JPH08119870A - Agent for normalizing turn over from rice - Google Patents

Abstract

PURPOSE: To obtain a turn over-normalizing agent from rice which is safe and inexpensive and capable of readily processing and completely free from care even if always used over a long period. CONSTITUTION: This turn over-normalizing agent contains (1) a ground material of germinated rice, (2) an extract of rice or germinated rice, (3) a material obtained by subjecting rice or germinated rice containing water to enzymatic decomposition or reacting the hydrolyzate with KOJI (Japanese malted rice), (4) a material obtained by subjecting rice or germinated rice to enzymatic decomposition or reacting rice or germinated rice with KOJI before extraction or simultaneously with extraction or after extraction in extracting the rice or germinate rice or/and (5) a material obtained by carrying out alcohol fermentation or an organic solvent fermentation of an extract of rice or germinated rice or a material obtained by carrying out enzymatic decomposition or a material obtained by reacting rice or germinated rice with KOJI.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a turnover normalizing agent obtained from rice or sprouted rice as a raw material.

[0002]

2. Description of the Related Art "Beautiful skin" means that the skin is fresh and moist, the texture of the skin is fine, and the skin ridges and crevices are clear and regular, and it is firm. On the contrary, when you look at the skin with "rough skin", the water in the stratum corneum is lost, and it is in a dull, dull state. Furthermore, due to this,
The epidermal cells accelerate turnover, incomplete keratin is formed, and the stratum corneum becomes thicker, impedes the secretion of sebum, etc., becomes dry and becomes more and more rough. In addition, even if the skin has sufficient water, if the turnover of the stratum corneum occurs abnormally, rough skin occurs (such as keratosis).

Turnover is the division of cells from the base of epidermal cells into differentiation into stratum corneum cells, and the normal cycle is 28 days. In order to keep the "beautiful skin" as described above, it is inevitable that the turnover is normal. In the past, water was replenished to the stratum corneum with "moisturizers" and the like, but at present the thing that normalizes the turnover of the skin itself has not been established.

[0004]

Due to the stress of today's social life and changes in dietary differentiation, "rough skin" is becoming more noticeable on Japanese skin, which is said to be beautiful worldwide. In the past, a material with a moisturizing effect was blended to keep the skin moisturized. However, it does not improve the metabolism of the skin because it is only on the stratum corneum. Also, moisturizers alone have reached the limit of keeping skin healthy. Therefore, unlike the conventional moisturizers, a material that makes the skin itself healthy is needed. The present invention
It is an object of the present invention to develop a turnover normalizing agent from rice that is safe, easy to process and has no fear of being used for a long period of time.

[0005]

[Means for Solving the Problems] From the viewpoint of animal and plant harmony, the present inventors have conducted research on various plant components centering on rice, which is a staple food. In the process, it has become clear that rice has a number of potential and benefits that were previously unpredictable. Therefore, we have conducted a comprehensive utilization study on rice, which is used as a staple food and which has been proven to be highly safe. As one of the themes, we have conducted intensive studies on a turnover normalizing agent from rice, found a component having this effect, and completed the present invention.

In the present invention, a component having an effect on the turnover normalizing agent contained in rice and sprouted rice has not yet been elucidated, but rice and sprouted rice are described below. Those treated in this way were found to have the effect of normalizing turnover.

A product obtained by crushing germinated rice as it is, or containing it. Rice or germinated rice extract as it is or containing it. Enzyme-decomposed or hydrolyzed rice hydrolyzed as it is, or containing it. When extracting rice or sprouted rice, the one that has been subjected to enzymatic decomposition or koji before or at the same time as or after the extraction is used as it is or containing it. An extract of rice or germinated rice or a product of enzymatic decomposition or koji which has been subjected to alcohol fermentation or organic acid fermentation as it is or containing it.

The rice used in the present invention means japonica,
Regardless of indica rice, it refers to non-glutinous rice, brown rice such as sticky rice, and white rice, regardless of variety and type. Further, 92% or more of red rice bran or 92% or less of white rice bran, which appears during whitening, may be used, which is inexpensive and economical. Also,
Germinated rice is used. In addition, since the active ingredient is stable to heat and light, the above raw materials are dipping, steaming, roasting (all sand roasting, net roasting, hot air roasting, etc.),
The raw material treatment such as steam roasting, surface modification such as freeze-drying, photo-modification such as UV irradiation, pressure roasting such as Patrice, and frying may be performed, and the effect was not changed.

