JP6969169B2 - Multilayer film and packaging - Google Patents

Description

The present invention relates to multilayer films and packages.

Solid preparations such as tablets and capsules are widely used as pharmaceuticals, dietary supplements (health foods) and the like. These solids are stored, for example, in PTP (press through pack) packaging until the time of their use. In PTP packaging, for example, a cover film is attached to a transparent film having a protruding portion on a surface opposite to the protruding side of the protruding portion, except for the protruding portion, and the protruding portion of the transparent film and the cover film are attached to each other. The solid agent is stored and packaged in the storage portion formed by. When taking the solid agent stored in such a package, the user applies a force to the stored solid agent from the protruding portion side via the transparent film to break the cover film and solidify the solid agent. The solid agent is taken out from the package by extruding.

On the other hand, in recent years, when taking a solid preparation packaged in PTP, the so-called accidental ingestion, in which the solid preparation is accidentally taken in the packaged state without being taken out from the package, is mainly for the elderly. It occurs frequently. In that case, the transparent film of the package is relatively hard, and a part of the outer circumference thereof is angular and sharp, so that the user often injures the throat and the digestive organs thereafter.

Similarly, detergents, pesticides, etc. are examples of substances that are prone to accidental ingestion. Unlike PTP packaging, these are packaged in a water-soluble film, but liquid detergents in particular are colored and scented and resemble food and drink, including their appearance, so they are accidentally swallowed or accidentally eaten. There is a danger of.
Therefore, in order to prevent such accidental ingestion and accidental ingestion, a package made of a water-soluble film containing a bitterness component is disclosed (see Patent Document 1). When such a package is contained in the mouth, the bitterness component is transferred from the water-soluble film into the mouth, so that the person who contains the package feels strong bitterness, becomes uncomfortable and abnormal, and does not swallow the package. , Guided to spit out.

Japanese Unexamined Patent Publication No. 2016-108426

However, it is uncertain whether the water-soluble film disclosed in Patent Document 1 can be used as it is for the production of a PTP package.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a novel film capable of producing a PTP package having an accidental ingestion prevention effect, and a package using the same.

In order to solve the above problems, the present invention adopts the following configuration.
[1]. A bitterness component-containing layer arranged so as to be one outermost layer and a sealant layer arranged so as to be the other outermost layer are provided, and the bitterness component-containing layer comprises denatonium benzoate or its own as a bitterness component. A multilayer film containing a derivative and water-soluble.
[2]. The multilayer film according to [1], wherein the internal haze of the bitterness component-containing layer is 40% or less.
[3]. The multilayer film according to [1] or [2], wherein the total content of denatonium benzoate and its derivatives in the bitterness component-containing layer is 1.2% by mass or less.
[4]. The multilayer film according to any one of [1] to [3], wherein the bitterness component-containing layer contains a water-soluble resin.
[5]. The multilayer film according to any one of [1] to [4], wherein the sealant layer contains one or more selected from the group consisting of polypropylene-based resin and polyethylene-based resin.

[6]. A package having the multilayer film according to any one of [1] to [5], wherein a storage portion for a packaged object is formed by the sealant layer of the multilayer film, and the multilayer film is formed. The package body in which the bitterness component-containing layer is the outermost layer on the side opposite to the storage portion side of the package body.
[7]. A cover film is further provided on the sealant layer side of the multilayer film, and the multilayer film has a protrusion protruding toward the bitterness component-containing layer side in a part of the region thereof, and the protrusion of the multilayer film. The package according to [6], wherein the storage portion is formed by the portion and the cover film, and a region other than the protruding portion of the multilayer film is adhered to the cover film.

According to the present invention, a novel film capable of producing a PTP package having an accidental ingestion prevention effect and a package using the film are provided.

It is sectional drawing which shows typically one Embodiment of the multilayer film of this invention. It is sectional drawing which shows the other embodiment of the multilayer film of this invention schematically. It is a perspective view which shows typically one Embodiment of the package of this invention. FIG. 3 is a cross-sectional view taken along the line I-I of the package shown in FIG.

<< Multilayer film >>
The multilayer film of the present invention comprises a bitterness component-containing layer arranged so as to be one outermost layer, and a sealant layer arranged so as to be the other outermost layer, and the bitterness component-containing layer is bitter. It contains denatonium benzoate or a derivative thereof as an ingredient, and is water-soluble.

The multilayer film of the present invention has a multilayer structure in which the bitterness component-containing layer is separately provided from the sealant layer, and the bitterness component-containing layer is water-soluble, so that when it is contained in the mouth, it suffers from bitterness. Can be clearly perceived. Further, since the bitterness component-containing layer contains denatonium benzoate or a derivative thereof as the bitterness component, unpleasant bitterness can be clearly perceived when the multilayer film is contained in the mouth. That is, the multilayer film of the present invention is extremely excellent in the effectiveness of bitterness when it is contained in the mouth. In addition, since denatonium benzoate and its derivatives cause an extremely small amount of unpleasant bitterness to be perceived in the mouth, the multilayer film was contained in the mouth even if it had a bitterness component-containing layer having a low content of these components. Extremely excellent in the effectiveness of bitterness.

Therefore, the multilayer film is extremely useful for producing a package having an accidental ingestion prevention effect. As the package to be manufactured, a PTP (press through pack) package for packaging a solid agent such as a tablet or a capsule is particularly suitable. Here, examples of the solid preparation include pharmaceuticals, dietary supplements (health foods), and the like.

In the present specification, the "multilayer film" means the multilayer film of the present invention unless otherwise specified.
Hereinafter, first, the overall configuration of the multilayer film of the present invention will be described.

FIG. 1 is a cross-sectional view schematically showing an embodiment of the multilayer film of the present invention. In addition, in the figure used in the following description, in order to make it easy to understand the features of the present invention, the main part may be enlarged and shown, and the dimensional ratio of each component is the same as the actual one. Is not always the case.

The multilayer film 1 shown here includes a bitterness component-containing layer 12 arranged so as to be one outermost layer, and a sealant layer 11 arranged so as to be the other outermost layer, and further contains a bitterness component. The adhesive layer 13 is provided between the layer 12 and the sealant layer 11. That is, the multilayer film 1 is configured by laminating the sealant layer 11, the adhesive layer 13, and the bitterness component-containing layer 12 in this order in the thickness direction.
In the multilayer film 1, the adhesive layer 13 is laminated on the sealant layer 11 in direct contact with the sealant layer 11, and the bitterness component-containing layer 12 is laminated on the adhesive layer 13 in direct contact with the adhesive layer 13. ..

