JPH0415763B2 - - Google Patents
Info
- Publication number
- JPH0415763B2 JPH0415763B2 JP60048034A JP4803485A JPH0415763B2 JP H0415763 B2 JPH0415763 B2 JP H0415763B2 JP 60048034 A JP60048034 A JP 60048034A JP 4803485 A JP4803485 A JP 4803485A JP H0415763 B2 JPH0415763 B2 JP H0415763B2
- Authority
- JP
- Japan
- Prior art keywords
- arbutin
- skin
- mucopolysaccharide
- present
- sticky
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 24
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 14
- 229960000271 arbutin Drugs 0.000 claims description 12
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000003020 moisturizing effect Effects 0.000 description 8
- 239000006210 lotion Substances 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 229940058015 1,3-butylene glycol Drugs 0.000 description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 description 4
- 125000003158 alcohol group Chemical group 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 229940010747 sodium hyaluronate Drugs 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- -1 hydroquinone glycoside Chemical class 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229940094517 chondroitin 4-sulfate Drugs 0.000 description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 description 1
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- NPPRLEYXLWDOKT-WYRLRVFGSA-N benzene-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC1=CC=C(O)C=C1.OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O NPPRLEYXLWDOKT-WYRLRVFGSA-N 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Description
［産業上の利用分野］
本発明は保湿効果に優れ、かつべたつきのない
使用感触を有する皮膚外用剤に関する。
［従来の技術］
皮膚の水分を適正な範囲に保つことは皮膚の健
康の面から非常に大切なことであり、保湿を目的
とした化粧料は多くみられる。また、医薬品にも
保湿成分が配合されて、主剤の効果をより高めて
いる例が見受けられる。
皮膚の保湿に関与する物質についての研究も進
んでおり、現在ではプロピレングリコールやソル
ビトールなどの多価アルコールをはじめとして数
多くの保湿剤が使用されるに至つている。
このような状況のもとで、とくに最近、注目を
集めているのがムコ多糖である。ムコ多糖は皮膚
の天然湿因子でもあり、その保湿作用は強力であ
る。
しかしながら、ムコ多糖は保湿作用の優秀さと
は裏腹にべたつきの強い使用感触をもつており、
皮膚外用剤、とくに化粧料に配合するには難点と
なつていた。
［発明が解決しようとする問題点］
本発明者らはこのような事情にかんがみてムコ
多糖のべたつきをおさえることを目的に鋭意検討
した結果、ムコ多糖とともに特定のハイドロキノ
ンの配糖体を配合すると、上記問題が解決するこ
とを見いだし、本発明を完成するに至つた。
［問題点を解決するための手段］
すなわち、本発明はムコ多糖の一種又は二種以
上と、アルブチン（ハイドロキノン−β−Ｄ−グ
ルコース）0.1〜30重量％とを含有することを特
徴とする皮膚外用剤である。
本発明で用いるムコ多糖はヒアルロン酸、コン
ドロイチン−４−硫酸、コンドロイチン−６−硫
酸、デルマタン硫酸、ケラタン硫酸、ヘパリンな
どのムコ多糖およびそれらの塩であり、これらの
なかから一種又は二種以上が適宜選ばれて用いら
れる。
配合量は皮膚外用剤全量中の0.001〜10重量％、
好ましくは0.01〜３重量％ある。0.001重量％未
満では保湿効果に乏しく、また、べたつきも少な
い。10重量％を越えると本発明のハイドロキノン
の配糖体を併用してもべたつきをおさえることが
困難となる。
本発明において、ムコ多糖とともに皮膚外用剤
中に配合され、ムコ多糖のべたつきをおさえるア
ルブチンの配合量は皮膚外用剤全量中の0.1〜30
重量％、好ましくは６〜20重量％である。
ムコ多糖および上記アルブチンを配合できる皮
膚外用剤は、通常の皮膚外用剤、たとえば、水溶
液系、可溶化系、乳化系、粉末分散系、水−油２
層系、水−油−粉末３層系など、どのような基剤
でもよく、用途も化粧水、乳液、クリーム、パツ
クなどの基礎化粧料、口紅、フアンデーシヨンな
どのメーキヤツプ化粧料、シヤンプー、リンス、
ヘアトニツクなどの頭髪化粧料などの化粧料、医
薬部外品など多岐にわたるが、なかでも、透明ま
たは半透明の化粧水に応用したときにとくに真価
を発揮する。化粧水は一般に水−アルコールベー
スであるので、使用後のべたつきがとくに感じら
れるからである。
本発明の皮膚外用剤には必要に応じて、本発明
の効果を損なわない範囲で、保湿剤、増粘剤、防
腐剤、乳化剤、酸化防止剤、金属イオン封鎖剤、
紫外線吸収剤、粉末、顔料、薬剤、色素、香料な
どを配合できる。
［発明の効果］
本発明の皮膚外用剤は、ムコ多糖を配合して保
湿効果に優れているにもかかわらず、ムコ多糖特
有のべたつきがなく、かつ安定性、安全性も良好
で優れた皮膚外用剤である。
［実施例］
つぎに実施例により本発明をさらに詳細に説明
する。本発明は、これによつて何ら限定されるも
のではない。
実施例１ 化粧水
エタノール 20.0
１，３−ブチレングリコール 5.0
ヒアルロン酸ナトリウム 0.3
