JP7032213B2 - Management equipment and programs - Google Patents

Description

Embodiments of the present invention relate to management devices and programs.

Radiopharmaceuticals are drugs using RI (radioisotope). Since this RI has a short half-life, it is necessary to prepare radiopharmaceuticals in the hospital in consideration of the half-life. In the preparation of radiopharmaceuticals, for example, when preparing radiopharmaceuticals in a hospital, a radiologist or the like purchases a generator and a kit preparation including a kit from the outside. A radiologist or the like prepares a radiopharmaceutical using the purchased kit preparation.

At this time, the radiologist or the like calculates the required amount of radioactivity required for the test based on the date and time of administration of the radiopharmaceutical contained in the test order to the patient, the age of the patient, the weight of the patient, and the like. The radiologist and the like select a generator and a kit to be used for preparing a radiopharmaceutical based on the calculated required amount of radioactivity. The radiologist, etc. determine the calculated required amount of radioactivity and various parameters for preparing the radiopharmaceutical based on the selected generator, kit, etc., and prepare a preparation procedure manual. The radiologist, etc. prepares the radiopharmaceutical according to the prepared preparation procedure manual.

However, the calculation of the required radioactivity amount and the preparation of the preparation procedure manual are a heavy burden on the radiologist and the like, and require a lot of time. Therefore, radiopharmaceuticals cannot be prepared efficiently.

Japanese Unexamined Patent Publication No. 2005-324007

An object to be solved by the present invention is to improve the efficiency of the work of preparing a radiopharmaceutical drug.

According to the embodiment, the management device includes a calculation unit, a determination unit, and a presentation unit. The calculation unit calculates the required radioactivity amount based on the patient information regarding the patient and the examination order information regarding the radiological examination. The determination unit determines a method for preparing a radiopharmaceutical drug based on the calculated required radioactivity amount and the radioactivity concentration of the radioactivity solution that can be supplied in the hospital. The presentation unit presents the determined preparation method.

FIG. 1 is a block diagram showing a medical information system including a management device according to an embodiment. FIG. 2 is a block diagram showing a functional configuration of the management device shown in FIG. FIG. 3 is a flowchart showing the operation of the processing circuit when the management device according to the embodiment determines various parameters for preparing a radiopharmaceutical drug. FIG. 4 is a flowchart showing the operation of the processing circuit when the management device according to the embodiment determines various parameters for preparing a radiopharmaceutical drug. FIG. 5 is a diagram showing a list of inspection orders displayed on the display of the RIS terminal according to the embodiment. FIG. 6 is a diagram showing radiopharmaceutical information according to the embodiment. FIG. 7 is a diagram showing inspection information according to the embodiment. FIG. 8 is a diagram showing generator information according to the embodiment. FIG. 9 is a diagram showing kit information according to the embodiment. FIG. 10 is a diagram showing elution radioactivity information according to the embodiment. FIG. 11 is a diagram showing elution radioactivity information according to the embodiment. FIG. 12 is a diagram showing a list of preparation methods displayed on a display included in the RIS terminal according to the embodiment. FIG. 13 is a diagram showing details of a preparation method displayed on a display included in the RIS terminal according to the embodiment. FIG. 14 is a flowchart showing the operation of the processing circuit when the management device according to the embodiment warns and displays an inspection exceeding the upper limit value regarding the amount of radioactivity for each inspection. FIG. 15 is a diagram showing another example of a list of preparation methods displayed on a display included in the RIS terminal according to the embodiment. FIG. 16 is a block diagram showing a medical information system including a RIS server according to another embodiment. FIG. 17 is a block diagram showing a functional configuration of the RIS server shown in FIG.

Hereinafter, embodiments will be described with reference to the drawings.

FIG. 1 is a block diagram showing an example of a medical information system including the management device 23 according to the present embodiment. The medical information system shown in FIG. 1 includes a hospital information system (HIS) 1, a radiation department information management system (RIS) 2, a medical diagnostic imaging apparatus 3, and a medical image management system (PACS:). Picture Archiving and Communication System) 4 is provided.

The hospital information system 1, the radiation department information management system 2, the medical diagnostic imaging device 3, and the medical image management system 4 are connected to a local network, transmit information to a predetermined device, and information transmitted from the predetermined device. To receive. The medical information system may be connected to an external network in addition to the local network or instead of the local network.

The hospital information system 1 manages information generated in the hospital. Information generated in the hospital includes patient information, examination order information, and the like. Each record included in the patient information has, as items, a patient ID, a patient name, a gender, a height, a weight, an age, a blood type, and the like. Each record included in the test order information includes, as items, an order number that can identify the test, patient ID, hospitalization or outpatient classification, test code, medical treatment subject, radiopharmaceutical drug, test site, test type, scheduled test date and time, etc. Has. The order number is a number issued when the examination order information is input, and is, for example, an identifier for uniquely specifying the examination order information in one hospital. The patient ID is given to each patient and is, for example, an identifier for uniquely identifying a patient in one hospital. The test code is an identifier for uniquely identifying the test, which is defined in, for example, one hospital. The medical treatment subject indicates, for example, the special field classification of medical treatment in medical treatment. Specifically, the medical treatment subjects are internal medicine, surgery, and the like. The radiopharmaceutical is an identifier for uniquely identifying the radiopharmaceutical. Examination sites include kidneys, lungs, livers, testes and the like. Test types include renal scintigram, lung scintigram, liver scintigram, testis scintigram test and the like.

In the hospital information system 1, for example, when examination order information is input from a medical doctor. The input examination order information and the patient information specified by this examination order information are transmitted to the radiation department information management system 2.

The radiation department information management system 2 is a system that manages inspection reservation information related to radiation inspection work. The radiation department information management system 2 includes a RIS server 21, a RIS terminal 12, and a management device 23.

The RIS server 21 manages information related to radiation inspection work in the radiation department information management system 2.

The RIS server 21 receives, for example, inspection order information transmitted from the hospital information system 1, adds various setting information to the received inspection order information, accumulates the collected information, and manages the accumulated information as inspection reservation information. Specifically, when the RIS server 21 receives the patient information and the examination order information transmitted from the hospital information system 1, the RIS server 21 operates the medical diagnostic imaging apparatus 3 based on the received patient information and the examination order information. Generate the required inspection appointment information. The examination reservation information includes, for example, information necessary for performing an examination such as an order number, a patient ID, an examination type, a procedure, an examination site, a body position, and an imaging direction.

At this time, the RIS server 21 receives, for example, a radiological examination request based on patient information and examination order information from the RIS terminal 22, and generates examination reservation information based on the received radiological examination request. The RIS server 21 reserves an examination based on, for example, an irradiation record that records various setting information set in the medical image diagnostic apparatus 3 at the time of the past examination in addition to the received patient information and the examination order information. Information may be generated.

The RIS server 21 transmits the generated examination reservation information to the medical diagnostic imaging apparatus 3. Then, the RIS server 21 receives from the medical image diagnostic device 3 the test execution information representing the test execution result generated as a result of the test performed by the medical image diagnostic device 3. The RIS server 21 outputs the received examination execution information to the hospital information system 1.

The RIS terminal 22 is connected to the RIS server 21 and the management device 23, and is used, for example, by a radiologist or the like to carry out various tasks in the radiation department. The RIS terminal 22 includes, for example, an input interface (not shown), a display, and a communication interface (not shown).

The input interface is realized by, for example, a mouse, a keyboard, a touch panel in which instructions are input by touching the operation surface, and the like. The input interface receives, for example, a display instruction from an operator. The input interface converts the display instruction from the operator into an electric signal and outputs the electric signal to the processing circuit.

The display displays various information in order to carry out various operations of the radiation department. As the display, for example, a CRT display, a liquid crystal display, an organic EL display, an LED display, a plasma display, and any other display known in the art can be appropriately used. The display also includes a display with a portable input interface.

The management device 23 manages, for example, information about radiopharmaceuticals used in hospitals. The details of the management device 23 will be described later.

The medical image diagnosis device 3 is a device that performs an examination by photographing a patient or the like. The medical image diagnostic apparatus 3 includes, for example, an X-ray computed tomography apparatus, an X-ray diagnostic apparatus, a magnetic resonance imaging apparatus, a nuclear medicine diagnostic apparatus, an ultrasonic diagnostic apparatus, and the like. The medical diagnostic imaging apparatus 3 performs an examination based on, for example, the examination reservation information transmitted from the RIS server 21. The medical diagnostic imaging apparatus 3 generates examination execution information and transmits it to the RIS server 21.

In addition, the medical image diagnostic device 3 generates medical image data by performing an examination. The medical image data is, for example, X-ray CT image data, X-ray image data, MRI image data, nuclear medicine image data, ultrasonic image data, and the like. The medical image diagnostic apparatus 3 generates a medical image file by converting the generated medical image data into a format compliant with, for example, a DICOM (Digital Imaging and Communication in Medicine) standard. The medical image file is, for example, a file in a format compliant with the DICOM standard. The medical image diagnosis device 3 transmits the generated medical image file to the medical image management system 4.

