JP6611365B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that performs qualitative and quantitative analysis of biological samples such as blood and urine.

  Automatic analyzers perform quantitative and qualitative analysis of specific components contained in samples by automatically dispensing and adding various reagents to biological samples such as blood and urine (hereinafter simply referred to as samples). Yes.

  As a technique relating to such reagent dispensing, for example, in Patent Document 1 (Japanese Patent Laid-Open No. 2011-33426), a reagent discharge channel including a nozzle for discharging a reagent and a reagent container are held. There is a difference between the first reagent holding mechanism, the reagent flow path with one end inserted in the reagent container mounted on the first reagent holding mechanism, the cell containing the reagent discharged from the nozzle, and the flow path. An automatic analyzer comprising a syringe pump for generating pressure, and a three-pronged channel for connecting the reagent discharge channel, the reagent channel, and a channel connected to the syringe pump, the first analyzer holding a reagent container An automatic analyzer including a second reagent holding mechanism and a drive mechanism that allows the nozzle to access the cell and the second reagent holding mechanism is disclosed.

JP 2011-33426 A

  By the way, in the above-mentioned automatic analyzer of the prior art, by controlling the operation of a single syringe and a valve device provided in a pipe line, nozzles for discharging various types of reagents from each reagent container to each reagent. It adopts a configuration to transfer individually. However, in the above-described prior art, there is a problem that the cost of the apparatus is increased and the control is complicated because the configuration using many valve devices is used. Moreover, there is a possibility that the quality may be deteriorated such as dilution of reagents with system water or mixing of different kinds of reagents (contamination), and it is also required to suppress these occurrences.

  The present invention has been made in view of the above, and an object of the present invention is to provide an automatic analyzer capable of dispensing a reagent with a simpler structure while suppressing a decrease in the quality of the reagent accompanying dispensing. To do.

  In order to achieve the above object, according to the present invention, the first reagent is transferred from a reagent container containing a first reagent, which is one of a plurality of reagents, to a first discharge section corresponding to the first reagent. A first flow path for sending, and a second container for sending the second reagent from a reagent container containing a second reagent different from the first reagent to a second discharge section corresponding to the second reagent A flow path, a syringe pump that generates a differential pressure in the first and second flow paths, and a flow path that is disposed so as to connect the syringe pump and a waste liquid tank to which a waste liquid containing a reagent to be discarded is sent And at a position different from the first branch portion in the adjustment flow path, the first branch portion connecting the middle of the first flow path and the adjustment flow path in three or more branches. A second branch portion connecting the middle of the second flow path and the adjustment flow path by branching in three or more directions; To that there was example.

  ADVANTAGE OF THE INVENTION According to this invention, a reagent can be dispensed with a simpler structure, suppressing the fall of the quality of the reagent accompanying dispensing.

It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on 1st Embodiment. 1 is a diagram schematically showing an overall configuration of an automatic analyzer according to a first embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 1st Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 1st Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 1st Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 1st Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on the modification of 1st Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on the other modification of 1st Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on 2nd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 2nd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 2nd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 2nd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 2nd Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on 3rd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 3rd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 3rd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 3rd Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 3rd Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on the modification of 3rd Embodiment. It is a figure which shows the flow-path structure of the reagent dispensing mechanism which concerns on 4th Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 4th Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 4th Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 4th Embodiment. It is a figure which shows one state in operation | movement of the reagent dispensing mechanism which concerns on 4th Embodiment.

  Embodiments of the present invention will be described with reference to the drawings.

<First Embodiment>
A first embodiment of the present invention will be described with reference to FIGS. 1, 2, and 3A to 3D.

  FIG. 2 is a top view of the overall configuration of the automatic analyzer according to the present embodiment.

  In FIG. 2, an automatic analyzer 300 includes a sample container rack 302 that stores a plurality of sample containers 301 that hold biological samples such as blood and urine to be analyzed (hereinafter simply referred to as samples), and a sample container rack. A rack transport line 303 for transporting 302, and a plurality of reagent containers 304 for storing various assay reagents used for sample analysis, a luminescent label reagent container for storing a reagent containing a luminescent label reagent, and a magnetic particle reagent for storing magnetic particles An incubator disk 309 (a plurality of reaction containers 320 for mixing and reacting a reagent container disk 305 covered with a reagent container disk cover 307 and a sample and an assay reagent) Reaction disc) and the incubator device from the sample container 301 by rotation and vertical movement. A sample dispensing nozzle 310 for dispensing a sample into the reaction container 320 of the disk 309, a reagent dispensing nozzle 311 for dispensing assay reagent from the reagent container 304 to the reaction container 320 of the incubator disk 309 by rotation and vertical movement, and reaction A reaction solution stirring mechanism 314 for stirring the reaction solution of the sample and the assay reagent stored in the container 320; a buffer solution container 321 storing a buffer solution containing a luminescence-inducing reagent containing a component that promotes luminescence of the luminescent label; The cleaning liquid container 322 containing the cleaning liquid, the mixed liquid (reaction liquid) mixed in the reaction container 320 of the incubator disk 309 by rotation and vertical movement, the buffer liquid stored in the buffer liquid container 321, and the cleaning liquid container 322 The suction nozzle 323 for sucking the stored cleaning liquid, the initial preparation operation before the analysis process, the dispensing operation of each part, and the analysis A control unit 319 that controls the operation of the entire automatic analyzer 300 including analysis processing by the knit 318, a detection flow path, a photodetector, and the like, and a reaction solution and a reagent (buffer solution) sucked by the suction nozzle 323 Etc.) is generally configured from an analysis unit 318 (measurement unit) that performs an analysis process. In addition to the assay reagent, a system reagent bottle containing a system reagent commonly used for a plurality of analysis items can be installed below the work surface of the apparatus. The analysis unit 318 has a plurality of ejection units 327 through which a plurality of types of system reagents used in the analysis unit 318 are fed, and the system reagent is fed to the ejection unit 327 by a reagent transfer mechanism. Hereinafter, this system reagent is simply referred to as “reagent”.

  FIG. 1 is a diagram showing a flow path configuration of the reagent transfer mechanism according to the present embodiment.

  This reagent transfer mechanism is configured below the upper surface of the overall configuration of the automatic analyzer shown in FIG. In the present embodiment, the plurality of reagent discharge units 327 are described as the first discharge unit 102A and the second discharge unit 106A.

