JP6617535B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition that contains an α-olefin sulfonate, has an excellent oral biofilm removal effect, suppresses the bitter taste of the α-olefin sulfonate, and has excellent appearance stability over time.

  Generally, it is known that the caries biofilm in the oral cavity is an aggregate of bacteria. Therefore, in order to remove the caries biofilm, it is important to disperse bacterial aggregates.

  So far, the applicant has blended the α-olefin sulfonate among the anionic surfactants in combination with the condensed phosphate and the amphoteric surfactant, so that the oral biofilm removal effect is excellent and the bitterness is excellent. The composition for oral cavity which is suppressed and has a good feeling of use was proposed (Patent Document 1; International Publication No. 2015/008823). Moreover, the composition for oral cavity in which the oral biofilm removal effect was excellent by using an acylamino acid salt and / or arginine in combination with the α-olefin sulfonate, and the bitterness derived from the α-olefin sulfonate was also suppressed ( Patent Document 2; JP 2013-151474 A).

International Publication No. 2015/008823 JP 2013-151474 A

  However, in the dentifrice composition containing the α-olefin sulfonate, when the arginine is added, the bitterness derived from the α-olefin sulfonate can be suppressed, while liquid separation occurs over time. It was found that there was a problem with appearance stability.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that contains an α-olefin sulfonate, has a suppressed bitter taste, and has excellent appearance stability over time.

  As a result of intensive studies to achieve the above object, the inventors of the present invention combine (A) α-olefin sulfonate and (B) alanine and / or lysine in the dentifrice composition. As a result, it was found that the bitter taste of the component (A) was suppressed and the appearance stability of the preparation was excellent over time, and the present invention was made.

In the present invention, the above-mentioned problem relating to the bitterness control of the dentifrice composition containing the component (A) is specifically achieved by the component (B), and the bitterness of the component (A) is hardly felt. It provides a feeling of use, and can provide excellent appearance stability that prevents the occurrence of liquid separation or the like even when stored at 50 ° C. for 3 months.
More specifically, in Patent Document 2 proposed by the applicant as described above, bitterness is suppressed by blending an α-olefin sulfonate and arginine into the oral composition. As a result of investigations on this technology, when an amino acid arginine is added to a dentifrice composition containing an α-olefin sulfonate, it is liquid-separated particularly in a dentifrice composition after storage over a long period of time. It has been found that a problem arises that the appearance of the preparation cannot be stably maintained. Therefore, as a result of further investigation, when the alanine and / or lysine of the component (B) is used as the amino acid, the formulation appearance can be stabilized unexpectedly over time and the bitter taste of the component (A) can be suppressed. The effect was able to be given.
In Comparative Example 11 described in Patent Literature 2, sodium lauryl sulfoacetate and lysine are blended in the mouthwash, but the bitterness is not suppressed, and Patent Literature 2 refers to the appearance of the preparation over time. Nor. From patent document 2, the bitterness suppression of (A) component by (B) component and the improvement of external appearance stability cannot be estimated.

Therefore, the present invention
[1]
(A) an α-olefin sulfonate having 14 to 16 carbon atoms ;
(B) toothpaste composition characterized by containing alanine and <br/>,
[2]
(A) an α-olefin sulfonate having 14 to 16 carbon atoms;
(B) with lysine
A toothpaste composition characterized by comprising the following.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition which contains alpha-olefin sulfonate, the bitterness of alpha-olefin sulfonate is suppressed, and the external appearance stability is excellent also with time can be provided.

  The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) an α-olefin sulfonate and (B) alanine and / or lysine, and can be particularly suitably prepared as a toothpaste.

  (A) As α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably α-olefin sulfonic acid having 14 carbon atoms. Salts, especially sodium salts (generic name; sodium tetradecenesulfonate). Commercially available products that can be used for oral preparations can be obtained. For example, “K Lipolane PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used. By selecting α-olefin sulfonate as a surfactant, an oral biofilm removal effect can be obtained.

  (A) As for the compounding quantity of the alpha olefin sulfonate of a component, 0.04-1.5% (mass%, the following is similar) of the whole composition is preferable, More preferably, it is 0.1-1.5%. More preferably, it is 0.1 to 1%. The greater the amount, the greater the biofilm removal effect, but the bitterness becomes stronger, and if it is 1.5% or less, the bitterness can be sufficiently suppressed.

