JPH07258050A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a component for the oral cavity, containing common salt, sodium bicarbonate and a germicide, excellent in treating and preventing effects on periodontosis and good in taste and touch. CONSTITUTION:This composition for the oral cavity contains granular common salt having 150-450mum average diameter, granular sodium bicarbonate having 100-300mum average diameter and one or two or more germicides selected from the group consisting of salts of chlorhexidine, quaternary ammonium salts, triclosan, hinokitiol, isopropylmethylphenol and an alkyldiaminoethylglycine hydrochloride as active ingredients. The contents of the ingredients are >=10wt.% common salt and 0.001-0.1wt.% germicides at (1/0.5) to (1/3) weight ratio of the common salt to the sodium bicarbonate. Furthermore, a water-insoluble polishing agent can be blended for use as a dentifrice and an oily ingredient or a water-soluble polymer can be blended for use as a gingival coating agent. Thereby, the composition has no unpleasant salty taste of the common salt and an effective concentration of the germicides in the oral cavity can be maintained high without blending the germicides at a high concentration.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing salt, baking soda and a bactericide. More specifically, it is excellent in the treatment / prevention effect of periodontal disease and has no unpleasant saltiness of salt. Further, the present invention relates to an oral composition capable of maintaining a high effective concentration of a disinfectant in the oral cavity without adding a high concentration of the disinfectant and having a good taste and feel.

[0002]

2. Description of the Related Art Periodontal diseases are two major diseases in the oral region along with caries. In particular, alveolar pyorrhea, in today's aging society,
It is a serious problem. Therefore, its prevention and treatment has a very important meaning in oral hygiene, and toothpaste containing salt as a medicinal agent is commercially available as a dentifrice intended for them. It is considered that salt absorbs tissue fluid in inflamed gingiva to improve circulation in the gingiva locally.

On the other hand, bactericides such as chlorhexidine hydrochloride, quaternary ammonium salts, triclosan, hinokitiol, isopropylmethylphenol and alkyldiaminoethylglycine hydrochloride are widely used for the prevention and treatment of gingivitis, like salt. The bactericidal agent is completely different from the action of the above-mentioned salt, and exerts an effect by acting on periodontal disease-causing bacteria which is a direct cause of periodontal disease. Therefore, by using the salt and the bactericidal agent in combination, Since a synergistic effect on the prevention and treatment of gingivitis can be expected, many toothpaste formulations containing both are commercially available.

However, in a toothpaste containing a salt and a bactericide, if a high concentration of salt is added for the purpose of improving the effect of improving gingivitis, saltiness increases, which causes discomfort and salivary glands at the same time. There is a problem that the amount of saliva secreted is increased by stimulating urine and as a result, the salt is diluted and the effective concentration of salt in the oral cavity decreases. Further, the bactericide contained in the toothpaste is also diluted with saliva in the same manner as salt, and there is a problem that its effectiveness is lower than that obtained when the bactericide is contained alone. To reduce the effective concentration of the disinfectant, it is possible to prevent the effective concentration of the disinfectant from decreasing by adding a high concentration of the disinfectant in advance. Has a limited blending concentration in terms of color, taste, safety, etc.,
Some measures are required.

Therefore, an object of the present invention is to provide excellent treatment / preventive effects for periodontal diseases, to avoid the unpleasant saltiness of salt, and to add a high concentration of bactericide to the oral cavity of the bactericide. (EN) It is intended to provide an oral composition capable of maintaining a high effective concentration and having a good taste and feel.

[0006]