  In FIG. 1, the reagent transfer mechanism is a flow path for sending a first reagent from a reagent container 101 containing a first reagent, which is one of a plurality of reagents, to a first discharge unit 102A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The flow path 107A, 107B (second flow path), the syringe pump 108 that generates a differential pressure in each flow path (including the flow paths 103A, 103B, 107A, 107B) constituting the reagent dispensing mechanism, and discarded The adjustment flow path 115E arranged to connect the waste liquid tank 114 to which the waste liquid containing the reagent and the syringe pump 108 are connected, and the middle of the flow paths 103A and 103B (that is, the flow path 103A and the flow path 103B connected in series) Connection Min) and the adjustment channel 115E are connected to each other at a position different from the first branch part 116A formed by a three-direction channel and the first branch part 116A in the adjustment channel 115E. A second branch portion 116C formed of a three-way flow path in which the middle of 107B (that is, a connecting portion between flow path 107A and flow path 107B connected in series) and adjustment flow path 115E is provided. Yes.

  116 A of 1st branch parts have the 1st connection flow path 115A which connects the connection part of flow paths 103A and 103B, and the adjustment flow path 115E, and the 2nd branch part 116C is the flow path 107A. , 107B and the adjustment flow path 115E, and the second connection flow path 115B is connected to the adjustment flow path 115E at a position different from the first connection flow path 115A. Configured.

  Upstream (flow path 103B) and downstream (flow path 103A) with respect to the first branch 116A in the flow paths 103A and 103B, and upstream with respect to the second branch 116C in the flow paths 107A and 107B. Two-way valves 104 </ b> A to 104 </ b> D for switching between blocking and communicating of the flow paths are arranged on the (flow path 107 </ b> B) and the downstream side (flow path 107 </ b> A), respectively. When the two-way valves 104A to 104D are in the valve closed state, the flow of the flow paths 103A, 103B, 107A, and 107B is blocked, and in the valve open state, they are communicated.

  The waste liquid tank 114 is connected to the adjustment flow path 115E by a flow path 115D at a position different from the first and second branch portions 116A and 116C in the adjustment flow path 115E. A connecting portion between the flow path 115D and the adjustment flow path 115E constitutes a branching portion 116B. The flow path 115D is provided with a two-way valve 104F that switches between blocking and communication of the flow path. When the two-way valve 104F is in a valve closed state, the flow of the flow path 115D is blocked and in a valve open state. Is communicated to.

  The syringe pump 108 is connected to the adjustment channel 115E by the channel 115C at a position different from the first and second branch portions 116A and 116C and the branch portion 116B in the adjustment channel 115E. A connecting portion between the flow path 115D and the adjustment flow path 115E constitutes a branch portion 116D. The syringe pump 108 increases the volume in the syringe pump 108 by pulling the plunger 109 to suck in system water (described later) from the flow path 115C side, and decreases the volume in the syringe pump 108 by pushing the plunger 109. System water (described later) is pushed out toward the flow path 115C.

  A system water container 110 is connected to the syringe pump 108 via a flow path 113 (system water flow path). The flow path 113 includes a pump 112 that sends system water from the system water container 110 to the syringe pump 108 through the flow path 113, and a deaeration device 111 that reduces the dissolved oxygen concentration of the system water sent by the pump 112. And a two-way valve 104E that switches between blocking and communicating the flow path 113 between the deaerator 111 and the syringe pump 108. When the two-way valve 104E is closed, the flow of the flow path 113 is blocked, and when the two-way valve 104E is opened, the flow is communicated.

  The adjustment flow path 115E is formed by an annular flow path, and a branching part 116A, a branching part 116B, a branching part 116C, and a branching part 116D are arranged in order in the clockwise direction in FIG. Yes. In other words, the waste liquid tank 114 and the syringe pump 108 are connected to the adjustment flow path 115E through the flow path 115D, and the syringe pump 108 is connected to the adjustment flow path 115E through the flow path 115C. Connected through.

  The operation of the reagent dispensing mechanism according to the present embodiment configured as described above will be described with reference to FIGS. 3A to 3D.

  3A to 3D are diagrams each showing a state during the operation of the reagent transfer mechanism.

  In FIG. 3A, the reagent transfer mechanism is in the initial state, the plunger 109 of the syringe pump 108 is stopped at the initial position (minimum volume position), and all the two-way valves are closed. The flow paths 103A and 103B and the flow path 115A are filled with the first reagent, the flow paths 107A and 107B and the flow path 115B are filled with the second reagent, and the flow paths 115C, 115D and 115E are filled with the system water. Yes.

  Subsequently, as shown in FIG. 3B, only the two-way valve 104A is opened, and the plunger 109 is pulled to send the first reagent to the flow paths 103B and 115A and a part of the flow path 115E.

  Subsequently, as shown in FIG. 3C, the two-way valve 104A is closed, the two-way valve 104B is opened, and the plunger 109 is pushed, so that the first reagent becomes the flow path 103A and the flow path 115A. , 115E and discharged from the first discharge portion 102A to the reaction vessel 102. At this time, the plunger 109 does not move to the initial position. That is, a part of the first reagent in the annular flow path 115E is left in the flow path 115E.

  Subsequently, as shown in FIG. 3D, the two-way valve 104B is closed, the two-way valves 104E and 104F are opened, the plunger 109 is returned to the initial position, and the system water pressurized by the pump 112 is syringed. By sending the solution to the pump 108, the solution in the flow paths 115C, 115D, and 115E is sent to the waste liquid tank 114 together with the system water. At this time, the open / close state of each two-way valve, the position of the plunger, the location of each solution, and the like in the reagent transfer mechanism are in the initial state.

  In the above description, the case where the first reagent in the reagent container 101 is sent to the reaction container 102 has been described as an example, but the case where the second reagent in the reagent container 105 is sent to the reaction container 106 is also described. It is the same. That is, in the operation described with reference to FIGS. 3A to 3D, the operation of the two-way valve 104 </ b> A and the two-way valve 104 </ b> C is interchanged, and the operation of the two-way valve 104 </ b> B and the two-way valve 104 </ b> D is interchanged. The second reagent is fed to 106.

