JPH07124241A - Ceramic functional material offering field for bone derivation and osteogenesis and its manufacture - Google Patents

Abstract

PURPOSE:To provide the status of porous space forming porous quality, capable of exhibiting an excellent function as an implant. CONSTITUTION:This is a ceramic functional material to provide a field for bone derivation and osteogenesis, made of the sintered body of a calcium phosphate compound having a plurality of spherical spaces 13 with a diameter between 10 and 450mum to provide a field for osteogenesis and a plurality of micro spaces 14 of a size between 0.01 and 0.5mum for keeping the spaces 13 communicated with the external surface of the material and for communication with one another.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a ceramic functional material comprising a calcium phosphate-based compound sintered body having excellent biocompatibility and providing a site for osteoinduction and osteogenesis, and a method for producing the same.

[0002]

2. Description of the Related Art Implantation with an artificial material has been performed as a measure for repairing the function of living hard tissues and soft tissues. As the material of the implant material,
Metals, plastics, and ceramics have been used alone or as a composite. The most important function required for implant materials is compatibility with living tissues.
From this point of view, it is said that the ceramic material is less harmful and stable in existence as compared with other materials in the living body. Among the ceramic materials, calcium phosphate-based compound ceramics, in particular, have a composition similar to that of hard tissue in the living body, and it has been evaluated as an optimal material as an implant material, and it has already been used as an artificial bone material, especially as a bone defect filling material. It has been commercialized.

Here, when a porous calcium phosphate compound ceramics is considered as a material for filling a bone defect, the cells and binding factors necessary for bone formation in body fluid through direct binding to surrounding living bone and pores are transferred. It is established, and as a result, new bone is formed in the pores, and finally it can be expected to be combined with living bone. Therefore, most of the calcium phosphate compound implant materials today consist of porous compacts.

However, almost no detailed reports have been found on the relationship between the morphology of the pore spaces constituting this porous molded article and bone formation, and this point is also noted in the actual commercialized porous implant material. The reality is that the structure has not been designed and managed with due consideration.
For example, when the pores that should originally be in contact with the outer surface of the material are in an occluded state, communication of body fluid in the implant material is not established, almost no bone formation is observed in the pores, and the inert material is not formed. As a result, the entire implant material does not sufficiently bond to the surrounding living bone, and is rejected from the living body as a foreign body for a long period of time to be discharged. In addition, there is sufficient stomatal space, and both cells and body fluids can communicate, but conversely, macrophages and foreign body giant cells can freely communicate, so that bone formation is delayed and the function as an implant material cannot be achieved due to lack of calcification amount. Also happens. As described above, although the design of the pore space is an important factor for determining the success or failure of the implant material, the conventional porous implant material has not been sufficiently studied both ideologically and technically.

[0005]

It is an object of the present invention to solve the above-mentioned drawbacks of the prior art and to design the shape of the pore space constituting the porous body so as to exhibit an excellent function as an implant material. It is an object of the present invention to provide a ceramic functional material capable of effectively providing the above and a method for producing the same.

[0006]

SUMMARY OF THE INVENTION As a result of earnest research, the present inventors have found that a plurality of spherical spaces having a specific diameter and specific dimensions for communicating the space with the outer surface of a material around the space and also for communicating with each other. It was found that a porous calcium phosphate compound sintered body having a plurality of fine spaces of can achieve the above object,
The present invention has been completed.

That is, the ceramic functional material for providing a place for osteoinduction and osteogenesis according to the present invention comprises a sintered body of a calcium phosphate-based compound, and the sintered body has a diameter of 10 mm.
In the range of ˜450 μm, it has a plurality of spherical spaces that provide a field for bone formation, and has a size of 0.0 that connects the space and the outer surface of the material to the periphery of the space and also communicates with each other.
It is characterized by having a plurality of fine spaces of 1 to 0.5 μm.

