JPH0622352Y2 - Body fluid treatment circuit member - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to an improvement of a pressure detector for a body fluid treatment circuit such as hemodialysis and plasma exchange. The present invention relates to a body fluid treatment circuit member which is effective for body fluid treatment by suppressing residual bubbles and generation of thrombus during circulation of body fluid without impairing detection accuracy.

[Prior Art] FIG. 13 is a schematic diagram showing a conventional anticoagulant dialysis method using a body fluid treatment circuit member 71.

The body fluid treatment circuit member 71 includes a pressure detection unit 72 and a body fluid filtration unit 73.
The pressure detector section 72 is configured by liquid-tightly containing a flexible inner tube 75 in a hard outer tube 74, and a body fluid filter section 73.
Is a hard drip chamber body 76 with a mesh filter 77 loaded therein.

In the figure, 81 is a hemodialyzer, which is connected to a vein side circuit 82 on the downstream side and an arterial side circuit 83 on the upstream side. Vein side circuit 82
A body fluid treatment circuit member 71 is attached in the middle of. Blood drawn from the patient is fed to the arterial circuit 83, hemodialyzer 8
1. After passing through the bodily fluid treatment circuit member 71, it was filtered by the filter 77 of the bodily fluid filtering member 73 and returned to the patient through the vein side circuit 82.

[Problems to be Solved by the Invention] However, in the body fluid treatment circuit member 71, since the body fluid filtration unit 73 and the pressure detection unit 72 are separately manufactured and then connected, there are many manufacturing steps. In addition to the time-consuming work, the individual shapes have to be larger and the cost is higher.

As described above, since the whole shape is large, the filling amount of body fluid is large, and particularly when blood is used in dialysis, thrombus tends to occur. If the contact time with the material forming the body fluid treatment circuit member 71 (foreign matter for blood) increases, thrombosis is likely to occur, so it is desirable to shorten the contact time as much as possible.

[Means for Solving the Problems] Therefore, the present invention focuses on downsizing of the body fluid treatment circuit member and does not impair the pressure detection accuracy of the body fluid to minimize the occurrence of bubbles in the blood and the formation of thrombus. As a result of repeated studies on the improvement of the pressure detector that can be suppressed, the following idea was reached.

That is, according to claim 1 of the present invention, a body fluid treatment circuit member to be mounted in a body fluid treatment circuit, wherein the first fusion fluid is formed by leaving a body fluid passage in an intermediate portion of a body tube made of a hard resin. An adhesion part, a second fusion part formed at one end of the body tube, a third fusion part formed at the other end of the body tube, a first fusion part and a first fusion part. An inner pipe which is arranged in a space between two fusion-bonding parts, one end of which is fixed to the first fusion-bonding part and the other end of which is fixed to the second fusion-bonding part to form a pressure detecting part. And a space between the first fusion bonding portion and the third fusion bonding portion, which is fixed inside the first fusion bonding portion or the third fusion bonding portion or the main body tube. A mesh filter forming an excess portion, a pressure monitor line attached to the second fusion-bonding portion, and a pressure monitor line attached to the second fusion-bonding portion The is first fused portion and the second
Body fluid guide tube that communicates with the space between the fusion-bonding parts, and the first fusion-bonding part and the third fusion-bonding part attached to the third fusion-bonding part.
And a bodily fluid guide tube communicating with the space between the fusion-bonded parts of

Further, according to claim 2 of the present invention, instead of the third fusion-bonding portion, a cap member is fixed to different end portions of the main body tube, and the cap member or the first fusion-bonding portion or the second fusion-bonding portion is formed. A mesh filter is fixed to the fusion-bonded part of the above.

[Operation] The body fluid circulating in the body fluid treatment circuit flows into the main body tube from one body fluid guide tube and passes in a short time through the pressure detection unit and the body fluid filtration unit which are formed with the first fusion section as a boundary. And flows out from the other liquid guide tube. The pressure detection unit and the body fluid filtration unit flow through the body fluid passage of the first welding unit.