In addition, in this specification, these layers constituting a multilayer film may be referred to as a film. For example, the bitterness component-containing layer may be referred to as a bitterness component-containing film.

The sealant layer 11 enables adhesion between the sealant layers 11 or between the sealant layer 11 and other members. By providing the sealant layer 11, the multilayer film 1 can easily form a package as described later.

The bitterness component-containing layer 12 contains denatonium benzoate or a derivative thereof as the bitterness component, and is water-soluble. By providing the bitterness component-containing layer 12, the multilayer film 1 and the package made by using the multilayer film 1 have an excellent accidental ingestion prevention effect, as will be described later.

The adhesive layer 13 adheres the sealant layer 11 and the bitterness component-containing layer 12.
The adhesive layer 13 is an arbitrary component and can be omitted in the multilayer film 1. However, the provision of the adhesive layer 13 further stabilizes the multilayer structure of the multilayer film 1.

One surface (sometimes referred to as "first surface" in the present specification) 1a of the multilayer film 1 on the bitterness component-containing layer 12 side, in other words, the exposed surface 12a of the bitterness component-containing layer 12 will be described later. It is an exposed surface in the package to be used.
On the other hand, the other surface (sometimes referred to as "second surface" in the present specification) 1b of the multilayer film 1 on the sealant layer 11 side, in other words, the exposed surface 11b of the sealant layer 11 is a packaging described later. In the body, it is a surface that constitutes a storage portion for storing the packaged object, and is a contact surface with the packaged object.

FIG. 2 is a cross-sectional view schematically showing another embodiment of the multilayer film of the present invention.
In the drawings after FIG. 2, the same components as those shown in the already described figures are designated by the same reference numerals as in the case of the already described figures, and detailed description thereof will be omitted.

The multilayer film 2 shown here is the same as the multilayer film 1 shown in FIG. 1, except that the multilayer film 2 is not provided with the adhesive layer 13.
That is, the multilayer film 2 is composed of the sealant layer 11 and the bitterness component-containing layer 12 laminated in the thickness direction thereof. In the multilayer film 2, the bitterness component-containing layer 12 is laminated on the sealant layer 11 in direct contact with the sealant layer 11.

One surface (first surface) 2a on the bitterness component-containing layer 12 side of the multilayer film 2, in other words, the exposed surface 12a of the bitterness component-containing layer 12 is an exposed surface in the package described later.
On the other hand, the other surface (second surface) 2b of the multilayer film 2 on the sealant layer 11 side, in other words, the exposed surface 11b of the sealant layer 11 is for accommodating the object to be packaged in the package described later. It is a surface that constitutes the storage unit and is a contact surface with the object to be packaged.

The multilayer film of the present invention is not limited to the above-described embodiment, and a partial configuration may be changed, deleted or added as long as the effect of the present invention is not impaired.
For example, even if the multilayer film 1 shown in FIG. 1 and the multilayer film 2 shown in FIG. 2 both have a sealant layer 11, a bitterness component-containing layer 12, and a layer other than the adhesive layer 13 (not shown). good.
The other layer may be appropriately selected depending on the intended purpose, and is not particularly limited.

However, in the multilayer film 1 and the multilayer film 2 of the present invention, since the sealant layer 11 and the bitterness component-containing layer 12 are both the outermost layers, the other layers are on the sealant layer 11 side of the bitterness component-containing layer 12. In addition, it is arranged at a position closer to the bitterness component-containing layer 12 than the sealant layer 11.
Next, the components of the multilayer film of the present invention will be described in detail.

<Bitter component-containing layer>
The bitterness component-containing layer is one of the outermost layers (the outermost layer, that is, the outermost layer) of the multilayer film, contains denatonium benzoate or a derivative thereof as the bitterness component, and is water-soluble.
The bitterness component-containing layer is indispensable for the multilayer film and the package formed by using the multilayer film to exhibit the effect of preventing accidental ingestion. In the package, the bitterness component-containing layer in the multilayer film is exposed.

Denatonium benzoate is a compound (quaternary ammonium salt) represented by the following formula, has a melting point of about 168 ° C., is solid at room temperature, and is difficult to volatilize.
Since denatonium benzoate exhibits an unpleasant bitterness in an extremely small amount, the bitterness component-containing layer (bitterness component-containing film), the multilayer film provided with the layer, and the package constructed using the same are excellent. Has the effect of preventing accidental ingestion.

In the present invention, the "derivative of denatonium benzoate" means "a compound having a structure in which one or more hydrogen atoms of denatonium benzoate are substituted with a group (substituent) other than a hydrogen atom". do.
In the present specification, the term "group" includes not only an atomic group formed by bonding a plurality of (two or more) atoms but also one atom, unless otherwise specified.

In the denatonium benzoate derivative, the type of the substituent in which the hydrogen atom is substituted is not particularly limited as long as the derivative is a bitter component. Examples of the substituent include an alkyl group, an aryl group, a hydroxyl group, an amino group, a carboxy group, a halogen atom (fluorine atom, chlorine atom, bromine atom, iodine atom and the like), and these are examples.
When the number of the substituents in one molecule of the denatonium benzoate derivative is two or more, these two or more substituents may all be the same, all may be different, or some of them may be different. May only be the same. When the substituents in one molecule of the denatonium benzoate derivative are two or more, the combination and ratio thereof can be arbitrarily selected according to the purpose.
In the denatonium benzoate derivative, the position of the substituent is not particularly limited as long as the derivative is a bitter component.

The denatonium benzoate derivative is preferably solid at room temperature like denatonium benzoate, and for example, the melting point of the denatonium benzoate derivative is preferably equal to or higher than that of denatonium benzoate.

The bitterness component-containing layer may contain one or more selected from the group consisting of denatonium benzoate and its derivatives as the bitterness component, and may contain only denatonium benzoate or one kind. Alternatively, it may contain only two or more kinds of denatonium benzoate derivatives, or may contain both denatonium benzoate and one or more kinds of denatonium benzoate derivatives.

The bitterness component-containing layer may contain denatonium benzoate or a derivative thereof as an essential component, but it is preferable that the bitterness component-containing layer retains these essential components and contains a resin for forming the main structure of the bitterness component-containing layer.
Along with denatonium benzoate or a derivative thereof, the bitterness component-containing layer containing the resin can stably maintain its structure, for example, denatonium benzoate or a derivative thereof from the bitterness component-containing layer to other places is not intended. The transition can be strongly suppressed.