The medical image management system 4 is a system for managing various medical image files. The medical image management system 4 stores, for example, a medical image file transmitted from the medical image diagnostic apparatus 3.

Next, the details of the management device 23 according to the present embodiment will be described with reference to FIG. FIG. 2 is a block diagram showing a functional configuration of the management device 23 shown in FIG.

The management device 23 shown in FIG. 2 has a processing circuit 230, a memory 240, and a communication interface 250. The processing circuit 230, the memory 240, and the communication interface 250 are connected to each other so as to be able to communicate with each other via, for example, a bus.

The processing circuit 230 is a processor that functions as the center of the management device 23. The management device 23 realizes a function corresponding to the control program stored in the memory 240 or the like.

The memory 240 is a storage device such as an HDD (hard disk drive), an SSD (solid state drive), and an integrated circuit storage device that stores various information. Further, the memory 240 may be a drive device or the like that reads / writes various information between a CD-ROM drive, a DVD drive, and a portable storage medium such as a flash memory. The memory 240 stores a control program or the like according to the present embodiment. The program may be stored and distributed in a non-transient storage medium, read from the non-transient storage medium, and installed in the memory 240, for example.

Further, the memory 240 stores, for example, drug information 241. The drug information 241 contains, for example, information about the drug. In the drug information 241 for example, an item for specifying a radiopharmaceutical drug and an item related to restrictions on ordering the radiopharmaceutical drug are associated with each other.

Further, the memory 240 stores, for example, inspection information 242. The test information 242 includes, for example, the radiopharmaceutical required for the test and information for calculating the required radiopharmaceutical amount of the radiopharmaceutical. In the test information 242, for example, an item specifying the test and an item relating to the radiopharmaceutical amount of the radiopharmaceutical used in the test are associated with each other.

Further, the memory 240 stores, for example, generator information 243 regarding a generator that generates a daughter nuclide from a parent nuclide. The parent nuclide is, for example, molybdenum 99 (99Mo). The daughter nuclide is, for example, radioactive technetium-99 (99mTc). The combination of parent nuclide and daughter nuclide used in the generator is not limited to 99Mo-99mTc, and any combination as long as the half-life of the parent nuclide is much longer than the half-life of the daughter nuclide and the radiation equilibrium is established. But it may be. The generator information 243 includes, for example, information about a generator stored in the hospital and a generator delivered in the hospital on the day of the examination. In the generator information 243, for example, an item that specifies a generator and an item that represents the characteristics of the generator are associated with each other.

The memory 240 also stores, for example, kit information 244 for a kit used in the preparation of radiopharmaceuticals. Kit information 244 includes, for example, information about kits stored in the hospital and kits scheduled to be delivered to the hospital on the day of the examination. In the kit information 244, an item that identifies the kit and an item that represents the characteristics of the kit are associated with each other.

Further, the memory 240 stores elution radioactivity information 245 representing information on the amount of elution radioactivity for each generator and each inspection date and time. The elution radioactivity information 245 contains, for example, information on the amount of radioactivity that can be eluted at each time on the inspection day after the delivery date for the generator stored in the hospital and the generator scheduled to be delivered in the hospital on the inspection day. include. In the elution radioactivity information 245, for example, for each generator and for each capacity of the elution vial for accommodating the radioactive solution containing the daughter nuclide eluted from the generator, each time of the inspection date after the delivery date and the half-life Is associated with the amount of elutionable radioactivity calculated in consideration of.

The communication interface 250 performs data communication with the hospital information system 1, the RIS server 21, the RIS terminal 22, the medical image diagnostic device 3, and the medical image management system 4 connected via the hospital network. The standard for communication with the hospital information system 1, the RIS server 21, the RIS terminal 22, the medical image diagnostic device 3, and the medical image management system 4 may be any standard, and for example, HL7 (Hearth Level 7). DICOM, or both, etc. may be mentioned.

The processing circuit 230 according to the present embodiment has an acquisition function 231, a calculation function 232, a determination function 233, and a display control function 234.

The acquisition function 231 is a function for acquiring information regarding an inspection using a radiopharmaceutical. By executing the acquisition function 231, the processing circuit 230 acquires patient information regarding the patient and examination order information regarding the radiological examination from, for example, the RIS server 21. Further, by executing the acquisition function 231, the processing circuit 230 acquires the value of the body weight measured for the patient included in the examination order information, for example, via the communication interface 250. Specifically, the processing circuit 230 acquires, for example, the value of the patient's body weight measured on the day before the examination day via the communication interface 250. The weight value of this patient is input, for example, via an input interface included in the RIS terminal 22. The patient's body weight value is, for example, a value obtained at a date and time as close as possible to the scheduled examination date and time, for example, a value measured on the day before the scheduled examination date. The value of the patient's body weight is not limited to the value measured on the day before the examination day, and may be a value measured on a date and time closer to the examination day, for example, on the day of the examination.

The calculation function 232 is a function for calculating various parameters necessary for preparing a radiopharmaceutical drug. By executing the calculation function 232, the processing circuit 230 calculates the required amount of radioactivity required for the examination related to the examination order, for example, based on the patient information and the examination order information. Specifically, the processing circuit 230 calculates the required radioactivity amount based on the inspection order information, the inspection information 242, and the body weight acquired by the acquisition function 231.

Further, the processing circuit 230 refers to the generator information 243 and the elution radioactivity information 245, and acquires the radioactivity concentration determined by the generator, the volume of the elution vial, and the inspection date and time. This radioactivity concentration represents the radioactivity concentration of the daughter nuclide that can be eluted from the generator into the elution vial.

Based on the calculated radioactivity amount and the acquired radioactivity concentration, the processing circuit 230 determines the amount of the withdrawn liquid to be withdrawn from the elution vial containing the radioactivity solution for each combination of the capacity of the generator, the kit, and the elution vial. calculate.

The determination function 233 is a function for determining a method for preparing a radiopharmaceutical drug. By executing the determination function 233, the processing circuit 230 determines whether to prepare the radiopharmaceutical product using the syringe formulation or the kit formulation based on, for example, the test order information and the drug information 241. A syringe formulation represents a syringe-type radiopharmaceutical that can be administered directly to a patient. A kit formulation represents a set of kits for preparing a radiopharmaceutical drug in a hospital and administering it to a patient. The kit formulation includes a generator and a combination of kits.

Further, the processing circuit 230 determines a preparation method for preparing a radiopharmaceutical drug based on the required radioactivity amount calculated by the calculation function 232 and the radioactivity concentration of the radioactivity solution that can be supplied in the hospital. Specifically, the processing circuit 230 selects generator candidates and kit candidates based on the required radioactivity amount calculated by the arithmetic function 232 for the test order determined to prepare the radiopharmaceutical using the kit formulation. do.

The processing circuit 230 determines whether or not the amount of the withdrawn liquid of the elution vial calculated by the calculation function 232 is equal to or more than a predetermined amount. The processing circuit 230 selects an elution vial having a calculated sampling liquid amount of a predetermined amount or more as a candidate for an elution vial to be used for preparing a radiopharmaceutical. The processing circuit 230 determines one elution vial to be used in the inspection according to each inspection order from the selected elution vial candidates. This determines the volume combination of the set of generators, kits, and elution vials used in each test.

The display control function 234 is a function for presenting information on radiopharmaceuticals used in the hospital. By executing the display control function 234, the processing circuit 230 presents, for example, a method of preparing the radiopharmaceutical used in the test determined by the determination function 233. Specifically, the processing circuit 230 indicates on the display provided in the RIS terminal 22 which of the syringe preparation and the kit preparation is used to prepare the radiopharmaceutical drug.

Further, the processing circuit 230 presents a method for preparing the radiopharmaceutical drug when the radiopharmaceutical drug is prepared using the kit preparation. Specifically, the processing circuit 230 displays, for example, a generator used for preparation, a kit, various parameters necessary for preparation, and the like on a display included in the RIS terminal 22.

Further, the display control function 234 is an example of the presentation unit described in the claims.

The acquisition function 231, the calculation function 232, the determination function 233, and the display control function 234 may be incorporated as a control program, or the processing circuit 230 itself incorporates a dedicated hardware circuit capable of executing each function. You may.

Next, various operations of the management device 23 according to the present embodiment will be described with reference to the drawings.