The ceramic functional material of the present invention comprises a sintered body of a calcium phosphate compound. Here, as the calcium phosphate-based compound, CaHP
O ₄ , Ca ₃ (PO ₄ ) ₂ , Ca ₁₀ (PO ₄ ) ₆ (O
H) ₂ or the like may be used alone or in combination. In hydroxyapatite, C which constitutes this
It is also possible to employ one in which a part or all of a, PO ₄ , and OH are substituted with other elements or atomic groups.

The ceramic functional material of the present invention has a diameter of 1 in the above-mentioned calcium phosphate compound sintered body.
A plurality of spherical spaces of 0 to 450 μm and 0.01 to 0.5
It has a plurality of micro spaces of μm. Diameter 10-450μ
The spherical space of m provides a place for recognizing bone formation and a place for coexisting the activation and production functions of osteogenic cells based on the traffic of plasma components in blood. When the diameter of the true spherical space is less than 10 μm, invasion of bone-forming cells is delayed and bone formation and maturation are delayed, and when it exceeds 450 μm, the cells do not recognize the field early and, conversely, the blood vessels are not recognized. It exerts a new growth effect. On the other hand, in such a structure,
There is a risk that the strength of the implant material itself may be reduced. Therefore, the space has a shape as close to a true sphere as possible,
Moreover, it is desirable that they are evenly distributed in the implant material. Further, by making the space spherical, in addition to promoting bone formation, external stress applied to the implant material can be dispersed appropriately without concentration.

On the other hand, a plurality of microspaces around the spherical space, which communicate with the outer surface of the material and which communicate with each other, further have the effect of a filter, and the body fluid, plasma components in blood, and bone ancestors. It allows only cells to be transported, occupies the spherical space, promotes the activation of cells involved in bone formation, and provides the function of producing such cells. Since it is possible to communicate cells involved in bone formation, body fluids, and plasma components even in the spherical space alone, it is considered that the above-mentioned microscopic space is not necessary at first glance, but in the spherical space alone, cells are present inside the spherical space. When a sufficient amount of inhabitants have been occluded and bone formation has taken place, and this has matured to form an osteon structure, the true spherical space becomes an occluded state, and the cells and the passages for nutritional supplementation from the external surface of the material to the next space are formed. You will be refused. As described above, in the microscopic space, even when a sufficient amount of cells inhabit the inside of the spherical space and the communication with the outer surface of the material becomes insufficient, not only the nutrient components but also the mass transfer supply to the cells are provided. It fulfills the function of a dedicated passageway. For that, the fine space is
It must not have a structure that allows cells to enter inside and block the passage. Therefore, the size of the fine space is 0.01 to
It is necessary to be 0.5 μm. This size is 0.
When it is less than 01 μm, it becomes difficult for the body fluid and plasma components to communicate, and when it exceeds 0.5 μm, monocytes and migratory cells may invade the fine space.

The ceramic functional material of the present invention having the above-mentioned structure has an excellent bone forming function, and its form can be any form such as granular, cubic, rectangular parallelepiped, prismatic, columnar or disc-shaped. You can The size may be various, but is relatively large, for example, 3c.
In a block-shaped implant material having a size of m or 5 cm, it takes a relatively long time for bone formation to proceed to the central portion, and in an extreme case, bone formation occurs only on the outside of the implant material. The cells involved in bone formation may not be able to enter the part.

Therefore, in the case of a relatively large implant material, it is preferable to form at least one tubular passage that connects a pair of opposing surfaces of the implant material. By arranging this implant material along the blood flow direction of the defect part of the living body, it becomes possible to increase and proliferate new blood vessels in the space up to the central part, and it becomes possible to secure blood flow and bone formation. It becomes possible to supply the relevant cells and nutrients sufficiently. That is, the tubular passage is intended to allow cells, body fluids, and plasma components involved in bone formation to be transported to the central portion of the implant material along the original blood flow direction. The passage has a diameter of 0.6 to
It is preferably 1.2 mm. This diameter is 0.6m
If it is less than m, it becomes difficult for the blood flow and blood components to pass through without being impaired due to bone formation, and if it exceeds 1.2 mm, the strength of the entire implant material may be reduced.