It is preferable that the resin is water-soluble, that is, the bitterness component-containing layer contains a water-soluble resin. As used herein, the term "water-soluble resin" means a resin having solubility in water at room temperature or under heating conditions, unless otherwise specified. Further, the "normal temperature" means a temperature that is not particularly cooled or heated, that is, a normal temperature, and examples thereof include a temperature of 15 to 25 ° C. Here, "heating" means heating at a temperature lower than the boiling point of water.

The water-soluble resin is not particularly limited, but is preferably a polyvinyl alcohol-based resin.
The polyvinyl alcohol-based resin is a resin that can be regarded as having a structural unit derived from a vinyl alcohol or a vinyl ester compound, and more specific examples thereof include polyvinyl alcohol and modified polyvinyl alcohol.

The vinyl ester compound is a monomer, and preferred examples thereof include vinyl carboxylic acid esters such as vinyl formate, vinyl acetate, trifluorovinyl acetate, vinyl propionate, and vinyl butyrate, and halogenated carboxylic acid vinyl esters. Can be mentioned.
Among them, the vinyl ester compound is preferably vinyl acetate.

The polyvinyl alcohol may be a known one, and preferred examples thereof include a saponified product of a polymer of the vinyl ester compound.

The modified polyvinyl alcohol may also be known, and for example, it is preferably a hydrophilic group-modified polyvinyl alcohol having a hydrophilic group, and more preferably an anionic group-modified polyvinyl alcohol.
Anionic group Examples of the anionic group in the modified polyvinyl alcohol include a carboxy group (-C (= O) -OH), a sulfo group (-S (= O) _2- OH), and a phosphate group (-O-P). (= O) -OH ₂ ) and the like can be mentioned.
The hydrophilic group-modified polyvinyl alcohol can be produced, for example, by copolymerizing a monomer having a hydrophilic group with the vinyl ester compound and then saponifying the obtained copolymer. However, the method for producing hydrophilic group-modified polyvinyl alcohol is not limited to this.

The water-soluble resin is preferably a completely saponified or partially saponified polymer of the vinyl ester compound.

The bitterness component-containing layer may contain other components that do not fall under any of denatonium benzoate, its derivatives and the above-mentioned resin, as long as the effects of the present invention are not impaired.
The other components are not particularly limited and can be arbitrarily selected depending on the intended purpose.
The other component in the bitterness component-containing layer may be only one type, two or more types, or two or more types, and the combination and ratio thereof can be arbitrarily selected according to the purpose.

Examples of the other components include other bitter components that do not fall under any of denatonium benzoate and its derivatives.

The other bitterness component is not particularly limited.
Other bitterness components include, for example, inorganic metal salts, plant alkaloids, steroids, peptides, terpenoids, glycosides, flavonoids and the like.
Other bitter ingredients, more specifically, for example, magnesium chloride, caffeine, velverin, diketopiperazine, limonene, genthiopicroside, catechin, naringin, mordecine, quercetin, aucbin, amarogentin, dihydrofoliamentin, gen. Thiopicrin, swellthiamarin, sueroside, gentioflaboside, centauroside, methaphorin, harpagoside, centerpicrin, syricin, conjulandin, absintin, altabsin, kunicin, lacchucin, lactucopicrin, salonitenolide, α-tujon, β-tujon , Desoxylymonen, Ichangin, Isoobakunic acid, Obakunon, Obakunic acid, Nomilin, Nomilic acid, Malbi, Pramalbin, Carnosol, Carnosic acid, Quassin, Quinine hydrochloride, Quinine sulfate, Kinine dihydrogenate, Kinine disulfate, Colombine, Threonine, Methionin , Tryptophan, arginine, histidine, valine, aspartic acid, octaacetylsulose, hop extract (eg, humron, etc.), quinine bamboo extract and the like.

The lower limit of the total content of denatonium benzoate and its derivatives in the bitterness component-containing layer is not particularly limited as long as the effects of the present invention are not impaired. However, the total content is preferably 0.01% by mass or more, more preferably 0.04% by mass or more, further preferably 0.06% by mass or more, and 0.08% by mass. % Or more is particularly preferable. When the total content is at least the lower limit, the bitterness component-containing layer (bitterness component-containing film), the multilayer film provided with the layer, and the package made by using the multilayer film are prevented from accidentally swallowed. The effect will be higher.

The upper limit of the total content of denatonium benzoate and its derivatives in the bitterness component-containing layer is not particularly limited as long as the effects of the present invention are not impaired. However, the total content is preferably 3% by mass or less, more preferably 2% by mass or less, further preferably 1.6% by mass or less, and 1.2% by mass or less. Is particularly preferred. When the total content is not more than the upper limit, the bitterness component-containing layer (bitterness component-containing film), the multilayer film provided with the layer, and the package made by using the multilayer film are highly accidentally swallowed. While maintaining the preventive effect, the haze (internal haze) of these bitterness component-containing layers and the like can be suppressed to a smaller size. Then, in the package, the stored items (packaged objects) in the storage section can be more easily visually recognized via the multilayer film.

In the present invention, the total content of denatonium benzoate and its derivatives in the bitterness component-containing layer has a numerical range determined by any combination of any of the above-mentioned lower limit values and any of the upper limit values. It can be adjusted as appropriate.
For example, the total content is preferably 0.01 to 3% by mass, more preferably 0.04 to 2% by mass, still more preferably 0.06 to 1.6% by mass, and particularly preferably 0.08 to 1%. Although it can be .2% by mass, these numerical ranges are examples of preferable numerical ranges of the total content.

The total content of denatonium benzoate and its derivatives in the bitterness component-containing layer shown in the above numerical range is particularly suitable when the bitterness component-containing layer contains the resin.

The total content of denatonium benzoate, its derivative and the resin in the bitterness component-containing layer is not particularly limited, but is preferably 85% by mass or more, more preferably 90% by mass or more, and 95% by mass. The above is particularly preferable, and for example, it may be any one of 97% by mass or more, 98% by mass or more, 99% by mass or more, and the like. When the total content is at least the lower limit, the bitterness component-containing layer (bitterness component-containing film), the multilayer film provided with the layer, and the package made by using the multilayer film are prevented from accidentally swallowed. The effect will be higher.
On the other hand, the upper limit of the total content is 100% by mass.