FIG. 3 is a flowchart showing the operation of the processing circuit when the management device 23 according to the present embodiment determines various parameters for preparing a radiopharmaceutical drug. In the following description, the processing circuit 230 holds a flag related to the mode of preparation of the radiopharmaceutical used, for example, a kit flag and a syringe flag in the internal memory for each test order included in the acquired test order information. And. When the kit flag = 1, the kit flag indicates that the radiopharmaceutical used in the test according to the corresponding test order is prepared using the kit preparation. When the syringe flag = 1, the syringe flag indicates that the radiopharmaceutical used in the test according to the corresponding test order is prepared using the syringe preparation. It is assumed that the initial values of the kit flag and the syringe flag are set to 0, respectively. Further, for each combination of the generator and the kit, it is assumed that two types of elution vials having a capacity of 5 ml and 10 ml can be combined. The elution vial shall be the one enclosed in the kit. In addition, it is assumed that the hospital according to this embodiment adopts a comprehensive medical expense payment system (DPC: Diagnosis Procedure Combination).

The processing circuit 230 executes the acquisition function 231 when a start instruction for starting the preparation of the radiopharmaceutical drug is input via, for example, the input interface of the RIS terminal 22 and the communication interface, and the processing circuit 230 executes the acquisition function 231 via the communication interface 250. For example, patient information and examination order information are acquired from the RIS server 21 (step SA1). The processing circuit 230 may acquire patient information and examination order information from, for example, the hospital information system 1 via the communication interface 250.

The processing circuit 230 executes the display control function 234, generates information representing an examination order list based on the acquired patient information and examination order information, and displays the examination order list on the display of the RIS terminal 22 (step). SA2). Specifically, the processing circuit 230 transmits information representing the inspection order list to the RIS terminal 22 via the communication interface 250. As a result, the inspection order list is displayed on the display of the RIS terminal 22. FIG. 5 is a diagram showing an example of a list of inspection orders displayed on the display of the RIS terminal 22 according to the present embodiment. In the list of test orders shown in FIG. 5, the order number, patient ID, patient name, hospitalization or outpatient classification, weight, test code, radiopharmaceutical drug, test site, test type, and test date and time are listed for the four test orders. It is displayed. Further, in the inspection order list shown in FIG. 5, the area for displaying the body weight is blank. Further, in FIG. 5, the character string "Enter the weight" prompting the input of the weight is displayed in the blank area for displaying the weight.

When the examination order list shown in FIG. 5 is displayed on the display of the RIS terminal 22, the processing circuit 230 receives the input of the patient's weight from the RIS terminal 22 for each examination via the communication interface 250 (step SA3). At this time, for example, a radiologist or the like visually recognizes the display of the RIS terminal 22 and inputs the weight of the patient via the input interface of the RIS terminal 22. At this time, for each test order shown in FIG. 5, the patient to be tested for the test related to the test order having the order number "00001" is "50" kg, and the test related to the test order having the order number "000010". "100" kg for the target patient, "60" kg for the patient to be tested for the test order with the order number "00100", and the patient to be tested for the test order with the order number "01000" It is assumed that "100" kg is input for each.

The processing circuit 230 reads the setting file in which the weight of the patient to be inspected for the inspection according to the inspection order is input in advance on the day before the scheduled inspection date without going through the input interface of the RIS terminal 22. The patient's weight value may be obtained.

For example, when the processing circuit 230 receives the input of the patient's weight for all the tests displayed in the test order list shown in FIG. 5 in step SA3, the processing circuit 230 receives the order number included in the test order information acquired in step SA1. The inspection order of "00001" is read for one record (step SA4). That is, the processing circuit 230 has an order number "00001", a patient ID "10001", an inpatient or outpatient "hospitalization", a test code "20001", a radiopharmaceutical drug "X injection", and a test site "10001" shown in FIG. Read the record related to the test order of "Kidney", test type "renal scintigram", and test date and time "2018.3.21 13:30".

The processing circuit 230 executes the determination function 233, refers to the read test order and the drug information 241 stored in the memory 240, and can the radiopharmaceutical used in the test related to the test order be ordered externally. Whether or not it is determined (step SA5). FIG. 6 is a diagram showing an example of drug information 241 according to the present embodiment. Each record included in the drug information 241 shown in FIG. 6 has, as an item, a radiopharmaceutical and whether or not it can be outsourced. Outsourcing availability indicates whether the corresponding radiopharmaceutical can be ordered outside the hospital. As shown in FIG. 6, it is shown that the radiopharmaceutical "X injection" according to the read test order can be ordered outside the hospital because the outsourcing possibility item is "OK".

Therefore, the processing circuit 230 determines that the radiopharmaceutical product "X injection" having the read order number "00001" can be ordered externally (Yes in step SA5), and the read order number "00001". It is determined whether or not the test related to the test order is an inpatient test by referring to the case of inpatient or outpatient included in the test order (step SA6).

The processing circuit 230 determines in the drug information 241 that if the item for whether or not the radiopharmaceutical can be outsourced included in the read test order is "impossible", it cannot be ordered externally (No in step SA5), and the test order is concerned. Is set to kit flag = 1 (step SA9).

As shown in FIG. 5, the processing circuit 230 determines that it is an inpatient examination because it is "inpatient" whether it is inpatient or outpatient corresponding to the examination order having the order number "00001" (Yes in step SA6). ), The kit flag = 1 is set for the inspection order having the read order number "00001" (step SA7). In addition, when the distinction between inpatient and outpatient is "hospitalization", the kit flag = 1 is set under the comprehensive medical fee payment system, in the case of inpatient examination, medication, injection, diagnostic imaging, examination, etc. This is because the medical fee for a certain period of time is fixed for each classification of the disease name, for example, and it is preferable for the hospital side to prepare a kit preparation having a relatively low cost compared to the syringe preparation from the viewpoint of keeping the cost low.

In step SA6, if the inpatient or outpatient category corresponding to the read inspection order is "outpatient", the processing circuit 230 determines that the inspection related to the inspection order is not an inpatient inspection (No in step SA6). , Syringe flag = 1 is set for the inspection order (step SA9). In the case of outpatient examination, setting the syringe flag = 1 when the distinction between inpatient and outpatient is "outpatient" is to purchase a syringe product with a fixed price from the outside from the viewpoint of convenience of cost billing procedure. This is because it is preferable to prepare the product.

When the kit flag = 1 is set for the inspection order having the order number "00001" (step SA7), the processing circuit 230 determines whether or not all the inspection orders included in the inspection order information have been read (step SA10).

Since the processing circuit 230 has not read all the inspection orders (No in step SA10), among the inspection orders included in the inspection order information, for example, one record related to the inspection order having the next order number "00010" is 1. Read the record (step SA4). That is, the processing circuit 230 has an order number "00010", a patient ID "10010", another "hospitalization" for hospitalization or outpatient, a test code "20010", a radiopharmaceutical drug "Y injection", and a test site "10010" shown in FIG. Read the record related to the test order of "lung", test type "lung scintigram", and test date and time "2018.3.21 14:30".

The processing circuit 230 executes the processing from step SA5 to step SA9 for the read record. At this time, the processing circuit 230 refers to the drug information 241 shown in FIG. 6 in step SA5, and the radiopharmaceutical drug “Y injection solution” related to the test order having the read order number “000010” cannot be ordered externally. Judgment is made (No in step SA5), and the kit flag = 1 is set for the inspection order (step SA9).

When the kit flag = 1 is set for the inspection order having the order number "000010" (step SA9), the processing circuit 230 determines whether or not all the inspection orders included in the inspection order information have been read (step SA10).

Since the processing circuit 230 has not read all the inspection orders (No in step SA10), for example, it reads a record related to the inspection order having the next order number “00100” (step SA4). That is, the processing circuit 230 has an order number “00100”, a patient ID “10100”, an inpatient or outpatient “outpatient”, a test code “20100”, a radiopharmaceutical drug “Z injection”, and a test site “ Read the record related to the test order of "liver", test type "liver scintigram", and test date and time "2018.3.21 15:00".

The processing circuit 230 executes the processing from step SA5 to step SA9 for the read record. At this time, the processing circuit 230 refers to the drug information 241 in step SA5, and determines that the radiopharmaceutical drug “Z injection solution” related to the test order having the read order number “00100” can be ordered externally (step). SA5 Yes). Further, in step SA6, the processing circuit 230 determines that it is an outpatient examination because the distinction between inpatient and outpatient corresponding to the examination order having the order number “00100” is “outpatient” (No in step SA6). The syringe flag = 1 is set for the record related to the inspection order whose read order number is “00100” (step SA8).

When the syringe flag = 1 is set for the inspection order having the order number "00100" (step SA8), the processing circuit 230 determines whether or not all the inspection orders included in the inspection order information have been read (step SA10).