Means for Solving the Problems As a result of intensive studies aimed at achieving the above object, the present inventors have found that the following (1) to (1) to (3) can be obtained by adding baking soda to a dentifrice containing salt and a bactericide.
It was found that the effect of (3) is exhibited. (1) For example, a dentifrice formulated with 15% by weight of salt, 15% by weight of sodium bicarbonate and 100 ppm of benzethonium chloride (bactericide) is 15% by weight of salt and 100% of benzethonium chloride.
Compared with both the dentifrice containing ppm and the dentifrice containing 15 wt% of baking soda and 100 ppm of benzethonium chloride, an extremely excellent effect of improving gingivitis can be obtained. A dentifrice containing 15% by weight of sodium chloride, 15% by weight of baking soda, and 100 ppm of benzethonium chloride is used as a dentifrice.
Compared to the dentifrice containing 0 wt% and benzethonium chloride 100 ppm, almost the same dehydration effect (squeezing effect) is obtained, and the former is remarkably less salty than the latter, so compared to the latter. It does not promote the secretion of saliva so that the effective concentration of benzethonium chloride in the oral cavity can be kept high. (2) By using salt having a specific average particle diameter, the dissolution rate of salt into saliva can be adjusted, and as a result,
Not only can saltiness during tooth brushing be adjusted appropriately, palatability can be significantly enhanced, but also effective concentration of benzethonium chloride in the oral cavity can be maintained high. (3) By using baking soda having a specific average particle size, the time during which the granular salt can be sensed in the oral cavity can be freely adjusted, and as a result, an excellent taste and feel can be imparted to the dentifrice. Since the saltiness of the product can be adjusted appropriately, the effective concentration of benzethonium chloride in the oral cavity can be kept high. .

The present invention has been made based on the above findings, and provides an oral composition containing the following components (a), (b) and (c). (A) Salt (b) Baking soda (c) Bactericide

The oral composition of the present invention will be described in detail below. The salt which is the component (a) of the oral composition of the present invention has an average particle size of 150 to 450 μm, preferably 1
50 to 350 μm, particularly preferably 150 to 300 μm
m, most preferably 200 to 300 μm of granular salt is preferably used, and by using such granular salt,
It is possible to maintain a high effective concentration in the oral cavity of the bactericide which is the component (c). Also, the average particle size of the granular salt is 15
If it is less than 0 μm, salt is rapidly dissolved in saliva in the oral cavity, and saltiness may be rapidly developed.
Further, if the average particle size of the granular salt exceeds 450 μm, the feeling in the oral cavity becomes poor, and in extreme cases, there is a risk of damaging the soft tissues in the oral cavity such as the gums.

The baking soda which is the component (b) of the oral composition of the present invention has an average particle size of 45 to 450 μm, preferably 100 to 300 μm, and particularly preferably 200 to.
It is preferable to use granular baking soda of 300 μm, and by using such granular baking soda, the effective concentration in the oral cavity of the bactericide as the component (c) can be kept high. Also,
When the average particle size of the granular baking soda is less than 45 μm, the baking soda is rapidly dissolved in saliva in the oral cavity, and the time during which the granular salt can be sensed becomes short. The average particle size of the granular baking soda is 450μ.
If it is more than m, there is a fear that the feeling will be bad, and within 2 minutes which is the average brushing time, baking soda cannot be completely dissolved in saliva in the oral cavity, and it is spited wastefully without exerting any effect. It may happen.

The above-mentioned granular baking soda is not particularly limited in its production method, but crystals precipitated by passing carbon dioxide in a pure sodium carbonate solution at 50 ° C. or lower are filtered off, dried in a carbon dioxide stream and ground. Those obtained by the production method are preferred.

The bactericide which is the component (c) of the oral composition of the present invention is not particularly limited as long as it can be applied to the oral cavity. For example, chlorhexidine salts and quaternary ammonium salts. , Triclosan, hinokitiol, isopropylmethylphenol, alkyldiaminoethylglycine hydrochloride and the like. As the salts of chlorhexidine, chlorhexidine hydrochloride,
Examples thereof include chlorhexidine gluconate, and examples of the quaternary ammonium salts include benzethonium chloride, cetylpyridinium chloride, decalinium chloride, and benzalkonium chloride. Among the above-mentioned compounds, the chlorhexidine salts and the quaternary ammonium salts are particularly preferable as the above-mentioned (c) component bactericide.

In order for the oral composition of the present invention to have an appropriate taste of salt and to exert the maximum dehydrating effect, the salt as the component (a) is 10% by weight or more, particularly 10 to 3
It is preferable to contain 0% by weight, more preferably 15 to 20% by weight. Further, in the oral composition of the present invention, the weight compounding ratio (salt / sodium bicarbonate) of the salt as the component (a) and the baking soda as the component (b) is in the range of 1 / 0.5 to 1/3. Of which, 1
It is preferably within the range of /0.8 to 1/2, and more preferably within the range of 1 / 1.1 to 1/2. In addition, the oral composition of the present invention contains the bactericidal agent (component (c)) in an amount of 0.001 to
It is preferable to contain 0.1% by weight, particularly 0.005 to 0.02% by weight.