The content of the other component in the bitterness component-containing layer is not particularly limited and can be appropriately adjusted according to the type of the other component, but is usually preferably 15% by mass or less, preferably 10% by mass or less. It is more preferably 5% by mass or less, and for example, it may be any of 3% by mass or less, 2% by mass or less, 1% by mass or less, and the like. When the content is not more than the upper limit, the effect of the present invention is further enhanced.
On the other hand, the lower limit of the content is 0% by mass.

The smaller the internal haze of the bitterness component-containing layer, the more preferably 40% or less, more preferably 35% or less, and particularly preferably 30% or less. Since the internal haze of the bitterness component-containing layer is not more than the upper limit value, in a package constructed by using the multilayer film described later, the stored items in the storage section can be more easily visually recognized via the multilayer film. can.
The lower limit of the internal haze of the bitterness component-containing layer is not particularly limited. However, the bitterness component-containing layer having an internal haze of 1% or more can be formed more easily.

As used herein, the terms "haze" and "internal haze" mean those measured in accordance with JIS K 7136: 2000. Further, "haze" means the sum of the inner haze and the outer haze (all haze) unless otherwise specified.

The internal haze of the bitterness component-containing layer is, for example, the type and content of the components contained in the bitterness component-containing layer, such as the above-mentioned denatonium benzoate, its derivative, the resin, and the other components, and the bitterness component-containing layer. By adjusting the thickness, it can be adjusted as appropriate.

The bitterness component-containing layer may be composed of one layer (single layer) or may be composed of two or more layers. When the bitterness component-containing layer is composed of a plurality of layers, the plurality of layers may be the same or different from each other, and the combination of the plurality of layers is not particularly limited as long as the effect of the present invention is not impaired.

In the present specification, not only in the case of the bitterness component-containing layer, but also in the case of "a plurality of layers may be the same or different from each other", "all layers may be the same or all layers". May be different, and only some of the layers may be the same. ”Furthermore,“ a plurality of layers are different from each other ”means that“ at least one of the constituent materials and the thickness of each layer is different from each other. It means that.

The thickness of the bitterness component-containing layer is not particularly limited, but is preferably 0.1 to 30 μm, more preferably 1 to 20 μm, and particularly preferably 2 to 10 μm. When the thickness of the bitterness component-containing layer is at least the above lower limit value, the strength of the bitterness component-containing layer is further improved. Further, when the thickness of the bitterness component-containing layer is not more than the upper limit value, it is possible to avoid an excessive thickness.
When the bitterness component-containing layer is composed of a plurality of layers, the total thickness of these plurality of layers may be set to be the thickness of the above-mentioned preferable bitterness component-containing layer.

<Sealant layer>
The sealant layer is the other outermost layer (the outermost layer, that is, the outermost layer) of the multilayer film, and makes it easy for the multilayer film to form a package as described later. In the package, the sealant layer in the multilayer film comes into contact with the contents to be packaged.

The sealant layer is not particularly limited as long as it has an adhesive function (sealing property) and does not adversely affect the stored items in the package. However, the sealant layer preferably has a high light transmittance from the viewpoint that the stored items can be easily visually recognized from the outside of the package.

Examples of the sealant layer include those containing a known resin as a sealing material.
Examples of the resin contained in the sealant layer include polypropylene-based resin; polyethylene-based resin; polystyrene; polyamide; polyester such as polyethylene terephthalate; cyclic olefin polymer; cyclic olefin copolymer; petroleum resin; polyvinyl chloride, polyvinylidene chloride, and polychloro. Halogen-based resins (resins having a halogen atom) such as trifluoroethylene, polytetrafluoroethylene, polyvinylfluoride, and polyvinylidene fluoride; fluororesin copolymers such as ethylene / tetrafluoroethylene copolymers and the like can be mentioned.
However, when the sealant layer contains a petroleum resin, the sealant layer also includes a resin other than the petroleum resin.

The polypropylene-based resin is a resin having a structural unit derived from propylene such as polypropylene.
Examples of the polypropylene-based resin include crystalline polypropylene-based resin and the like.
Examples of the crystalline polypropylene-based resin include a crystalline propylene homopolymer, a crystalline propylene-ethylene random copolymer, a crystalline propylene-α-olefin random copolymer, and one or both of ethylene and α-olefin. , A crystalline block copolymer obtained by copolymerizing with propylene, and the like.
Examples of the α-olefin include α-olefins having 4 to 10 carbon atoms such as 1-butene, 1-pentene, 1-hexene, 1-octene and 1-decene.

The polyethylene-based resin is a resin having a structural unit derived from ethylene.
Examples of the polyethylene-based resin include low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), metallocene-catalyzed linear low-density polyethylene (metallocene LLDPE), medium-density polyethylene (MDPE), and high-density polyethylene (HDPE). , Polyethylene-based copolymer and the like.

Among the polyethylene-based resins, examples of the polyethylene-based copolymer include a copolymer of ethylene and a vinyl group-containing monomer.
Examples of the copolymer of ethylene and the vinyl group-containing monomer include maleic anhydride graft-modified linear low-density polyethylene, ethylene-vinyl acetate copolymer, ethylene-methyl acrylate copolymer, and ethylene-. Examples thereof include an ethyl (meth) ethyl acrylate copolymer, an ethylene- (meth) acrylic acid copolymer, an ethylene-ethyl acrylate-maleic anhydride copolymer, and an ethylene copolymer such as ionomer.
In addition, in this specification, "(meth) acrylic acid" is a concept including both "acrylic acid" and "methacrylic acid".

The resin contained in the sealant layer may be of only one type, may be of two or more types, and when there are two or more types, the combination and ratio thereof can be arbitrarily selected according to the purpose.

When the sealant layer contains the resin, it may contain components other than the resin.
Examples of the other components in the sealant layer include antioxidants, antistatic agents, crystal nucleating agents, inorganic particles, organic particles, thickeners, thickeners, heat stabilizers, lubricants, infrared absorbers, and ultraviolet rays. Examples thereof include various known additives such as absorbents.
The other components contained in the sealant layer may be only one kind, may be two or more kinds, and when there are two or more kinds, the combination and the ratio thereof can be arbitrarily selected according to an object.