Since the processing circuit 230 has not read all the inspection orders (No in step SA10), for example, it reads the record related to the inspection order having the last order number “01000” (step SA4). That is, the processing circuit 230 has an order number “01000”, a patient ID “11000”, an inpatient or outpatient “outpatient”, a test code “21000”, a radiopharmaceutical drug “Y injection”, and a test site “11000” shown in FIG. Read the records related to the test order, which is "testis", test type "testis scintigram", and test date and time "2018.3.21 16:00". The processing circuit 230 executes the processing from step SA5 to step SA10 on the read record. At this time, the processing circuit 230 refers to the drug information 241 in step SA5, and determines that the radiopharmaceutical drug “Y injection solution” related to the test order having the read order number “01000” cannot be ordered externally (step SA5). No), the kit flag = 1 is set for the inspection order (step SA9).

When the kit flag = 1 is set for the inspection order having the order number "01000" (step SA9), the processing circuit 230 determines whether or not all the inspection orders included in the inspection order information have been read (step SA10).

Since the processing circuit 230 has read the records related to all the inspection orders (Yes in step SA10), the arithmetic function 232 is executed, and among the inspection orders included in the acquired inspection order information, the kit flag = 1 is set. With respect to the inspection order, the required radioactivity amount is calculated with reference to the inspection information 242 (step SA11). FIG. 7 is a diagram showing an example of inspection information 242 according to the present embodiment. Each record included in the test information 242 shown in FIG. 7 has, as items, a test code, a radiopharmaceutical drug, a test site, a test type, a weight variable flag, a required radioactivity amount per unit mass (MBq / kg), and a required radioactivity amount. It has a (reference value) (MBq) and an upper limit value (MBq). The variable body weight flag indicates whether or not the required amount of radioactivity to be administered to the patient depends on the weight of the patient. The upper limit value (MBq) represents the upper limit value of the amount of radioactivity that allows exposure. The required radioactivity amount (MBq / kg) per unit mass is, for example, a value in consideration of the examination site, the examination type, the age of the patient, and the like.

For example, in the inspection information 242 shown in FIG. 7, the processing circuit 230 acquires the weight variable flag of the record corresponding to the inspection code included in the inspection order in which the kit flag = 1 is set, and the required radioactivity amount per unit mass. do. Further, the processing circuit 230 acquires the weight input in step SA3 for the patient of the corresponding test order for the record in which the weight variable flag = 1. Then, the processing circuit 230 calculates the required radioactivity amount using the acquired required radioactivity amount per unit mass and the body weight.

Specifically, the processing circuit 230 has, for example, a test code "20001", a radiopharmaceutical drug "X injection", a test site "kidney", a test type "kidney scintigram", a weight variable flag "1", and a unit mass. Read the records having the required radioactivity amount "0.76" (MBq / kg), the required radioactivity amount (reference value) "-" (MBq), and the upper limit value "250" (MBq). In the processing circuit 230, the weight variable flag is 1 for the read record, and the weight “50” kg is input in step SA3, so that the required radioactivity amount is 0.76 (MBq / kg) × 50 (kg). = 38 (MBq) is calculated.

Further, the processing circuit 230 has, for example, a test code "20010", a radiopharmaceutical drug "Y injection", a test site "lung", a test type "lung scintigram", a weight variable flag "1", and required radiation per unit mass. Read the records having the capacity "1.80" (MBq / kg), the required radioactivity (reference value) "-" (MBq), and the upper limit value "400" (MBq). In the processing circuit 230, the weight variable flag is 1 for the read record, and the body weight “100” kg is input in step SA3, so that the required radioactivity amount is 1.80 (MBq / kg) × 100 (kg). = 180 (MBq) is calculated.

Further, the processing circuit 230 has, for example, a test code "20100", a radiopharmaceutical drug "Z injection", a test site "liver", a test type "liver scintigram", a weight variable flag "0", and required radiation per unit mass. Read the records having the capacity "-" (MBq / kg), the required radioactivity amount (reference value) "-" (MBq), and the upper limit value "600" (MBq). Since the weight variable flag "0" is 0 for the read record, the processing circuit 230 acquires the required radioactivity amount (reference value) value "200" MBq as the required radioactivity amount.

Further, the processing circuit 230 has, for example, a test code "21000", a radiopharmaceutical drug "Y injection", a test site "testis", a test type "testis scintigram", a weight variable flag "1", and required radiation per unit mass. Read the records having the capacity "4.50" (MBq / kg), the required radioactivity amount (reference value) "-" (MBq), and the upper limit value "400" (MBq). Since the body weight "100" kg is input to the read record in step SA3, the processing circuit 230 calculates the required radioactivity amount as 4.50 (MBq / kg) x 100 (kg) = 450 (MBq). ..

The processing circuit 230 refers to the generator information 243 and the kit information 244 stored in the memory 240 for the inspection order in which the kit flag = 1 is set, and is a candidate for the generator used for the preparation of the radiopharmaceutical, and the kit. Select a candidate (step SA12). FIG. 8 is a diagram showing an example of generator information 243 according to the present embodiment. Each record included in the generator information 243 shown in FIG. 8 has, as items, a generator number, a generator name, a test date, and a radioactivity amount. The generator number is, for example, an identifier that can uniquely identify a generator managed in a hospital. The generator name is a character string that identifies the generator. The test date is a reference date set as a reference for indicating when and how much radioactivity is contained in a radiopharmaceutical drug. At this time, even if the generator names are the same, different generators are represented if the test dates are different. The amount of radioactivity represents the amount of radioactivity that can be eluted at a predetermined time on the test date.

Further, FIG. 9 is a diagram showing an example of kit information 244 according to the present embodiment. Each record contained in the kit information 244 shown in FIG. 9 has a kit number, a kit name, and a dose (MBq) as items. The kit number is, for example, an identifier that can uniquely identify a kit managed in a hospital. The kit name is a character string that can identify the kit. The dose (MBq) represents, for example, the target dose based on the procedure manual or package insert attached to the kit. This target amount may have a certain range.

At this time, since the required radioactivity amount of the processing circuit 230 is 38 (MBq) for the inspection order having the order number “00001” shown in FIG. 5, for example, the generator number shown in FIG. 8 is 1. Select a generator, that is, a generator whose generator name is "99Mo-99mTc", whose test date is "2018.3.12", and whose radioactivity amount is "7.4" GBq. Further, the processing circuit 230 has a generator whose generator number is 2 shown in FIG. 8, that is, a generator name of "99Mo-99mTc", a test date of "2018.3.19", and a radioactivity amount of "7.4" GBq. Select a generator as a candidate. The selection criterion of the generator is, for example, that the required amount of radioactivity can be eluted at the inspection date and time. Further, since the processing circuit 230 has a required radioactivity amount of 38 (MBq) for the inspection order having the order number “00001”, the kit number 1 shown in FIG. 9 is 1, that is, the kit name is “A”. , A kit having a dose (MBq) of "37-185" is selected as a candidate. The selection criteria for the kit is, for example, that the required radioactivity is within the range indicated by the dose (MBq).

Further, since the processing circuit 230 has a required radioactivity amount of 180 (MBq) for the inspection order having the order number “000010” shown in FIG. 5, for example, the generator number shown in FIG. 8 is 1 and Select the generator that is 2. as a candidate. Further, since the processing circuit 230 has a required radioactivity amount of 180 (MBq) for the inspection order having the order number “000010”, the kit having the kit number 1 shown in FIG. 9 is selected as a candidate. Further, the processing circuit 230 selects a kit having the kit number 2 shown in FIG. 9, that is, a kit having the kit name "B" and a dose (MBq) of "74-555" as a candidate.

Further, since the processing circuit 230 has a required radioactivity amount of 450 (MBq) for the inspection order having the order number “01000” shown in FIG. 5, for example, the generator number shown in FIG. 8 is 1 and Select the generator that is 2. as a candidate. Further, the processing circuit 230 uses, for example, a kit having a kit number of 2 shown in FIG. 9 because the required radioactivity amount is 450 (MBq) for the inspection order having the order number “01000” shown in FIG. Select as a candidate.

Since the syringe flag = 1 is set in the processing circuit 230 for the inspection order having the order number “00100” shown in FIG. 5, the generator candidate and the kit candidate are not selected.

The processing circuit 230 determines the elution time for the generator selected for each test order with the kit flag = 1 and the kit, and is a unit of the radioactive solution containing the daughter nuclide to be eluted in each elution vial enclosed in the kit. Obtain the amount of radioactivity per volume (step SA13). Specifically, in the processing circuit 230, for example, for the inspection order having the order number "00001", the inspection date and time is "2018.3.21 13:30", so that the elution time is set to, for example, one hour before the inspection date and time. It will be decided on "2018.3.21 12:30". Then, the processing circuit 230 refers to the elution radioactivity information 245 for each of the generator and the kit selected in step SA12, and acquires the radioactivity amount. 10 and 11 are diagrams showing elution radioactivity information 245 according to the present embodiment. The elution radioactivity information 245 shown in FIG. 10 indicates the amount of radioactivity per unit volume that can be eluted from the generator at each time on the inspection day for each test day when an elution vial having a capacity of 5 ml is used. show. Further, the elution radioactivity information 245 shown in FIG. 11 is the radiation per unit volume that can be eluted from the generator at each time of the inspection day for each test day when the elution vial of the type having a capacity of 10 ml is used. Represents the ability.