Although the rice and germinated rice are effective as they are, they are preferably crushed for practical use. In order to pulverize the rice and the sprouted rice into powder, a pulverizer or a rice mill may be used and a general method may be used. When sprouting rice, germinated rice is soaked in water or sprayed with water to germinate. The temperature for germination is 5 to 70 ° C. However, the temperature and time do not matter as long as they germinate. Also, if there is a risk of water spoiling during germination, replace the water so that it does not decay, or
It is preferable to carry out some preservatives. Here, germination means
It refers to everything from just before germination to germinated ones. The germinated rice is washed well before use. At this time, it may be dried before use.

When extracting rice or germinated rice, or subjecting it to enzymatic decomposition or koji, the raw material rice is pulverized into granules or powders, thereby increasing the surface area and improving efficiency. You don't have to grind, but in this case,
It takes a long time to decompose and extract the rice tissue.

When extracting rice or sprouted rice with water,
High extraction temperature is efficient, but extraction can be sufficiently performed even at low temperature. However, at a low temperature of 40 ° C. or lower, it is desirable to make the pH acidic or alkaline, or add a preservative or alcohol to treat the rice so that it does not spoil. The extraction time may be long or short as long as the active ingredient can be extracted, and may be determined depending on the extraction temperature. The extraction may be carried out under pressure, at normal pressure, or under reduced pressure. Also, rice soaking water or a liquid mashed in soaking water may be used. In other words, any method may be used as long as the rice ingredients come out.

[0012] In the case of water extraction, the gelatinization phenomenon is the most problematic. If it becomes pasty, not only the extraction efficiency will deteriorate, but it will be extremely difficult in actual work. In order to prevent this, the reaction may be carried out by adding amylase or acidification may be carried out with hydrochloric acid or the like to cut the starch. By using this method, it can be sufficiently solved and there is no problem in practice.
Since the active ingredient in the extract is stable to acid and alkali, it is also effective to perform acid decomposition extraction or alkali decomposition extraction. In this case, neutralization and desalting are performed if necessary.

Also in the case of extraction with an organic solvent, it is desirable to pulverize or pulverize rice as much as possible before extraction. The organic solvent may be a general organic solvent such as alcohol, acetone, n-hexane, methanol, etc., but if it is harmful to the human body, it is necessary to completely remove the solvent after extraction, so a safe one is preferable.

When enzymatically decomposing rice or sprouted rice, first, water is added to the rice or sprouted rice, and then an enzyme is added. The amount of water added is appropriately selected depending on the yield, workability, purpose of final use, and the like. The optimum water temperature is the optimum temperature of the enzyme or koji, but enzymatic decomposition is sufficiently carried out even at low temperatures for a long time. However, if the temperature is lower than 40 ° C., some kind of preservative is required. The temperature may be high as long as it is decomposed. The decomposition time depends on the temperature and the like, but may be short or long as long as the decomposition is performed.

The enzyme used here is one or more of starch degrading enzyme, proteolytic enzyme, lipolytic enzyme, fiber degrading enzyme, lignin degrading enzyme and pectin degrading enzyme. When koji is used, the amount of water added, the temperature of action and the time of action are the same as in the case of enzymatic decomposition. The koji to be used may be generally used koji, and the type and variety of koji mold are not limited.

Further, in carrying out the above-mentioned extraction, the above-mentioned enzymatic decomposition and koji may be applied before the extraction, at the same time as the extraction or after the extraction. Here, when enzymatic decomposition or koji is allowed to act simultaneously with extraction, specifically, enzymatic decomposition or koji is allowed to act in an organic solvent, or enzymatic decomposition or koji is allowed to act under reduced pressure extraction.