When forming a plurality of tubular passages as described above, it is preferable that the passages are present at intervals of 3 to 5 mm from each other in the cross section of the implant material orthogonal to the passages. If this distance is less than 3 mm, the strength of the implant material may be reduced, and if it exceeds 5 mm, the cells and nutrients involved in bone formation may not be sufficiently supplied to the details.

From the viewpoint of bone formation, it is advantageous that a large number of tubular passages are provided at a short interval, and from the aspect of strength of an implant material, a few passages at long intervals are advantageous. Therefore, in order to sufficiently cause bone formation in as few passages as possible, the tubular passages should be arranged in hexagonal symmetry on the cross section orthogonal to the passages and the distance between them should be 3 to 5 mm. Is preferred. With such an arrangement, the distance from any point in the implant material to the tubular passage can be up to 5 mm.

Next, a method of manufacturing the ceramic functional material of the present invention will be described. The method for producing a ceramic functional material according to the present invention has a particle size of 5 to 5 as a ceramic raw material powder.
A molded body containing pore spaces or containing a spherical heat-dissipating substance is prepared by a dry or wet method using spherical calcium phosphate-based compound particles having a diameter of 10 to 450.
A porous calcination having a plurality of spherical spaces in the range of μm and a plurality of fine spaces having a size of 0.01 to 0.5 μm that communicates the space with the outer surface of the material and also communicates with each other around the space. It is characterized by producing a tie.

The formation of a fine space of 0.01 to 0.5 μm is achieved by preliminarily granulating the powder of the calcium phosphate compound as a raw material into spherical particles of 5 to 10 μm. In the method of the present invention, the spherical particles having such a particle size are used as the raw material powder to prepare a molded body, which is then fired to produce the porous sintered body having the above-described spatial structure. However, the molded body can be manufactured by a dry method or a wet method. As a dry method, for example, there is a method in which a raw material powder is mixed with a spherical heat-dissipating substance having a particle diameter of 12 to 700 μm and compression-molded to produce a molded body (compacted powder). Here, examples of the heat-dissipating substance include naphthalene, adamantane, trimethylnorbornane, p-dichlorobenzene, a mixture of adamantane and trimethylnorbornane, sublimable substances such as cyclododecane, and synthetic substances such as polymethylmethacrylate, polypropylene, polystyrene, and polyethylene. Resins may be mentioned. The particle size of the heat-dissipating substance is selected in consideration of the fact that the space generated by the disappearance of the substance during firing shrinks due to firing shrinkage. Generally, it is said that linear contraction causes 0.6 to 0.8 times contraction. Examples of the wet method include a method in which a foaming slurry is prepared using a foaming agent such as hydrogen peroxide and egg white, and the resulting slurry is cast and dried by heating to prepare a molded product having a large number of pore spaces. To be

The molded body produced by the above method is fired, for example, in an electric furnace under a sufficiently controlled design of temperature rising gradient in consideration of the type of calcium phosphate compound used and the desired pore space diameter. As a result, a sintered body having the above spatial structure can be obtained.

In the ceramic functional material of the present invention,
Various methods can be adopted for producing a functional material having at least one pair of facing surfaces and at least one tubular passage having a diameter of 0.6 to 1.2 mm connecting the surfaces. . Specifically, the molded body manufactured by the above method is processed and molded into a shape having at least a pair of facing surfaces, and then one or more tubular passages connecting the facing surfaces are formed by machining and fired. Method, raw material powder, spherical heat-dissipating substance having a particle diameter of 12 to 700 μm, and a method for producing a green compact by using a tubular passage forming material having a diameter of 0.7 to 1.8 mm and comprising a heat-dissipating substance, and firing , A foaming slurry of raw material powder is prepared using a foaming agent, and the slurry is put in a mold whose bottom surface is a flat surface. The heat-dissipating substance is contained in this slurry, and at least the length from the liquid surface to the bottom surface is reached. And a method in which one or more tubular passage-forming materials having a diameter of 0.7 to 1.8 mm are hung to prepare a molded body and then fired,
A foaming slurry of raw material powder is prepared using a foaming agent, and at least one tubular passage forming pin having a diameter of 0.7 to 1.8 mm and a length reaching the liquid surface is erected on the bottom surface of the slurry. Examples include a method of casting into a mold to prepare a molded body, drying the molded body, and firing the molded body removed from the mold.