At this time, the processing circuit 230 refers to, for example, the elution radioactivity information 245 shown in FIG. 10, the generator whose generator number is 1 shown in FIG. 8, and the kit whose kit number is 1 shown in FIG. And for the combination of 5 ml capacity, since the test date of the generator is "2018.3.12" and the elution time is "2018.3.21 12:30", "85" (MBq / ml) is obtained as the amount of radioactivity per unit volume. do. Further, the processing circuit 230 refers to the elution radioactivity information 245 shown in FIG. 10, for example, a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a kit having a kit number of 1. For the combination of 5 ml capacity, the test date of the generator is "2018.3.19" and the elution time is "2018.3.21 12:30", so "496" (MBq / ml) is obtained as the amount of radioactivity per unit volume. ..

Further, the processing circuit 230 refers to, for example, the elution radioactivity information 245 shown in FIG. 11, a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a kit having a kit number of 1. For the combination of capacity 10 ml, since the test date of the generator is "2018.3.12" and the elution time is "2018.3.21 12:30", "43" (MBq / ml) is obtained as the amount of radioactivity per unit volume. .. Further, the processing circuit 230 refers to the elution radioactivity information 245 shown in FIG. 11, for example, a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a kit having a kit number of 1. For the combination of capacity 10 ml, since the test date of the generator is "2018.3.19" and the elution time is "2018.3.21 12:30", "248" (MBq / ml) is acquired as the amount of radioactivity per unit volume. ..

Further, the processing circuit 230 also acquires the amount of radioactivity per unit volume for the inspection order having the order number “000010” as well as the inspection order having the order number “00001”. Specifically, in the processing circuit 230, the inspection date and time is "2018.3.21 14:30" for the inspection order having the order number "000010", so that the elution time is, for example, one hour before the inspection date and time. It will be decided on "2018.3.21 13:30". Then, the processing circuit 230 refers to the elution radioactivity information 245 for each of the generator and the kit selected in step SA12, and acquires the radioactivity amount. The processing circuit 230 has a radioactivity amount "75" per unit volume for a combination of the generator with the generator number 1 shown in FIG. 8, the kit with the kit number 1 or 2 shown in FIG. 9, and a capacity of 5 ml. MBq / ml) is obtained. Further, the processing circuit 230 has a radioactivity amount "442" per unit volume for a combination of the generator whose generator number is 2 shown in FIG. 8, the kit whose kit number is 1 or 2 shown in FIG. 9, and the capacity of 5 ml. "(MBq / ml) is acquired.

Further, the processing circuit 230 has a radioactivity amount "38" per unit volume for a combination of the generator whose generator number is 1 shown in FIG. 8, the kit whose kit number is 1 or 2 shown in FIG. 9, and the capacity of 10 ml. "(MBq / ml) is acquired. Further, the processing circuit 230 has a radioactivity amount "221" per unit volume for a combination of the generator whose generator number is 2 shown in FIG. 8, the kit whose kit number is 1 or 2 shown in FIG. 9, and the capacity of 10 ml. "(MBq / ml) is acquired.

Further, the processing circuit 230 also acquires the amount of radioactivity per unit volume for the inspection order having the order number “01000” as well as the inspection order having the order number “00001”. Specifically, in the processing circuit 230, the inspection date and time is "2018.3.21 16:00" for the inspection order having the order number "01000", so that the dissolution time is, for example, one hour before the inspection date and time. It will be decided on "2018.3.21 15:00". Then, the processing circuit 230 refers to the elution radioactivity information 245 for each of the generator and the kit selected in step SA12, and acquires the radioactivity amount. Obtain the radioactivity amount "63" (MBq / ml) per unit volume for the combination of the generator whose generator number is 1 shown in FIG. 8, the kit whose kit number is 2 shown in FIG. 9, and the capacity of 5 ml. .. Obtain the radioactivity amount "372" (MBq / ml) per unit volume for the combination of the generator having the generator number 2 shown in FIG. 8, the kit having the kit number 2 shown in FIG. 9, and the capacity of 5 ml. ..

Further, the processing circuit 230 has a radioactivity amount "32" per unit volume for a combination of the generator whose generator number is 1 shown in FIG. 8, the kit whose kit number is 2 shown in FIG. 9, and the capacity of 10 ml. MBq / ml) is obtained. Obtain the radioactivity amount "186" (MBq / ml) per unit volume for the combination of the generator having the generator number 2 shown in FIG. 8, the kit having the kit number 2 shown in FIG. 9, and the capacity of 10 ml. ..

The processing circuit 230 extracts the radioactive solution from each elution vial based on the required radioactivity amount calculated in step SA11 and the radioactivity amount per unit volume acquired in step SA13 for the inspection order in which the kit flag = 1 is set. The amount of withdrawal liquid is calculated for each combination of generator, kit, and elution vial volumes (step SA14).

Specifically, the processing circuit 230 has a half-life of 99 mTc, for example, because the required radioactivity amount at the inspection date and time "2018.3.21 13:30" is "38" MBq for the inspection order having the order number "00001". It is calculated that the required radioactivity amount at the elution time "2018.3.21 12:30" is "43" MBq in consideration of the fact that is 6 hours.

The processing circuit 230 is a combination of an inspection order having an order number of "00001", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a capacity of 5 ml. Since the required radioactivity amount at the elution time "2018.3.21 12:30" is "43" MBq and the radioactivity amount per unit volume is "85" (MBq / ml), the amount of the withdrawn liquid is 0.51 ml. (Rounded to the third place in the minority points). Further, the processing circuit 230 is a combination of an inspection order having an order number of "00001", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a capacity of 5 ml. Since the required radioactivity amount at the elution time "2018.3.21 12:30" is "43" MBq and the radioactivity amount per unit volume is "496" (MBq / ml), the amount of the withdrawn liquid is 0.09 ml. (Rounded to the third place in the minority points).

Further, the processing circuit 230 is a combination of an inspection order having an order number of "00001", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a capacity of 10 ml. Since the required radioactivity amount at the elution time "2018.3.21 12:30" is "43" MBq and the radioactivity amount per unit volume is "43" (MBq / ml), the amount of the withdrawn liquid is 1.00 ml. (Rounded to the third place in the minority points). Further, the processing circuit 230 is a combination of an inspection order having an order number of "00001", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a capacity of 10 ml. Since the required radioactivity amount at the elution time "2018.3.21 12:30" is "43" MBq and the radioactivity amount per unit volume is "248" (MBq / ml), the amount of the withdrawn liquid is 0.17 ml. (Rounded to the third place in the minority points).

Further, the processing circuit 230 also calculates the amount of the extracted liquid for the inspection order having the order number “000010” in the same manner as the inspection order having the order number “00001”. Specifically, the processing circuit 230 has a half-life of 99 mTc, for example, because the required radioactivity amount at the inspection date and time "2018.3.21 14:30" is "180" MBq for the inspection order having the order number "000010". It is calculated that the required radioactivity amount at the elution time "2018.3.21 13:30" is "202" MBq in consideration of the fact that is 6 hours.

The processing circuit 230 includes an inspection order having an order number of "00010", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 or 2 shown in FIG. 9, and a capacity of 5 ml. For the combination of, the amount of withdrawn liquid is calculated as 2.69 ml (rounded to the first decimal place). Further, the processing circuit 230 includes an inspection order having an order number of "000010", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 or 2 shown in FIG. 9, and a capacity of 5 ml. For the combination of, the amount of the withdrawn liquid is calculated as 0.46 ml (rounded to the first decimal place).

Further, the processing circuit 230 includes an inspection order having an order number of "00010", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 or 2 shown in FIG. 9, and a capacity of 10 ml. For the combination of, the amount of the withdrawn liquid is calculated as 5.32 ml (rounded to the first decimal place). Further, the processing circuit 230 includes an inspection order having an order number of "00010", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 1 or 2 shown in FIG. 9, and a capacity of 10 ml. For the combination of, the amount of the withdrawn liquid is calculated as 0.91 ml (rounded to the first decimal place).

Further, the processing circuit 230 calculates the amount of the extracted liquid for the inspection order having the order number "01000" as well as the inspection order having the order number "00001". Specifically, the processing circuit 230 has a half-life of 99 mTc, for example, because the required radioactivity amount at the inspection date and time "2018.3.21 16:00" is "450" MBq for the inspection order having the order number "01000". It is calculated that the required radioactivity amount at the elution time "2018.3.21 15:00" is "506" MBq in consideration of the fact that is 6 hours.