In the present invention, it is more effective if organic acid fermentation such as alcohol fermentation, lactic acid fermentation or acetic acid fermentation is carried out at the same time as or after the above-mentioned respective treatments. When carrying out this alcoholic fermentation, the extract obtained as described above, the enzymatic decomposition product (including those obtained by combining enzymatic decomposition and extraction) or the one obtained by allowing koji to act as it is, or after pressing and filtering The obtained liquid is subjected to alcohol fermentation. In addition, enzymatic decomposition and alcohol fermentation may be performed simultaneously. That is, after water is added to rice or sprouted rice, an enzyme or koji, and then sake mother or yeast are added to perform saccharification and alcohol fermentation. When producing in large quantities, considering the balance between saccharification and fermentation, it is desirable to add rice or sprouted rice in three or more stages according to sake brewing. Especially when treating a small amount, it is effective to add them all at once. At this time, if there is concern about spoilage, an acid is added or suitable preservative that does not hinder fermentation is applied.

When alcohol fermentation is carried out, there are advantages such as elimination of stickiness, easy concentration, and easy concentration of the active ingredient. When carrying out lactic acid fermentation, it is similar to the case of alcoholic fermentation. In this case, lactic acid bacteria are added instead of liquor or yeast to carry out lactic acid fermentation. Lactic acid fermentation is carried out by a general ordinary method, and the type of lactic acid bacterium and the conditions for lactic acid fermentation do not matter.

Next, in the case of acetic acid fermentation, the fermented product obtained as described above is used as it is, or after being diluted to 4-5% of alcohol, acetic acid bacteria are added to carry out acetic acid fermentation. For alcohol-free products, acetic acid fermentation may be carried out by adding alcohol. Acetic acid fermentation is carried out by a general ordinary method, and the type of acetic acid bacterium and the conditions of acetic acid fermentation are not limited.

The product of the present invention obtained as described above is used as it is without separating the residue, or after being pressed and filtered. When used as is, sterilize or sterilize the product. If necessary, aeration fermentation with yeast, alcohol precipitation, synthetic adsorbents and the like may be used for sugar removal. When the product of the present invention is blended, depending on the actual application, cream, face wash, emulsion, lotion, and
Cosmetics such as cleansing, packs, soaps, ointments, bath preparations, lotions, tinctures, lentiments, jellies, aerosols and other external medicines are used as dosage forms. The other compounding ingredients may be any of those usually used, and further, other medicinal agents may be used in combination.

The results obtained for the turnover normalizing action of the product of the present invention are described below. (A) Normalization effect on turnover in animal experiment (1) Experimental animal Rabbit: New Zealand White 3 weeks old, body weight 2000 g Male (2) Inducer β-Ione 100% is used as a stock solution. (3) Method All the application is performed with a brush so that the ears are soft and uniform.

The above treatment is carried out for the first 10 days, and thereafter, the present invention is further applied only to the left ear lobe for 10 days (once a day). After that, only observation is continued, and a biopsy is performed 30 days after the start of the experiment. This is a 6 mm trepan, and one part of the ear wing is extracted, fixed with formalin, and surrounded by paraffin HE.
It was stained and examined histologically.

In this experiment, application of a fragrance called β-Ionon causes dermatitis in rabbit ears, which promotes division of epidermal basal cells and promotes epidermal turnover. The results of the above experiment are shown in Table 1. The control was compared with the control by pouring water in place of the product of the present invention.

[0024]

[Table 1]

Furthermore, histological examination was conducted on three typical properties observed due to abnormal turnover. Keratin hyperplasia is a condition in which the loss of keratinocytes is delayed or the keratin is abnormally thickened due to keratin hyperplasia. It is that in humans, the thickening of the stratum corneum is also seen in the elbows and the like. The product of the present invention remarkably suppresses this hyperkeratosis in animal experiments as compared with the control group.

Parakeratosis is a change in the stratum corneum observed in the process of incomplete keratinization, leaving a nucleus in keratinocytes and usually eliminating the granule layer. It is thought that the upward movement of keratinocytes is so rapid that removal of the nucleus occurs in time. Even in humans, the percentage of “nucleated cells” left by the nucleus due to this parakeratosis is increasing in the stratum corneum of people with the phenomenon of “rough skin”. On the other hand, people with fresh skin have a high proportion of “nucleated cells”. Therefore, it is considered that nucleated cells are reduced by suppressing keratokeratosis, and beautiful and well-textured skin is maintained. The product of the present invention remarkably suppresses this parakeratosis phenomenon.

Abnormal keratinization means that individual keratinized cells are
It refers to a state where erroneous keratinization occurs locally, and keratinocytes are keratinized at the height of the spinous layer and the granular layer, and the intracellular structure is unstructured and shows eosinophilicity. This is a phenomenon that shows an abnormal turnover. The product of the present invention exhibits a remarkable suppressing effect even in this abnormal keratinization.

