JPH0710720A - Water-soluble protection agent for cuticle and hair and water-soluble agent for external use - Google Patents

Abstract

PURPOSE:To obtain an effective water-soluble protection agent for cuticle and hair and an water-soluble agent for external use. CONSTITUTION:This protection agent for cuticle and hair is produced by compounding acetates of zinc and magnesium and/or a molybdic acid salt with acetic acid diluted with water (about 500 times dilution) to adjust a zinc acetate concentration of about 12g/l, a magnesium acetate concentration of about 6g/l and a molybdic acid salt (Na salt, K salt, etc.) concentration of about 100mg/l. This water-soluble agent for external use is produced by compounding acetates of zinc and magnesium to a neutral or acidic external agent soluble in water (e.g. an aqueous solution containing iodine and potassium iodide) to adjust a zinc acetate concentration of about 10g/l and a magnesium acetate concentration of about 5g/l.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a water-soluble protective agent for epidermis and hair, and a neutral or acidic water-soluble external preparation.

[0002]

2. Description of the Related Art Generally, an epidermal protective agent is mainly composed of oil-based agents for replenishing sebum, and oil-soluble vitamin agents and the like are mixed therein.
However, the fact is that there is almost no protective effect against epidermal diseases called skin rashes.

[0003] Hair loss prevention is an important condition for hair growth, and what is called a hair growth agent is mainly focused on the correspondence, and vasodilating components, cell activating components, moisturizing agents, sebum secretion inhibitors, etc. include. However, the effect of protecting the scalp and hair is poor, and hair loss prevention and the like are insufficient.

As a neutral or acidic water-soluble external preparation, a 70% ethanol solution of iodine and potassium iodide (hereinafter abbreviated as "iodine solution") is an excellent disinfectant, but its frequent use causes harmful effects such as skin rash. It is easy to occur.

[0005]

The present invention has been made to solve the above-mentioned conventional problems, and provides a water-soluble and effective protective agent for epidermis and hair, and an improved water-soluble external preparation. Is what you are trying to do.

[0006]

The protective agent for epidermis and hair according to the present invention is characterized by blending acetic acid salt of zinc and magnesium and / or molybdate salt with acetic acid diluted with water. The acetic acid concentration cannot be unconditionally limited because it is related to the blending amount, but it is standard to dilute glacial acetic acid about 300 to 900 times, and PH after dissolution adjustment is about 5 to 6. , The desired dilution ratio. Regarding the blending amount, it cannot be unconditionally limited depending on the degree of demand, etc., but zinc acetate: 2.5 to 25 g / l, magnesium acetate: 1.5 to 15 g / l, molybdate is sodium or potassium salt: 25 to 250 m
g / l is the standard amount. If it is less than the lower limit, the effect is not sufficient, and if it exceeds the upper limit, the effect cannot be expected to increase.

The water-soluble external preparation according to the present invention is characterized in that zinc and magnesium acetate are mixed with a neutral or acidic external preparation. The blending amount cannot be unconditionally limited depending on the degree of demand, but zinc acetate: 2.5-20
g / l, magnesium acetate: 1.5 to 10 g / l is the standard compounding amount.

[0008]

The skin and hair protectant according to the present invention is prepared by blending zinc and magnesium in water-diluted acetic acid with their acetates, whereby the common ionic effect of acetate ions causes
The acidity is suppressed, and stable weak acidic region can be maintained. That is, it has a characteristic that the fluctuation of PH is small even when diluted. This is an important condition for protecting the scalp and hair, since it is necessary for stabilizing the easy solubility of minerals, and since the healthy epidermis is kept weakly acidic, it is an essential condition to protect the scalp and hair. The agent is compatible with these purposes. That is, since all of these minerals are in the form of easily soluble, they are easy to act and highly effective. It has been found that the combination of zinc and magnesium and / or molybdate has a significant synergistic effect on the protection of the epidermis and hair. Further, it was confirmed that this synergistic effect is effective even when blended with a neutral or acidic external preparation.

[0009]

EXAMPLES Hereinafter, typical examples of the present invention will be described in detail. The molecular formula of the acetate used is zinc acetate: [Zn (OOCC
_{H 3) 2 · 2H 2 O} ], magnesium _{acetate: [Mg (OOCCH 3) 2} · 4H
₂ O] and the molecular formula of molybdate is sodium molybdate: [Na ₂ MoO ₄ · 2H ₂ O] and potassium molybdate:
[K ₂ MoO ₄ ]. In addition, as a compounding method, acetate is directly compounded and dissolved in water-diluted acetic acid, and molybdate is separately dissolved in water and then compounded and adjusted. All of Examples 1 to 3 are in the weakly acidic region (PH≈5.5 ± 0.3), which is important for protecting the epidermis and hair.

