JP6832616B2 - Liquid oral composition - Google Patents

Description

The present invention relates to a liquid oral composition in which the stability of allantoin and / or its derivative is improved, the storage stability is excellent, and the retention is improved while the stickiness in the oral cavity is suppressed.

Allantoin and its derivatives have anti-inflammatory action, cell activation action, hemostatic action, bactericidal action, anti-ulcer action and the like, and are used in oral compositions. However, it is known that allantoin and its derivatives are easily decomposed in the coexistence with water and have inferior storage stability when blended in a liquid oral composition (see, for example, Non-Patent Document 1).

Therefore, conventionally, various preparation techniques for improving the stability of allantoin and / or its derivatives have been studied in liquid oral compositions. For example, Patent Document 1 describes (A) isopropylmethylphenol, (B) allantin, (C) polyoxyethylene hydrogenated castor oil having an average addition molar number of 40 to 100 mol, and (D) citric acid. A liquid oral composition containing a predetermined amount of citric acid or an alkaline agent other than citrate, or a combination of citric acid and citric acid or an acid other than citric acid suppresses the hydrolysis of allantin. It is disclosed to get. Further, Patent Document 2 contains (A) allantin or a salt thereof, (B) lactic acid and an alkali metal salt thereof, and (C) a transparent liquid in which a predetermined amount of water is blended and the pH is adjusted to 4.5 to 6. It is disclosed that the oral composition can also suppress the hydrolysis of allantin. Further, conventionally, it is known that the decomposition of allantoin and its derivatives in the coexistence with water can be suppressed to some extent by blending a lower alcohol such as ethanol.

However, in the liquid oral composition, there are cases where the conventional formulation technology for stabilizing allantoin and / or its derivative cannot cope with the diversifying formulation of the liquid oral composition in recent years due to the limitation of the formulation. is there.

Further, in the liquid oral composition, it is important that the allantoin and / or its derivative has excellent retention in the oral cavity in order to effectively exert the medicinal effect. Conventionally, it is known that the retention of a liquid oral composition in the oral cavity can be improved by blending a thickener. However, the improvement of the retention property by blending the thickener is usually accompanied by stickiness, and therefore has a drawback that the usability is lowered.

Shinya Yamamoto et al., Stability of allantoin and identification of its degradation products, Pharmaceutical Journal, 113 (7), 515-524, 1993

Japanese Unexamined Patent Publication No. 2010-143889 Japanese Unexamined Patent Publication No. 2013-1651

An object of the present invention is to provide a formulation technique that enables stabilization of allantoin and / or a derivative thereof, suppression of stickiness in the oral cavity, and improvement of retention in a liquid oral composition.

As a result of diligent studies to solve the above problems, the present inventor has found that the liquid oral composition containing polyvinylpyrrolidone together with allantoin and / or its derivative and water has the stability of allantoin and / or its derivative. Has been improved, and it has been found that it can have excellent storage stability. Furthermore, it has also been found that the liquid oral composition has improved retention and can have an excellent usability while suppressing stickiness in the oral cavity. The present invention has been completed by further studies based on these findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. It is characterized by containing (A) at least one selected from the group consisting of allantoin and its derivatives, (B) at least one selected from the group consisting of polyvinylpyrrolidone and its derivatives, and (C) water. , Liquid oral composition.
Item 2. Item 2. The liquid oral composition according to Item 1, which has a pH of 4 to 6.
Item 3. Item 2. The liquid oral composition according to Item 1 or 2, wherein the component (B) has a weight average molecular weight of 50 to 3 million.
Item 4. Item 2. The liquid oral composition according to any one of Items 1 to 3, wherein the content of the component (B) is 0.1 to 20% by weight.
Item 5. Item 2. The liquid oral composition according to any one of Items 1 to 4, wherein the content of the component (A) is 0.001 to 1% by weight.
Item 6. The liquid oral composition according to any one of claims 1 to 5, further comprising at least one selected from the group consisting of citric acid and salts thereof.
Item 7. Item 8. The liquid oral composition according to any one of Items 1 to 6, which is a liquid dentifrice.
Item 8. At least one selected from the group consisting of (A) allantoin and its derivatives, and (C) at least one selected from the group consisting of polyvinylpyrrolidone and its derivatives in a liquid oral composition containing water. A method for stabilizing allantoin and / or a derivative thereof in the liquid oral composition, which comprises blending seeds.
Item 9. At least one selected from the group consisting of (A) allantoin and its derivatives, and (C) at least one selected from the group consisting of polyvinylpyrrolidone and its derivatives in a liquid oral composition containing water. A method for improving the retention of the liquid oral composition in the oral cavity, which comprises blending seeds.