Component (B) is the amino acid alanine and / or lysine, preferably alanine. When alanine is used, the occurrence of liquid separation is prevented and the appearance stability is further improved.
Commercially available products can be used for alanine and lysine, such as L-lysine hydrochloride and DL-alanine (both manufactured by Ajinomoto Co., Inc.).

  The amount of component (B) is preferably 0.04 to 0.6%, more preferably 0.1 to 0.5% of the entire composition. When the blending amount is within the above range, the bitterness derived from the component (A) can be satisfactorily suppressed and the appearance stability over time can be sufficiently maintained. When it is 0.04% or more, bitterness can be sufficiently suppressed, and appearance stability (liquid separation) can be sufficiently maintained. The content of 0.6% or less is preferable because discoloration can be prevented in addition to liquid separation.

  Furthermore, in the present invention, (A) / (B) indicating the blending ratio of the component (A) and the component (B) is preferably 0.1 to 10, more preferably 0.3. -10, more preferably 0.3-4. When the mass ratio of (A) / (B) is within the above range, the bitterness is further suppressed, and the stability of the appearance of the preparation (liquid separation) after long-term storage is more excellent. If it is less than 0.1, the appearance of the preparation after long-term storage may be deteriorated, and if it exceeds 10, strong bitterness may be exhibited.

  The dentifrice composition of the present invention can be prepared in the form of a liquid, liquid, paste or the like as a toothpaste, a liquid dentifrice, a liquid dentifrice, a moisturizing dentifrice or the like, particularly as a toothpaste. In this case, in addition to the above components, other optional components according to the dosage form and the like can be appropriately blended within a range not impeding the effects of the present invention. Specifically for toothpastes, abrasives, binders, thickeners, (A) surfactants other than α-olefin sulfonates, and if necessary, sweeteners, preservatives, pigments, fragrances, various active ingredients Etc. may be blended.

As the abrasive, silica-based abrasive such as crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, Examples thereof include aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, and synthetic resin-based abrasive.
The blending amount of the abrasive is usually 5 to 70%, particularly 10 to 50% of the whole composition.

  Examples of the binder include gums such as xanthan gum, cellulose derivatives such as sodium carboxymethyl cellulose, linear sulfur-containing polysaccharides such as carrageenan, and superabsorbent polymer substances such as sodium polyacrylate. From the viewpoint of improving liquid separation, gums such as xanthan gum are particularly suitable. The compounding amount of the binder is usually 0 to 10%, particularly 0.1 to 5% of the whole composition.

  Examples of the thickener include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as propylene glycol, butylene glycol, glycerin and polyethylene glycol. The blending amount of the thickening agent is usually 0 to 70%, particularly 3 to 50% of the whole composition.

Non-ionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, alkylolamide, etc. Surfactants, and polyoxyethylene hydrogenated castor oil is particularly preferable. When mix | blending a nonionic surfactant, the compounding quantity has the preferable range of 0.1 to 5%.
In addition, an anionic surfactant other than the α-olefin sulfonate may not be added, and the blending amount may be 0%. However, as long as the effect of the present invention is not hindered, alkyl sulfates, sulfates of glycerin fatty acid esters, etc. An anionic surfactant may be added in an amount of 10%, particularly 5% or less, particularly 1% or less to enhance foamability.
The total blending amount of the surfactant with respect to the entire composition is 0.04 to 10%, particularly 0.1 to 5% including the component (A).

Examples of the sweetening agent include saccharin sodium. Examples of the preservative include benzoates such as sodium benzoate, and paraoxybenzoates such as methyl paraben, ethyl paraben, and butyl paraben.
Examples of the dye include edible dyes such as brilliant blue and tartrazine, and pigments such as titanium oxide.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and l-mentor , Carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentane -3-Carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone , Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethanol Toothpaste compositions such as single-flavored ingredients such as luthioacetate, and strawberry flavors, apple flavors, banana flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, tropical fruit flavors, etc. It can be used in combination with known perfume materials used in the above. Moreover, although a compounding quantity is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a composition. It is preferable to use 0.1 to 2% of the fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material in a composition.