Whichever method is adopted, it is particularly important to set the temperature rising temperature gradient during sintering, and the gap between the spherical particles constitutes the above-mentioned fine space under the complete control of grain growth. Manufacturing control. This fine space serves as the above-mentioned filter, and the spherical space formed by the foaming agent serves as a place for recognizing bone-forming cells and further serves as a living space. In addition, the tubular passage (through hole) will provide a growth space for blood vessels while being implanted in bone tissue.

[0020]

1 to 3 show an embodiment of a ceramic functional material (implant material) according to the present invention.
The implant material 11 has a prismatic shape, and a plurality of tubular passages 12 are formed in the longitudinal direction thereof. One of the tubular passages 12 is located at the center of the prismatic body,
The remaining tubular passages are hexagonally symmetrical to this central tubular passage.
are arranged so as to form a gonal symmetry). In the illustrated example, six peripheral tubular passages 12b and 12 are provided on each of two virtual concentric circles centered on the central tubular passage 12a.
c is located. This hexagonal symmetric shape gives the most favorable results.

FIG. 3 schematically shows a spherical space 13 and a fine space 14 formed in the implant material 11. The fine space 14 is the spherical space 13,
The spherical space 13 is connected to the outer surface of the implant material 11 or the inner surface of the tubular passage 12.

4 and 5 show a ceramic functional material according to the present invention as a columnar implant material 11A. Similar to FIGS. 4 and 5, the tubular passage 12A includes a central tubular passage 12a and a peripheral tubular passage 12b arranged on a virtual concentric circle centered on the passage 12a.
The central tubular passage 12a and the peripheral tubular passage 12b also have a hexagonal symmetrical shape.

The intervals between the tubular passages 12 are preferably determined so that the distance from any point in the implant material to the tubular passages is about 5 mm at the maximum. In the example of FIGS. 4 and 5, the intervals of the tubular passages 12 are made equal to each other by 3 to 5
mm, the distance from any point in the implant material to the tubular passage is 5 mm or less.

Next, the present invention will be described in more detail based on specific examples, but the present invention is not limited thereto.

Specific Example 1 Hydroxyapatite is wet-synthesized by a known method, and the obtained hydroxyapatite slurry is spray-dried using a rotary spray dryer to obtain hydroxyapatite spherical powder having a particle size of 5 to 9 μm. Obtained. Obtained spherical hydroxyapatite powder 200
100 g of powdered ovalbumin was added to g and gently mixed with a dry ball mill. The particle size of the obtained mixed powder was 6.5 μm. To this mixed powder, 500 g of water was added, and the mixture was stirred for 15 minutes with a hand mixer to foam, then transferred to a glass petri dish having a diameter of 20 cm and a depth of 5 cm, and the temperature was 80 ° C.
24 hours in the dryer. Then, the dried body is used with a diamond disk to have a diameter of 1.2 cm and a height of 1 cm.
, A through hole (tubular passage) with a diameter of 1.2 mm is opened at the center point of the cross section so as to penetrate through the opposite surfaces, and at equal intervals from the center point of the cross section at 4 mm intervals.
After 6 pieces were opened at equal distances, they were baked in an electric furnace at 1100 ° C. for 2 hours to obtain implant materials. The size of the sintered body is
As predicted by firing shrinkage in advance, the diameter of the cylinder is 8 m
m, the height was 7 mm, the distance between the through holes was 3 mm, and the diameter of the through holes was 0.8 mm. When the pore size was measured as a pore distribution by a mercury porosimeter, a bipolar distribution of a fine space of 0.3 μm and a space of 350 μm on average was confirmed.