The oral composition of the present invention contains, as the salt (a) component and the sodium bicarbonate (b) component, a granular salt having a particle size outside the range of 150 to 450 μm and a particle size of 4
Although it may contain granular baking soda outside the range of 5 to 450 μm, the content of granular salt having a particle size of less than 150 μm and the content of granular salt having a particle size of more than 450 μm are both 10% by weight or less. Preferably, the content of granular baking soda having a particle size of less than 45 μm is 50% by weight or less, particularly 20% by weight or less, and the content of granular baking soda having a particle size of more than 450 μm is 3%.
It is preferably 0% by weight or less, particularly preferably 15% by weight or less.

The oral composition of the present invention comprises the above-mentioned (a) salt, (b) baking soda, and (c) bactericide, which are blended in an oral vehicle according to a conventional method, and a toothpaste, a liquid dentifrice, and a powder dentifrice. , A gum application agent (pasta agent for oral cavity) and the like. When the oral composition of the present invention is used as a dentifrice, the above-mentioned oral vehicle includes a water-insoluble abrasive [component (d)], a binder, a wetting agent, a surfactant, a fragrance, and a sweetener. , Preservatives, dyes, water, water-soluble fluorides, silicones, and other active ingredients are appropriately used.

Examples of the water-insoluble abrasives (component (d)) include calcium hydrogen phosphate for toothpaste, heavy calcium carbonate, light calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, potassium metaphosphate, silicic acid anhydride, and hydrous water. Examples thereof include silicic acid, aluminum silicate, calcium silicate, zirconium silicate, bentonite, zeolite, aluminum oxide, aluminum hydroxide, alumina, resin and mixtures thereof. Of these, silicic acid anhydride, hydrous silicic acid, calcium silicate,
Aluminum silicate, heavy calcium carbonate, light calcium carbonate, aluminum hydroxide, and alumina are particularly preferable in order to obtain a dentifrice having good storage stability, and in order to obtain good flavor stability, hydroxide is preferable. Aluminum is more preferred.

As the above-mentioned binder, sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, tragacanth gum,
Starch, sodium polyacrylate, etc. are mentioned.
The wetting agent is polyethylene glycol,
Propylene glycol, sorbitol, glycerin, maltitol, xylitol and the like can be mentioned. Of these, glycerin and sorbitol are particularly preferable.

The surface active agent is used as a foaming agent or a stabilizer for an oily substance, and various surface active agents are used. Examples of preferred surfactants include alkyl sulfates, alkylbenzene sulfonates,
Monoalkyl phosphate ester salt, N-acyl sarcosinate salt, N-acyl glutamate salt, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer (pluronic type), sucrose fatty acid ester, alkyl glycosides, Examples thereof include sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, carbobetaine, hydroxycarbobetaine, phosphobetaine, hydroxyphosphobetaine, sulfobetaine and hydroxysulfobetaine. Among these, water-soluble nonionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, sucrose fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester and Amphoteric surfactants are especially preferred.

Further, as the above-mentioned fragrance, spearmint oil, peppermint oil, winder green oil, sassafras oil, clove oil, sage oil, eucalyptus oil, mayonnaise oil,
Natural flavors such as cinnamon oil, thyme oil, lemon oil and orange oil; and synthetic flavors such as 1-menthol, anethole, carvone, eugenol, thymol and methyl salicylate. Further, as the sweetener, saccharin,
Examples include saccharin sodium, stevioside, neohesperidyl dihydrochalcone, berlartin, p-methoxycinnamic aldehyde, glycyrrhizate, aspartame (aspartyl phenylalanine methyl ester) and the like. Further, as the preservative, benzoic acid, sodium benzoate, para-hydroxybenzoic acid,
Para-hydroxy benzoic acid ester etc. are mentioned.

Examples of the above water-soluble fluorides include sodium fluoride and sodium monofluorophosphate. Further, as the above-mentioned other active ingredients, chlorophyll compounds, ε-aminocaproic acid, tranexamic acid, vitamin C, vitamin E, nicotinic acid ester, allantoinchlorohydroxyaluminum, azulene,
Examples thereof include lysozyme chloride, β-glycyrrhetinic acid, dipotassium glycyrrhizinate, protease, and crude drug extract.