The liquid oral composition of the present invention has improved stability of allantoin and / or its derivative, suppresses a decrease in the content of allantoin and / or its derivative even after long-term storage, and has a good appearance. The properties can be maintained. In particular, the liquid oral composition of the present invention can stabilize allantoin and / or its derivative without blending a monohydric lower alcohol such as ethanol, so that there are few restrictions on formulation. It is also possible to avoid irritation of monovalent lower alcohol and formulate a formulation suitable for use by people with alcohol hypersensitivity.

In addition, the liquid oral composition of the present invention can improve the retention while suppressing stickiness in the oral cavity, so that a good usability can be obtained.

1. 1. Liquid Oral Composition The liquid oral composition of the present invention is derived from at least one selected from the group consisting of allantoin and its derivatives (hereinafter, may be referred to as component (A)), polyvinylpyrrolidone and its derivatives. It is characterized by containing at least one selected from the group (hereinafter, may be referred to as component (B)) and water (hereinafter, may be referred to as component (C)). Hereinafter, the liquid oral composition of the present invention will be described in detail.

Component (A) The liquid oral composition of the present invention contains at least one selected from the group consisting of allantoin and its derivatives as the component (A). Allantoin and / or its derivative has a drawback of being inferior in stability, but according to the present invention, by blending the component (B) described later, allantoin and / or its derivative is stable in the presence of water. It is possible to improve the retention while suppressing stickiness in the oral cavity while improving the sexuality.

Allantoin is a compound also called 5-ureidohydantoin, and is a known drug known to have anti-inflammatory action, cell activating action, hemostatic action, bactericidal action, anti-ulcer action and the like.

The derivative of allantoin is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include allantoin chlorohydroxyaluminum and allantoinhydroxyaluminum. These allantoin derivatives may be used alone or in combination of two or more.

In the liquid oral composition of the present invention, as the component (A), one kind may be selected and used from allantoin and its derivatives, or two or more kinds may be used in combination. Among these components (A), allantoin is preferably mentioned from the viewpoint of improving stability even more effectively.

In the liquid oral composition of the present invention, the content of the component (A) may be appropriately set according to the medicinal effect to be provided in the liquid oral composition, the formulation form of the liquid oral composition, and the like. However, for example, 0.001 to 1% by weight, preferably 0.005 to 0.8% by weight, and more preferably 0.01 to 0.5% by weight can be mentioned.

(B) Component The liquid oral composition of the present invention contains at least one selected from the group consisting of polyvinylpyrrolidone and its derivatives as the component (B). In the liquid oral composition of the present invention, polyvinylpyrrolidone and / or its derivative contributes to the improvement of the stability of allantoin and / or its derivative in the presence of water, and stays while suppressing stickiness in the oral cavity. It also plays a role in improving sex.

Polyvinylpyrrolidone is a water-soluble polymer compound in which N-vinyl-2-pyrrolidone is polymerized.

Derivatives of polyvinylpyrrolidone are not particularly limited as long as they are water-soluble and pharmaceutically acceptable, and examples thereof include copolymers containing N-vinyl-2-pyrrolidone as a constituent monomer. Specific examples of the derivative of polyvinylpyrrolidone include a copolymer of N-vinyl-2-pyrrolidone and a vinyl monomer having a vinyl group copolymerizable with N-vinyl-2-pyrrolidone.

In the polyvinylpyrrolidone derivative, examples of the vinyl monomer copolymerized with vinylpyrrolidone include ethylenically unsaturated carboxylic acids such as acrylic acid and methacrylic acid and salts thereof. In the derivative of polyvinylpyrrolidone, these vinyl monomers may be used alone or in combination of two or more.

These polyvinylpyrrolidone derivatives may be used alone or in combination of two or more.