From the above results, the product of the present invention is
Significantly suppresses parakeratosis and abnormal keratinization. That is, this is an improvement in turnover abnormality, and it can be said that the product of the present invention has a turnover normalizing effect. (B) Normalization effect on turnover in human skin (Measurement of the number of nucleated cells in human scalp) (1) Method The measurement shown in FIG. 1 is performed by determining the ratio of nucleated cells in keratinocytes of the scalp. The product of the present invention was applied under the conditions.

After 7 days, the product of the present invention was washed on the face, and sufficiently rubbed on the skin of the scalp, and after 7 days, 14 days, and 21 days.
After a day, scalp keratinocytes were collected. The collected scalp keratinocytes were treated as follows and the nucleated cells were measured. Scalp nucleated cells and 0.1% Triton x-100
3 ml of 0.075 M phosphate buffer containing is placed in an ice-cooled test tube. Take 0.25 ml of this solution, and use Triton x-1.
Dilute 2-fold with 00 phosphate buffer. Drop a drop of Fuchsin-Crystal Violet in it. After shaking for 1 minute, measurement is performed with a hemocytometer. 100 keratinocytes are counted and the number of nucleated cells among them is recorded. The test subjects were 5 persons (male) with abnormal scalp, and the proportion of nucleated cells was calculated as the average value of 5 persons.
The results are shown in Table 2.

[0030]

[Table 2]

From the above results, those with abnormal scalp are
Almost 90% occupied the nucleated cells before coating. However, the ratio of nucleated cells was remarkably reduced by applying the product of the present invention. The large number of nucleated cells is considered to cause the phenomenon of parakeratosis in the epidermal cells. This keratokeratosis is a change in the stratum corneum that occurs in the process of incomplete keratinization, leaving the nucleus in the keratinocytes and moving the keratinocytes upwards too rapidly, so that removal of the nucleus is in time. It is believed that it will occur without.

Due to the occurrence of this parakeratosis, the skin exhibits properties such as "bulky skin", "shark skin" and "keratin thickening", and dandruff with many "dandruff" on the scalp. The cause of this parakeratosis is caused by the abnormal turnover.

As described above, the marked reduction of nucleated cells by application of the product of the present invention leads to improvement of the parakeratosis phenomenon, that is, normalization of turnover. Therefore, the product of the present invention normalizes the turnover even in humans.

[0034]

【Example】

(Example 1) 1 kg of rice without germ was soaked in water at 25 ° C for 3 days to germinate rice. After thoroughly washing the germinated rice, it is dried at 50 ° C. for 24 hours, and then,
The product was finely pulverized to obtain 990 g of the product of the present invention. (Example 2) Brown rice was crushed to obtain a crushed brown rice product 500
g was obtained. 1500 ml of water was added to this pulverized product, the pH was lowered with hydrochloric acid, and the mixture was left for 10 days. Then, it was squeezed with a squeezing machine to neutralize the resulting clear liquid to obtain 1200 ml of the product of the present invention and 760 g of a residue.

(Example 3) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 2 was carried out to obtain another 1190 ml of the product of the present invention. (Example 4) Brown rice is crushed to obtain 500 crushed brown rice.
g was obtained. Liquefaction enzyme 10g and water 1500m to this crushed material
1 was added. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. After that, squeeze with a wringer,
1420 ml of the product of the present invention and 560 g of a residue were obtained.

Example 5 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 4 was carried out to obtain another 1400 ml of the product of the present invention. (Example 6) Brown rice is crushed by a crusher to obtain crushed brown rice 500
g was obtained. 1500 ml of 2N-NaOH was added to this pulverized product and the mixture was left for 5 days. Then, it was squeezed with a squeezing machine to obtain 1350 ml of the clear liquid and 650 g of the residue. 1 of this clarified liquid
It was neutralized with 0N-HCL to obtain 1480 ml of the product of the present invention.

Example 7 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 6 was carried out to obtain another 1490 ml of the product of the present invention. (Embodiment 8) Brown rice is crushed to obtain a crushed brown rice product 500
g was obtained. 1500 ml of 95% ethanol is added to this pulverized product.
Was added and left for 5 days. After that, squeeze with a wringer,
1300 ml of clear liquid and 650 g of residue were obtained. 2000 ml of water was added to this clarified solution, and the mixture was concentrated by a rotary evaporator to obtain 1500 ml of the product of the present invention.