When the oral composition of the present invention is used as a paste-like dentifrice composition such as a toothpaste or a liquid dentifrice, all the components of the above-mentioned oral vehicle for dentifrice may be blended. Basically, 10 to 75% by weight of a water-insoluble polishing agent [(d) component], 0.5 to 5% by weight of a binder, 10 to 85% by weight of a wetting agent and water are added to an oral vehicle. It is preferable to contain it by weight percent. Here, the content of the water-insoluble abrasive [component (d)] is 20 to 20 in the case of toothpaste.
It is preferably 75% by weight, and 10 to 30% by weight in the case of a liquid dentifrice. Further, in the case of a solid composition such as a powder dentifrice, a solid component can be blended among the components of the oral vehicle for the above dentifrice, but basically, a water-insoluble abrasive in the oral vehicle [ The component (d)] is preferably added in an amount of 60 to 99% by weight. Further, it is preferable to add 0.01 to 5% by weight of the flavor and sweetener in the oral vehicle in total.

When the oral composition of the present invention is used as a gingival application agent, the oral vehicle may be an oily component or a water-soluble polymer [(e) component], a wetting agent and a surfactant. , Flavors, sweeteners, preservatives, dyes, water, water-soluble fluorides, silicones, and other active ingredients are used as appropriate.

Examples of the oily component [component (e)] include petroleum jelly, lanolin, liquid paraffin, natural fats and oils, higher fatty acid esters such as isopropyl myristate, octyldodecyl myristate, and higher fatty acids such as palmitic acid and isostearic acid. , Higher alcohols such as myristyl alcohol and cetyl alcohol, squalane, and silicone oil. As the above water-soluble polymer [component (e)], those exemplified as the above-mentioned binder can be used, and of these, hydroxyethyl cellulose is particularly preferable. Further, a water-soluble polymer such as polyethylene glycol or polyoxyethylene polyoxypropylene block copolymer can also be preferably used. The gingival coating agent contains 10 to 50% by weight of the oily component or the water-soluble polymer [component (e)] in the coating agent.
It is preferable to contain a wetting agent and water in an amount of 20 to 70% by weight.

The pH of the oral composition of the present invention is
Is preferably in the range of 5 to 9.5, particularly 6 to 8.

[0024]

The composition for oral cavity of the present invention does not make the unpleasant saltiness of salt feel, and as a result, the salivary secretion is suppressed, so that the effective concentration in the oral cavity of the incorporated bactericide is reduced. In addition to effectively acting, the excellent dehydrating power and bactericidal power of salt and baking soda and the effect of the bactericide act synergistically to effectively prevent periodontal disease.

[0025]

EXAMPLES The present invention will be described in detail below with reference to examples, but the present invention is not limited thereto. still,
The average particle diameters of the granular salt and the baking soda used in the examples are obtained by the following measuring method.

[Measurement Method of Average Particle Size of Granular Salt and Granular Baking Soda] 1) 50 g of the oral composition was placed in a 300 ml beaker of granular salt, and 5000 ml of saturated saline solution (100 times volume) was poured into the beaker and stirred with a homomixer. , Completely suspend the oral composition. Only about 1% of sodium bicarbonate is dissolved in saturated saline, but by dissolving it in a large excess amount of saturated saline, only sodium bicarbonate can be completely dissolved. Granular salt is recovered from the above suspension using a 200-mesh sieve (American standard sieve LC584), and washed with saturated saline and ethanol on the mesh. After leaving it in the electric dryer (100 ° C) for about 30 minutes,
After collecting the collected granular salt in a petri dish and measuring the weight, meshes of various sizes (35, 45, 60, 80, 120,
170, 230, 325 mesh), and the weight of the granular salt remaining on each sieve is measured. From this weight distribution, a geometric mean diameter is obtained and this is used as the mean particle diameter. 2) Granular baking soda 1) The measurement is performed in the same manner as in 1) except that saturated sodium bicarbonate water is used instead of saturated saline.