The obtained implant material was embedded in the femur bone marrow of a beagle adult dog, and taken out as a tissue after 2 weeks and 4 weeks, and the state of bone formation mainly in the implant tissue structure was observed. Two weeks after the implantation, a lining cell structure was formed on the inner wall of the spherical space even in the central part of the implant material, and formation of a stained image that was considered to be new bone was recognized. Furthermore, after 4 weeks, most of the inside of the spherical space was filled with new bone, and a remarkable bone formation image was shown as compared with the case of the conventional structure, that is, the tissue structure without fine space.

SPECIFIC EXAMPLE 2 An implant material produced by the same method as in Specific Example 1 was processed into a double-layered disc shape of a disk having a diameter of 15 mm and a thickness of 4 mm and a disk having a diameter of 12 mm and a thickness of 4 mm. An old Beagle dog (10-year-old dog) was perforated with a bone having a diameter of 13 mm on the side of the skull to form a bone defect, and the implant material was embedded therein. In this state, there was a gap of 1 mm around, and it shook when pressed with a finger. Here, sutures were performed while being held down by the cap-shaped aponeurosis, and left for 3 days. As a result of confirming the swaying property of the implant site from the scalp surface with the fingertip on the 3rd day, it was observed that the implant material did not sway at the implant site and the fixation was almost completed. After 3 weeks, a beagle dog was sacrificed and autopsy was performed. As a result, the gap between the implant material and the bone void in the skull perforation was obviously covered with new bone, and very good fusion and histological findings were obtained. It was

Example 3 Half of the cross-sectional area from the lower part of the right and left tibial epiphyses of an adult beagle dog
The implant material cut out in cm ² and 15 mm in length and processed into a similar shape (the material is the same as in Example 1) was substituted and filled. Immediately after surgery, 3 days, 1 week, 3
X-ray findings were obtained at week 5, week 5, week 7, week 9, week 12, week 26, and week 52, and in parallel with this, a blood biochemical search was performed. As for the X-ray image, as a result of observing mainly the changes in the shadow image of the boundary between the material and the bone and the new bone formation, a vigorous bone formation image was observed for 5 to 9 weeks. On the other hand, regarding the blood biochemical search, the alkaline phosphatase level was high over 7 to 9 weeks. This is extremely fast compared to reaching a high level in approximately 12 weeks with conventional homogeneous implant materials. This fact indicates that the implant material according to the present invention has significantly superior osteogenicity as compared with the conventional one.

Concrete Example 4 The dried product of Concrete Example 1 was used as it was in an electric furnace at 1100 ° C. for 2 hours.
After firing for a long time and coarsely crushing with a basket-type crusher, sieving with an ASTM standard sieve gives a particle size of 250-5.
A 00 μm granular implant material was produced. This granular implant material has a true spherical space of 80 μm and 0.
It had a fine space of 3 μm. The femur of a beagle juvenile was artificially fractured under anesthesia, the above-mentioned granular implant material was filled in the bone marrow, and after reduction, it was sutured and further fixed with a cast bandage. The casts were removed 3 days, 7 days, and 2 weeks after the operation, and the findings based on the X-ray image were observed, and then fixed again by the casts. After 3 weeks, a shadow image clearly showing callus formation was observed, so the patient was released from fixation and moved to free walking, but thereafter, abnormalities such as re-fracture did not occur, and normal recovery was performed, and X-ray was performed. As a finding, it could be judged to be cured after 7 weeks.

SPECIFIC EXAMPLE 5 The implant material prepared by firing in the same manner as in Specific Example 4 was coarsely crushed by a basket crusher and sieved at 140 mm to 140 mesh by 0.3 mm intervals by an ASTM standard sieve, Each population was created. Then
Based on a particle size ratio of 0.1 mm, the particle size ratio is approximately 2 x 2
^It was blended so as to have a close-packed particle size distribution of ^1/2 to obtain a granular implant material for fixing an artificial head.