In the pressure detection part, the flexible inner tube expands or contracts according to the body fluid flow rate passing through it, and the pressure monitor line detects the pressure fluctuation in the gap between the outer tube and the flexible inner tube. is doing.

Further, in the body fluid filtration portion, the fine foreign matter contained in the body fluid is removed by the mesh filter.

[Embodiment] FIG. 1 (a) is a schematic view showing a first embodiment of the member for body fluid treatment circuit of the present invention. FIG. 1 (b) is FIG. 1 (a).
A-A sectional drawing of is shown.

In the body fluid treatment circuit member 1, a fused portion 4 is formed in an intermediate portion of a tubular body 2 made of, for example, hard polyvinyl chloride, leaving a body fluid passageway 3, and the fusion portion 4 is separated to detect pressure. A part 5 and a body fluid filtration part 6 are formed.

The pressure detecting portion 5 has therein a thin flexible inner tube 7 made of, for example, soft polyvinyl chloride, and both ends of the flexible inner tube 7 are formed by high frequency welding together with the main body 2. It is fixed by the fused portions 4 and 8.

The body fluid filtration part 6 is, for example, a mesh filter made of polyester, polyamide, or the like, or a hydrophilic polymer having a receding contact angle with water of 45 degrees or less on the surface thereof (eg, hydroxyethyl methacrylate, hydroxypropyl methacrylate, methoxyethyl acrylate, ethoxy). A mesh filter coated with ethyl acrylate, a polymer of diacetone acrylamide, or the like) or a filter made of hard polyvinyl chloride and integrally formed with a ring portion and a mesh portion (hereinafter abbreviated as "filter 9") And the open end portion 15 of the filter 9 is fixed together with the main body 2 by the fusion bonding portion 4 formed by high frequency welding.

Further, a blood outflow pipe 10 is fixed to the upper end of the main body 2, and a blood inflow pipe 11 is fixed to the lower end of the main body 2 to the fusion-bonded portions 8 and 12 by high frequency welding.

In the figure, 13 is a deaeration line, and 14 is a pressure monitor line, which are fixed by a fusion-bonding portion 8 formed by high-frequency welding.
The degassing line 13 may be fixed to either the fusion bonding section 4 or 8. In FIG. 1, the fusion-bonding portion 4 is the first fusion-bonding portion, the fusion-bonding portion 4 is the second fusion-bonding portion, and the fusion-bonding portion 12 is the third fusion-bonding portion.

The following modes are conceivable as other examples of the body fluid treatment circuit member 1 of FIG. 1 (a).

That is, the body fluid treatment circuit member 1a shown in FIG. 2 has the open end portion 15a of the cap-shaped filter 9a arranged in the body fluid filtration portion 6a.
The circumferential surface of is fixed to the inner wall of the main body 2a by high frequency welding.

The body fluid treatment circuit member 1b of FIG. 3 is an example in which the pressure detecting portion 5b and the body fluid filtering portion 6b are formed so that the opposing angles thereof are 90 degrees. That is, in this example, the fusion-bonding portion 4 in the middle portion of the main body and the fusion-bonding surface of the end fusion-bonding portion 12 on the body fluid filtration portion 6b side are formed so as to be twisted with respect to the axis of the main body. ing. This twist angle is arbitrary. The fusion-bonding surface of the end fusion-bonding portion 8 on the pressure detecting portion 5b side is formed in the same direction as the intermediate fusion-bonding portion 4.

In FIG. 4, the body fluid treatment circuit member 1c is configured such that, when the body fluid treatment circuit member 1c is attached to the body fluid treatment circuit, the pressure detection portion 5c is located above the main body 2c and the body fluid filtration portion 6c is located below. Is. The pressure monitor line 14c is connected to the fused portion 12c.
The filter 9c is fixed to the main body 2 with the open end 15c.
It is fixed by the fusion-bonding part 8c formed by high frequency welding together with c. On the other hand, the flexible inner tube 7c has fused portions 4c and 12c formed by high frequency welding together with the main body 2 at both ends.
It is fixed by. In FIG. 4, the fused portion 4c is the first fused portion, the fused portion 12c is the second fused portion, and the fused portion 8c is the third fused portion.