Example 9 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 8 was carried out to obtain another 1500 ml of the product of the present invention. (Example 10) Brown rice was crushed to obtain a crushed brown rice product 50
0 g was obtained. 300 g of koji and 1500 ml of water
Was added and the mixture was allowed to stand at 55 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1230 ml of the product of the present invention and 1000 g of a residue.

(Example 11) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 10 was carried out,
1210 ml of another product of the present invention was obtained. (Example 12) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. 2 g of protease and 150 water
0 ml was added and the mixture was left at 50 ° C. for 20 hours. Then, the product was squeezed with a squeezing machine to obtain 1310 ml of the product of the present invention and 670 g of a residue.

(Example 13) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 12 was carried out,
Another 1380 ml of the product of the present invention was obtained. (Example 14) Brown rice is crushed to obtain 50 crushed brown rice.
0 g was obtained. 2 g of lipolytic enzyme and 150 water
0 ml was added and the mixture was left at 50 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1290 ml of the product of the present invention and 680 g of a residue.

Example 15 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 14 was carried out,
Another 1360 ml of the product of the present invention was obtained. (Example 16) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. 2 g of fiber-degrading enzyme and 150 water
0 ml was added and the mixture was left at 50 ° C. for 20 hours. Then, the product was squeezed with a squeezing machine to obtain 1330 ml of the product of the present invention and 650 g of a residue.

Example 17 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 16 was carried out,
Another 1370 ml of the product of the present invention was obtained. (Example 18) Brown rice was crushed to obtain a crushed brown rice product 50
0 g was obtained. 2g starch degrading enzyme and 150g water
0 ml was added and the mixture was left at 55 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1380 ml of the product of the present invention and 600 g of a residue.

(Example 19) The same operation as in Example 18 was carried out using 500 g of the product of the present invention obtained in Example 1,
Another 1400 ml of the product of the present invention was obtained. (Example 20) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. Add 2 g of pectin-degrading enzyme and 1 part of water to this ground product.
500 ml was added and left at 50 ° C. for 20 hours. After that, squeezing with a squeezing machine, 1320 ml of the present invention product and residue 660
g was obtained.

Example 21 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 20 was carried out,
Another 1300 ml of the product of the present invention was obtained. (Example 22) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. To this pulverized product, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of starch degrading enzyme, 2 g of pectin degrading enzyme and 1500 ml of water were added, and the mixture was heated at 50 ° C. for 2 hours.
It was left for 0 hours. After that, the product of the present invention 14
20 ml and 560 g of residue were obtained.

(Example 23) The same operation as in Example 22 was carried out using 500 g of the product of the present invention obtained in Example 1,
Another 1440 ml of the product of the present invention was obtained. (Example 24) The same operation as in Example 22 was carried out to obtain 2000 g of an enzymatic decomposition product of rice. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, it was squeezed with a squeezing machine to obtain 1400 ml of the product of the present invention and 550 g of a residue.

Example 25 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 24 was carried out,
1420 ml of another product of the present invention was obtained. (Example 26) Brown rice was crushed to obtain a crushed brown rice product 50
0 g was obtained. To this crushed product, 300 g of koji and 1500 ml of 40% ethanol were added, and the mixture was left at 55 ° C. for 48 hours. After that, squeeze with a squeezing machine and clarified liquid 1300 ml and residue 850
g was obtained. Then, 1000 ml of water was added to the clarified liquid, and the mixture was concentrated by a rotary evaporator to obtain the product 13 of the present invention.
00 ml was obtained.

Example 27 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 26 was carried out,
Another 1300 ml of the product of the present invention was obtained. (Example 28) Rice extract 20 was prepared in the same manner as in Example 4.
00g was obtained. To this extract, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of starch degrading enzyme and 2 g of pectin degrading enzyme were added, and the mixture was left at 50 ° C. for 24 hours. Then, it was squeezed with a squeezing machine to obtain 1400 ml of the product of the present invention and 580 g of a residue.