  Examples of active ingredients (medicinal ingredients) include bactericidal or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, zinc gluconate and zinc citrate, ethane hydroxydiphospho Calculus preventive agent such as nate, tranexamic acid, glycyrrhizic acid and salts thereof, anti-inflammatory agent such as allantochlorohydroxyaluminum, coating agent such as hydroxyethylcellulose dimethyldiallylammonium chloride, enzyme agent such as dextranase, mutanase, lysozyme chloride, Vitamins such as ascorbic acid and tocopherol acetate, astringents such as sodium chloride, hypersensitivity inhibitors such as aluminum lactate, strontium chloride and potassium nitrate, sodium fluoride, Sodium fluorophosphate, and fluoride such as stannous fluoride, can be used in pharmaceutically acceptable range.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in the table.

<Evaluation method for bitterness>
The lack of bitterness of the dentifrice composition was sensory evaluated by the following method.
1 g of the dentifrice composition was placed on a toothbrush and brushed for 3 minutes, and then judged according to the following criteria. The average value of five evaluators was obtained, and the lack of bitterness was evaluated based on the following evaluation criteria.
Evaluation criteria 5: Feel no bitterness 4: Feel almost no bitterness 3: Feel a little bitterness 2: Feel bitterness 1: Feel a strong bitterness Evaluation standard ◎: Average value is 4 or more and 5 or less ○: Average value is 3 or more and less than 4 points Δ: Average value is 2 or more and less than 3 points ×: Average value is 1 or more and less than 2 points

<Appearance stability evaluation method>
The prepared dentifrice composition was filled in a laminate tube, and five of each were stored at 50 ° C. for 3 months. Thereafter, the dentifrice composition returned to room temperature was extruded onto a straw half paper, and the state of liquid separation was determined based on the following criteria. Five average values were obtained and appearance stability was evaluated based on the following evaluation criteria.
Rating criteria 5: Liquid separation is not observed, or liquid separation of less than 0.5 cm ² is observed 4: Liquid separation of 0.5 cm ² or more and less than 1.5 cm ² is observed 3: 1.5 cm ² or more Liquid separation of less than 5 cm ² is observed 2: Liquid separation of 2.5 cm ² or more and less than 3.5 cm ² is observed 1: Liquid separation of 3.5 cm ² or more is observed Evaluation Criteria A: Average value is 4 or more 5 points or less ○: Average value is 3 or more and less than 4 points ×: Average value is less than 3 points

Details of the raw materials used are shown below.
(A) Sodium tetradecene sulfonate; manufactured by Lion Specialty Chemicals Co., Ltd., trade name K Lipolane PJ-400CJ
(B) Alanine; DL-alanine, manufactured by Ajinomoto Co., Inc. (B) lysine; L-lysine hydrochloride, manufactured by Ajinomoto Co., Inc.

  As shown in Tables 1 and 2, in Examples having the configuration of the present invention, the bitterness due to sodium tetradecenesulfonate was suppressed, and the appearance stability was excellent. Moreover, the oral biofilm removal effect was also favorable. Furthermore, in the Example which used alanine as (B) component, the discoloration with time was also prevented and the formulation external appearance became more stable. On the other hand, as shown in Table 3, when arginine was used in combination with sodium tetradecenesulfonate, the bitter taste of sodium tetradecenesulfonate was suppressed, but the appearance stability deteriorated.

Claims (6)

(A) an α-olefin sulfonate having 14 to 16 carbon atoms ;
(B) toothpaste composition characterized by containing alanine and <br/>. (A) an α-olefin sulfonate having 14 to 16 carbon atoms;
(B) with lysine
A toothpaste composition comprising: (A) / (B) is from 0.1 to 10 as a mass ratio claim 1 or 2 toothpaste composition. (A) component from 0.04 to 1.5 mass%, (B) a component containing 0.04 to 0.6 wt% claim 1, 2 or 3 toothpaste composition. Further, (A) any one toothpaste composition according to claim 1 the amount of anionic surfactant other than component is 0 to 10 mass%. Additionally, toothpaste composition of any one of claims 1 to 5 containing Nebayuizai 0.1 to 10 mass%.