The body fluid treatment circuit member 1d shown in FIG. 5 is constructed by fixing the circumferential surface of the open end portion 15d of the filter 9d arranged in the body fluid filtration portion 6d to the inner wall of the main body 2d by high frequency welding.

The body fluid treatment circuit member 1e of FIG. 6 is formed such that the pressure detecting portion 5e and the body fluid filtering portion 6e face each other at an angle of 90 degrees. That is, as compared with FIG. 4, the fusion-bonding surfaces of the fusion-bonding portion 4c at the intermediate portion of the main body and the end-fusion-bonding portion 12c on the pressure detecting portion 5e side are twisted with respect to the axial center of the main body. Has been formed. This twist angle is arbitrary.

FIG. 7 is a schematic view showing a second embodiment of the member for body fluid treatment circuit according to the present invention. The body fluid treatment circuit member 21 includes a body 22 made of, for example, hard polyvinyl chloride, and a body fluid passage 23 left in the body 22 to form a fusion portion 24. The fusion portion 24 is separated from the pressure detection portion 25 and the body fluid. A filter portion 26 is formed.

The pressure detection unit 25 has a thin flexible inner tube 27 made of, for example, soft polyvinyl chloride, arranged inside, and both ends of the flexible inner tube 27 are formed by high frequency welding together with the main body 22. It is fixed by the fusion-bonding portions 24 and 32.

A filter 29 is disposed inside the bodily fluid filtration part 26, and an open end 35 of the filter 29 is fixed together with the body 22 by a fusion part 24 formed by high frequency welding.

Further, a blood outflow pipe 30 and a pressure monitor line 34 are fixed to the lower end portion of the main body 22 by a high frequency welding from the fusion bonding portion 32. On the other upper end, a trap cap 37, which is integrally formed with a body fluid inflow pipe 31 and a connection pipe 36 of the degassing line 33, is attached. In FIG. 7, the fusion-bonding portion 24 is the first fusion-bonding portion, and the fusion-bonding portion is the second fusion-bonding portion.

The following modes are conceivable as other examples of the body fluid treatment circuit member 21 of FIG.

That is, the body fluid treatment circuit member 21a shown in FIG. 8 has the circumferential surface of the open end portion 35a of the filter 29a arranged in the body fluid filtration portion 26a fixed to the inner wall of the main body 22a by high frequency welding.

In the body fluid treatment circuit member 21b of FIG. 9, the open end portion 35b of the filter 29b arranged in the body fluid filter member 26b is fixed together with the main body 22b by the fusion portion 38 formed by the high frequency welding leaving the body fluid passage 39. It was done. In addition, in FIG. 9, the fused portion 38 is the second fused portion.

Next, an example in which the body fluid treatment circuit member 1 of the present invention is used for hemodialysis will be described. FIG. 10 shows an example of use in normal dialysis, and FIG. 11 shows an example of use in reduced anticoagulant dialysis.

In FIG. 10, reference numeral 41 denotes a hemodialyzer, on the upstream side of the hemodialyzer 41, an arterial circuit 42 is attached via a blood inlet 44, and on the downstream side a vein circuit 43 is attached via a blood outlet 45. ing.

The body fluid treatment circuit member 1 is attached in the middle of the vein side circuit 43.

The dialysate enters from the lower inlet 46 of the hemodialyzer 41 and the upper outlet.
It is refluxed so as to flow to 47.

After priming physiological saline into the hemodialyzer 41, the arterial circuit 42, and the venous circuit 43 to expel air bubbles therein, the arterial circuit 42 and the venous circuit 43 are connected to the patient via the shunts 48 and 49. After connecting to the blood, the blood pump 50 is driven to introduce blood into the hemodialyzer 41 through the arterial circuit 42, and the blood is brought into contact with dialysate to remove waste products (hazardous substances of low molecular weight) and purified blood. Is returned to the patient via the vein side circuit 43 and the body fluid treatment circuit member 1.