The content of the resin in the sealant layer is preferably 90% by mass or more, more preferably 95% by mass or more, particularly preferably 98% by mass or more, and for example, 99% by mass or more. There may be.
On the other hand, the upper limit of the content of the resin in the sealant layer is 100% by mass.

In other words, the content of the other components in the sealant layer containing the resin is preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably 2% by mass or less. Preferably, it may be, for example, 1% by mass or less.
On the other hand, the lower limit of the content of the other components in the sealant layer containing the resin is 0% by mass.

When the sealant layer contains a petroleum resin, the ratio of the content of the petroleum resin to the total content of the resin in the sealant layer is preferably 3 to 35% by mass.

The sealant layer preferably contains one or more selected from the group consisting of polypropylene-based resin and polyethylene-based resin, and preferably contains petroleum resin in addition to these resins.
In the sealant layer, the ratio of the total content of the polypropylene-based resin, the polyethylene-based resin, and the petroleum resin to the total content of the resin is preferably 80% by mass or more, more preferably 90% by mass or more. , 95% by mass or more is particularly preferable, and 100% by mass may be used. That is, the sealant layer may contain, as the resin, one or more selected from the group consisting of polypropylene-based resin and polyethylene-based resin, and further, if necessary, petroleum resin. When the ratio of the total content is equal to or higher than the lower limit, the sealant layer has a better sealing property.

The sealant layer may be composed of one layer (single layer) or may be composed of two or more layers. When the sealant layer is composed of a plurality of layers, the plurality of layers may be the same as or different from each other, and the combination of the plurality of layers is not particularly limited as long as the effect of the present invention is not impaired.

The thickness of the sealant layer is not particularly limited, but is preferably 100 to 500 μm, more preferably 150 to 400 μm, and particularly preferably 200 to 350 μm. When the thickness of the sealant layer is at least the above lower limit value, the sealant layer has a better sealing property. Further, when the thickness of the sealant layer is not more than the upper limit value, it is possible to avoid an excessive thickness.
When the sealant layer is composed of a plurality of layers, the total thickness of the plurality of layers may be set to be the above-mentioned preferable thickness of the sealant layer.

<Adhesive layer>
The adhesive layer is arranged between the bitterness component-containing layer and the sealant layer, and these layers are adhered to further stabilize the multilayer structure of the multilayer film.
The adhesive layer is not particularly limited as long as it has such characteristics. However, the adhesive layer preferably has a high light transmittance from the viewpoint that the stored items can be easily visually recognized from the outside of the package.

Examples of the adhesive layer include those containing an adhesive resin, and examples of the adhesive resin contained in the adhesive layer include polyolefin resins and the like.

The polyolefin-based resin is a resin having a structural unit derived from an olefin, and may be a modified polyolefin such as an acid-modified polyolefin into which an acidic group has been introduced.
Examples of the polyolefin-based resin include polyethylene-based copolymers, polypropylene-based copolymers, butene-based copolymers, and modified products (modified copolymers) of these copolymers. These polyolefin-based resins are preferably random copolymers, graft copolymers, or block copolymers in terms of further improving adhesiveness.

As the polyethylene-based copolymer, for example, among the polyethylene-based resins mentioned above as the resin contained in the sealant layer, the same as the polyethylene-based copolymer, a modified product thereof (modified copolymer), and the like can be used. Can be mentioned.
Examples of the polypropylene-based copolymer include a copolymer of propylene and a vinyl group-containing monomer, a modified product thereof (modified copolymer), and the like, and more specifically, for example, maleic anhydride graft. Examples thereof include modified linear low-density polypropylene and propylene-based thermoplastic elastomers.
Examples of the butene-based copolymer include a copolymer of 1-butene and a vinyl group-containing monomer, a copolymer of 2-butene and a vinyl group-containing monomer, and a modified product (modified copolymer weight) of these copolymers. Coalescence) and the like.

The adhesive resin contained in the adhesive layer may be of only one type, may be of two or more types, and when there are two or more types, the combination and ratio thereof can be arbitrarily selected according to the purpose.

The adhesive layer may be composed of one layer (single layer) or may be composed of two or more layers. When the adhesive layer is composed of a plurality of layers, the plurality of layers may be the same as or different from each other, and the combination of the plurality of layers is not particularly limited as long as the effect of the present invention is not impaired.

The thickness of the adhesive layer is not particularly limited, but is preferably 0.1 to 30 μm, more preferably 0.5 to 20 μm, and particularly preferably 1 to 10 μm. When the thickness of the adhesive layer is at least the above lower limit value, the adhesive layer has better adhesiveness. Further, when the thickness of the adhesive layer is not more than the upper limit value, it is possible to avoid an excessive thickness.
When the adhesive layer is composed of a plurality of layers, the total thickness of the plurality of layers may be set to be the above-mentioned preferable thickness of the adhesive layer.

The smaller the internal haze of the multilayer film, the more preferably 40% or less, more preferably 35% or less, and particularly preferably 30% or less. When the internal haze of the multilayer film is equal to or less than the upper limit value, the stored items in the storage portion can be more easily visually recognized via the multilayer film in the package described later.
The lower limit of the internal haze of the multilayer film is not particularly limited. However, a multilayer film having an internal haze of 1% or more can be manufactured more easily.

<< Manufacturing method of multilayer film >>
The multilayer film of the present invention is, for example, a feed block method in which a resin or a resin composition used as a material for forming each layer is melt-extruded using several extruders, a co-extrusion T-die method such as a multi-manifold method, and the like. It can be manufactured by an air-cooled or water-cooled coextrusion inflation method or the like.

Further, in the multilayer film of the present invention, a resin, a resin composition or the like which is a material for forming any of the layers thereof is coated on the surface of another layer for forming the multilayer film, and if necessary. It can also be produced by forming a laminated structure in a multilayer film by drying and, if necessary, further laminating layers other than these so as to have a desired arrangement form.

Further, in the multilayer film of the present invention, two or more films for forming any two or more layers are separately prepared in advance, and these films are subjected to a dry laminating method or an extrusion laminating method using an adhesive. It can also be manufactured by laminating and laminating by any of a method, a hot melt laminating method and a wet laminating method, and if necessary, further laminating so that a layer other than these is in a desired arrangement form. At this time, as the adhesive, an adhesive capable of forming the adhesive layer may be used.

Further, in the multilayer film of the present invention, as described above, two or more films prepared separately in advance are laminated by laminating them by a thermal (heat) laminating method or the like without using an adhesive. If necessary, it can also be manufactured by further laminating layers other than these so as to have a desired arrangement form.