POE（ポリオキシエチレン、以下同じ、15モ
ル）オレイルエーテル 0.8
エチルパラベン 0.1
アルブチン 6.0
精製水 残余
（製法） エタノールの一部にPOEオレイルエ
ーテルおよびエチルパラベンを溶解する。べつ
に精製水とエタノールの残部に１，３−ブチレ
ングリコール、ヒアルロン酸ナトリウムおよび
アルブチンを溶解する。エタノール相を水相中
に添加、可溶化して化粧水を得た。
実施例 ２
実施例１のアルブチンを1.0重量％に減量した
他は実施例１に準じて、実施例２を得た。
比較例 １
実施例１のアルブチンを除いた他は実施例１に
準じて、比較例１を得た。
実施例１〜２、比較例１の使用性（べたつき）
を、女性美容専門パネルの実使用試験によつて判
定、評価した。
（判定）
Ａ；べたつかない。
Ｂ；わずかにべたつくが、使用性上問題のない範
囲である。
Ｃ；べたつく。
Ｄ；著しくべたつく。
結果を表−１に示す。
アルブチンが、ムコ多糖のべたつきを防止して
いることが明らかである。
[Industrial Field of Application] The present invention relates to an external preparation for skin that has an excellent moisturizing effect and a non-sticky feeling when used. [Prior Art] Maintaining skin moisture within an appropriate range is extremely important from the perspective of skin health, and many cosmetics are available for the purpose of moisturizing. In addition, there are cases in which moisturizing ingredients are added to pharmaceutical products to further enhance the effectiveness of the main ingredient. Research into substances involved in skin moisturization is progressing, and many moisturizers are now in use, including polyhydric alcohols such as propylene glycol and sorbitol. Under these circumstances, mucopolysaccharides have been attracting particular attention recently. Mucopolysaccharide is also a natural moisturizing factor for the skin, and its moisturizing effect is strong. However, despite its excellent moisturizing effect, mucopolysaccharides have a strong sticky feel when used.
It has been difficult to incorporate it into external skin preparations, especially cosmetics. [Problems to be Solved by the Invention] In view of the above circumstances, the inventors of the present invention conducted extensive studies with the aim of suppressing the stickiness of mucopolysaccharide, and found that when a specific hydroquinone glycoside is blended with mucopolysaccharide. The inventors have found that the above problem can be solved, and have completed the present invention. [Means for Solving the Problems] That is, the present invention provides a skin characterized by containing one or more mucopolysaccharides and 0.1 to 30% by weight of arbutin (hydroquinone-β-D-glucose). It is an external preparation. The mucopolysaccharides used in the present invention are mucopolysaccharides such as hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, keratan sulfate, and heparin, and their salts, and one or more of these are mucopolysaccharides and salts thereof. It is selected and used as appropriate. The blending amount is 0.001 to 10% by weight of the total amount of the skin external preparation.
Preferably it is 0.01 to 3% by weight. If it is less than 0.001% by weight, it will have poor moisturizing effect and will also be less sticky. If the amount exceeds 10% by weight, it becomes difficult to suppress stickiness even when the hydroquinone glycoside of the present invention is used in combination. In the present invention, the amount of arbutin that is blended together with mucopolysaccharide in the skin external preparation to suppress the stickiness of the mucopolysaccharide is 0.1 to 30% of the total amount of the skin external preparation.