The blood introduced into the body fluid treatment circuit member 1 through the vein side circuit 43 passes through the flexible inner tube 7a of the pressure detection unit 5, the body fluid passage 3, the filter 9 and the body fluid outflow tube 10 to the vein side. Spilled to circuit 43.

If a pressure fluctuation occurs in the blood during dialysis, the thin flexible inner tube 7 is sensitively expanded and contracted, so that the pressure can be transmitted to the pressure gauge 51 via the pressure monitor line 14, so that it can be quickly known. be able to.

Even if microaggregates in the blood or minute dusts in the extracorporeal circulation circuit are contained, they are blocked by the filter 9 and do not enter the patient's body. Even if minute bubbles are mixed in the main body 2, they can be easily removed from the degassing line 13.

The physiological saline, which is densely filled in the body fluid treatment circuit member 1, is sequentially replaced with blood from the lower part to the upper portion, and then blood is constantly filled in the body fluid treatment circuit member 1 and the blood is refluxed. Since blood does not come into contact with air, there is no risk of blood clots.

Further, the swelling of the filter 9 due to the fluid pressure of the blood passing through the filter member 6 is small as a factor that makes it difficult for the thrombus to occur, and the blood quickly passes through the central portion of the filter 9, so that the pressure detecting unit 5 is substantially provided. It is conceivable that the time to stay inside is short.

In FIG. 11, reference numeral 41a is a hemodialyzer, and a downstream side of the hemodialyzer 41a has a vein side circuit 43a via a blood outlet 45a and an upstream side has an arterial side circuit 42a via a blood inlet 44a. It is connected.

The body fluid treatment circuit member 1 is attached in the middle of the vein side circuit 43a.

The dialysate is refluxed so as to enter from the upper inlet port 46a of the hemodialyzer 41a and flow out to the lower outlet port 47a.

Hemodialyzer 41a, arterial side circuit 42a, venous side circuit 43a prime saline solution, after expelling the bubbles in, shunts 48a, 49a arterial side circuit 42a, venous side circuit 43a through After connecting to the patient, the blood pump 50a is operated to introduce blood into the hemodialyzer 41a through the upstream arterial circuit 42a and contact with the dialysate to generate waste products (low molecular weight harmful substances).
The blood that has been removed and purified is returned to the patient via the downstream venous circuit 43a and the body fluid treatment circuit member 1.

The blood introduced into the body fluid treatment circuit member 1 via the vein side circuit 43a is treated in the same manner as described above, and the microaggregates in the blood or the removal of fine dust and bubbles in the extracorporeal circulation circuit, the pressure fluctuation The detection was performed in the same manner, and the same was true in that thrombus did not occur. Finally, an example of the method for manufacturing the body fluid treatment circuit member of the present invention will be described for the case of the body fluid treatment circuit member 1 of FIG. 1 (a) (see FIG. 12).

In the figure, 55a and 55b are molds and are formed symmetrically with each other.
The mold 55a is basically composed of three holding parts 56a, 57a, 58a, and the holding parts 56a, 57a, 58a are integrally or separately mounted on the entire mold, and each of them is attached to the mold. ,
Clamping grooves 59a, 60a, 61a, 62a, 63a of the blood inflow pipe 11 and the like are formed.

The fusion of the blood inflow pipe 11 and the like to the main body 2 is performed as follows. Blood circulation tubes 68 are attached to metal rods 64, 65, 66 and 67 made of a conductive material such as iron, stainless steel, brass and duralumin.
And the flexible inner tube 7 and the filter 9 together with the flexible inner tube 7 and the filter 9 are placed in the main body 2, and the clamping grooves 59a, 60a, 61a, 62a, 63a of the blood inflow tube 11 of the molds 55a, 55b are attached. And align.