In the liquid oral composition of the present invention, as the component (B), one kind may be selected and used from polyvinylpyrrolidone and its derivatives, or two or more kinds may be used in combination. Among these components (B), polyvinylpyrrolidone is preferably mentioned from the viewpoint of more effectively improving the stability of allantoin and / or its derivative, suppressing stickiness, and improving the retention.

The weight molecular weight of polyvinylpyrrolidone and / or its derivative is not particularly limited, but is preferable from the viewpoint of more effectively improving the stability of allantoin and / or its derivative, suppressing stickiness, and improving retention. Is 50 to 3 million, more preferably 40,000 to 3 million. Here, the weight average molecular weight of polyvinylpyrrolidone and / or a derivative thereof refers to a value measured by gel filtration chromatography / multi-angle light scattering photometer (GPC / MALLS).

In the liquid oral composition of the present invention, the content of the component (B) may be appropriately set according to the formulation form of the liquid oral composition, and for example, 0.1 to 20% by weight. Can be mentioned. In particular, from the viewpoint of more effectively improving the stability of allantoin and / or its derivative, suppressing stickiness, and improving retention, the content of the component (B) is preferably 0.15 to 20 weight by weight. %, More preferably 0.15 to 5% by weight.

Further, in the liquid oral composition of the present invention, the ratio of the component (B) to the component (A) should be within the range of the contents of the components (A) and (B) described above. Specifically, the component (B) is usually 0.1 to 20000 parts by weight, preferably 0.18 to 1000 parts by weight, and more preferably 0.3 to 500 parts by weight per 1 part by weight of the component (A). The weight part is mentioned.

(C) component The liquid oral composition of the present invention contains water as the (C) component. Allantoin and / or its derivatives tend to be less stable in the coexistence with water, but according to the liquid oral composition of the present invention, allantoin and / or its derivatives are caused in the coexistence with water. It is possible to effectively suppress the decrease in stability of.

In the liquid oral composition of the present invention, the water content is appropriately set according to the formulation form and the like, and is, for example, 50 to 99.3% by weight, preferably 51 to 99.3% by weight. More preferably, 51 to 99% by weight is mentioned.

Monovalent lower alcohol The liquid oral composition of the present invention may contain a monohydric lower alcohol, if necessary, in addition to the components (A) to (C). Specific examples of such monohydric lower alcohols include monohydric alcohols having 1 to 6 carbon atoms such as ethanol, propanol, butanol, pentanol, hexanol, and isopropanol. These monohydric lower alcohols may be used alone or in combination of two or more.

Monovalent lower alcohol can contribute to the stabilization of allantoin and / or its derivatives in the presence of water, but is contraindicated for people with alcohol hypersensitivity, which causes irritation in the oral cavity. There are drawbacks such as. On the other hand, according to the liquid oral composition of the present invention, even if the amount of monohydric lower alcohol is small or not contained, the allantoin and allantoin in the presence of water are produced by the component (B). / Or the derivative thereof can be stabilized, so that the above-mentioned drawbacks of the monohydric lower alcohol can be reduced or eliminated. In view of such effects of the present invention, the content of the monohydric lower alcohol in the liquid oral composition of the present invention is preferably less than 10% by weight, more preferably less than 5% by weight, and more preferably 1% by weight. %, In particular, it is most preferable that the monohydric lower alcohol is substantially not contained. Here, the fact that the monohydric lower alcohol is substantially not contained means that the monohydric lower alcohol is not blended except for a trace amount of the monohydric lower alcohol that is inevitably mixed. Specifically, it means that the monohydric lower alcohol is less than 0.1% by weight.

Citric acid and / or a salt thereof Further, the liquid oral composition of the present invention may contain citric acid and / or a salt thereof in addition to the above-mentioned components. The inclusion of citric acid and / or a salt thereof makes it possible to enhance the stabilizing effect of allantoin and / or its derivative in the presence of water.

The salt of citric acid used in the present invention is not particularly limited as long as it is pharmaceutically acceptable, but alkali metal salts such as sodium salt and potassium salt; alkaline earth such as calcium salt and magnesium salt. Examples include metal salts; aluminum salts; ammonium salts and the like. These citric acid salts may be used alone or in combination of two or more.