Example 1 Zinc acetate was mixed at 12 g / l and magnesium acetate at 6 g / l into 500-fold diluted glacial acetic acid, and the dissolution was adjusted.

Example 2 To glacial acetic acid diluted 500 times, 12 g / l of zinc acetate, 6 g / l of magnesium acetate and 100 mg / l of sodium molybdate were added and dissolved and adjusted.

Example 3 To glacial acetic acid diluted 500 times, 12 g / l of zinc acetate, 6 g / l of magnesium acetate and 100 mg / l of potassium molybdate were added and dissolved and adjusted.

As a result of protecting the epidermis of Examples 1 to 3, 2 to 7 days a day were observed for "crack" and "rash" symptoms caused by household detergents.
When used three times, the "crack" was cured within 2-3 days and the "rash" was completely cured within a few days. When used in the same manner for eczema, a healing effect was observed after about 2 weeks,
After about 1 month, the cure was almost complete except for wrinkles. Any subsequent application can prevent recurrence, and no worsening phenomenon such as rash can be seen. In addition, Examples 2 and 3 showed slightly higher effectiveness against "rash" and eczema, but there was almost no difference between Examples 2 and 3. However, when only a water-diluted acetic acid solution (500 times) was used in the same manner, there was almost no effect, and the use of a commercially available protective cream did not completely cure the disease.

As a result of the hair protection of Examples 1 to 3, it was confirmed that dandruff and hair loss are obviously reduced after about 1 week by sprinkling this agent on the skin after washing the hair at intervals of one day. did it. However, water diluted acetic acid solution (500
However, there was almost no effect. still,
Although Examples 2 and 3 tended to be highly effective, Example 2
The difference between 3 and 3 was hardly recognized.

Example 4 The improved iodine solution (test solution) in this example was prepared as follows. First, 65% iodine and potassium iodide were added to 70% ethanol (containing 30% water).
An iodine solution was prepared by mixing and mixing so that the amount was 35 g / l. Next, the same amount of 70% ethanol was added to this iodine solution to prepare a diluted iodine solution. The improved iodine solution used as the test solution was prepared by adding zinc acetate to 70% ethanol.
It was prepared by adding the same amount of the above iodine solution to a zinc-magnesium solution prepared by mixing 20 g / l and magnesium acetate to 10 g / l and adjusting the dissolution. Therefore, the net concentrations of zinc acetate and magnesium acetate in the modified iodine solution are 10 g / l and 5 g / l, respectively. The zinc-magnesium solution may be blended with a known external preparation other than the iodine solution.

As a result of the application of Example 4, the improved iodine solution was used once or twice a day for several athlete's foot caused by Trichophyton on the toe crotch, and a smooth healing tendency was observed within half a month. It was completely cured. It has been confirmed that, even if it is used for a long period of time, no deterioration phenomenon such as a rash is observed, which is extremely advantageous for prevention and its effect is sufficient.
On the other hand, when a dilute iodine solution and a commercially available diluted iodine tincture were used under the same conditions, a slight healing tendency was observed, and then a "fever" and "rash" occurred, and inflammatory pain was also associated. It got worse.

[0017]

INDUSTRIAL APPLICABILITY As described in detail above, the present invention can provide a water-soluble and effective water-soluble protective agent for epidermis and hair, and an improved water-soluble external preparation. Further, since the present invention is completely water-soluble rather than oily, there is no discomfort in use, and even when continuously used for a long period of time, no deterioration phenomenon such as rash is seen, and therefore, it can be used for prevention. , Very useful. Moreover, it is speculated that these results show that there is an excellent anti-inflammatory effect without side effects. In addition, since all the mineral components are in the form of easily soluble, they are easy to act and highly effective.

Claims (2)

[Claims] 1. A water-soluble protective agent for epidermis and hair, characterized in that acetic acid salts of zinc and magnesium and / or molybdate are mixed with acetic acid diluted with water. 2. A water-soluble external preparation characterized in that a neutral or acidic water-soluble external preparation is blended with zinc and magnesium acetate to improve curability and suppress adverse effects.