JP7078819B2 - Wet wiper - Google Patents

Description

The present invention relates to a wet wiper that contains substantially no ethanol.

Wet wipers are generally used for removing dirt and germs from fingers and cleaning various instruments, and tend to be handled with bare hands. As a conventionally known wet wiper, for example, a wet wiper impregnated with a chemical solution containing paraoxybenzoic acid ester, ethanol, propylene glycol and the like is known (see, for example, Patent Document 1).

Here, a wet wiper impregnated with a chemical solution containing ethanol is known for the purpose of cleaning the environment in a hospital, disinfecting a table, a bed, or the like. Ethanol is known as a sterilizing agent that is effective against general viable bacteria (gram-positive and gram-negative bacteria), tubercle bacilli, fungi, viruses, etc. and is highly safe for the human body, and is contained in the chemical solution of wet wipers. It is widely used as a disinfectant.

Japanese Patent Application Laid-Open No. 02-061000

However, since ethanol has the effect of coagulating stains containing proteins such as blood, it is difficult to clean and sterilize stains containing proteins with a wet wiper impregnated with a chemical solution containing ethanol. .. On the other hand, when ethanol is not added to the chemical solution, there is a problem that the sterilization performance of the wet wiper impregnated with this chemical solution becomes insufficient. Therefore, the present invention has been made in view of the above problems, and provides a wet wiper impregnated with a chemical solution containing a minimum amount of ethanol, which exhibits excellent sterilization performance. The purpose is to do.

In view of the above problems, the inventors of the present invention have conducted diligent research. As a result, it was found that the above-mentioned problems can be solved by a wet wiper containing a quaternary ammonium salt, propynyl butylcarbamic acid iodide, and a polyaminopropyl biguanide impregnated with an aqueous solution containing substantially no ethanol. , The present invention has been completed. Specifically, the present invention provides the following.

(1) The first aspect of the present invention is a wet wiper in which a non-woven fabric is impregnated with a chemical solution, wherein the chemical solution contains 0.001 to 0.05% by mass of benzalkonium chloride and 0.001 to 0.02% by mass of iodine butylcarbamate. It contains propynyl, 0.01-0.1 % by mass of polyaminopropyl biguanide, the ethanol concentration in the drug solution is less than 0.10% by mass, and the drug solution contains 0.1-1.0% by mass of a nonionic surfactant. It is a wet wiper that does not contain an anionic surfactant as a surfactant and is impregnated with the chemical solution of 26 parts by mass or more and 34 parts by mass or less with respect to 10 parts by mass of the non-woven fabric.

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( 2 ) The second aspect of the present invention is the wet wiper according to (1), wherein the drug solution is further benzoic acid, benzoic acid salts, chlorcrezole, chlorobutanol, salicylic acid, salicylates, sorbicic acid. , Solhibinates, dehydroacetic acid, dehydroacetate, trichlorohydroxydiphenyl ether, paraoxybenzoic acid ester, paraoxybenzoic acid sodium salt, phenoxyethanol, phenol, lauryldiaminoethylglycine sodium, resorcin, benzoate pantothenyl ethyl ether, isopropylmethylphenol, Consists of cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, chlorhexidine gluconate, chlorxylenol, chlorhexidine, alkylisoquinolinium bromide, timole, trichlorocarbanilide, halocarban, hinokithiol, pyrithione zinc, and silver ion antibacterial agents. It is characterized by containing at least one antibacterial agent selected from the group.

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Since the chemical solution of the wet wiper of the present invention is an aqueous solution containing substantially no ethanol, stains containing proteins can be cleaned cleanly. Further, in the wet wiper of the present invention, since the chemical solution contains quaternary ammonium salts, propynyl iodide butylcarbamate, and polyaminopropyl biguanide, sufficient sterilization is sufficient even if ethanol is not substantially contained. Can demonstrate its performance.

Hereinafter, embodiments for carrying out the present invention will be described in detail.