Among citric acid and its salts, preferably citric acid and its salts, more preferably citric acid, citric acid, from the viewpoint of enhancing the stabilizing effect of allantin and / or its derivatives in the presence of water more effectively. Examples include sodium citrate.

The content of citric acid and / or a salt thereof in the liquid oral composition of the present invention is not particularly limited, but is, for example, 0.05 to 2.0% by weight, preferably 0.1 to 1.8% by weight. %, More preferably 0.1 to 1.5% by weight.

Further, in the liquid oral composition of the present invention, the ratio of citric acid and / or its salt to the component (A) is within the range of the contents of the above-mentioned component (A) and citric acid and / or its salt. However, specifically, citric acid and / or a salt thereof is usually 0.005 to 2000 parts by weight, preferably 0.125 to 360 parts by weight per 1 part by weight of the component (A). Parts, more preferably 0.125 to 300 parts by weight.

Other Ingredients In addition to the above-mentioned ingredients, the liquid oral composition of the present invention contains ingredients usually used in the art, depending on the formulation form of the oral composition, as long as the effects of the present invention are not impaired. It may be contained. Such ingredients include, for example, preservatives, bactericides, antibacterial agents, anti-inflammatory agents, glucosyl transferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar preventives, dentin strengthening / remineralizing agents. , Thickeners, wetting agents, excipients, fragrances, sweeteners, cooling agents, pigments, deodorants, surfactants, pH adjusters and the like.

Examples of preservatives, bactericides, and antibacterial agents include hinokithiol, benzoic acids, salicylic acids, sorbic acids, parabens, decalinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine chloride, chlorhexidine gluconate, isopropylmethylphenol, and triclosan. , Cetylpyridinium chloride, lysoteam chloride, chlorhexidine hydrochloride, potassium iodide and the like.

Examples of the anti-inflammatory agent include tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamins and the like.

Examples of GTase inhibitors include extracts of evening primrose plants of the family Evening Primrose, extracts of grapevine plants of the family Grapes, dextranase, mutanase, tastain, tannins, ellagic acid, polyphenols, oolong tea extract, green tea extract, etc. Examples include senburi, evening primrose, tannin, citrus, gentiana, senso, dragon and yellow primrose.

Examples of the plaque inhibitor include zinc citrate and gluconic acid.

Examples of the hypersensitivity inhibitor include potassium nitrate, strontium chloride and the like.

Examples of the tartar preventive agent include polyphosphates, zeolites, ethane hydroxydiphosphonates and the like.

Examples of the dentin strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate, stannous fluoride and the like.

Examples of the thickener include polysaccharides such as purulan, purulan derivatives, and starch; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, and carboxymethyl cellulose salts (sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, etc.). , Methyl cellulose, ethyl cellulose, polyacrylic acid, polyacrylic acid salt (sodium polyacrylate, acrylate / acrylate octyl ester copolymer, etc.), copolymer of methacrylic acids (methacrylic acid and n-butyl acrylate) Polymers, polymers of methacrylic acid and methyl methacrylicate, polymers of methacrylic acid and ethyl acrylate, etc.) and other cellulose-based polymer substances; synthetic polymer substances such as carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, etc. Lectin, alginic acid, alginate (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, triisopropanolamine alginate, ammonium alginate, butylamine alginate, diamylamine alginate, etc.), sodium chondroitin sulfate, agar, chitosan , Natural polymer substances such as carrageenan; amino acid polymer substances such as collagen and gelatin; rubber polymer substances such as Arabic gum, Karaya gum, tragacanth gum, xanthan gum, locust bean gum, gua gum, tamarind gum, gellan gum, etc. Be done.

Examples of the wetting agent include glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, and erythritol.

Examples of the excipient include lactose, sucrose, mannitol, starch, dextrin, crystalline cellulose, silica (light anhydrous silicic acid, etc.) and the like.

Examples of the fragrance include natural fragrances (fennel oil and the like), synthetic fragrances, and blended fragrances thereof.

Examples of the sweetener include sodium saccharin, stebioside, stevia extract, aspartame, xylitol, candy, honey, sorbitol, maltitol, mannitol, erythritol, sugars (lactose, sucrose, fructose, glucose, etc.).