When producing the multilayer film of the present invention, two or more of the methods for forming any of the layers (films) in the multilayer film described above may be combined.

The resin composition used as a material for forming any of the layers in the multilayer film is adjusted in type and content so that the layer to be formed contains the desired component in the desired content. , Can be manufactured. For example, the ratio of the content of components that do not vaporize at room temperature (for example, components other than the solvent) in the resin composition is usually the content of the components in the layer formed from the resin composition. Is the same as the ratio of.

<< Packaging >>
The package of the present invention is a package provided with the multilayer film of the present invention described above, and the storage portion of the object to be packaged is formed by the sealant layer of the multilayer film, and the bitterness of the multilayer film is formed. The component-containing layer is the outermost layer on the side opposite to the storage portion side of the package. By having such a structure, the package of the present invention has an excellent effect of preventing accidental ingestion.

When the package is contained in the mouth, the bitterness component-containing layer comes into direct contact with the tongue. Then, denatonium benzoate or a derivative thereof is transferred to the mouth from this bitterness component-containing layer. As mentioned above, denatonium benzoate and its derivatives cause a very small amount of unpleasant bitterness in the mouth. Therefore, when the package is contained in the mouth, a person immediately feels an abnormality and immediately takes it out of the mouth or exhales it. Guided by. Therefore, even if a person accidentally puts the package in his / her mouth, he / she does not swallow the package, and accidental ingestion is significantly suppressed.

As described above, the reason why the package is immediately abnormal when it is contained in the mouth is that denatonium benzoate and its derivatives are significantly more bitter than other bitter components and are extremely unpleasant. However, the fact that the bitterness component-containing layer is water-soluble is also a major factor. Since the bitterness component-containing layer is water-soluble, the package is rapidly dissolved when it is contained in the mouth, and accordingly, denatonium benzoate or a derivative thereof is rapidly eluted in the mouth. Therefore, not only denatonium benzoate or its derivative present in the surface or shallow region directly in contact with the tongue, but also denatonium benzoate or its derivative present in the deeper region is transferred from the bitterness component-containing layer into the mouth. It is presumed that the total amount of denatonium benzoate and its derivatives involved in perception is significantly high.

The package is particularly suitable as a PTP package for packaging a solid agent such as a tablet or a capsule. As described above, examples of the solid preparation include pharmaceuticals, dietary supplements (health foods) and the like.

Preferred of the package is, for example, a cover film provided on the sealant layer side of the multilayer film, and the multilayer film projects toward the bitterness component-containing layer side in a part of the region thereof. The accommodating portion is formed by the projecting portion of the multilayer film and the cover film, and a region other than the projecting portion of the multilayer film is adhered to the cover film. Things can be mentioned.

FIG. 3 is a perspective view schematically showing an embodiment of the package of the present invention, and FIG. 4 is a cross-sectional view taken along the line I-I of the package shown in FIG.

The package 10 shown here includes a multilayer film 1, and is configured to further include a cover film 101 on the sealant layer 11 side (second surface 1b side) of the multilayer film 1. The multilayer film 1 is formed with a protruding portion 1c constituting the storage portion 10a of the package 10.
The package 10 is a PTP film (packaging container) as a blister pack, and the tablet 102 can be hermetically stored in the storage portion 10a.

The second surface 1b of the multilayer film 1 is adhered to one surface of the cover film 101 (sometimes referred to as the "first surface" in the present specification) 101a. However, the multilayer film 1 has a protruding portion 1c protruding toward the bitterness component-containing layer side 12 side (first surface 1a side) in a part of the region, and the second surface 1b in the protruding portion 1c is , Is not adhered to the first surface 101a of the cover film 101. As described above, in the package 10, the protrusion 1c of the multilayer film 1 and the cover film, more specifically, the second surface 1b of the protrusion 1c of the multilayer film 1 and the first surface of the cover film 101. The storage portion 10a is formed by the 101a. Then, in the package 10, the region other than the protruding portion 1c of the multilayer film 1 is adhered to the cover film 101.

In the package 10, as described above, the internal haze of the multilayer film 1 can be made sufficiently small, and in that case, the tablets 102 stored in the storage portion 10a via the multilayer film 1 can be more easily stored. It is visible.
Further, since the package 10 has excellent adhesion between the multilayer film 1 and the cover film 101, the storage portion 10a of the package 10 is highly airtight, and the tablet 102 stored in the storage portion 10a is deteriorated in quality. It is suppressed.

Examples of the constituent material of the cover film 101 include aluminum and the like.

A slit 10b is formed in the multilayer film 1 and the cover film 101. The slit 10b has an arbitrary configuration and does not necessarily have to be formed, but the formation of the slit 10b makes it easy to divide the package 10 according to the specific number of tablets 102 stored in the storage portion 10a. Therefore, the convenience of the package 10 is improved.

Here, as the package 10, the outer shape of the storage portion 10a is shown to have a truncated cone shape, but the outer shape of the storage portion 10a is not limited to this, and depends on the shape of the tablet 102 to be stored. And can be selected arbitrarily. For example, the outer shape of the storage portion 10a may be a polygonal shape such as a triangle, a quadrangle, a pentagon, or a hexagon when the package 10 is viewed from the side of the multilayer film 1 in a plan view, or an oval shape. And so on.

Further, here, the package 10 includes eight storage portions 10a, but the number of storage portions 10a is not limited to this, and may be one or two or more (however, however). It may be 8).

As described above, the multilayer film of the present invention is preferably used for producing a PTP package, but it can also be used for producing other packages. Examples of the other package include those configured by using a multilayer film having no protrusion for forming a storage portion.
As such other packages, more specifically, for example, multilayer films having no protrusions of the present invention are arranged so that the sealant layers face each other, and the vicinity of the peripheral edge of the sealant layers. The regions of the present invention are bonded to each other; the multilayer film having no protrusion of the present invention and the other film are arranged so as to face each other so that the sealant layer of the multilayer film faces the other film side. , A region in the vicinity of the peripheral edge of the sealant layer and a region in the vicinity of the peripheral edge of the other film are bonded to each other. The other film may be another multilayer film that does not fall under the present invention, or may be a single-layer film.

<< Manufacturing method of packaging >>
The package of the present invention can be manufactured by using the multilayer film and laminating the multilayer film and another film, multilayer films, or the like so as to form a desired storage portion.