  As described above, by leaving the first reagent in the annular flow path 115E, the reagent diluted with the system water by diffusion remains in the flow path 115E (see FIG. 3C). The remaining diluted reagent is sent to the waste liquid tank 114 by the system water sent from the pump 112 (see FIG. 3D). Therefore, the flow paths 115C, 115D, and 115E are filled with the system water, and the reagent diluted with the system water is not sent to the flow paths 115A and the flow paths 103A and 103B. Further, the reagent does not remain in the flow path 115E. Therefore, the diluted reagent is not sent to the reaction vessel 102. Furthermore, since the channels 115C, 115D, and 115E are filled with system water, the dispensing operation is performed on the second reagent after the dispensing operation (FIGS. 3A to 3D) is performed on the first reagent. Even if it performs, a 1st reagent and a 2nd reagent do not mix.

  The effect of the present embodiment configured as described above will be described.

  In the conventional automatic analyzer, by controlling the operation of a single syringe and a valve device provided in a pipe line, various types of reagents are individually supplied from each reagent container to a discharge nozzle corresponding to each reagent. Some have adopted a transporting configuration. However, in such a conventional technique, there is a problem in that the cost of the apparatus is increased and the control is complicated because a configuration using a relatively special valve device corresponding to the demand for chemical resistance and the like is used. is there. Moreover, there is a possibility that the quality may be deteriorated such as dilution of reagents with system water or mixing of different kinds of reagents (contamination), and it is also required to suppress these occurrences.

  In addition, as another conventional automatic analyzer, a dispenser for dispensing a reagent to a sample in a reaction container is provided, and a multiple switching valve is provided between a discharge channel of a syringe and each retraction tube. Some of them have a function of selectively moving one of them, and a plurality of reagents are individually moved from one to a liquid delivery destination using one syringe. However, in such a conventional technique, there is a problem that the cost of the apparatus increases because a multiple switching valve having a complicated shape and an expensive shape is used. In addition, when the operation of sending the reagent remaining in the flow path to the waste liquid tank is not performed, the reagent remaining in the flow path is diffused and diluted in the system water, and the reagent diluted with the system water is There was also a problem of moving to the target liquid delivery destination. Furthermore, there is also a problem that when the diluted reagent remains in the flow channel and the operation of feeding another reagent is performed, the reagents are mixed with each other.

  Furthermore, as another automatic analyzer of the prior art, in a dispensing device that quantifies or qualitatively analyzes components such as blood and urine, and discharges a plurality of reagents from different reagent discharge nozzles with a single syringe. The check valve connected to the reagent bottle and the other check valve connected to the discharge nozzle are connected with a T-shaped tube, and a single syringe is connected to the third branch of the T-shaped tube with a pipe and a branched tube. Some of the reagent flow paths are connected to a branch pipe through a solenoid valve as a valve. However, in such a conventional technique, although a plurality of reagents are moved from one to the destination using one syringe, the number of valves including a backflow prevention valve increases as the number to be dispensed increases. It will increase. For this reason, there existed a problem that apparatus cost became high and control became complicated. If there is no operation to send the reagent remaining in the flow path to the waste tank, the reagent remaining in the flow path is diffused and diluted in the system water. There was also a problem of moving to the liquid tip. Furthermore, when the operation of feeding another reagent is performed while the diluted reagent remains in the flow path, there is a problem that the reagents are mixed.

  In contrast, in the present embodiment, the first reagent is sent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first ejection unit 102A corresponding to the first reagent. The flow paths 103A and 107B and the flow paths 107A and 107B for sending the second reagent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent A syringe pump 108 that generates a differential pressure in the flow paths 103A, 103B, 107A, and 107B, a waste liquid tank 114 to which a waste liquid containing a reagent to be discarded is sent, and an adjustment flow path that is arranged to connect the syringe pump 108 115E, a first branch part 116A formed by three or more flow paths in which the middle of the flow paths 103A and 103B and the adjustment flow path 115E are connected, and a first branch in the adjustment flow path 115E Since the second branch portion 116C formed by a flow path in three or more directions in which the middle of the flow paths 107A and 107B and the adjustment flow path 115E are connected is provided at a position different from the section 116A. The reagent can be dispensed with a simpler configuration while suppressing the deterioration of the reagent quality accompanying the injection.

<Modification of the first embodiment>
A modification of the first embodiment of the present invention will be described with reference to FIG.

  In this modification, the inner diameter of the adjustment channel (the cross-sectional area of the channel) is formed to be smaller than that of the other channels.

  FIG. 4 is a diagram showing a flow path configuration of the reagent transfer mechanism according to this modification. In the figure, the same members as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In FIG. 4, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first discharge unit 102 </ b> A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The syringe pump 108 that generates a differential pressure in the flow paths 107A and 107B (second flow path), each flow path (including the flow paths 103A, 103B, 107A, and 107B) constituting the reagent transfer mechanism, and the discarded reagent The adjustment flow path 117 disposed so as to connect the waste liquid tank 114 to which the waste liquid containing the liquid and the syringe pump 108 are connected, and the middle of the flow paths 103A and 103B (that is, the flow paths 103A and 103B connected in series) Connection ) And the adjustment channel 115E are connected to each other at a position different from the first branch part 116A formed by a three-direction channel and the first branch part 116A in the adjustment channel 117. A second branch part 116 </ b> C formed by a three-way channel in which the middle channel (that is, the connecting portion of the channel 107 </ b> A and the channel 107 </ b> B connected in series) and the adjustment channel 117 are connected is provided. .

  The inner diameter (the cross-sectional area of the flow path) of the adjustment flow path 117 is formed to be smaller than other flow paths such as the flow paths 115A and 115B.

  Other configurations are the same as those of the first embodiment.

  Also in the present modification configured as described above, the same effects as those of the first embodiment can be obtained.

  In addition, since the flow path 117 having a reduced inner diameter is installed, the area of the interface between the reagent and the system water can be reduced as compared with the first embodiment, and the diffusion of the reagent into the system water can be reduced. Further suppression can be achieved.

<Other Modifications of First Embodiment>
Another modification of the first embodiment of the present invention will be described with reference to FIG.

  In the present modification, the types of reagents that can be fed are increased by adding reagent containers, discharge units, flow paths, and the like to the first embodiment.

  FIG. 5 is a diagram showing a flow path configuration of the reagent transfer mechanism according to this modification. In the figure, the same members as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In this modification, a case is illustrated in which a reagent is sent from three reagent containers 101, 105, and 118 that contain different reagents to three ejection units 102A, 106A, and 120A corresponding to the respective reagents for dispensing. .