Examples of the refreshing agent include menthol, menthone, camphor, borneol, geraniol, and essential oils containing these.

Examples of the pigment include natural pigments, synthetic pigments, and mixtures thereof.

Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract and the like.

Examples of the surfactant include polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristolyl sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride. Anionic surfactants such as sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutarmate, sodium N-methyl-N-acyl taurine; polyoxyethylene hydrogenated castor oil, sho Sugar fatty acid ester, maltose fatty acid ester, maltol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan monostearate, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene poly Nonionic surfactants such as oxypropylene fatty acid ester and polyglycerin fatty acid ester; coconut oil fatty acid amide propyl betaine, lauryl dimethylamino acetate betaine, lauryl dimethyl amine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole Amphoteric surfactants such as lumbetaine, N-lauryl diaminoethyl glycine, N-myristyl diaminoethyl glycine, N-alkyl-1-hydroxyethyl imidazoline betaine sodium; lauryl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzethonium chloride, benza chloride Examples thereof include cationic surfactants such as luconium and stearyldimethylbenzylammonium chloride.

Examples of the pH adjuster include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, and phosphorus. Examples thereof include sodium hydrogen acid.

pH and Viscosity The viscosity of the liquid oral composition of the present invention is not particularly limited, and examples thereof include 5 to 100 mPa · S as the viscosity at 25 ° C. From the viewpoint of more effectively suppressing stickiness and improving retention, the viscosity of the liquid oral composition of the present invention at 25 ° C. is preferably 7 to 70 mPa · S, more preferably 18 to 40 mPa · S. Be done. Here, the viscosity at 25 ° C. means the viscosity at 25 ° C. measured by a B-type rotational viscometer (spindle: LV spindle No. 2, rotation speed 60 rpm).

The liquid oral composition of the present invention may be provided with the viscosity by blending the component (B) in the above-mentioned content, but in order to adjust the viscosity, the component (B) is required. In addition to this, the pressure-sensitive adhesive and the viscous agent may be appropriately added.

Further, the pH of the liquid oral composition of the present invention may be appropriately set within a range where application to the oral cavity is permitted, but from the viewpoint of further improving the stability of allantoin and / or its derivative. , Usually 4 to 6, preferably 4 to 5.6, and more preferably 4 to 5.3. Here, the pH is a value measured under a temperature condition of 25 ° C.

The pH of the liquid oral composition of the present invention can be adjusted by adding the above-mentioned pH adjuster.

Formulation form The formulation form of the liquid oral composition of the present invention is not limited as long as it is liquid and can be applied to the oral cavity and stay in the oral cavity for a certain period of time. For example, a liquid dentifrice or a liquid dentifrice. , Mouthwash (liquid dentifrice, mouthwash may be generally called mouth rinse, mouth wash, dental rinse, etc.), oral hygiene agent such as mouth refreshing agent (mouth spray, etc.). Among these, a liquid dentifrice, a liquid dentifrice, and a mouthwash are preferable, and a liquid dentifrice and a mouthwash are more preferable.

2. 2. Stabilizing method and stabilizer of allantoin and / or its derivative As described above, by blending polyvinylpyrrolidone and / or its derivative in a liquid oral composition containing allantoin and / or its derivative and water. , Allantoin and / or its derivative in the liquid oral composition can be stabilized and storage stability can be improved.

Therefore, the present invention further comprises (B) polyvinylpyrrolidone and its derivatives in a liquid oral composition containing (A) at least one selected from the group consisting of allantoin and its derivatives, and (C) water. Provided is a method (stabilization method) for stabilizing allantoin and / or a derivative thereof in the liquid oral composition, which comprises blending at least one selected from the above group.

Further, the present invention is intended to stabilize allantoin and / or its derivative in a liquid oral composition containing (A) at least one selected from the group consisting of allantoin and its derivative, and (C) water. Provided is a stabilizer used in (B), which comprises at least one selected from the group consisting of polyvinylpyrrolidone and its derivatives as an active ingredient.

The type and amount of the components used in the stabilizing method and stabilizer of the present invention, the liquid oral composition to be applied, and the like are as described in "1. Liquid oral composition" above. ..

