JPH0791316B2 - 新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途 - Google Patents

新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途

Info

Publication number: JPH0791316B2
Authority: JP; Japan
Prior art keywords: cyclosporine; iii; treatment; orthorhombic; cyclosporin
Prior art date: 1987-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP63321857A

Other languages

English (en)

Japanese (ja)

Other versions

JPH01211598A (ja

Inventor

ダニエル・ジロン

マーチン・リスト

フリードリッヒ・リヒテル

ヤスユキ・ウイケ

ハンス・ペーター・ウェーバー

Original Assignee

サンド・アクチエンゲゼルシャスト

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1995-10-04

1988-12-20 Application filed by サンド・アクチエンゲゼルシャスト filed Critical サンド・アクチエンゲゼルシャスト

1989-08-24 Publication of JPH01211598A publication Critical patent/JPH01211598A/ja

1995-10-04 Publication of JPH0791316B2 publication Critical patent/JPH0791316B2/ja

2010-10-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

JP63321857A 1987-12-21 1988-12-20 新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途 Expired - Lifetime JPH0791316B2 (ja)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US136230		1987-12-21
US17261388A	1988-03-24	1988-03-24
US172613		1988-03-24
US21254888A	1988-06-28	1988-06-28
US212548		1994-03-11

Publications (2)

Publication Number	Publication Date
JPH01211598A JPH01211598A (ja)	1989-08-24
JPH0791316B2 true JPH0791316B2 (ja)	1995-10-04

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP63321857A Expired - Lifetime JPH0791316B2 (ja)	1987-12-21	1988-12-20	新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (fr)
KR (1)	KR100188305B1 (fr)
AT (1)	AT403163B (fr)
AU (1)	AU626274B2 (fr)
BE (1)	BE1002665A4 (fr)
CA (1)	CA1341396C (fr)
CH (1)	CH677926A5 (fr)
CY (1)	CY1799A (fr)
DE (1)	DE3843054C2 (fr)
DK (1)	DK175220B1 (fr)
ES (1)	ES2012580A6 (fr)
FI (1)	FI89065C (fr)
FR (1)	FR2624863B1 (fr)
GB (1)	GB2211848B (fr)
GR (1)	GR1002486B (fr)
HK (1)	HK102894A (fr)
HU (1)	HU203564B (fr)
IE (1)	IE62006B1 (fr)
IL (1)	IL88719A0 (fr)
IT (1)	IT1235356B (fr)
LU (1)	LU87409A1 (fr)
MY (1)	MY103943A (fr)
NL (1)	NL195096C (fr)
NO (1)	NO177228C (fr)
NZ (1)	NZ227384A (fr)
SE (1)	SE503174C2 (fr)
SG (1)	SG99494G (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (fr) *	1992-05-13	1997-01-15	Sandoz Ltd.	Compositions ophtalmiques contenant une cyclosporine
EP1142568A1 (fr)	1992-09-25	2001-10-10	Novartis AG	Compositions pharmaceutiques à base de cyclosporines
CZ287806B6 (en)	1994-11-03	2001-02-14	Novartis Ag	Cyclosporin pharmaceutical preparation for oral administration and process of its preparation
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en) *	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
TR199901686T2 (xx)	1997-01-30	1999-09-21	Norvartis Ag	Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CN100548271C (zh)	2004-01-20	2009-10-14	阿勒根公司	用于眼部的局部治疗、并优选包括有曲安奈德及透明质酸的组合物
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
EP2714720B1 (fr) *	2011-05-27	2018-12-26	Allergan, Inc.	Forme cristalline de cyclosporine a, procédés de préparation et procédés d'utilisation associés
WO2013074616A1 (fr) *	2011-11-15	2013-05-23	Allergan, Inc.	Suspensions autoclavables de la forme 2 de cyclosporine a
EP3067363B1 (fr) *	2011-11-15	2018-01-17	Allergan, Inc.	Procédé de crystallisation de la cyclosporine a en forme 2
JP6363506B2 (ja)	2011-11-15	2018-07-25	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ２型の懸濁剤
KR102029513B1 (ko) *	2011-11-15	2019-10-07	알러간, 인코포레이티드	사이클로스포린 제2형의 지속 작용 제형
WO2024085235A1 (fr) *	2022-10-20	2024-04-25	中外製薬株式会社	Procédé de production de cristaux peptidiques cycliques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5259180A (en) *	1975-11-04	1977-05-16	Sandoz Ag	Improving concerning organic compound
JPS53139789A (en) *	1977-05-10	1978-12-06	Sandoz Ag	Improvement of organic compound
JPS5555150A (en) *	1978-10-18	1980-04-22	Sandoz Ag	Cyclosporin derivatives*their manufacture and medical composition containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active IP Right Cessation
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 CA CA000586611A patent/CA1341396C/fr not_active Expired - Fee Related
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/xx unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5259180A (en) *	1975-11-04	1977-05-16	Sandoz Ag	Improving concerning organic compound
JPS6277399A (ja) *	1975-11-04	1987-04-09	ザンドツ　アクチエンゲゼルシヤフト	シクロスポリンｃ
JPS53139789A (en) *	1977-05-10	1978-12-06	Sandoz Ag	Improvement of organic compound
JPS5555150A (en) *	1978-10-18	1980-04-22	Sandoz Ag	Cyclosporin derivatives*their manufacture and medical composition containing them