  In FIG. 5, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first discharge unit 102 </ b> A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The flow path 107A, 107B (second flow path) and the reagent container 118 containing a third reagent different from the first and second reagents are transferred from the reagent container 118 to the third discharge section 119A corresponding to the third reagent. 3 generates a differential pressure in the flow paths 120A and 120B (third flow path) for sending the reagent and each flow path (including the flow paths 103A, 103B, 107A, 107B, 120A and 120B) constituting the reagent transfer mechanism. Syringe pump 108 to be removed and the reagent to be discarded The adjustment flow path 124E disposed so as to connect the waste liquid tank 114 to which the waste liquid is sent and the syringe pump 108, and the middle of the flow paths 103A and 103B (that is, the connecting portion of the flow path 103A and the flow path 103B connected in series) ) And the adjustment channel 124E are connected to each other at a position different from the first branch part 116A formed by a three-way channel and the first branch part 116A in the adjustment channel 124E. A second branch part 116C formed of a three-way flow path in which the middle (that is, the connecting portion of the flow path 107A and the flow path 107B connected in series) and the adjustment flow path 124E are connected, and the adjustment flow path At a position different from the first and second branch portions 116A and 116B in 124E, the middle of the flow paths 120A and 120B (that is, the flow paths of the flow paths 120A and the series-connected flow paths 120A and 120B). It includes a third branch portion 116E of 120B of the connecting portion) and the adjustment channel 124E is formed in the flow path of the connected 3 direction.

  116 A of 1st branch parts have the 1st connection flow path 115A which connects the connection part of the flow paths 103A and 103B, and the adjustment flow path 124E, and the 2nd branch part 116C is the flow path 107A. , 107B and the adjustment channel 124E, and the second connection channel 115B is connected to the adjustment channel 124E at a position different from that of the first connection channel 115A. The third branch part 116E is a connection channel that connects the connection portions of the channels 120A and 120B and the adjustment channel 124E, and the first and second connection flows in the adjustment channel 124E. The third connecting flow path 124F is connected to a position different from the paths 115A and 115B.

  The first branch section 116A in the flow paths 103A and 103B (flow path 103B) and the downstream side (flow path 103A), and the upstream side (the flow path 107B in relation to the second branch section 116C in the flow paths 107A and 107B. ) And the downstream side (flow path 107A) and the upstream side (flow path 120B) and the downstream side (flow path 120A) with respect to the third branch 116E in the flow paths 120A and 120B, respectively. Two-way valves 104A to 104D, 104G, and 104H for switching between shut-off and communication are arranged. When the two-way valves 104A to 104D, 104G, and 104H are in the valve closed state, the flow of the flow paths 103A, 103B, 107A, 107B, 120A, and 120B is blocked, and in the valve open state, they are communicated.

  The waste liquid tank 114 is connected to the adjustment flow path 124E by the flow path 115D at a position different from the first to third branch portions 116A, 116C, and 116E in the adjustment flow path 124E. A connecting portion between the flow path 115D and the adjustment flow path 124E constitutes a branching portion 116B. The flow path 115D is provided with a two-way valve 104F that switches between blocking and communication of the flow path. When the two-way valve 104F is in a valve closed state, the flow of the flow path 115D is blocked and in a valve open state. Is communicated to.

  The syringe pump 108 is connected to the adjustment flow path 124E by a flow path 115C at a position different from the first to third branch portions 116A, 116C, 116E and the branch portion 116B in the adjustment flow path 124E. A connecting portion between the flow path 115D and the adjustment flow path 124E constitutes a branch portion 116D. The syringe pump 108 pulls the plunger 109 to increase the volume in the syringe pump 108 to suck in system water from the flow path 115C side, and pushes the plunger 109 to decrease the volume in the syringe pump 108 to draw system water. It pushes out to the flow path 115C side.

  The adjustment flow path 124E is formed by an annular flow path, and sequentially branches in the clockwise direction in FIG. 5 along the annular adjustment flow path 116A, branching part 116B, branching part 116C, branching part 116E, branching part 116D. Is arranged.

  Other configurations are the same as those of the first embodiment.

  Also in the reagent transport mechanism of the present modification configured as described above, the first reagent in the reagent container 101 can be fed to the reaction container 102 by performing the same operation as in the first embodiment. . That is, in the operation described with reference to FIGS. 3A to 3D of the first embodiment, the same operation as that of the two-way valve 104A is performed, and the same operation as that of the two-way valve 104B is performed. One reagent can be sent to the reaction vessel 102. The same applies to the case where the second reagent in the reagent container 105 is sent to the reaction container 106 (or the case where the third reagent in the reagent container 118 is sent to the reaction container 119). In the feeding of the first reagent from the reagent container 101 to the reaction container 102, the operation of the two-way valve 104A and the operation of the two-way valve 104C (or the two-way valve 104G) are interchanged, and the operation of the two-way valve 104B. By switching the operation of the two-way valve 104D (or the two-way valve 104H), the second reagent is transferred from the reagent container 105 to the reaction container 106 (or the third reagent is transferred from the reagent container 118 to the reaction container 119). Liquid delivery).

  Also in the present modification configured as described above, the same effects as those of the first embodiment can be obtained.

  In addition, the number of reagents that can be fed from the reagent container to the reaction container can be increased to three.

  In this modification, the case where there are three types of reagents is shown. However, according to the number n of reagent types, the flow path connecting the reagent container and the discharge unit, the connection flow path, and the adjustment flow path 124E are connected. By providing n + 2 branch portions, the types of reagents that can be fed from the reagent container to the reaction container can be increased.

  In addition, when the device cost and control complexity can be allowed, the adjustment flow path 124E and the two-way valve 104F are not installed, but the connection flow paths 115A to 115D and 124F are newly arranged. It is good also as a structure which connects and switches a flow path by a multiple valve.

<Second Embodiment>
A second embodiment of the present invention will be described with reference to FIGS. 6 and 7A to 7D.

  In the present embodiment, air insertion channels 121A and 121B for inserting air into the first and second branch portions 116A and 116D in the first embodiment are provided.