On the other hand, two Beagle old dogs (10-year-old dogs) were prepared and a condition of load loading was required from the standpoint of clarifying the effectiveness of the implant material. An artificial head replacement for the foot was performed. In other words, a femoral bone was cut near the site of the vastus lateralis muscle (Vastus lat) using a medium-sized dog artificial head manufactured by Richards Manufacturing Company (Memphis, Tennessee, USA), and the stem of the granular implant material in the bone marrow cavity was almost removed. It was fixed by filling it strongly until it became completely undisturbed. After the surgery, one animal should stop spraying Novectorin (anti-infective agent; trademark, manufactured by Yoshitomi Pharmaceutical Co., Ltd.) on the sutured site.
The animals were housed in a fence for a week, and the other one was restrained on the hind foot side using a plaster bandage, this was continued for 2 weeks, and thereafter, it was transferred to free walking. At present, 20 weeks each, but no abnormalities such as clear zones around the stem as X-ray findings were observed, and cloud-like shadows around the granules were observed, but plastic surgery showed that Especially loosening is not allowed.

Specific Example 6 A granular implant material having a diameter of 0.1 to 0.5 mm was produced by firing in the same manner as in Specific Example 4 and sieving. This granule has a true spherical space of 50 μm and 0.3
It had a fine space of μm. A male miscellaneous dog, which is considered to have a congenital malformation with a curved spine, was subjected to spinal orthodontic surgery by external fixation, and the above-mentioned granular implant material was filled in the bone defect site generated in the corrected site. After surgery, findings based on X-ray images were obtained over time, and the time for removal of the external fixator was searched. A cloud-like shadow image was observed around the filled granules 1 month after the operation, but it was judged that the progression of callus formation and bone union was considered, and the safety device was taken into consideration, and the fixator was removed 2 months after the operation. I went. After about a year, no abnormal findings such as deformation of the surgical site have been obtained.

[0033]

The functional material comprising the porous calcium phosphate compound sintered body according to the present invention is an implant having an optimum pore space structure from the viewpoint of biocompatibility, in particular, induction of new bone and progress of calcification as field recognition. Is the material
The true spherical space having a diameter of 10 to 450 μm provides a place for recognizing bone formation and a place for coexisting the activation and production functions of osteogenic cells based on the traffic of plasma components in blood,
The micro space of 0.01 to 0.5 μm has a function of a filter, transports only plasma components in body fluids and blood, and has a function of occupying the spherical space and promoting activation of cells involved in bone formation. Have. The functional material according to the present invention may further have tubular passages capable of supplying cellular components directly involved in bone formation in the implant tissue structure without obstructing blood flow which is originally required, and this form is relatively large. Suitable for implant materials. The implant material of the present invention having a tubular passage enables the growth and proliferation of new blood vessels in the space up to the central portion of the implant material by being embedded along the blood flow direction of the defect portion of the living body, As a result, it becomes possible to ensure the supply of cells and nutrients involved in bone formation. As a result, compared with the conventional implant material, bone formation is performed at an extremely early stage, and stable mature ossification can be advanced over a long period of time. Finally, the complex with living bone (Biocom
form the posite), and semipermanently perform the function required as bone.

[Brief description of drawings]

FIG. 1 is a perspective view of a prismatic implant material showing one embodiment of the present invention.

FIG. 2 is a cross-sectional explanatory view of the implant material shown in FIG.

FIG. 3 is a diagram schematically showing the same spherical space, fine space, and annular passage.

FIG. 4 is a perspective view of a cylindrical implant material showing another embodiment of the present invention.

5 is a cross-sectional explanatory view of the implant material shown in FIG.