% by weight, preferably 6-20% by weight. The skin external preparations that can contain the mucopolysaccharide and the above-mentioned arbutin include the usual skin external preparations, such as aqueous solutions, solubilized systems, emulsified systems, powder dispersion systems, water-oil 2
Any type of base may be used, such as layer type, water-oil-powder three-layer type, etc., and can be used for basic cosmetics such as lotion, emulsion, cream, and pack, makeup cosmetics such as lipstick, foundation, shampoo, etc. rinse,
It is used in a wide variety of applications, including cosmetics such as hair tonics, and quasi-drugs, but its true value is particularly demonstrated when applied to transparent or translucent lotions. This is because lotions are generally water-alcohol based and feel particularly sticky after use. The skin external preparation of the present invention may contain, as necessary, a humectant, a thickener, a preservative, an emulsifier, an antioxidant, a sequestering agent, within a range that does not impair the effects of the present invention.
UV absorbers, powders, pigments, drugs, pigments, fragrances, etc. can be added. [Effects of the Invention] Although the skin external preparation of the present invention contains mucopolysaccharide and has an excellent moisturizing effect, it does not have the stickiness characteristic of mucopolysaccharide, and has good stability and safety, and is excellent for the skin. It is an external preparation. [Example] Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited to this in any way. Example 1 Lotion ethanol 20.0 1,3-butylene glycol 5.0 Sodium hyaluronate 0.3 POE (polyoxyethylene, the same hereinafter, 15 mol) oleyl ether 0.8 Ethylparaben 0.1 Arbutin 6.0 Purified water Remaining (manufacturing method) POE in part of the ethanol Dissolve oleyl ether and ethyl paraben. Separately, dissolve 1,3-butylene glycol, sodium hyaluronate, and arbutin in the remaining purified water and ethanol. The ethanol phase was added to the aqueous phase and solubilized to obtain a lotion. Example 2 Example 2 was obtained according to Example 1 except that the amount of arbutin in Example 1 was reduced to 1.0% by weight. Comparative Example 1 Comparative Example 1 was obtained according to Example 1 except that arbutin was used. Usability of Examples 1-2 and Comparative Example 1 (stickiness)
were judged and evaluated through actual use tests by a panel specializing in women's beauty. (Judgment) A: Not sticky. B: Slightly sticky, but within a range that poses no problem in terms of usability. C: Sticky. D: Significantly sticky. The results are shown in Table-1. It is clear that arbutin prevents mucopolysaccharide from becoming sticky.
【表】
実施例３ フアンデーシヨン
(A) セタノール 3.5
ステアリン酸 2.0
脱臭ラノリン 5.0
ワセリン 2.0
スクワラン 8.0
グリセリルモノオレート 2.5
POE(10)ベヘニルアルコール 0.5
エチルパラベン 0.2
ブチルパラベン 0.2
(B) コンドロイチン−６−硫酸ナトリウム 5.0
アルブチン 0.5
１，３−ブチレングリコール 2.0
調合粉末＊ 15.0
トリエタノールアミン 0.25
精製水 残余
調合粉末＊……酸化チタン5.0、カオリン3.0、
タルク5.0、酸化鉄2.0よりなる粉末。
（製法） (A)の油相部と(B)の水相部を別々に加熱
撹拌する。油相部を水相部に添加し、乳化、冷
却してフアンデーシヨンを得た。
実施例４ 化粧水
(A) 精製水 全体が100になる量
グリセリン 2.0
ヒアルロン酸ナトリウム 0.5
アルブチン 15.0
１，３−ブチレングリコール 2.0
(B) エタノール 15.0
精製レシチン 0.02
POE（60）硬化ヒマシ油 1.0
香 料 0.05
メチルパラベン 0.1
（製法） (A)の水相部および(B)のアルコール部を
それぞれ均一溶解した後、水相部にアルコール
部を加えて可溶化し、化粧水を得た。
実施例５ 水性エツセンス
(A) 精製水 全体が100になる量
１，３−ブチレングリコール 10.0
マルチトール 2.0
ヒアルロン酸ナトリウム 0.2
コンドロイチン−４−硫酸ナトリウム 0.1
アルブチン 1.0
ジプロピレングリコール 5.0
カルボキシメチル（セルロース） 0.2
(B) エタノール 5.0
POE（60）硬化ヒマシ油 1.0
ビタミンＥアセテート 0.1
香 料 0.05
オレイルアルコール 0.2
メチルパラベン 0.2
(C)水酸化カリリウム 0.1
（製法） (A)の水相部および(B)のアルコール部を
それぞれ均一溶解した後、水相部にアルコール
部を加えて混合可溶化し、ついで(C)の水酸化カ