  FIG. 6 is a diagram showing a flow path configuration of the reagent transfer mechanism according to the present embodiment. In the figure, the same members as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In FIG. 6, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first ejection unit 102 </ b> A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The syringe pump 108 that generates a differential pressure in the flow paths 107A and 107B (second flow path), each flow path (including the flow paths 103A, 103B, 107A, and 107B) constituting the reagent transfer mechanism, and the discarded reagent The adjustment flow path 115E arranged so as to connect the waste liquid tank 114 to which the waste liquid containing the liquid and the syringe pump 108 are connected, and the middle of the flow paths 103A and 103B (that is, the flow paths 103A and 103B connected in series) Connection Min), the first branch part 122A formed by the four-direction flow path to which the adjustment flow path 115E and the air insertion flow path 121A are connected, and the first branch part 122A in the adjustment flow path 115E different from the position , In the middle of the flow paths 107A and 107B (that is, the connecting portion of the flow path 107A and the flow path 107B connected in series), the adjustment flow path 115E, and the four-direction flow path connected to the air insertion flow path 121B. And a second branch part 122B.

  The first branch portion 122A includes a first connection channel 115A that connects the connection portion of the channels 103A and 103B and the adjustment channel 115E, and the second branch portion 122B includes the channel 107A. , 107B and the adjustment flow path 115E, and the second connection flow path 115B is connected to the adjustment flow path 115E at a position different from the first connection flow path 115A. Configured.

  The end of the air insertion channel 121A opposite to the first branch portion 122A is open to the atmosphere, and the two-way valve 104I is disposed in the air insertion channel 121A. Similarly, the end of the air insertion channel 121B opposite to the second branch portion 122B is open to the atmosphere, and the two-way valve 104J is disposed in the air insertion channel 121B. When the two-way valves 104I and 104J are in the valve closed state, the flow of each of the flow paths 121A and 121B is blocked, and in the valve open state, they are communicated.

  The waste liquid tank 114 is connected to the adjustment channel 115E by the channel 115D at a position different from the first and second branch portions 116A and 116C in the adjustment channel 115E. The connecting portion constitutes a branching portion 116B. The syringe pump 108 is connected to the adjustment channel 115E by the channel 115C at a position different from the first and second branch parts 122A and 122B and the branch part 116B in the adjustment channel 115E. A connecting portion between 115D and adjustment flow path 115E constitutes a branching portion 116D.

  The adjustment flow path 115E is formed by an annular flow path, and a branching part 122A, a branching part 116B, a branching part 122B, and a branching part 116D are arranged in this order in the clockwise direction in FIG. Yes.

  The operation of the reagent transport mechanism according to the present embodiment configured as described above will be described with reference to FIGS. 7A to 7D.

  7A to 7D are diagrams each showing one state during the operation of the reagent transfer mechanism.

  In the initial state of the reagent transfer mechanism, the plunger 109 of the syringe pump 108 is stopped at the initial position (minimum volume position), and all the two-way valves are closed. The flow paths 103A and 103B and the flow path 115A are filled with the first reagent, the flow paths 107A and 107B and the flow path 115B are filled with the second reagent, and the flow paths 115C, 115D and 115E are filled with the system water. Yes.

  First, as shown in FIG. 7A, only the two-way valve 104I is opened, and the plunger 109 is pulled to suck air (segmented air) from the air insertion channel 121A into the adjustment channel 115E.

  Subsequently, as shown in FIG. 7B, while the two-way valve 104I is closed, only the two-way valve 104A is opened, and the plunger 109 is pulled to allow the first reagent to flow through the flow paths 103B, 115A and Liquid is fed to a part of the flow path 115E.

  Subsequently, as shown in FIG. 7C, the two-way valve 104A is closed, the two-way valve 104B is opened, and the plunger 109 is pushed, so that the first reagent becomes the flow path 103A and the flow path 115A. , 115E and discharged from the first discharge portion 102A to the reaction vessel 102. At this time, the plunger 109 does not move to the initial position. That is, a part of the first reagent in the annular flow path 115E is left in the flow path 115E.

  Subsequently, as shown in FIG. 7D, the two-way valve 104B is closed, the two-way valves 104E and 104F are opened, the plunger 109 is returned to the initial position, and the system water pressurized by the pump 112 is syringed. By sending the solution to the pump 108, the solution in the flow paths 115C, 115D, and 115E is sent to the waste liquid tank 114 together with the system water. At this time, the open / close state of each two-way valve, the position of the plunger, the location of each solution, and the like in the reagent transfer mechanism are in the initial state.

  In the above description, the case where the first reagent in the reagent container 101 is sent to the reaction container 102 has been described as an example, but the case where the second reagent in the reagent container 105 is sent to the reaction container 106 is also described. It is the same. That is, in the operations described with reference to FIGS. 7A to 7D, the operations of the two-way valve 104A and the two-way valve 104C and the operations of the two-way valve 104B and the two-way valve 104D are interchanged, and the two-way valve 104I and the two-way valve By switching the operation of 104J, the second reagent is fed from the reagent container 105 to the reaction container 106.

  Other configurations are the same as those of the first embodiment.

  In the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

  In addition, since segmented air is inserted between the reagent and system water in the flow path, it is possible to further suppress the dilution of the reagent with the system water and to suppress the deterioration of the reagent quality caused by dispensing. can do.

  In the present embodiment, since air is inserted into the flow path, there is a possibility that the accuracy of the reagent discharge amount to the reaction container may be lower than when air is not inserted due to the elasticity of air. is there. Therefore, in order to ensure the accuracy of the reagent discharge amount, a sensor for measuring the liquid amount may be installed in the reaction container to control the discharge liquid amount of the reagent.

<Third Embodiment>
A third embodiment of the present invention will be described with reference to FIGS. 8 and 9A to 9D.

  In the present embodiment, instead of the annular adjustment flow channel in the first embodiment, a single flow channel in which a waste liquid tank and a syringe pump are connected to both ends is configured.