Example 1 and Comparative Examples 1 and 2 Toothpastes 1 to 3 having the following compounding compositions were prepared by a conventional method. With respect to each of the obtained toothpastes 1 to 3, the effect of improving gingivitis was evaluated by the method described below. The results are shown in [Table 1] below. [Evaluation Method for Gingivitis Improvement Effect] 1. Subjects: A total of 30 men and women with mild gingivitis were divided into 3 groups. 2. How to use toothpaste; 2 after breakfast and before bedtime
Once, 1 g of the test toothpaste is put on a toothbrush [the hardness of the "bulb at the tip of the hair" manufactured by Kao Corporation; normal] and brushed for 3 minutes. 3. The test sites were the upper and lower anterior teeth, and the PMA index, which is an index of gingivitis, was measured at the first examination and after 4 weeks, and the average value of each was calculated. Then, the degree of improvement of gingivitis was calculated by the formula shown in the following [Equation 1].

[0028]

[Equation 1]

Toothpaste 1 (Comparative Example 1) (% by weight) -Special grade purified salt (average particle size 250 μm) 15.0-sorbitol 14.0-glycerin 8.0-carboxymethyl cellulose sodium 1.5-sodium lauryl sulfate 2.0-saccharin sodium 0.1-aluminum hydroxide 40.0-benzethonium chloride 0.01-perfume 0.8-water balance

Toothpaste 2 (Comparative Example 2) (wt%)-Baking soda (average particle size 100 μm) 15.0-sorbitol 14.0-glycerin 8.0-carboxymethyl cellulose sodium 1.5-sodium lauryl sulfate 2. 0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 40.0 ・ Benzethonium chloride 0.01 ・ Fragrance 0.8 ・ Water balance

Toothpaste 3 (Example 1) (% by weight) -Special grade purified salt (average particle size 250 μm) 15.0-Baking soda (average particle size 100 μm) 15.0-sorbitol 14.0-glycerin 8.0・ Carboxymethyl cellulose sodium 1.5 ・ Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 40.0 ・ Benzethonium chloride 0.01 ・ Perfume 0.8 ・ Water balance

[0032]

[Table 1]

As is apparent from the results shown in Table 1 above, the toothpaste 3 of the present invention (Example 1) is a toothpaste 1 containing no baking soda (Comparative Example 1) and a salt containing no salt. Compared with Dentifrice 2 (Comparative Example 2), the effect of improving gingivitis is significantly higher.

Examples 2 to 4 and Comparative Examples 3 to 4 Toothpastes 4 to 8 having the following compounding compositions were prepared by a conventional method. For each of the obtained toothpastes 4 to 8, 10 panelists evaluated the tightness and saltiness of the gums according to the following criteria. In addition, the saliva concentration of benzethonium chloride (bactericidal agent), which is a blending component, was measured by the following method. The results are shown in [Table 2] below. Tightness of gums is good: It feels tight. Normal: A little tight. Bad: Does not feel tight. Good saltiness: Just right. Normal: Slightly salty. Bad: Salty and uncomfortable. Method for measuring saliva concentration of benzethonium chloride After brushing toothpaste with 1 g of toothpaste for 1 minute, collect 1 ml of saliva from the oral cavity with a pipette, dilute appropriately with the following diluting solution, filter and then use a high-speed liquid. Perform a quantitative test by the chromatographic method. Diluting solution: Acetonitrile and water are mixed at a ratio of 65:35. Using this solution as a solvent, a solution containing 0.03 M of sodium lauryl sulfate and 0.1 M of sodium perchlorate is prepared and used as a diluting solution.

Toothpaste 4 (Comparative Example 3) (% by weight) -Special grade purified salt (average particle size 250 μm) 15.0-Sorbitol 14.0-Glycerin 8.0-Carboxymethyl cellulose sodium 1.5-Sodium lauryl sulfate 2.0-saccharin sodium 0.1-aluminum hydroxide 40.0-benzethonium chloride 0.01-perfume 0.8-water balance

Toothpaste 5 (Example 2) (% by weight) -Special grade purified salt (average particle size 250 μm) 15.0-Baking soda (average particle size 100 μm) 20.0-Sorbitol 14.0-Glycerin 8.0・ Carboxymethyl cellulose sodium 1.5 ・ Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 20.0 ・ Benzethonium chloride 0.01 ・ Perfume 0.8 ・ Water balance

Toothpaste 6 (Example 3) (% by weight) -Special grade purified salt (average particle size 250 μm) 15.0-Baking soda (average particle size 250 μm) 20.0-sorbitol 14.0-glycerin 8.0・ Carboxymethyl cellulose sodium 1.5 ・ Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 20.0 ・ Benzethonium chloride 0.01 ・ Perfume 0.8 ・ Water balance