For example, the package 10 shown in FIGS. 3 and 4 can be manufactured using a known PTP packaging machine.
More specifically, first, the protrusion 1c is formed on the multilayer film 1 by vacuum forming, compressed air forming, plug forming, or the like. Even if the multilayer film 1 is heated when the protrusion 1c is formed in this way, the volatilization of denatonium benzoate and its derivative in the bitterness component-containing layer 12 is suppressed due to the high melting point. As a result, in the obtained molded product, a decrease in the total content of denatonium benzoate and its derivative in the bitterness component-containing layer 12 is suppressed.

Next, the protruding portion 1c of the multilayer film 1 is filled with the tablet 102, which is an object to be stored, and then the cover film 101 is superposed on the multilayer film 1 to bond the multilayer film 1 and the cover film 101. Adhesion at this time can be performed, for example, by applying various known laminating methods.
Then, if necessary, a slit 10b is formed in the multilayer film 1 and the cover film 101 by using a sewing machine blade, a half-cut blade, or the like.
As a result, the package 10 is obtained.

The above-mentioned manufacturing method is a method of manufacturing a package by manufacturing a multilayer film, forming a protrusion on the multilayer film, and adhering a cover film, but the packaging has a protrusion. The package can also be manufactured by other methods.
For example, a raw material film that is the same as the multilayer film is used except that it does not have a bitterness component-containing layer, and a protrusion similar to that formed in the multilayer film is formed on the raw material film, and then the protrusions are formed on the raw material film. A bitterness component-containing layer is formed on the protruding side surface of the protruding portion of this raw material film (the surface opposite to the side provided with the sealant layer) to produce a multilayer film, and a cover film is applied to this multilayer film. The package can also be manufactured by adhering.
At this time, the bitterness component-containing layer can be formed on the raw material film by adopting any of the layer forming (laminating) methods described in the above-mentioned method for producing a multilayer film. For example, a method of forming the bitterness component-containing layer by coating the surface of the raw material film on the protruding side with a resin composition for forming the bitterness component-containing layer and drying it if necessary is preferable.

On the other hand, unlike the package 10 and the like, another package configured by using the multilayer film having no protrusion can be manufactured by, for example, the following method.
First, the multilayer films having no protrusions, or the multilayer film having no protrusions and another film are combined so as to form a storage portion, and the sealant layer of the multilayer film forms the other film (that is, the protrusions). The multilayer film that does not have or the other film) is arranged so as to face each other, and the storage object is arranged in the area that serves as the storage portion between the pair of the arranged films.
Next, the region near the peripheral edge of the sealant layer of the multilayer film is overlapped with the surface of the other film and bonded so as to form the storage portion. Adhesion at this time can be performed, for example, by applying various known laminating methods.
Then, if necessary, a slit is formed in the bonded multilayer films or the multilayer film and other films by using a sewing machine blade, a half-cut blade, or the like.
From the above, the other package can be obtained.

<< How to use the package >>
The package of the present invention in which the object is stored in the storage portion is used as follows.
That is, when the package is a PTP package having the protrusion, the multilayer film in the protrusion is formed by applying a force in the direction from the bitterness component-containing layer to the sealant layer on the protrusion. The force is also applied to the stored items in the storage section. When this force exceeds a certain value, the cover film is torn by the force applied to the cover film by the stored items in the storage unit, and the stored items are pushed out of the package. As a result, the stored items are taken out from the package.

When handling the package with bare hands, such as when applying force to the protruding part of the multilayer film, there is no factor to transfer denatonium benzoate and its derivatives from the bitterness component-containing layer to the hand. Or it is minor. Therefore, under normal handling, denatonium benzoate and its derivatives are difficult to adhere to the hands. In addition, denatonium benzoate is approved as a food additive in Japan, and if such a highly safe ingredient is used, there is no safety problem even if this ingredient adheres to the hand.

Up to this point, the method of using the PTP package has been described, but other packages other than the PTP package can also be used by a normal method. For example, a package constructed using the multilayer film having no protrusions may be combined with a multilayer film having no protrusions, which is cut from the storage portion or adhered to each other so as to form the storage portion. By peeling off one film (that is, the multilayer film having no protrusion or the other film) so as to be separate from each other, the package is taken out from the package.

Hereinafter, the present invention will be described in more detail with reference to specific examples. However, the present invention is not limited to the examples shown below.

<Manufacturing of multilayer film>
[Example 1]
An adhesive composition containing an acid-modified polyolefin is applied to one surface of a polypropylene (PP, homopolypropylene containing 5 to 30% by mass of petroleum resin) film (thickness 300 μm) to be a sealant layer, and dried. As a result, an adhesive layer (thickness 6 μm) was formed.
Next, a resin composition for forming a bitterness component-containing layer containing denatonium benzoate and polyvinyl alcohol (PVA) (kensification degree 97.5-99.0 mol%) is applied onto the above-mentioned adhesive layer. Then, by drying, a bitterness component-containing layer (thickness 5 μm) having a content of denatonium benzoate of 1% by mass and a content of polyvinyl alcohol (PVA) of 99% by mass was formed.
As a result, a multilayer film in which the sealant layer, the adhesive layer, and the bitterness component-containing layer are laminated in this order in the thickness direction is obtained.

[Example 2]
As the resin composition for forming the bitterness component-containing layer, those having different contents of denatonium benzoate and polyvinyl alcohol are used, the content of denatonium benzoate is 0.1% by mass, and the content of polyvinyl alcohol (PVA) is contained. The sealant layer, the adhesive layer and the bitterness component-containing film layer are arranged in this order in the same manner as in Example 1 except that the bitterness component-containing layer (thickness 5 μm) is formed in an amount of 99.9% by mass. , A multilayer film formed by laminating in these thickness directions was produced.

[Example 3]
As the resin composition for forming the bitterness component-containing layer, those having different contents of denatonium benzoate and polyvinyl alcohol are used, the content of denatonium benzoate is 0.01% by mass, and the content of polyvinyl alcohol (PVA) is contained. The sealant layer, the adhesive layer, and the bitterness component-containing film layer are arranged in this order in the same manner as in Example 1 except that the bitterness component-containing layer (thickness 5 μm) is formed in an amount of 99.99% by mass. , A multilayer film formed by laminating in these thickness directions was produced.