Example 29 Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 28 was carried out,
Another 1390 ml of the product of the present invention was obtained. (Example 30) In the same manner as in Example 24, 2000 g of an enzyme-decomposed extract of rice was obtained. Yeast was added to this enzyme-decomposed extract, and alcoholic fermentation was carried out for 16 days. Then, it was squeezed with a squeezing machine to obtain 1880 ml of the product of the present invention and 80 g of a residue.

(Example 31) The same operation as in Example 30 was carried out using 500 g of the product of the present invention obtained in Example 1,
Another 1800 ml of the product of the present invention was obtained. (Example 32) In the same manner as in Example 24, 2000 g of an enzyme-decomposed extract of rice was obtained. The enzyme-decomposed extract was sterilized by boiling, cooled to 37 ° C., 200 ml of a starter in which lactic acid bacteria had been cultured in advance was added, and the mixture was well stirred and sealed, and
Lactic acid fermentation was performed at 7 ° C for 2 days. Then, it was squeezed with a squeezing machine to obtain 1380 ml of the product of the present invention and 590 g of a residue.

(Example 33) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 32 was carried out,
Another 1400 ml of the product of the present invention was obtained. (Example 34) The product 1000 of the present invention obtained in Example 24.
80 ml of 95% ethanol was added to ml, and acetic acid fermentation was performed for 20 days. Then, it is filtered and the product of the present invention 990 m
1 was obtained.

(Example 35) The same operation as in Example 34 was carried out using 500 g of the product of the present invention obtained in Example 1,
Another 1000 ml of the product of the present invention was obtained. Examples of the case where the products of the present invention obtained in the above examples are blended into a lotion type and an emulsion type will be described below. The formulation examples are not limited to the examples below.

(Example 36) The product of the present invention obtained in Example 24 10.0% by weight sorbitol 3.0% by weight glycerin 5.0% by weight purified water 76.4% by weight allantoin 0.1% by weight polyoxy Ethylene castor oil derivative 0.5% by weight Ethanol 5% by weight The above ingredients were mixed and dissolved by a conventional method to obtain a lotion type product.

Example 37 The product of the present invention obtained in Example 30 20.0% by weight Stearic acid 1.3% by weight Cetanol 0.7% by weight Beeswax 2.0% by weight Polyoxyethylene (11) mol oleic acid Ester 1.2 wt% Glycerin monostearate 0.8 wt% Quinceseed extract (5% aqueous solution) 15.0 wt% Dipropylene glycol 5.0 wt% Ethanol 3.0 wt% Methylparaben 0.3 wt% Fragrance 0.3% by weight Purified water 50.4% by weight

Dipropylene glycol was added to purified water,
The mixture is heated and stirred, and the temperature is maintained at 70 ° C.
A quince seed extract, a fragrance, and ingredients other than ethanol are added and stirred, and then uniformly emulsified with a homogenizer. The remaining emulsion was gradually added to the obtained emulsion with stirring while cooling, and the mixture was cooled to room temperature to obtain an emulsion type product.

[0055]

According to the present invention, an excellent turnover normalizing agent which is simply and completely safe and has a turnover normalizing effect can be obtained by continuous external application. Up until now, rice has been the staple food, so little has been developed about its manufacturing method and use in new fields other than food. Furthermore, rice has been the staple food, and its safety has been well demonstrated. That is, the present invention not only finds a very excellent turnover normalizing agent, but also finds a new application for use, which is said to be overproduction of rice, and can increase consumption by improving the image of rice. Is extremely meaningful.

[Brief description of drawings]

FIG. 1 is an explanatory diagram showing application conditions of the product of the present invention in a test for measuring the number of nucleated cells in human scalp.

Claims (5)

[Claims] 1. A turnover normalizing agent comprising a crushed product of germinated rice as it is or containing it. 2. A turnover normalizing agent comprising rice or an extract of germinated rice as it is or containing it. 3. A turnover normalizing agent, which is obtained by enzymatically decomposing or hydrolyzing rice hydrolyzed with hydrolyzed rice as it is, or containing it. 4. When extracting rice or sprouted rice, enzyme-decomposed or koji-acted ones before or at the same time as or after extraction are used as they are, or normalization of turnover comprising the same is carried out. Agent. 5. Normalization of turnover comprising the extract of rice or germinated rice or the product of enzymatic decomposition or koji which has been subjected to alcohol fermentation or organic acid fermentation as it is or containing it. Agent.