リウムを加えてエツセンスを得た。[Table] Example 3 Foundation (A) Setanol 3.5 Stearic acid 2.0 Deodorized lanolin 5.0 Vaseline 2.0 Squalane 8.0 Glyceryl monooleate 2.5 POE(10) behenyl alcohol 0.5 Ethylparaben 0.2 Butylparaben 0.2 (B) Sodium chondroitin-6-sulfate 5.0 Arbutin 0.5 1,3-butylene glycol 2.0 Preparation powder* 15.0 Triethanolamine 0.25 Purified water Remaining Preparation powder*...Titanium oxide 5.0, Kaolin 3.0,
Powder consisting of talc 5.0 and iron oxide 2.0. (Production method) Heat and stir the oil phase (A) and the water phase (B) separately. The oil phase was added to the water phase, emulsified, and cooled to obtain a foundation. Example 4 Lotion (A) Purified water Amount to make the total 100 Glycerin 2.0 Sodium hyaluronate 0.5 Arbutin 15.0 1,3-butylene glycol 2.0 (B) Ethanol 15.0 Purified lecithin 0.02 POE (60) Hydrogenated castor oil 1.0 Fragrance 0.05 Methylparaben 0.1 (Production method) After uniformly dissolving the water phase (A) and the alcohol part (B), the alcohol part was added to the water phase for solubilization to obtain a lotion. Example 5 Aqueous essence (A) Purified water 1,3-butylene glycol 10.0 Maltitol 2.0 Sodium hyaluronate 0.2 Sodium chondroitin-4-sulfate 0.1 Arbutin 1.0 Dipropylene glycol 5.0 Carboxymethyl (cellulose) 0.2 ( B) Ethanol 5.0 POE (60) Hydrogenated castor oil 1.0 Vitamin E acetate 0.1 Fragrance 0.05 Oleyl alcohol 0.2 Methyl paraben 0.2 (C) Potassium hydroxide 0.1 (Production method) The aqueous phase part of (A) and the alcohol part of (B), respectively. After homogeneous dissolution, an alcohol part was added to the aqueous phase to mix and solubilize, and then potassium hydroxide (C) was added to obtain essence.
Claims (1)
0.1〜30重量％とを含有することを特徴とする皮
膚外用剤。1 One or more mucopolysaccharides and arbutin
A skin external preparation characterized by containing 0.1 to 30% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4803485A JPS61207310A (en) | 1985-03-11 | 1985-03-11 | External agent for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4803485A JPS61207310A (en) | 1985-03-11 | 1985-03-11 | External agent for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61207310A JPS61207310A (en) | 1986-09-13 |
| JPH0415763B2 true JPH0415763B2 (en) | 1992-03-19 |
Family
ID=12792026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4803485A Granted JPS61207310A (en) | 1985-03-11 | 1985-03-11 | External agent for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61207310A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01213227A (en) * | 1988-02-23 | 1989-08-28 | Tadashi Koyake | Ointment and solution |
| JP3634113B2 (en) * | 1997-03-31 | 2005-03-30 | 株式会社資生堂 | Topical skin preparation |
| JP2005187354A (en) * | 2003-12-25 | 2005-07-14 | Lion Corp | Aqueous external preparation composition |
| MX2009007048A (en) * | 2006-12-26 | 2009-07-10 | Romano Dev Inc | Skin lightening composition for hyperpigmented skin. |
| CN108553321B (en) * | 2018-05-09 | 2021-08-10 | 重庆医药高等专科学校 | Pearlescent lipstick and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5781410A (en) * | 1980-11-11 | 1982-05-21 | Tokitaka Mori | Remedy for skin pigmentation |
| JPS57183707A (en) * | 1981-05-02 | 1982-11-12 | Shiseido Co Ltd | Cosmetic |
| JPS57185208A (en) * | 1981-05-07 | 1982-11-15 | Shiseido Co Ltd | Skin cosmetic |
| JPS6016906A (en) * | 1983-07-07 | 1985-01-28 | Pola Chem Ind Inc | External drug for skin |
-
1985
- 1985-03-11 JP JP4803485A patent/JPS61207310A/en active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5781410A (en) * | 1980-11-11 | 1982-05-21 | Tokitaka Mori | Remedy for skin pigmentation |
| JPS57183707A (en) * | 1981-05-02 | 1982-11-12 | Shiseido Co Ltd | Cosmetic |
| JPS57185208A (en) * | 1981-05-07 | 1982-11-15 | Shiseido Co Ltd | Skin cosmetic |
| JPS6016906A (en) * | 1983-07-07 | 1985-01-28 | Pola Chem Ind Inc | External drug for skin |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61207310A (en) | 1986-09-13 |
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