated adhesive article |
| US7434798B2 (en) | 2001-05-05 | 2008-10-14 | Lts Lohmann Therapie-Systeme Ag | Grouping of film-like or sheet-like materials |
| US9884030B2 (en) | 2010-07-12 | 2018-02-06 | Toyobo Co., Ltd. | Patch backing for water-based pasty preparation |
| US10583043B2 (en) | 2010-07-12 | 2020-03-10 | Teikoku Seiyaku Co., Ltd. | Backing having three-layer structure and aqueous patch using the backing |
| JP2020158454A (en) * | 2019-03-27 | 2020-10-01 | バンドー化学株式会社 | Base sheet for patches, and patches |
-
1995
- 1995-02-17 JP JP5207595A patent/JPH08217668A/en not_active Withdrawn
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953602B2 (en) | 1999-09-17 | 2005-10-11 | Avery Dennison Corporation | Pattern coated adhesive article |
| US7434798B2 (en) | 2001-05-05 | 2008-10-14 | Lts Lohmann Therapie-Systeme Ag | Grouping of film-like or sheet-like materials |
| KR100878101B1 (en) * | 2001-05-05 | 2009-01-14 | 에르테에스 로만 테라피-시스테메 아게 | Grouping of film-like or sheet-like materials |
| WO2004058232A1 (en) * | 2002-12-26 | 2004-07-15 | Kowa Co., Ltd. | Adhesive patch |
| WO2004096536A1 (en) * | 2003-04-28 | 2004-11-11 | Kuraray Co., Ltd. | Moisture-permeable elastomer sheet |
| JP2005089469A (en) * | 2003-09-18 | 2005-04-07 | Bristol Myers Squibb Co | Adhesive structure for attaching to skin |
| US9884030B2 (en) | 2010-07-12 | 2018-02-06 | Toyobo Co., Ltd. | Patch backing for water-based pasty preparation |
| US10583043B2 (en) | 2010-07-12 | 2020-03-10 | Teikoku Seiyaku Co., Ltd. | Backing having three-layer structure and aqueous patch using the backing |
| JP2020158454A (en) * | 2019-03-27 | 2020-10-01 | バンドー化学株式会社 | Base sheet for patches, and patches |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20020507 |