<Wet wiper>
The wet wiper of the present invention is a non-woven fabric impregnated with a predetermined chemical solution.

[Non-woven fabric]
As the non-woven fabric, wood pulp fiber, recycled fiber such as rayon, natural fiber such as cotton, synthetic fiber such as polyethylene, polypropylene and polyethylene terephthalate are used in a chemical bond method, a spunlace method, a spunbond method, a needle punch method and an airlaid method. , Wet spun lace method, melt bond method and other known processing methods can be used. The ratio of each fiber used for the non-woven fabric and each processing method for integrating the non-woven fabric may be appropriately selected according to the texture and mechanical strength required for the wet wiper.

The wet wiper can be provided as a roll body, but in manufacturing the roll body of the wet wiper, the above-mentioned non-woven fabric is perforated at regular intervals perpendicular to the winding direction, and the non-woven fabric is rolled. It is preferable to wind it up in a shape. The nonwoven fabric sheet may or may not be folded in two or more by a folding line parallel to the length direction, and the total width of the nonwoven fabric sheet is preferably 90 mm or more and 400 mm or less, and is parallel to the length direction. The folding width when folded by a smooth fold line is preferably 45 mm or more and 200 mm or less, the winding length of the non-woven fabric is preferably 8 m or more and 100 m or less, and the basis weight of the non-woven fabric is 20 g / m ² or more. It is preferably 50 g / m ² or less. By setting the winding length and folding width of the non-woven fabric within the above ranges, the wet wiper has a size that is easy to use. Further, by setting the basis weight within the above range, the wet wiper has an appropriate texture and strength.

The wet wiper may be a single-wafer, as found in handheld wet wipers. In that case, the dimension per wet wiper is preferably 140 mm or more and 400 mm or less in the length direction, and preferably 140 mm or more and 400 mm or less in the width direction. It is preferable that the single-wafer body of the wet wiper can be taken out one by one in a pop-up format, and the wet wipers stacked on the top and bottom are Z-folded or V-shaped and crossed with each other. preferable.

[Chemical solution]
In producing the wet wiper, the chemical solution impregnated in the nonwoven fabric is an aqueous solution containing at least quaternary ammonium salts, propynyl iodide butylcarbamate, and polyaminopropyl biguanide. By containing these three types of components, the wet wiper has excellent sterilization performance even when the aqueous solution which is the chemical solution impregnated in the wet wiper does not substantially contain ethanol.

The nonwoven fabric is preferably impregnated with a chemical solution of 25 parts by mass or more and 35 parts by mass or less per 10 parts by mass of the nonwoven fabric, and more preferably impregnated with a chemical solution of 28 parts by mass or more and 32 parts by mass or less. By keeping the amount of the chemical solution within the above range, when removing stains on fingers and various devices, the amount of the chemical solution does not become too large and the liquid does not remain, and the non-woven fabric has a sufficient bactericidal and antiseptic effect. It is possible to sufficiently remove dirt and germs with a small number of wiping times.

(Quaternary ammonium salts)
The quaternary ammonium salts that can be blended in the chemical solution impregnated in the wet wiper of the present invention are generally not particularly limited as long as they are quaternary ammonium salts having sterilization performance, and are benzethonium chloride and chloride. Examples thereof include stearyltrimethylammonium, benzalkonium chloride, cetylpyridinium chloride, and cetyltrimethylammonium chloride, but in the present invention, it is preferable to use benzalkonium chloride as the quaternary ammonium salt. This benzalkonium chloride is a drug having an effect mainly as a bactericidal agent against bacteria. The content of benzalkonium chloride in the chemical solution is preferably 0.001% by mass or more and 0.05% by mass or less, and more preferably 0.01% by mass or more and 0.05% by mass or less. By keeping the content of benzalkonium chloride within the above range, the manufacturing cost is kept within an appropriate range, the irritation to the skin is suppressed, and the feeling of use such as stickiness and sliminess is not caused. The bactericidal effect and the antifungal effect can be well maintained.