The processing circuit 230 is a combination of an inspection order having an order number of "01000", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and a capacity of 5 ml. Is calculated as 8.03 ml (rounded to the first decimal place). Further, the processing circuit 230 is a combination of an inspection order having an order number of "00010", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and a capacity of 5 ml. The amount of the withdrawn liquid is calculated as 1.36 ml (rounded to the first decimal place).

Further, the processing circuit 230 is a combination of an inspection order having an order number of "01000", a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and a capacity of 10 ml. Is calculated as 15.81 ml (rounded to the first decimal place). Further, the processing circuit 230 is a combination of an inspection order having an order number of "01000", a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and a capacity of 10 ml. The amount of the withdrawn liquid is calculated as 2.72 ml (rounded to the first decimal place).

The processing circuit 230 selects an elution vial having a calculated sampling liquid volume of, for example, 0.5 ml or more for the inspection order in which the kit flag = 1 is set, as a candidate for the elution vial used for the preparation of radiopharmaceuticals ( Step SA15). Specifically, the processing circuit 230 has, for example, a generator having a generator number of 1 shown in FIG. 8, a kit having a kit number of 1 shown in FIG. 9, and a kit having an inspection order of order number “00001”. The elution vial determined by the combination of the capacity of 5 ml, that is, the elution vial whose sampling amount is calculated to be 0.51 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. Further, in the processing circuit 230, the elution vial determined by the combination of the generator whose generator number is 1 shown in FIG. 8, the kit whose kit number is 1 shown in FIG. 9, and the capacity of 10 ml, that is, the amount of the withdrawn liquid is 1. The elution vial calculated to be 00 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. As a result, three elution vial candidates are selected.

The processing circuit 230 also selects elution vial candidates for the inspection order having the order number “000010” in the same manner as the inspection order having the order number “00001”. Specifically, the processing circuit 230 is an elution vial determined by a combination of a generator whose generator number is 1 shown in FIG. 8, a kit whose kit number is 1 or 2 shown in FIG. 9, and a capacity of 5 ml, that is, extraction. The elution vial calculated to have a liquid volume of 2.69 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. Further, in the processing circuit 230, the elution vial determined by the combination of the generator whose generator number is 1 shown in FIG. 8, the kit whose kit number is 1 or 2 shown in FIG. 9, and the capacity of 10 ml, that is, the amount of the extracted liquid is The elution vial calculated to be 5.32 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. Further, the processing circuit 230 has an elution vial determined by a combination of a generator whose generator number is 2 shown in FIG. 8, a kit whose kit number is 1 or 2 shown in FIG. 9, and a capacity of 10 ml, that is, a sampled liquid amount. The elution vial calculated to be 0.91 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. As a result, six elution vial candidates are selected.

The processing circuit 230 also selects elution vial candidates for the inspection order having the order number “01000” in the same manner as the inspection order having the order number “00001”. Specifically, the processing circuit 230 is an elution vial determined by a combination of a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and a capacity of 5 ml, that is, a sampled liquid amount. The elution vial calculated to be 1.36 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. Further, the processing circuit 230 has a generator having a generator number of 2 shown in FIG. 8, a kit having a kit number of 2 shown in FIG. 9, and an elution vial determined by a combination of a capacity of 10 ml, that is, the amount of the extracted liquid is 2. The elution vial calculated to be 72 ml is selected as a candidate for the elution vial used for the preparation of radiopharmaceuticals. As a result, two elution vial candidates are selected.

The processing circuit 230 does not select the elution vial for which the withdrawal liquid amount is calculated to be 8.03 ml because the withdrawal liquid amount exceeds the capacity of 5 ml. Further, the processing circuit 230 does not select the elution vial for which the withdrawal liquid amount is calculated to be 15.81 ml because the withdrawal liquid amount exceeds the capacity of 10 ml.

In the processing circuit 230, each elution vial determined by the combination of the inspection order in which the elution vial having a calculated sampling liquid volume of 0.5 ml or more was not selected, that is, the generator candidate, the kit candidate, and the elution vial capacity. When the predetermined condition is satisfied for the inspection order in which the amount of the withdrawn liquid calculated in the above is less than 0.5 ml for all the elution vials, a confirmation screen for selecting whether or not to change the preparation method is displayed. Specifically, in the processing circuit 230, when the radiopharmaceutical used in the inspection related to the inspection order can be externally ordered for the inspection order in which the elution vial having the calculated sampling liquid volume of 0.5 ml or more is not selected. Displays a confirmation screen for allowing a radiologist or the like to select whether or not to change the method of preparing the radiopharmaceutical drug from the method of preparing the radiopharmaceutical product in the hospital to the method of ordering the syringe product externally, for example, RIS. It is displayed on the display provided in the terminal 22.

The processing circuit 230 determines the elution vial to be used in the inspection from the elution vial candidates selected in step SA15 for each inspection order (step SA16). For example, when there are a plurality of elution vial candidates for the same inspection order, the processing circuit 230 preferentially allocates elution vial candidates from the one having the larger amount of sampling liquid calculated for the inspection order. Specifically, in the processing circuit 230, for example, for the inspection order having the order number "00001", the generator number shown in FIG. 8, which has a large amount of the calculated withdrawal liquid among the selected elution vials, is 1. A generator, a kit with a kit number of 1 shown in FIG. 9, and a candidate elution vial determined by a combination of 10 ml volumes are preferentially assigned.

Further, for example, when the same elution vial candidate is selected for a plurality of inspection orders, the processing circuit 230 is preferentially selected for the inspection order in which the number of selected elution vial candidates is small. Assign candidate elution vials. Specifically, in the present embodiment, for example, for the inspection order having the order number "00001" and the inspection order having the order number "000010", the same elution vial candidate, that is, the generator having the generator number 1 is used. , The kit whose kit number is 1 shown in FIG. 9, and the candidate of the elution vial determined by the combination of the capacity of 10 ml are selected. The processing circuit 230 sets the candidates for the elution vial as, for example, an inspection order having an order number "00001" in which three elution vial candidates are selected, and an order number "" in which six elution vial candidates are selected. Among the inspection orders of "000010", the inspection order having the order number "00001", in which the number of elution vial candidates selected in step SA15 is small, is preferentially assigned to the elution vial candidates.

As a result, the processing circuit 230 has a generator having a generator number of 1 shown in FIG. 8 and a kit having a kit number of 1 shown in FIG. 9 having a capacity of 10 ml for the inspection order having the order number “00001”. Candidate elution vials determined by the combination are determined as elution vials to be used in the inspection.

Further, in the processing circuit 230, for the inspection order having the order number "000010", for example, the elution vial used in the inspection determined for the inspection order having the order number "00001" is inspected having the order number "000010". Determined as the elution vial used in the order inspection.

At this time, for the test order having the order number “000010”, a 10 ml radioactive solution containing the elution daughter nuclide is extracted into an elution vial having a capacity of 10 ml at the elution time “2018.3.21 12:30”. Then, 1.00 ml of the radioactive solution is withdrawn for the inspection related to the inspection order having the order number "000010", but 9 ml of the radioactive solution remains in the elution vial. Therefore, in the processing circuit 230, the radioactive concentration of the radioactive solution is 34 (MBq / ml) at the inspection time “2018.3.21 14:30” for the inspection order having the order number “000010”. , The amount of the withdrawn liquid is recalculated as 180 (MBq) ÷ 34 (MBq / ml) = 5.29 ml (rounded off to the third minority point). When the amount of the withdrawn liquid is less than 0.5 ml or more than 9 ml, the processing circuit 230 is a candidate for another generator, a candidate for a kit, and a candidate for an elution vial determined by a combination of elution vial volumes. Determine the elution vial to be used for the inspection.

The processing circuit 230 determines the elution vial to be used in the inspection for the inspection order having the order number “01000” in the same manner as the inspection order having the order number “00001”. Specifically, the processing circuit 230 inspects the elution vial determined by the combination of the generator whose generator number is 2 shown in FIG. 8, the kit whose kit number is 2 shown in FIG. 9, and the capacity of 10 ml. Determine as the elution vial to use.

When the processing circuit 230 determines the elution vial to be used in each test, the display control function 234 is executed, and a list of preparation methods showing an outline of the preparation method of the radiopharmaceutical used in each test is displayed on the display provided in the RIS terminal 22. Display (step SA17). FIG. 12 is a diagram showing an example of a list of preparation methods for radiopharmaceuticals displayed on a display included in the RIS terminal 22 according to the present embodiment. In FIG. 12, for each test order, a radio button representing a selection button for displaying the details of the preparation method, an order number, a patient ID, a patient name, a radiopharmaceutical drug, a test date and time, a kit or a syringe, and a required amount of radioactivity. Is displayed.