After that, when the main body 2 is crushed from the molds 55a and 55b from above and below while the molds 55a and 55b are energized in the order of the metal rods 64, 65, 66 and 67, they come into contact with the sandwiching parts 56a, 57a and 58a. The main body 2, the blood inflow pipe 11 and the like are melted and fused.

[Effects of the Invention] According to the present invention described above, the following effects can be obtained.

In integrating the pressure detection unit and the body fluid filtration unit, since they are separated by the first welding unit, the pressure detection unit and the body fluid filtration unit function independently and do not affect each other. Therefore, pressure detection can be performed uniformly and stably.

The pressure detection part and the body fluid filtration part are integrally molded in the same main body tube, and by making the main body tube and the fusion part common or integrated, these pressure detection member and body fluid filtration member can be made compact. Can be planned. Further, since the raw materials used for the constituent members can be reduced and the manufacturing process can be reduced, mass production can be carried out at low cost. Furthermore, by making the whole compact, the body fluid passage time (residence time) between the pressure detection unit and the body fluid filtration unit is shortened, and the time for contact with the constituent materials (foreign matter) of these pressure detection unit and body fluid filtration unit As a result, the occurrence of thrombus is reduced.

[Brief description of drawings]

FIG. 1 (a) is a schematic view showing a first embodiment of a member for body fluid treatment circuit of the present invention, and FIG. 1 (b) is an A- line in FIG. 1 (a).
Sectional view A, FIGS. 2 to 6 are schematic views showing another embodiment of FIG. 1, FIG. 7 is a schematic view showing a second embodiment of the body fluid treatment circuit member of the present invention, and FIG. FIG. 9 and FIG. 9 are schematic views showing another embodiment of FIG. 7, FIG. 10 and FIG. 11 are schematic views showing an example of use of the body fluid treatment circuit member of the present invention, and FIG.
The drawings are schematic views showing a method for manufacturing a body fluid treatment circuit member of the present invention. FIG. 13 is a schematic view showing a conventional body fluid treatment circuit member and an example of its use. In the figure, 1 and 21 are members for body fluid treatment circuit, 2 and 22 are main bodies,
3, 23, 39 are body fluid passages, 4, 8, 12, 24, 32, 38 are fusion-bonded parts,
5, 25 are pressure detecting parts, 6, 26 are body fluid filtration parts, 7, 27
Is a flexible inner tube, 9 and 29 are filters, 10 and 30 are blood outflow tubes, 11 and 31 are blood inflow tubes, 13 and 33 are deaeration lines, and 14 and 34
Is a pressure monitor line, 15 and 35 are open ends, and 37 is a trap cap.

Claims (2)

[Scope of utility model registration request] 1. A body fluid treatment circuit member to be mounted in a body fluid treatment circuit, comprising: a first fusion-bonding portion formed by leaving a body fluid passage in an intermediate portion of a body tube made of hard resin; A second fusion-bonding part formed at one end of the body tube, a third fusion-bonding part formed at the other end of the body tube, and a space between the first fusion-bonding part and the second fusion-bonding part. An inner tube that is disposed in a space portion of the first end, is fixed to the first fusion-bonding portion at one end, and is fixed to the second fusion-bonding portion at the other end to form a pressure detection unit; A mesh filter that is arranged in a space between the attachment part and the third fusion part and is fixed to the inside of the first fusion part, the third fusion part, or the main body tube to form a body fluid filtration part. A pressure monitor line attached to the second fusing part, and a pressure monitor line attached to the second fusing part and the first fusing part Two
Body fluid guide tube that communicates with the space between the fusion-bonding parts, and the first fusion-bonding part and the third fusion-bonding part attached to the third fusion-bonding part.
A bodily fluid guide tube communicating with a space between the fusion-bonded parts of the bodily fluid treatment circuit member. 2. A cap member is fixed to different end portions of the main body tube in place of the third fusion-bonding portion, and the cap member or the first fusion-bonding portion or the second fusion-bonding portion is meshed. The body fluid treatment circuit member according to claim 1, wherein a filter is fixed.