Toothpaste 7 (Comparative Example 4) (% by weight) -Special grade purified salt (average particle size 250 μm) 20.0-sorbitol 14.0-glycerin 8.0-carboxymethyl cellulose sodium 1.5-sodium lauryl sulfate 2.0-saccharin sodium 0.1-aluminum hydroxide 35.0-benzethonium chloride 0.01-perfume 0.8-water balance

Toothpaste 8 (Example 4) (wt%)-Special grade purified salt (average particle size 150 μm) 15.0-Baking soda (average particle size 100 μm) 20.0-sorbitol 14.0-glycerin 8.0・ Carboxymethyl cellulose sodium 1.5 ・ Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 20.0 ・ Benzethonium chloride 0.01 ・ Perfume 0.8 ・ Water balance

[0040]

[Table 2]

As is clear from the results shown in Table 2 above, the toothpaste formulations 5 and 6 of the present invention (Examples 2 and 3) were
Satisfactory results were obtained for all evaluation items. In particular, salivary concentrations of benzethonium chloride are kept high. On the other hand, the toothpaste 4 which does not contain baking soda (Comparative Example 3) does not have a sufficient gum tightening effect, and the toothpaste 7 (Comparative Example 4) has an increased salt concentration without the addition of sodium bicarbonate.
The squeezing effect on the gums is improved, but the saltiness is increased, and as a result, the salivary concentration of benzethonium chloride is significantly reduced. Regarding the salt particle size, the toothpastes 5, 6 and 8 of the present invention (Examples 2, 3 and 4) provided satisfactory results for all evaluation items.

Example 5 and Comparative Examples 5 to 6 Toothpastes 9 to 11 having the following compounding compositions were prepared by a conventional method. With respect to each of the obtained toothpastes 9 to 11, the tightness and saltiness of the gums were evaluated in the same manner as in Example 2. Further, the concentration of chlorhexidine hydrochloride (bactericidal agent), which is a blending component, in saliva was measured by the following method. The results are shown in [Table 3] below.・ Method for measuring the concentration of chlorhexidine hydrochloride in saliva After brushing toothpaste with 1 g of toothpaste for 1 minute, collect 1 ml of saliva from the oral cavity with a pipette, dilute appropriately with the following diluting solution, and after filtration, high speed Perform quantitative tests by liquid chromatography. Diluting solution: Phosphoric acid is added to 0.05 M potassium hydrogen phosphate solution to adjust the pH to 2.5, and acetonitrile is mixed at a ratio of 4: 6. Using this solution as a solvent, a solution containing 10 mM of sodium lauryl sulfate is prepared and used as a diluent.

Toothpaste 9 (Comparative Example 5) (wt%)-Special grade purified salt (average particle size 250 μm) 15.0-sorbitol 14.0-glycerin 8.0-carboxymethyl cellulose sodium 1.5-sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 40.0 ・ Chlorhexidine hydrochloride 0.01 ・ Fragrance 0.8 ・ Water balance

Toothpaste 10 (Example 5) (wt%)-Special grade purified salt (average particle size 250 μm) 15.0-Baking soda (average particle size 100 μm) 20.0-sorbitol 14.0-glycerin 8.0・ Carboxymethyl cellulose sodium 1.5 ・ Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 20.0 ・ Chlorhexidine hydrochloride 0.01 ・ Perfume 0.8 ・ Water balance

Toothpaste 11 (Comparative Example 6) (wt%)-Special grade purified salt (average particle size 250 μm) 20.0-sorbitol 14.0-glycerin 8.0-carboxymethyl cellulose sodium 1.5-sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 35.0 ・ Chlorhexidine hydrochloride 0.01 ・ Fragrance 0.8 ・ Water balance

[0046]

[Table 3]

As is clear from the results shown in Table 3 above, the toothpaste 10 of the present invention (Example 5) provided satisfactory results for all evaluation items. In particular, the saliva concentration of chlorhexidine hydrochloride is kept high.
On the other hand, the toothpaste 9 that does not contain baking soda (Comparative Example 5) does not have a sufficient squeezing effect on the gums, and the toothpaste 11 (Comparative Example 6) that does not add sodium bicarbonate and increases only the salt concentration does not tighten the gums. Although the effect is improved, saltiness is increased, and as a result, salivary concentration of chlorhexidine hydrochloride is significantly reduced.