<Manufacturing of single layer film>
[Comparative Example 1]
As the resin composition for forming the bitterness component-containing layer, the same resin composition as that used in Example 2 was used, and this was applied onto a release film and dried to form a single-layer film, denatonium benzoate. A comparative bitterness component-containing layer (film) (thickness 300 μm) having a content of 0.1% by mass and a content of PP of 99.9% by mass was formed on the release film. In the present specification, the term "single-layer film" is not a layer (film) containing a bitter component in a multilayer film, and is not used as a multilayer film unless otherwise specified. Means a layered film.

<Evaluation of multilayer film and single-layer film>
[Test Example 1]
(Effectiveness of bitterness)
The multi-layer film and the single-layer film obtained above, and the PP (homo PP) film for comparison (thickness 300 μm) were sensory-evaluated for the effectiveness of bitterness by the following method.
That is, each film was cut into a size of 2 cm × 4 cm to prepare a test piece.
Next, a total of 14 subjects, 3 in their 20s, 6 in their 40s, 3 in their 50s, 1 in their 60s, and 1 in their 70s, were given one piece of each test piece in their mouths after a while. According to the following scoring method, (1) perception of bitterness and (2) quality of bitterness when perceived bitterness are scored, and the average score per person is calculated to be effective for bitterness. Gender was evaluated. In this evaluation, it can be said that the lower the average score, the higher the effectiveness of bitterness and the higher the effect of preventing accidental ingestion of the film. The results are shown in Table 1. The description of "-" in the evaluation result column in Table 1 means that the item has not been evaluated.

(Scoring method)
(1) Perception of bitterness Feeling bitterness ... 1 point If anything, I feel bitterness ... 2 points I do not feel bitterness ... 3 points (2) Quality of bitterness Unpleasant ... 1 point Either Speaking of unpleasant ... 2 points Not particularly unpleasant ... 3 points

[Test Example 2]
(Internal haze, light transmittance)
The bitterness component-containing layer (film) of Example 1 obtained above and the PP (homo PP) film for comparison (thickness 300 μm) were prepared in accordance with JIS K 7136 using a haze measuring machine. The light transmittance and the internal haze were determined. The results are shown in Table 1.

As is clear from the above results, the multilayer films of Examples 1 to 3 had higher bitterness effectiveness than Comparative Example 1. In particular, the multilayer films of Examples 1 and 2 were remarkably highly effective in bitterness. On the other hand, the single-layer film of Comparative Example 1 had low bitterness effectiveness.

When Example 2 and Comparative Example 1 in which the content of denatonium benzoate is the same in the bitterness component-containing layer are compared, the reason why a large difference in the effectiveness of bitterness was observed is presumed as follows. That is, although the bitterness component-containing layer (film) in Comparative Example 1 directly touches the tongue, it also serves as a sealant layer and does not contain a water-soluble resin, so that denatonium benzoate is difficult to elute in the mouth. Therefore, from this bitterness component-containing layer, it is presumed that only denatonium benzoate present in the surface or shallow region directly in contact with the tongue is transferred to the mouth, and the amount of denatonium benzoate involved in perception is remarkably small. On the other hand, in the bitterness component-containing layer in Example 2, since the contained components are only denatonium benzoate and PVA which is a water-soluble resin, denatonium benzoate is extremely easily eluted in the mouth. Therefore, from this bitterness component-containing layer, not only denatonium benzoate present in the surface or shallow region directly in contact with the tongue, but also denatonium benzoate present in the deeper region is transferred to the mouth and benzoic acid involved in perception. It is estimated that the amount of denatonium is significantly high. It is presumed that such a difference in the amount of denatonium benzoate transferred from the bitterness component-containing layer to the mouth is linked to a large difference in the effectiveness of bitterness.

In addition, the bitterness component-containing layer in Example 1 had a small internal haze. This is because the content of denatonium benzoate in the bitterness component-containing layer is low, and the internal haze of the bitterness component-containing layer in Example 1 is the same as the internal haze of the comparative PP film containing no denatonium benzoate. It was about. Since denatonium benzoate causes an unpleasant bitterness to be perceived in a very small amount, even if the content in the bitterness component-containing layer is small as described above, it contributes to sufficiently exhibit the effect of the present invention and also contains the bitterness component. It contributes to keep the internal haze of the layer small, and also contributes to keep the internal haze of the multilayer film small.
Since the bitterness component-containing layer in Examples 2 to 3 has a lower content of denatonium benzoate than the bitterness component-containing layer in Example 1, these internal hazes are inside the bitterness component-containing layer in Example 1. It is presumed to be equal to or less than the haze.
The multilayer films of Examples 1 to 3 can form a package having high visibility of stored items.

INDUSTRIAL APPLICABILITY The present invention can be used for packaging used for storage of pharmaceutical products, dietary supplements, and the like.

1,2 ... Multilayer film 1c ... Protruding part of multilayer film 10 ... Package 10a ... Storage part of package 12 ... Bitter component-containing layer 11 ... Sealant layer 13 ... Adhesive layer 101 ・ ・ ・ Cover film

Claims (6)

It comprises a bitterness component-containing layer arranged so as to be one outermost layer, and a sealant layer arranged so as to be the other outermost layer.
The bitter component-containing layer comprises denatonium benzoate or a derivative thereof as bitter component, and Ri soluble der,
The internal haze of the bitterness component-containing layer is 30% or less, and the content is 30% or less.
A multilayer film having a thickness of the bitterness component-containing layer of 2 to 10 μm. The multilayer film according to claim 1 , wherein the total content of denatonium benzoate and its derivatives in the bitterness component-containing layer is 1.2% by mass or less. The multilayer film according to claim 1 or 2 , wherein the bitterness component-containing layer contains a water-soluble resin. The multilayer film according to any one of claims 1 to 3 , wherein the sealant layer contains one or more selected from the group consisting of polypropylene-based resin and polyethylene-based resin. A package including the multilayer film according to any one of claims 1 to 4.
The sealant layer of the multilayer film forms a storage portion for the object to be packaged.
A package in which the bitterness component-containing layer of the multilayer film is the outermost layer on the side opposite to the storage portion side of the package. A cover film is further provided on the sealant layer side of the multilayer film.
The multilayer film has a protruding portion protruding toward the bitterness component-containing layer in a part of the region thereof.
The storage portion is formed by the protrusion of the multilayer film and the cover film.
The package according to claim 5 , wherein the region other than the protruding portion of the multilayer film is adhered to the cover film.

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