The list of preparation methods for the radiopharmaceutical shown in FIG. 12 shows that the radiopharmaceutical "X injection" used for the test related to the test order having the order number "00001" is prepared using the "kit" preparation. There is. Further, in the list of preparation methods for the radiopharmaceutical shown in FIG. 12, the radiopharmaceutical "Y injection solution" used for the test related to the test order having the order number "000010" is prepared using the "kit" preparation. Represents. Further, in the list of preparation methods for the radiopharmaceutical shown in FIG. 12, the radiopharmaceutical "Z injection" used for the inspection related to the inspection order having the order number "00100" is prepared using the "syringe" preparation. Represents. Further, in the list of preparation methods for the radiopharmaceutical shown in FIG. 12, the radiopharmaceutical "Y injection solution" used for the test related to the test order having the order number "01000" is prepared using the "kit" preparation. Represents. This enables radiologists and the like to easily recognize whether or not the radiopharmaceuticals used for the tests related to each test order should be prepared in the hospital.

When the processing circuit 230 displays the preparation method list, it accepts the selection of the radiopharmaceutical to be prepared from the RIS terminal 22 via the communication interface 250 (step SA18). At this time, for example, a radiologist or the like visually recognizes the display of the RIS terminal 22, and selects the radio button corresponding to the order number “00001” among the radio buttons shown in FIG. 12 via the input interface of the RIS terminal 22. select.

For example, when the radio button corresponding to the order number "00001" is selected, the processing circuit 230 displays the details of the preparation method, that is, the preparation method for the radiopharmaceutical corresponding to the selected radio button (step SA19). .. FIG. 13 is a diagram showing details of a preparation method displayed on a display included in the RIS terminal 22 according to the present embodiment.

FIG. 13 shows a method of preparing an inspection order corresponding to the order number “00001”. FIG. 13 shows various parameters required for the steps of elution from the generator, dilution and concentration adjustment, labeling, and dispensing. Specifically, in the step of elution from the generator, for example, as shown in FIG. 13, the generator name "99Mo-99mTc", the generator having the test date "2018.3.12", and the kit having the kit name "A". , And using an elution vial with a volume of "10" ml, it is indicated that the daughter nuclide of "430" MBq will be eluted at the elution time "12:30" on March 21, 2018 on the day of the inspection. .. This makes it possible for a radiologist or the like to easily grasp the elution method for eluting the radioactive solution from the generator.

Further, in the steps of dilution and concentration adjustment, for example, as shown in FIG. 13, the amount of radioactivity to be withdrawn from the elution vial is "43" MBq, and the amount of withdrawal liquid is "1.0" ml. The fact is displayed. In addition, it is displayed that the amount of physiological saline used for dilution and concentration adjustment is "3" ml. Further, as the amount of the adjusted radioactivity solution, that is, the adjusted technetium solution after diluting the radioactivity solution extracted from the elution vial with a physiological saline solution, the amount of radioactivity contained is "43" MBq, and the liquid of the adjusted technetium solution. It is displayed that the amount is "4.0" ml. This makes it possible for a radiologist or the like to easily grasp a method for diluting and adjusting the concentration of the radioactive solution contained in the elution vial.

In the labeling process, for example, as shown in FIG. 13, the normal temperature return time of the kit vial containing the reducing compound required for labeling adjustment is "13:00" on March 21, 2018, the day of the inspection. It is displayed that it is, and that the return time, that is, the room temperature leaving time is "5" minutes. Since the kit vial is usually stored in a refrigerator, a step of returning it to room temperature is required to increase the labeling rate. Further, after returning the kit vial to room temperature, it is indicated that "4" ml of the adjusted technetium solution is added to the kit vial. This makes it possible for a radiologist or the like to easily grasp the labeling method. It is assumed that the addition of "4" ml of prepared technetium solution to the kit vial produces "5" ml of labeled technetium solution containing "430" MBq of radioactivity.

Further, in the dispensing step, for example, as shown in FIG. 13, the amount of the labeling drug to be withdrawn from the kit vial containing the labeled technetium solution has a radioactivity amount of "43" MBq and a liquid amount of the labeling drug. It is displayed that it is "5.0" ml. Further, regarding the amount of the labeling drug at the scheduled start time of the test, it is displayed that the radioactivity amount is "38" MBq and the liquid amount of the labeling drug is "5.0" ml. This makes it possible for a radiologist or the like to easily grasp the dispensing method. Further, since the amount of radioactivity contained in the labeling drug at the scheduled start time of the examination is also displayed, the radiologist or the like can grasp the amount of radioactivity actually administered to the patient.

Further, the various parameters displayed in the details of the preparation method shown in FIG. 13 can be changed. For example, various parameters can be changed by designating the change button B1 shown in FIG. 13 via the input interface provided in the RIS terminal 22.

According to the present embodiment, the processing circuit 230 included in the management device 23 calculates the required radioactivity amount based on the patient information regarding the patient and the examination order information regarding the radiological examination. The processing circuit 230 determines a method for preparing a radiopharmaceutical drug based on the calculated required amount of radioactivity and the radioactivity concentration of the radiopharmaceutical solution that can be supplied in the hospital. The processing circuit 230 presents the determined preparation method on the display provided in the RIS terminal 22.

This eliminates the need for radiologists and the like to calculate various parameters necessary for preparing radiopharmaceuticals. In addition, since the method for preparing the radiopharmaceutical is displayed on the display of the RIS terminal 22, it is possible to support the preparation procedure manual by a radiologist or the like.

Therefore, according to the management device according to the present embodiment, it is possible to improve the efficiency of the work of preparing the radiopharmaceutical drug.

The display mode of the preparation method list is not limited to the preparation method list shown in FIG. For example, the management device 23 may display a warning display for the inspection order exceeding the upper limit value by using the upper limit value shown in FIG. 7 in the preparation method list. FIG. 14 is a flowchart showing an example of the operation of the processing circuit 230 when the management device 23 according to the present embodiment warns and displays an inspection exceeding the upper limit value regarding the amount of radioactivity for each inspection. In the following description, the processing circuit 230 shall execute the processing of the flowchart shown in FIG. 14 after executing the processing from step SA1 to step SA16 shown in FIGS. 3 and 4.

The processing circuit 230 refers to the inspection information 242 shown in FIG. 7 for each inspection order and acquires an upper limit value regarding the amount of radioactivity (step SB1). Specifically, the processing circuit 230 acquires the upper limit value "250" (MBq) because the inspection code "20001" is used for the inspection order having the order number "00001". Further, the processing circuit 230 acquires the upper limit value "400" (MBq) because the inspection code is the inspection code "20010" for the inspection order having the order number "00010". Further, the processing circuit 230 acquires the upper limit value "600" (MBq) because the inspection code is the inspection code "20100" for the inspection order having the order number "00100". Further, the processing circuit 230 acquires the upper limit value "400" (MBq) because the inspection code is "21000" for the inspection order having the order number "01000".

The processing circuit 230 compares the required radioactivity amount calculated in step SA11 with the acquired upper limit value for each inspection order (step SB2). Specifically, the processing circuit 230 compares the calculated required radioactivity amount “38” (MBq) with the upper limit value “250” (MBq) for the inspection order having the order number “01000”. Further, the processing circuit 230 compares the calculated required radioactivity amount “180” (MBq) with the upper limit value “400” (MBq) for the inspection order having the order number “000010”. Further, the processing circuit 230 compares the calculated required radioactivity amount “200” (MBq) with the upper limit value “600” (MBq) for the inspection order having the order number “00100”. Further, the processing circuit 230 compares the calculated required radioactivity amount “450” (MBq) with the upper limit value “400” (MBq) for the inspection order having the order number “01000”.

The processing circuit 230 sets the warning flag = 1 for the inspection order in which the required radioactivity amount exceeds the upper limit value (step SB3). Specifically, the processing circuit 230 sets the warning flag = 1 because the required radioactivity amount exceeds the upper limit value for the inspection order having the order number “01000”.

When the warning flag is set for the inspection order in which the required radioactivity exceeds the upper limit, the processing circuit 230 executes the display control function 234 and provides a list of preparation methods showing an outline of the preparation method of the radiopharmaceutical used in each inspection. It is displayed on the display provided in the terminal 22 (step SB4). At this time, the processing circuit 230 displays a list of preparation methods for the inspection order for which the warning flag = 1 is set, in a display mode that indicates that the warning target is set. For example, the processing circuit 230 displays a list of preparation methods by adding a color, a figure, or the like to the area for displaying the preparation method for the inspection order in which the warning flag = 1 is set. The processing circuit 230 assigns a predetermined identifier such as a character string to the area for displaying the preparation method for the inspection order so that it can be understood that the inspection order for which the warning flag = 1 is set is a warning target. You may display a list of preparation methods.

FIG. 15 is a diagram showing another example of a list of preparation methods displayed on a display included in the RIS terminal 22 according to the embodiment. In FIG. 15, for each test order, a radio button representing a selection button for displaying the details of the preparation method, an order number, a patient ID, a patient name, a weight (kg), a radiopharmaceutical drug, a test date and time, a kit formulation or a syringe. Separately, the required radioactivity amount (MBq) and the upper limit value (MBq) are displayed. According to FIG. 15, a predetermined color represented by dot hatching is attached to the area for displaying the preparation method for the inspection order having the order number “01000” in which the required radioactivity amount exceeds the upper limit value.