(Propinyl iodide butylcarbamate)
Propinyl iodide butylcarbamate is a drug that mainly acts as a preservative against fungi. The content of propynyl iodide butylcarbamate in the chemical solution is preferably 0.001% by mass or more and 0.02% by mass or less, and more preferably 0.005% by mass or more and 0.02% by mass or less. When the content of propynyl iodide butylcarbamate is within the above range, the production cost is suppressed to an appropriate range, the expression of odor peculiar to propynyl iodide butylcarbamate is also suppressed, and the bactericidal effect is achieved. And the antifungal effect can be maintained well.

(Polyaminopropyl biguanide)
Polyaminopropyl biguanide is a drug that acts as a preservative against various bacteria. The content of polyaminopropyl biguanide in the chemical solution is preferably 0.01% by mass or more and 0.1% by mass or less, and more preferably 0.05% by mass or more and 0.1% by mass or less. When the content of the polyaminopropyl biguanide is within the above range, the production cost can be suppressed to an appropriate range and the bactericidal effect can be well maintained.

(ethanol)
The chemical solution impregnated in the wet wiper of the present invention is an aqueous solution that does not substantially contain ethanol, and the ethanol concentration in the chemical solution is preferably less than 0.10% by mass, more preferably less than 500 ppm. It is more preferably 0%. Since the chemical solution impregnated in the wet wiper does not substantially contain ethanol, the ethanol in the chemical solution does not have a risk of coagulating protein stains, so that protein stains such as blood can be suitably wiped off.

(Nonion-based surfactant)
The chemical solution impregnated in the wet wiper of the present invention preferably further contains a nonionic surfactant. Nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid ester, and poly. Oxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene fatty acid amide, sorbitan mono fatty acid ester, sorbitan di fatty acid ester, sorbitan tri fatty acid ester, polyoxyethylene sorbitan mono fatty acid ester, polyoxyethylene sorbitan di fatty acid ester, polyoxyethylene sorbitantri Examples thereof include fatty acid esters, polyoxyethylene sorbitol fatty acid esters, glycerin fatty acid esters, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkylamines, and polyoxyethylene fatty acid amides. These nonionic surfactants may be used alone or in combination of two or more. The chemical solution impregnated in the wet wiper of the present invention preferably contains polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene cetyl ether, and glycerin fatty acid ester among these nonionic surfactants.

Since the chemical solution impregnated in the wet wiper of the present invention contains a nonionic surfactant, it does not easily foam during wiping and does not impair the usability of the wet wiper, but it is easy to wipe off general oil and fat stains. The content of the nonionic surfactant in the chemical solution is preferably 0.1% by mass or more and 1.0% by mass or less, and more preferably 0.2% by mass or more and 0.8% by mass or less.

(Anionic surfactant)
When an anionic surfactant is added to the chemical solution impregnated in the wet wiper of the present invention, bubbles are likely to be generated at the time of wiping and the usability is deteriorated. Therefore, it is preferable that the chemical solution does not contain the anionic surfactant. ..

(Other antibacterial agents)
The chemical solution impregnated in the wet wiper of the present invention preferably contains various antibacterial agents in addition to the components described above. By including an additional antibacterial agent in the chemical solution, the long-term storage stability of the wet wiper will be improved. The antibacterial agent is not particularly limited, but is not particularly limited, but is benzoic acid, benzoic acid salts, chlorcresol, chlorobutanol, salicylic acid, salicylates, solhibinic acid, sorbibates, dehydroacetic acid, dehydroacetate salts, trichloro. Hydroxydiphenyl ether, paraoxybenzoic acid ester, paraoxybenzoic acid sodium salt, phenoxyethanol, phenol, lauryldiaminoethylglycine sodium, resorcin, benzoate pantothenyl ethyl ether, isopropylmethylphenol, cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, gluconic acid List at least one antibacterial agent selected from the group consisting of chlorhexidine, chlorxylenol, chlorhexidine, alkylisoquinolinium bromide, timol, trichlorocarbanilide, halocarban, hinokithiol, pyrithionzinc, and silver ion antibacterial agents. Can be done. Among these, it is particularly preferable to use silver ion antibacterial agents, paraoxybenzoic acid esters, benzoates, and solhibinates.