[Explanation of symbols]

 11 11A Implant material 12 12A Tubular passageway 13 True spherical space 14 Fine space

Claims (13)

[Claims] 1. A sintered body of a calcium phosphate-based compound, wherein the sintered body has a diameter of 10 to 450 μm.
It has a plurality of spherical spaces that provide a place for bone formation, and a plurality of spaces having a size of 0.01 to 0.5 μm that communicates with the space and the outer surface of the material around the space and also with each other. A ceramic functional material that provides a place for osteoinduction and osteogenesis characterized by having a fine space. 2. The ceramic functional material according to claim 1, further comprising at least one tubular passage having at least a pair of opposing surfaces and connecting the surfaces with each other and having a diameter of 0.6 to 1.2 mm. 3. The diameter for connecting opposite surfaces to each other is 0.6.
The ceramic functional material according to claim 2, wherein the ceramic functional material has a plurality of tubular passages each having a diameter of up to 1.2 mm, and the passages are present at intervals of 3 to 5 mm on a cross section orthogonal to the passages. 4. The ceramic functional material according to claim 1, wherein the overall shape is prismatic. 5. The ceramic functional material according to claim 1, wherein the overall shape is cylindrical. 6. The tubular passage according to claim 4, wherein a plurality of tubular passages are arranged at equal intervals on a central tubular passage at the center of the columnar body and on one or more concentric virtual circles centering on the central tubular passage. A ceramic functional material having a peripheral tubular passage. 7. The ceramic functional material according to claim 6, wherein the tubular passages are arranged in hexagonal symmetry. 8. A ceramic raw material powder having a particle size of 5 to 5.
A spherical calcium phosphate-based compound particle having a diameter of 10 μm is used to prepare a molded body containing a pore space or a spherical heat-dissipating substance, and the molded body is fired to form a plurality of true spherical spaces having a diameter in the range of 10 to 450 μm and the periphery of the space. The size of connecting the space to the outer surface of the material and also to each other is 0.01 to
A method for producing a ceramic functional material for providing a place for osteoinduction and osteogenesis, comprising producing a porous sintered body having a plurality of 0.5 μm fine spaces. 9. At least one tubular passage having a diameter of 0.6 to 1.2 mm, which is formed by processing the molded body according to claim 8 into a shape having at least a pair of opposing surfaces and connecting the surfaces to each other. The method for producing a ceramics functional material according to claim 5, which is formed. 10. The method for producing a ceramics functional material according to claim 6, wherein the tubular passages that connect the opposing surfaces are formed by machining. 11. A spherical calcium phosphate-based compound particle having a particle size of 5 to 10 μm, a spherical heat-dissipating substance having a particle size of 12 to 700 μm, and a diameter of 0.7 comprising one or more heat-dissipating substances.
The method for producing a ceramics functional material according to claim 8, wherein a green compact is produced using a tubular passage forming material having a diameter of ˜1.8 mm, and the green compact is fired. 12. Spherical calcium phosphate-based compound particles having a particle size of 5 to 10 μm in water and a foaming agent or a particle size of 12 to 70.
A spherical heat-dissipating substance of 0 μm was added, and the slurry was sufficiently stirred in a mold having a flat bottom surface. The slurry was composed of the heat-dissipating substance and had a length of at least reaching from the liquid surface to the bottom surface and had a diameter of 0.7 to 1. 9. The method for producing a ceramics functional material according to claim 8, wherein one or more 8 mm tubular passage forming materials are hung to form a molded body, and the molded body is fired. 13. A spherical calcium phosphate-based compound particle having a particle size of 5 to 10 μm and a foaming agent or a particle size of 12 to 70 in water.
0 μm of spherical heat-dissipating substance was added, and the slurry was thoroughly stirred into a mold in which one or more tubular passage-forming pins having a diameter of 0.7 to 1.8 mm and reaching the liquid surface were upright on the bottom surface. The method for producing a ceramics functional material according to claim 8, wherein the molded body is cast to prepare a molded body, and after drying, the molded body removed from the mold is fired.