3. 3. A method for improving the retention of a liquid oral composition in the oral cavity and an agent for improving the retention in the oral cavity As described above, polyvinylpyrrolidone and / or a liquid oral composition containing allantin and / or a derivative thereof and water. By blending the derivative, the retention of the liquid oral composition in the oral cavity can be improved.

Therefore, the present invention further comprises (B) polyvinylpyrrolidone and its derivatives in a liquid oral composition containing (A) at least one selected from the group consisting of allantoin and its derivatives, and (C) water. Provided is a method for improving the retention of the liquid oral composition in the oral cavity (method for improving retention), which comprises blending at least one selected from the above group.

The present invention is also used to improve the retention of a liquid oral composition containing (A) at least one selected from the group consisting of allantin and its derivatives, and (C) water in the oral cavity. Provided is an oral retention improver, which comprises at least one selected from the group consisting of (B) polyvinylpyrrolidone and its derivatives as an active ingredient.

The type and amount of the component used in the retention improving method and the oral retention improving agent of the present invention, the liquid oral composition to be applied, and the like are described in the above "1. Liquid oral composition". It is a street.

Hereinafter, the present invention will be described in detail based on Examples and the like, but the present invention is not limited thereto.

Test example
1. 1. Test method Liquid dentifrices (Examples 1 to 16 and Comparative Examples 1 to 7) having the compositions shown in Tables 1 and 2 were prepared, and the pH, viscosity, and usability (retention in the oral cavity and oral retention and oral stability) were prepared by the methods shown below. The stability and appearance of allantoin after storage were evaluated.

1-1. Measurement of pH The pH of each liquid dentifrice at 25 ° C. was measured using a pH meter (model: F-53, manufactured by HORIBA, Ltd.).

1-2. Viscosity measurement The viscosity of each liquid dentifrice was measured using a B-type rotational viscometer (model: LVT, manufactured by Brookfield) under the following conditions.
Spindle: LV Spindle No. 2
Rotation speed: 60 rpm
LV spindle filter: 5
Measurement time: 30 seconds after the start of rotation Measurement temperature: 25 ° C

1-3. Evaluation of usability (retention and stickiness in the oral cavity) After containing 10 ml of each liquid dentifrice in the mouth and rinsing the mouth for 30 seconds, the retention and stickiness in the oral cavity were evaluated by the following method. .. This test was conducted by 5 panelists.
(Staying in the oral cavity)
The retention in the oral cavity was scored according to the following criteria.
Judgment criteria 3 points: After discharging the liquid dentifrice, the residual property of the liquid dentifrice is sufficiently felt.
2 points: After discharging the liquid dentifrice, the residual liquid dentifrice is felt.
1 point: After discharging the liquid dentifrice, the residual liquid dentifrice is slightly felt.
0 point: No residual liquid dentifrice is felt after discharging the liquid dentifrice.

Next, for each liquid dentifrice, the total score of the scores by the five panelists was calculated, and the retention in the oral cavity was evaluated according to the following evaluation classification.
Evaluation classification ◎: Total score is 12 to 15 points ○: Total score is 9 to 11 points △: Total score is 6 to 8 points ×: Total score is 0 to 5 points

(Sticky)
After the liquid dentifrice was discharged, "feeling stickiness in the oral cavity" was given as 0 point, and "not feeling sticky in the oral cavity" was given as 10 points, which were scored by the VAS (visual analog scale) method. Next, for each mouthwash, the average value of the scores by the five panelists was calculated, and the stickiness was evaluated according to the following evaluation classification.
Evaluation classification ◎: Average score is 9 to 10 points ○: Average score is 7 to 8 points △: Average score is 3 to 6 points ×: Average score is 0 to 2 points

1-5. Evaluation of stability and appearance of allantoin after storage 60 ml of each liquid dentifrice was filled in a glass container containing 80 ml, covered and sealed, and stored in a dark place at 60 ° C. for 2 weeks.

The content of allantoin contained in each liquid dentifrice before and after storage was measured by high performance liquid chromatography, and the stability of allantoin was evaluated according to the following evaluation classification, assuming that the content of allantoin before storage was 100%.
Evaluation classification ⊚: Allantoin remaining after storage is 95% or more.
◯: Allantoin remaining after storage is 91% or more and less than 95%.
Δ: The amount of allantoin remaining after storage is 90% or more and less than 91%.
X: The amount of allantoin remaining after storage is 88% or more and less than 90%.
XX: The amount of allantoin remaining after storage is less than 88.