Hereinafter, the present invention will be described in detail with reference to examples. The present invention is not limited to the examples shown below.

<Examples 1 to 5, Comparative Examples 1 to 7>
According to the formulation shown in Table 1, 0.05 part by mass of benzalconium chloride, 0.02 part by mass of propynyl iodide butylcarbamate, 0.1 part by mass of polyaminopropyl biguanide, and nonion were made with respect to 100 parts by mass of water. 0.5 parts by mass of the system surfactant, 0.5 parts by mass of the anionic surfactant, 0.02 parts by mass of the water-soluble silver compound as the silver ion antibacterial agent, and 80 parts by mass of ethanol were appropriately added. The obtained chemical solution was impregnated into a non-woven fabric at the impregnation rate shown in Table 1, and it was easy to remove oil stains, protein stains, fungi, gram-negative bacteria, and viruses. Ease of foaming, ease of wiping, and liquid residue were evaluated according to the criteria shown below.

(Easy to remove oil stains)
300 μL of castor oil was dropped on a stainless steel plate and spread in a circle with a diameter of 30 mm to prepare simulated oil stains. A wrap was wrapped around a melamine sponge having a bottom surface of 60 mm × 60 mm, a wet wiper was wrapped in a single layer on the outer layer thereof, a load of 20.8 gf / cm ² was applied using a weight, and the material was wiped off once. Oil stains after wiping were evaluated according to the following criteria.
〇: Good dirt removal △: Slightly bad dirt removal ×: Poor dirt removal

(Easy to remove protein stains)
300 μL of horse blood was dropped onto a stainless steel plate, spread in a circle having a diameter of 30 mm, dried at 50 ° C. for 5 minutes, and then the stainless steel plate was sufficiently dissipated to prepare simulated protein stains. A wrap was wrapped around a melamine sponge having a bottom surface of 60 mm × 60 mm, a wet wiper was wrapped in a single layer on the outer layer thereof, a load of 20.8 gf / cm ² was applied using a weight, and the material was wiped off in one direction. The wiping was performed while rotating the non-woven fabric by 90 ° for each wiping in order to eliminate the difference depending on the texture direction of the non-woven fabric.
〇: The number of wipes is 10 or less △: The number of wipes is 10 to 20 times ×: The number of wipes is 20 or more

(Effects on fungi)
Aspergillus niger, a test bacterium, was cultured in a potato dextrose agar medium and then suspended in purified water to adjust the number of bacteria to a predetermined number to prepare a test bacterium solution. Wet wiper is squeezed to adjust the squeezed solution, and 0.1 mL of the prescribed cells is inoculated into 10 mL of the solution as a test bacterial solution, and the mixture is allowed to act at room temperature for a predetermined time from 30 seconds to 10 minutes. The number of bacteria was measured on SCDLP agar medium using a diluted plate culture method (25 ° C., 5 days).

(Effects on Gram-positive and Gram-negative bacteria)
After culturing Escherichia coli and Pseudomonas aeruginosa, which are the test bacteria, in ordinary agar medium, suspend them in sterile physiological saline and adjust the number of bacteria to about ¹⁰⁸ cells / mL to prepare a test bacterial solution. Wet wiper was squeezed to adjust the squeezed solution, and 0.2 mL of Escherichia coli cells was ingested as a test bacterial solution in 19.8 mL of the solution, and the mixture was allowed to act at 25 ° C. for a predetermined time from 30 seconds to 10 minutes later. Then, 1 g of it was diluted with 9 mL of LP diluent. This was serially diluted and the viable cell count was measured using a pour-mixed plate culture method (30 ° C., 3 days) in SCDLP agar medium.