As a result, the radiologist or the like can easily grasp the inspection in which the calculated required radioactivity amount exceeds the upper limit value, and can change the radiopharmaceutical used for the inspection.

[Other embodiments]
In the above embodiment, the case where the management device according to the embodiment is provided separately from the RIS server has been described as an example, but the present invention is not limited to this. For example, the RIS server may be provided with each function provided in the management device according to the above embodiment. FIG. 16 is a block diagram showing a medical information system including the RIS server 21A according to another embodiment. The medical information system shown in FIG. 16 includes a hospital information system 1, a radiation department information management system 2A, a medical diagnostic imaging apparatus 3, and a medical image management system 4.

The hospital information system 1, the radiation department information management system 2A, the medical diagnostic imaging device 3, and the medical image management system 4 are connected to a local network and transmit information to a predetermined device and information transmitted from the predetermined device. To receive. The medical information system may be connected to an external network in addition to the local network or instead of the local network.

The function of the hospital information system 1 shown in FIG. 16 is the same as the function of the hospital information system 1 shown in FIG.

The radiation department information management system 2A shown in FIG. 16 is a system that manages inspection reservation information related to radiation inspection work. The radiation department information management system 2A includes a RIS server 21A and a RIS terminal 12.

The RIS server 21A has, for example, a function of managing information about radiopharmaceuticals used in a hospital, in addition to the function of the RIS server 21 shown in FIG. Details of the RIS server 21A will be described later. The function of the RIS terminal 22 shown in FIG. 16 is the same as the function of the RIS terminal 22 shown in FIG.
The function of the medical image diagnostic device 3 shown in FIG. 16 is the same as the function of the medical image diagnostic device 3 shown in FIG. The function of the medical image management system 4 shown in FIG. 16 is the same as the function of the medical image management system 4 shown in FIG.

Hereinafter, the details of the RIS server 21A according to another embodiment will be described. FIG. 17 is a block diagram showing a functional configuration of the RIS server 21A shown in FIG.

The RIS server 21A shown in FIG. 17 has a processing circuit 230, a memory 240A, and a communication interface 250. The processing circuit 230, the memory 240A, and the communication interface 250 are connected to each other so as to be communicable with each other via, for example, a bus.

The function of the communication interface 250 shown in FIG. 17 is the same as the function of the communication interface 250 shown in FIG.

The memory 240A shown in FIG. 17 is, for example, the test order information in addition to the drug information 241 and the test information 242, the generator information 243, the kit information 244, and the eluted radioactivity information 245 stored in the memory 240 shown in FIG. I remember 246. The information contained in the examination order information 246 includes the examination order information directly transmitted from the hospital information system 1.

The function of the processing circuit 230 shown in FIG. 17 is the same as the function of the processing circuit 230 shown in FIG.

The RIS server 21A according to another embodiment has a function of managing information on radiopharmaceuticals used in a hospital, in addition to the examination reservation function provided in the RIS server 21 shown in FIG. Further, the RIS server 21A directly receives the patient information and the examination order information from the hospital information system 1. This makes it possible to collectively manage information and manage information on radiopharmaceuticals used in hospitals without installing a new device.

Further, in the above embodiment, the processing circuit 230 executes the display control function 234, and for each inspection order, a combination of a set of generator candidates, a kit candidate, and an elution vial volume determined by the determination function 233 is used. , It was displayed on the display provided in the RIS terminal 22, but the present invention is not limited to this. For example, the processing circuit 230 executes the display control function 234, and for each inspection order, the RIS terminal 22 selects a combination of a plurality of generator candidates, kit candidates, and elution vial volumes selected by the determination function 233. It may be displayed on the provided display.

Further, in the above embodiment, the information for calculating the required radioactivity amount is the required radioactivity amount per body weight unit mass, but the information is not limited to this. For example, the information for calculating the required radioactivity amount may be the required radioactivity amount according to the body weight in a predetermined range. Specifically, for example, "required radioactivity for a body weight in the range of 30-50 kg is 555 MBq", "required radioactivity for a body weight in the range of 50-70 kg is 740 MBq", and "required radioactivity for a body weight in the range over 70 kg". The capacity is information such as "925MBq".

Further, in the above embodiment, the processing circuit 230 is not limited to, for example, allowing various parameters displayed in the details of the preparation method shown in FIG. 13 to be changed. For example, the processing circuit 230 may allow the "kit" or "syringe" displayed separately for the kit or syringe shown in FIG. 12 to be modified, for example, via an input interface included in the RIS terminal 22.

The word "processor" used in the above description is, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an integrated circuit for a specific application (Application Specific Integrated Circuit (ASIC)), or a programmable logic device (for example,). , Simple Programmable Logic Device (SPLD), Complex Programmable Logic Device (CPLD), and Field Programmable Gate Array (FPGA)). The processor realizes the function by reading and executing the program stored in the storage circuit. It should be noted that each processor of the present embodiment is not limited to the case where each processor is configured as a single circuit, and a plurality of independent circuits may be combined to form one processor to realize its function. good. Further, the plurality of components in FIGS. 1 and 2 may be integrated into one processor to realize the function.

According to at least one embodiment described above, the work of preparing a radiopharmaceutical drug can be streamlined.

Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These novel embodiments can be implemented in various other embodiments, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and variations thereof are included in the scope and gist of the invention, and are also included in the scope of the invention described in the claims and the equivalent scope thereof.

1 ... Hospital information system 2 ... Radiation department information management system 3 ... Medical image diagnostic device 4 ... Medical image management system 21 ... RIS server 22 ... RIS terminal 23 ... Management device 230 ... Processing circuit 240 ... Memory 250 ... Communication interface 231 ... Acquisition Function 232 ... Calculation function 233 ... Decision function 234 ... Display control function 241 ... Drug information 242 ... Test information 243 ... Generator information 244 ... Kit information 245 ... Elution radioactivity information 246 ... Test order information

Claims (9)

An arithmetic unit that calculates the required amount of radioactivity based on patient information about patients and examination order information about radiological examinations,
A decision-making unit that determines a method for preparing a radiopharmaceutical drug based on the calculated required amount of radioactivity and the radioactivity concentration of the radiopharmaceutical solution that can be supplied in the hospital.
A presentation unit that presents the determined preparation method, and
A management device equipped with. Further equipped with an acquisition unit for acquiring the weight of the patient on the day included in the examination order information,
The calculation unit calculates the required amount of radioactivity based on at least the acquired body weight.
The management device according to claim 1. The radioactive solution is a radioactive solution containing daughter nuclides eluted from a generator in the hospital.
The arithmetic unit
Based on the calculated required amount of radioactivity and the radioactivity concentration at the time of elution from the generator, the amount of liquid to be withdrawn from the radioactivity solution was calculated.
The decision-making part
The method for preparing the radiopharmaceutical is determined based on the calculated amount of the withdrawn liquid.
The management device according to claim 1 or 2. The determination unit selects candidate generators and candidate kits required for the preparation of the radiopharmaceutical.
The presenting unit presents the candidate of the selected generator and the candidate of the selected kit.
The management device according to claim 3. The calculation unit calculates the amount of the withdrawn liquid for each combination of the capacity of the generator candidate, the kit candidate, and the elution vial containing the radioactive solution.
Among the elution vials determined by the combination, the determination unit uses the elution vial having the calculated sampling liquid amount of a predetermined amount or more for each inspection order included in the inspection order information for the preparation. The management device according to claim 4, which is selected as a candidate for a vial. When the same elution vial candidate is selected for a plurality of inspection orders included in the inspection order information, the determination unit determines the number of the selected elution vial candidates among the plurality of inspection orders. The management device according to claim 5, wherein the candidate for the same elution vial is preferentially assigned to an inspection order having a small number of spills. Which of claims 1 to 6 the determination unit determines whether to prepare the radiopharmaceutical drug using a syringe preparation or a kit preparation based on whether the radiopharmaceutical product is prepared by hospitalization or outpatient treatment included in the test order information. Management device described in Crab. The management according to claim 7, wherein the decision-making unit determines that, for the radiopharmaceutical that cannot be ordered externally, the radiopharmaceutical is prepared using the kit formulation without reference to the hospitalization or outpatient. Device. On the computer
A calculation function that calculates the required amount of radioactivity based on patient information about the patient and test order information about the radiological examination, and
A decision function for determining a method for preparing a radiopharmaceutical based on the calculated required amount of radioactivity and the radioactivity concentration of a radiopharmaceutical solution that can be supplied in a hospital.
A presentation function that presents the determined preparation method, and
A program to execute.

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