  FIG. 8 is a diagram showing a flow path configuration of the reagent transfer mechanism according to the present embodiment. In the figure, the same members as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In FIG. 8, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first discharge unit 102 </ b> A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The syringe pump 108 that generates a differential pressure in the flow paths 107A and 107B (second flow path), each flow path (including the flow paths 103A, 103B, 107A, and 107B) constituting the reagent transfer mechanism, and the discarded reagent The adjustment flow path 125E disposed so as to connect the waste liquid tank 114 to which the waste liquid containing the liquid and the syringe pump 108 are connected, and the middle of the flow paths 103A and 103B (that is, the flow path 103A and the flow path 103B connected in series) Connection Min) and the adjustment channel 125E are connected to each other at a position different from the first branch part 116F formed by a three-direction channel and the first branch part 116F in the adjustment channel 125E. A second branch portion 116G formed of a three-way flow path in which the middle of 107B (that is, the connecting portion between flow path 107A and flow path 107B connected in series) and adjustment flow path 125E is provided. Yes.

  The first branch part 116F is configured to include a first connection channel 115A that connects the connection part of the channels 103A and 103B and the adjustment channel 125E, and the second branch part 116G includes the channel 107A. , 107B and the adjustment channel 125E, and a second connection channel 115B connected to the adjustment channel 125E at a position different from the first branch portion 116F. Configured.

  The waste liquid tank 114 is connected to the adjustment flow path 125E by a flow path 115D at one end of the adjustment flow path 125E. The syringe pump 108 is connected to the adjustment flow path 125E by the flow path 115C at the other end of the adjustment flow path 125E.

  The adjustment flow path 125E is formed by a single flow path in which the waste liquid tank 114 is connected to one end via the flow path 115D, and the syringe pump 108 is connected to the other end via the flow path 115C. A branching part 116F and a branching part 116G are arranged in this order from the syringe pump 108 side.

  In the present embodiment, the first and second branch portions 116F and 116G are described in the case where they are arranged at positions different from the end portions of the adjustment flow path 125E. Even when the second branch portions 116F and 116G are arranged at the end of the adjustment flow path 125E, a part of the flow paths 115C and 115D plays a part of the function of the adjustment flow path 125E. And can be regarded as a substantially similar configuration.

  The operation of the reagent transport mechanism according to the present embodiment configured as described above will be described with reference to FIGS. 9A to 9D.

  In FIG. 9A, the reagent transfer mechanism is in an initial state, the plunger 109 of the syringe pump 108 is stopped at the initial position (minimum volume position), and all the two-way valves are closed. The flow paths 103A and 103B and the flow path 115A are filled with the first reagent, the flow paths 107A and 107B and the flow path 115B are filled with the second reagent, and the flow paths 115C, 115D and 125E are filled with the system water. Yes.

  Subsequently, as shown in FIG. 9B, only the two-way valve 104A is opened, and the plunger 109 is pulled to send the first reagent to the flow paths 103B, 115A, 115E, and 115C.

  Subsequently, as shown in FIG. 9C, the two-way valve 104A is closed, the two-way valve 104B is opened, and the plunger 109 is pushed, so that the first reagent flows into the flow paths 103A, 115A, 115C. , 125E and discharged from the first discharge portion 102A to the reaction vessel 102. At this time, the plunger 109 does not move to the initial position. That is, a part of the first reagent in the flow paths 115C and 125E is left in the flow path 125E (or may be the flow path 115C).

  Subsequently, as shown in FIG. 9D, the two-way valve 104B is closed, the two-way valves 104E and 104F are opened, the plunger 109 is returned to the initial position, and the system water pressurized by the pump 112 is syringed. By sending the liquid to the pump 108, the solution in the flow paths 115C, 115D, and 125E is sent to the waste liquid tank 114 together with the system water. At this time, the open / close state of each two-way valve, the position of the plunger, the location of each solution, and the like in the reagent transfer mechanism are in the initial state.

  In the above description, the case where the first reagent in the reagent container 101 is sent to the reaction container 102 has been described as an example, but the case where the second reagent in the reagent container 105 is sent to the reaction container 106 is also described. It is the same. That is, in the operation described with reference to FIGS. 9A to 9D, the operation of the two-way valve 104 </ b> A and the two-way valve 104 </ b> C is interchanged, and the operation of the two-way valve 104 </ b> B and the two-way valve 104 </ b> D is interchanged. The second reagent is fed to 106.

  Other configurations are the same as those of the first embodiment.

  In the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

<Modification of Third Embodiment>
A modification of the third embodiment of the present invention will be described with reference to FIG.

  In the present modification, the number of reagents that can be fed is increased by adding reagent containers, discharge units, flow paths, and the like to the third embodiment.

  FIG. 10 is a diagram showing a flow path configuration of the reagent transfer mechanism according to this modification. In the figure, members similar to those of the third embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In this modification, a case is illustrated in which a reagent is sent from three reagent containers 101, 118, 105 containing different reagents to three ejection units 102A, 106A, 119A corresponding to the respective reagents for dispensing. .

  In FIG. 10, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first discharge unit 102A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The flow path 107A, 107B (second flow path) and the reagent container 118 containing a third reagent different from the first and second reagents are transferred from the reagent container 118 to the third discharge section 119A corresponding to the third reagent. 3 generates a differential pressure in the flow paths 120A and 120B (third flow path) for sending the reagent and each flow path (including the flow paths 103A, 103B, 107A, 107B, 120A and 120B) constituting the reagent transfer mechanism. Syringe pump 108 and the reagent to be discarded The adjustment flow path 125E arranged to connect the waste liquid tank 114 to which the waste liquid is sent and the syringe pump 108, and the middle of the flow paths 103A and 103B (that is, the connection between the flow path 103A and the flow path 103B connected in series) 107A, at a position different from the first branch part 116F formed by the three-way flow path in which the portion) and the adjustment flow path 124E are connected to the first branch part 116F in the adjustment flow path 125E. A second branch part 116G formed of a three-way flow path in which the middle of 107B (that is, the connecting portion of flow path 107A and flow path 107B connected in series) and adjustment flow path 125E are connected; At a position different from the first and second branch portions 116F and 116G in the path 125E, the middle of the flow paths 120A and 120B (that is, the flow path 120A connected in series) Includes a third branch portion 116H which the road 120B connecting portion) and the adjustment channel 125E is formed in the flow path of the connected 3 direction.

  The first branch part 116F is configured to include a first connection channel 115A that connects the connection part of the channels 103A and 103B and the adjustment channel 125E, and the second branch part 116G includes the channel 107A. , 107B and the adjustment channel 125E, the second connection channel 115B connected to a position different from the first connection channel 115A in the adjustment channel 125E. The third branch portion 116H is a connection channel that connects the connection portions of the channels 120A and 120B and the adjustment channel 125E, and the first and second connection flows in the adjustment channel 125E. The third connecting flow path 124F is connected to a position different from the paths 115A and 115B.