In addition, the appearance of each liquid dentifrice after storage was observed, and the appearance properties were evaluated according to the following evaluation classification.
Evaluation classification ⊚: It is clear with no precipitation or turbidity of the components.
Δ: Slight precipitation and turbidity of the components are observed.
X: Precipitation and turbidity of the components are clearly observed.

2. 2. Test Results The results obtained are shown in Tables 1 and 2. As is clear from Table 1, in the liquid dentifrice containing allantoin, polyvinylpyrrolidone, and water, allantoin was stably maintained and had good appearance properties even after storage at 60 ° C. for 2 weeks (Example). 1 to 15). In particular, when allantoin, polyvinylpyrrolidone, and water were contained, allantoin could be stabilized even if ethanol was not contained.

On the other hand, when a thickener other than polyvinylpyrrolidone was contained, allantoin decomposed over time, resulting in less than 90% of the initial composition, and the composition was no longer capable of exhibiting sufficient effectiveness. (Comparative Examples 1 to 6). Further, in Comparative Examples 1 to 6, the appearance properties could not be kept stable, and the retention in the oral cavity and the stickiness were not satisfied by the user.

Production example: Liquid dentifrice (mouthwash)
Liquid dentifrices (mouthwashes) having the compositions shown in Tables 3 to 5 were prepared. For each of the obtained liquid dentifrices (mouthwash), the feeling of use (retention in the oral cavity, stickiness), stability and appearance of allantoin after storage at 60 ° C for 2 weeks were carried out in the same manner as in the above test example. As a result of evaluation, all were good.

Claims (8)

(A) allantoin, allantoin aluminum chlorohydrate, and / or allantoin hydroxy aluminum, (B) polyvinylpyrrolidone down, (C) water, and at least one selected from (D) citric acid, and the group consisting of a salt thereof Liquid oral composition characterized by containing seeds (however, PEG-40 allantoin castor oil (hydrolyzed), chamomile extract, tokinsenka, citrus extract, stevia extract, colloidal silver, eucalyptus leaf, Except when containing hacka extract, menthol, methylparaben, iron oxide, acid red 14, blue 2 and brilliant black 1) . The liquid oral composition according to claim 1, which has a pH of 4 to 6. The liquid oral composition according to claim 1 or 2, wherein the component (B) has a weight average molecular weight of 50 to 3 million. The liquid oral composition according to any one of claims 1 to 3, wherein the content of the component (B) is 0.1 to 20% by weight. The liquid oral composition according to any one of claims 1 to 4, wherein the content of the component (A) is 0.001 to 1% by weight. The liquid oral composition according to any one of claims 1 to 5, which is a liquid dentifrice. Liquid oral composition containing at least one selected from the group consisting of (A) allantoin , allantoin chlorohydroxyaluminum, and / or allantoin hydroxyaluminum , (C) water, and (D) citric acid, and salts thereof. (However, PEG-40 allantoin oil (hydrolyzed), chamomile extract, tokinsenka, sardine extract, stevia extract, colloidal silver, eucalyptus leaf, peppermint extract, menthol, methylparaben, iron oxide, acid red 14, the excluded) where containing blue 2 and Brilliant black 1, (B), characterized in that blending polyvinylpyrrolidone down, allantoin of the liquid oral composition, allantoin aluminum chlorohydrate, and / or allantoin A method of stabilizing hydroxyaluminum. Liquid oral composition containing at least one selected from the group consisting of (A) allantoin , allantoin chlorohydroxyaluminum, and / or allantoin hydroxyaluminum , (C) water, and (D) citric acid, and salts thereof. (However, PEG-40 hydrogenated castor oil (hydrolyzed), chamomile extract, tokinsenka, citrus extract, stevia extract, colloidal silver, eucalyptus leaf, peppermint extract, menthol, methylparaben, iron oxide, acid red 14, in except when containing blue 2 and Brilliant black 1), (B), characterized in that blending polyvinylpyrrolidone down, a method for improving the retention in the oral cavity of the liquid oral composition.