Also Published As

Publication number	Publication date
NO885625D0 (no)	1988-12-19
ES2012580A6 (es)	1990-04-01
FI885869A0 (fi)	1988-12-19
AU626274B2 (en)	1992-07-30
IE62006B1 (en)	1994-12-14
IT8848690A0 (it)	1988-12-20
SG99494G (en)	1994-10-28
FI89065C (fi)	1993-09-30
IE883779L (en)	1989-06-21
IL88719A0 (en)	1989-07-31
NO177228C (no)	1995-08-09
SE8804570L (sv)	1989-06-22
BE1002665A4 (fr)	1991-04-30
KR890009975A (ko)	1989-08-05
DK705488D0 (da)	1988-12-19
NZ227384A (en)	1991-09-25
SE503174C2 (sv)	1996-04-15
GR880100850A (el)	1994-03-31
FR2624863A1 (fr)	1989-06-23
DK175220B1 (da)	2004-07-12
MY103943A (en)	1993-10-30
NL195096C (nl)	2004-02-09
GR1002486B (el)	1996-12-09
KR100188305B1 (ko)	1999-06-01
FR2624863B1 (fr)	1991-04-26
SE8804570D0 (sv)	1988-12-19
NO177228B (no)	1995-05-02
GB8829556D0 (en)	1989-02-08
CA1341396C (fr)	2002-11-05
CY1799A (en)	1995-02-17
LU87409A1 (fr)	1989-07-07
AU2705588A (en)	1989-06-22
DK705488A (da)	1989-06-22
NL8803125A (nl)	1989-07-17
IT1235356B (it)	1992-06-30
AT403163B (de)	1997-11-25
GB2211848B (en)	1991-11-06
DE3843054A1 (de)	1989-07-27
JPH01211598A (ja)	1989-08-24
ATA309588A (de)	1997-04-15
FI89065B (fi)	1993-04-30
CH677926A5 (fr)	1991-07-15
DE3843054C2 (de)	2003-08-21
FI885869A (fi)	1989-06-22
NO885625L (no)	1989-06-22
HUT49893A (en)	1989-11-28
HK102894A (en)	1994-09-30
GB2211848A (en)	1989-07-12
HU203564B (en)	1991-08-28

Publication	Publication Date	Title
JPH0791316B2 (ja)	1995-10-04	新規シクロスポリン結晶形、その製法、それを含有する医薬組成物およびその用途
KR100446170B1 (ko)	2004-11-20	사이클로스포린을함유하는약학조성물
US5756450A (en)	1998-05-26	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
JP3090666B2 (ja)	2000-09-25	薬理活性化合物および医薬賦形剤用可溶化剤としての水溶性モノエステル類
JPH11505257A (ja)	1999-05-18	親油性薬物の自己乳化性製剤
SE511398C2 (sv)	1999-09-20	Komposition innehållande cyklosporin och sackaros- eller raffinosmonolaurat
SK278320B6 (en)	1996-10-02	Process for producing of cyclosporine a
HU212727B (en)	1996-10-28	Process for producing pharmaceutical compositions in form of microemulsion-prae-concentrate or microemulsion containing cyclosporin(s) as active component
KR100256007B1 (ko)	2000-05-01	사이클로스포린을 함유하는 약학 조성물
KR100267149B1 (ko)	2000-09-15	사이클로스포린을 함유하는 약학 조성물

Legal Events

Date	Code	Title	Description
2004-08-31	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2005-08-23	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2006-10-03	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-10-09	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20081004 Year of fee payment: 13
2008-10-07	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20091004 Year of fee payment: 14
2008-12-20	EXPY	Cancellation because of completion of term
2009-03-11	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20091004 Year of fee payment: 14