  Upstream (flow path 103B) and downstream (flow path 103A) with respect to the first branch 116F in the flow paths 103A and 103B, and upstream (flow) with respect to the second branch 116G in the flow paths 107A and 107B. The flow path 107B) and the downstream side (flow path 107A), and the upstream side (flow path 120B) and the downstream side (flow path 120A) with respect to the third branch 116H in the flow paths 120A and 120B, respectively. Two-way valves 104A to 104D, 104G, and 104H for switching between blocking and communicating are disposed. When the two-way valves 104A to 104D, 104G, and 104H are in the valve closed state, the flow of the flow paths 103A, 103B, 107A, 107B, 120A, and 120B is blocked, and in the valve open state, they are communicated.

  The waste liquid tank 114 is connected to the adjustment flow path 125E by a flow path 115D at one end of the adjustment flow path 125E. The syringe pump 108 is connected to the adjustment flow path 125E by the flow path 115C at the other end of the adjustment flow path 125E.

  The adjustment flow path 125E is formed by a single flow path in which the waste liquid tank 114 is connected to one end via the flow path 115D, and the syringe pump 108 is connected to the other end via the flow path 115C. The branch portions 116H and 116F and the branch portion 116G are arranged in this order from the syringe pump 108 side.

  In the present modification, the first to third branch portions 116F, 116G, and 116H are described with reference to the case where the first to third branch portions 116F, 116G, and 116H are arranged at positions different from the end portions of the adjustment flow path 125E. Even when the third branch portions 116F, 116G, 116H are arranged at the end of the adjustment flow path 125E, a part of the flow paths 115C, 115D plays a part of the function of the adjustment flow path 125E. It can be considered that the configuration is substantially the same as the modified example.

  Other configurations are the same as those of the third embodiment.

  Also in this modification configured as described above, the same effects as those of the third embodiment can be obtained.

  In addition, the number of reagents that can be fed from the reagent container to the reaction container can be increased to three.

  In this modification, the case where there are three types of reagents is shown. However, according to the number n of reagent types, the flow path connecting the reagent container and the discharge section, the connection flow path, and the adjustment flow path 125E are connected. By providing n + 2 branch portions, the types of reagents that can be fed from the reagent container to the reaction container can be increased.

<Fourth embodiment>
A fourth embodiment of the present invention will be described with reference to FIGS. 11 and 12A to 12D.

  In the present embodiment, air insertion channels 121A and 121B for inserting air into the first and second branch portions 116F and 116G in the third embodiment are provided.

  FIG. 11 is a diagram showing a flow path configuration of the reagent transfer mechanism according to the present embodiment. In the figure, members similar to those of the third embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In FIG. 11, the reagent transport mechanism is a flow path for sending the first reagent from the reagent container 101 containing the first reagent, which is one of the plurality of reagents, to the first ejection unit 102A corresponding to the first reagent. 103A, 103B (first flow path) and the second reagent are sent from the reagent container 105 containing the second reagent different from the first reagent to the second discharge unit 106A corresponding to the second reagent. The syringe pump 108 that generates a differential pressure in the flow paths 107A and 107B (second flow path), each flow path (including the flow paths 103A, 103B, 107A, and 107B) constituting the reagent transfer mechanism, and the discarded reagent The adjustment flow path 125E disposed so as to connect the waste liquid tank 114 to which the waste liquid containing the liquid and the syringe pump 108 are connected, and the middle of the flow paths 103A and 103B (that is, the flow path 103A and the flow path 103B connected in series) Contact Part), the adjustment channel 125E, and the first branch part 132A formed by a four-direction channel to which the air insertion channel 121A is connected, and the first branch part 132A in the adjustment channel 125E different from the position. , In the middle of the flow paths 107A and 107B (that is, the connecting portion between the flow path 107A and the flow path 107B connected in series), the adjustment flow path 125E, and the four-direction flow path connected to the air insertion flow path 121B. The second branch part 132B is provided.

  The first branch portion 132A includes a first connection channel 115A that connects the connection portions of the channels 103A and 103B and the adjustment channel 125E, and the second branch portion 132B includes the channel 107A. , 107B and the adjustment channel 125E, the second connection channel 115B connected to a position different from the first connection channel 115A in the adjustment channel 125E. Configured.

  The end of the air insertion channel 121A opposite to the first branch portion 132A is open to the atmosphere, and the two-way valve 104I is disposed in the air insertion channel 121A. Similarly, the end of the air insertion channel 121B opposite to the second branch 132B is open to the atmosphere, and the two-way valve 104J is disposed in the air insertion channel 121B. When the two-way valves 104I and 104J are in the valve closed state, the flow of each of the flow paths 121A and 121B is blocked, and in the valve open state, they are communicated.

  The waste liquid tank 114 is connected to the adjustment flow path 125E by a flow path 115D at one end of the adjustment flow path 125E. The syringe pump 108 is connected to the adjustment flow path 125E by the flow path 115C at the other end of the adjustment flow path 125E.

  The adjustment flow path 125E is formed by a single flow path in which the waste liquid tank 114 is connected to one end via the flow path 115D, and the syringe pump 108 is connected to the other end via the flow path 115C. A branching part 132A and a branching part 132B are arranged in this order from the syringe pump 108 side.

  The operation of the reagent transport mechanism according to the present embodiment configured as described above will be described with reference to FIGS. 12A to 12D.

  12A to 12D are diagrams each showing a state during the operation of the reagent transfer mechanism.

  In the initial state of the reagent transfer mechanism, the plunger 109 of the syringe pump 108 is stopped at the initial position (minimum volume position), and all the two-way valves are closed. The flow paths 103A and 103B and the flow path 115A are filled with the first reagent, the flow paths 107A and 107B and the flow path 115B are filled with the second reagent, and the flow paths 115C, 115D and 125E are filled with the system water. Yes.

  First, as shown in FIG. 12A, only the two-way valve 104I is opened, and the plunger 109 is pulled to suck air (segmented air) from the air insertion channel 121A into the adjustment channel 125E.

  Subsequently, as shown in FIG. 12B, the two-way valve 104I is closed, and only the two-way valve 104A is opened, and the plunger 109 is pulled to allow the first reagent to flow through the flow paths 103B, 115A and Liquid is fed to a part of the flow path 125E.