(Presence / absence of virus effect)
Test virus suspensions for feline calicivirus (F-9) and influenza A virus (H1N1) were prepared. 0.1 mL of the test virus suspension was added to 10 mL of the test sample, and the mixture was left at 25 ° C. for 5 minutes. 0.5 mL of the mixed solution after standing was added to 4.5 mL of the inactivating agent (SXDLP medium) and mixed. The virus infection titer is measured by the plaque measurement method, and when the infection titer reduction rate is 99% or more, it is 〇, when the infection titer reduction rate is 50% or more and less than 99%, it is △, and when the infection titer reduction rate is less than 50%, it is ×. And said.

(Easy to foam)
A sensory evaluation was conducted on the ease of foaming for 30 panelists who were nursing workers. In this evaluation, as a result of visual observation, a sensory test was conducted in which one of the following evaluations was selected: no foaming, slightly more, or more. The evaluation of no bubbling was evaluated as 〇 when the evaluation was 24 to 30, the evaluation of no bubbling was evaluated as Δ by 16 to 23, and the evaluation of no bubbling was evaluated as × by 0 to 15.

(Easy to wipe off)
A sensory evaluation was conducted on the ease of wiping for 30 panelists who were nursing workers. In this evaluation, a sensory test was conducted in which one of the evaluations of easy to wipe, slightly difficult to wipe, and difficult to wipe was selected. The evaluation of easy wiping was evaluated as 〇 when the evaluation was 24 to 30, the evaluation of easy wiping was evaluated as Δ by 16 to 23, and the evaluation of easy wiping was evaluated as × by 0 to 15.

(Liquid residue)
A sensory evaluation was performed on the liquid residue for 30 panelists who were nursing workers. In this evaluation, a sensory test was performed in which one of the following evaluations was selected: no or little liquid residue, slightly large liquid residue, and large liquid residue. The evaluation of no or little liquid residue is from 24 to 30 people, the evaluation of no or little liquid residue is △ from 16 to 23 people, and the evaluation of no or little liquid residue is from 0 people. The time of 15 people was marked as x.

<Evaluation result>
As is clear from the examples and comparative examples, the wet wiper of the example is impregnated with a chemical solution containing quaternary ammonium salts, propynyl iodide butylcarbamate, and polyaminopropyl biguanide, which is substantially free of ethanol. , Protein stains can be effectively removed, and sufficient antibacterial performance is exhibited.

Claims (2)

A wet wiper made by impregnating a non-woven fabric with a chemical solution.
The drug solution contains 0.001 to 0.05% by weight of benzalkonium chloride , 0.001 to 0.02% by weight of propynyl iodide butylcarbamate, and 0.01 to 0.1% by weight of polyaminopropyl biguanide.
The ethanol concentration in the chemical solution is less than 0.10% by mass,
The chemical solution contains 0.1 to 1.0% by mass of a nonionic surfactant and does not contain an anionic surfactant as a surfactant.
A wet wiper in which 10 parts by mass of the nonwoven fabric is impregnated with 26 parts by mass or more and 34 parts by mass or less of the chemical solution. The drug solution further comprises benzoic acid, benzoates, chlorcresol, chlorobutanol, salicylic acid, salicylates, solhibinic acid, solhibinates, dehydroacetic acid, dehydroacetate, trichlorohydroxydiphenyl ether, paraoxybenzoic acid ester, paraoxybenzoic acid. Sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, pantothenyl ethyl benzoate, isopropylmethylphenol, cetylpyridinium chloride, chlorhexidine hydrochloride, orthophenylphenol, chlorhexidine gluconate, chlorxylenol, chlorhexidine, alkyliso bromide The wet wiper according to claim 1, which contains at least one antibacterial agent selected from the group consisting of quinolinium, timol, trichlorocarbanilide, halocarban, hinokithiol, pyrithion zinc, and silver ion antibacterial agents.