Example 6 Gingival massage cream composition shown below (gingiva application agent)
Was prepared according to a conventional method. The gingival massage cream composition was evaluated as having an appropriate saltiness and a high gingivitis improving effect. Gingival massage cream composition (% by weight) -Special grade purified salt (average particle size 250 μm) 10.0-Baking soda (average particle size 250 μm) 10.0-White petrolatum 5.0-Propylene glycol 4.0-PEG2000 20.0 (Polyethylene glycol: average molecular weight 2000) ・ PEG400 30.5 (Polyethylene glycol: average molecular weight 400) ・ Cetanol 5.0 ・ Benzethonium chloride 0.02 ・ Perfume 0.5 ・ Water balance

[0049]

EFFECTS OF THE INVENTION The oral composition of the present invention is excellent in the treatment / prevention effect of periodontal disease and has no unpleasant saltiness of salt,
Further, it is possible to maintain a high effective concentration of the disinfectant in the oral cavity without adding a high concentration of the disinfectant, and further, it is possible to obtain a good taste and feel (Claim 1). Further, the oral composition of the present invention, by using a salt of a specific average particle size and baking soda of a specific average particle size, it is possible to further improve the effect, and moderately salty in the oral cavity. And it can be maintained constant (claims 2 and 4).
Further, the oral composition of the present invention, by using a specific bactericidal agent, or by containing a salt and baking soda in a specific ratio, or by containing a specific amount of salt, the above effect is further Can be improved (claims 3, 5 and 6). Moreover, the oral composition of the present invention can be suitably used as a dentifrice by blending a water-insoluble abrasive (claims 7 to 10). Further, the oral composition of the present invention can be suitably used as a gingival coating agent by incorporating an oily component or a water-soluble polymer (claim 11).
And 12).

Claims (12)

[Claims] 1. A composition for oral cavity containing the following components (a), (b) and (c). (A) Salt (b) Baking soda (c) Bactericide 2. The average particle size of the component (a) is 150-4.
The oral composition according to claim 1, which is a 50 μm granular sodium chloride salt and the component (b) is a granular baking soda having an average particle size of 45 to 450 μm. 3. The bactericide is chlorhexidine salts, 4
Grade ammonium salts, triclosan, hinokitiol,
The oral composition according to claim 1 or 2, which is one or more selected from the group consisting of isopropylmethylphenol and alkyldiaminoethylglycine hydrochloride. 4. The average particle size of the granular salt is 150 to 350 μm.
The composition for oral cavity according to claim 2, wherein the average particle size of the granular sodium bicarbonate is 100 to 300 µm. 5. The composition for oral cavity according to claim 1, wherein the weight mixing ratio of salt and sodium bicarbonate (salt / sodium bicarbonate) is in the range of 1 / 0.5 to 1/3. 6. The oral composition according to claim 1, wherein the content of sodium chloride is 10% by weight or more. 7. The following components (a), (b) and (c):
A dentifrice containing the ingredient and the ingredient (d). (A) Salt (b) Baking soda (c) Bactericide (d) Water-insoluble abrasive 8. The average particle size of the component (a) is 150-4.
The dentifrice according to claim 7, wherein the dentifrice is 50 μm granular sodium chloride and the component (b) is granular baking soda having an average particle size of 45 to 450 μm. 9. The water-insoluble abrasive is one selected from the group consisting of anhydrous silicic acid, hydrous silicic acid, calcium silicate, aluminum silicate, heavy calcium carbonate, light calcium carbonate, aluminum hydroxide and alumina. Or the dentifrice according to claim 7 which is two or more kinds. 10. The dentifrice according to claim 7, wherein the water-insoluble abrasive is aluminum hydroxide. 11. The following component (a), component (b),
A gingival application agent containing the components (c) and (e). (A) Salt (b) Baking soda (c) Bactericide (e) Oily component or water-soluble polymer 12. The average particle size of the component (a) is 150 to 150.
The gingival application agent according to claim 11, which is 450 µm granular sodium chloride and the component (b) is granular baking soda having an average particle diameter of 45 to 450 µm.