  Subsequently, as shown in FIG. 12C, the two-way valve 104A is closed, the two-way valve 104B is opened, and the plunger 109 is pushed, so that the first reagent becomes the flow path 103A and the flow path 115A. , 125E and discharged from the first discharge portion 102A to the reaction vessel 102. At this time, the plunger 109 does not move to the initial position. That is, a part of the first reagent in the flow paths 115C and 125E is left in the flow path 125E (or may be the flow path 115C).

  Subsequently, as shown in FIG. 12D, the two-way valve 104B is closed, the two-way valves 104E and 104F are opened, the plunger 109 is returned to the initial position, and the system water pressurized by the pump 112 is syringed. By sending the liquid to the pump 108, the solution in the flow paths 115C, 115D, and 125E is sent to the waste liquid tank 114 together with the system water. At this time, the open / close state of each two-way valve, the position of the plunger, the location of each solution, and the like in the reagent transfer mechanism are in the initial state.

  In the above description, the case where the first reagent in the reagent container 101 is sent to the reaction container 102 has been described as an example, but the case where the second reagent in the reagent container 105 is sent to the reaction container 106 is also described. It is the same. That is, in the operations described with reference to FIGS. 12A to 12D, the operations of the two-way valve 104A and the two-way valve 104C and the operations of the two-way valve 104B and the two-way valve 104D are interchanged, and the two-way valve 104I and the two-way valve By switching the operation of 104J, the second reagent is fed from the reagent container 105 to the reaction container 106.

  Other configurations are the same as those of the third embodiment.

  In the present embodiment configured as described above, the same effects as those of the third embodiment can be obtained.

  In addition, since segmented air is inserted between the reagent and system water in the flow path, it is possible to further suppress the dilution of the reagent with the system water and to suppress the deterioration of the reagent quality caused by dispensing. can do.

  In addition, this invention is not limited to each above-mentioned embodiment, Various modifications and various combinations are included. Further, the above-described embodiments are described by way of example for easy understanding of the present invention, and are not necessarily limited to those having all the configurations described in the respective embodiments.

  That is, for example, the branch portions 116A, 116C, and 116E of other modified examples of the first embodiment in which the types of reagents that can be fed are increased by adding reagent containers, discharge units, flow paths, and the like, or In addition, in the branch portions 116F, 116G, and 116H of the modified example of the third embodiment, an air insertion flow path may be newly provided. Further, in each of the embodiments and modifications of the present invention, or in the combination as described above, it is conceivable to adopt a configuration in which the inner diameter of the adjustment channel is smaller than that of other channels.

101, 105, 118 ... Reagent container, 102, 106, 119 ... Reaction container, 102A, 106A, 119A ... Discharge part, 103A, 103B, 107A, 107B, 120A, 120B ... Flow path, 104A-104J ... Two-way valve, DESCRIPTION OF SYMBOLS 108 ... Syringe pump, 109 ... Plunger, 110 ... System water container, 111 ... Deaeration device, 112 ... Pump, 113 ... Flow path, 114 ... Waste liquid tank, 115A-115D, 124F ... Connection flow path, 115E, 117, 124E , 125E ... adjustment channel, 116A to 116H, 122A, 122B, 132A, 132B ... branching part, 121A, 121B ... air insertion channel, 300 ... automatic analyzer, 301 ... sample container, 302 ... sample container rack, 303 ... Rack transport line, 304 ... reagent container, 305 ... reagent container disk, 3 7 ... Reagent container disk cover, 309 ... Incubator disk, 310 ... Sample dispensing nozzle, 311 ... Reagent dispensing nozzle, 312 ... Reaction container / sample dispensing chip storage section, 313 ... Reaction container / sample dispensing chip storage section, 314 ... Reaction liquid stirring mechanism, 315 ... Disposal port, 316 ... Transport mechanism, 318 ... Analysis unit, 319 ... Control unit, 320 ... Reaction container, 321 ... Buffer container, 322 ... Washing liquid container, 323 ... Suction nozzle, 324 ... Opening portion, 325 ... sample dispensing tip, 326 ... tip mounting position, 327 ... reagent discharge portion

Claims (6)

A first flow path for sending the first reagent from a reagent container containing a first reagent which is one of a plurality of reagents to a first discharge section corresponding to the first reagent;
A second flow path for sending the second reagent from a reagent container containing a second reagent different from the first reagent to a second discharge section corresponding to the second reagent;
A syringe pump for generating a differential pressure in the first and second flow paths;
An adjustment flow path arranged to connect a waste liquid tank to which a waste liquid containing a reagent to be discarded is sent and the syringe pump;
A first branch portion connecting the middle of the first flow path and the adjustment flow path by branching in three or more directions;
A second branch part that connects the middle of the second flow path and the adjustment flow path in three or more directions at a position different from the first branch part in the adjustment flow path ;
The automatic analyzer is characterized in that the adjustment channel is a channel configured by an annular channel or a single channel in which the waste liquid tank and the syringe pump are connected to both ends . The automatic analyzer according to claim 1, wherein
The first branch portion includes a first connection channel that connects the middle of the first channel and the adjustment channel,
The second branch portion is a connection flow path that connects the middle of the second flow path and the adjustment flow path, and is connected to a position different from the first connection flow path in the adjustment flow path. An automatic analyzer comprising the second connecting flow path formed. The automatic analyzer according to claim 1 , wherein
The automatic analyzer is characterized in that the adjustment channel is formed to have a channel diameter smaller than that of the first and second channels. The automatic analyzer according to claim 1, wherein
The adjustment flow path is
A third flow path for sending the third reagent from the reagent container containing a third reagent different from the first and second reagents to a third discharge section corresponding to the third reagent;
An automatic analyzer further comprising: a third branch portion formed by a flow path in three or more directions in which the middle of the third flow path and the adjustment flow path are connected. The automatic analyzer according to claim 1, wherein
An automatic analyzer, wherein an air insertion channel for taking in air is connected to at least one of the first and second branch portions. The automatic analyzer according to claim 1, wherein
Two-way valves are provided on the upstream side and the downstream side of the first branch portion in the first flow path, and on the upstream side and the downstream side of the second branch section in the second flow path, respectively. An automatic analyzer characterized by that.

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