JP6674001B2 - Maillard reaction inhibitor - Google Patents
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- JP6674001B2 JP6674001B2 JP2018191338A JP2018191338A JP6674001B2 JP 6674001 B2 JP6674001 B2 JP 6674001B2 JP 2018191338 A JP2018191338 A JP 2018191338A JP 2018191338 A JP2018191338 A JP 2018191338A JP 6674001 B2 JP6674001 B2 JP 6674001B2
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Description
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤に関する。 The present invention relates to a novel Maillard reaction inhibitor containing a plant extract as an active ingredient.
メイラード反応は、還元糖のカルボニル基と蛋白質又はアミノ酸のアミノ基が非酵素的に縮合する反応で、シッフ塩基を経由して、アマドリ転移産物を生成する前期反応と、その後、アマドリ転移産物が分解され、さらに脱水、酸化、縮合、転移等の過程を経て、終末糖化産物群（ＡＧＥ）へと変化する後期反応とに分けられる。食品の加工、貯蔵の際に起こる褐変反応として食品科学の分野では古くからよく知られる現象である。 The Maillard reaction is a reaction in which the carbonyl group of the reducing sugar and the amino group of the protein or amino acid are non-enzymatically condensed.The first reaction is the formation of an Amadori transfer product via a Schiff base, and the Amadori transfer product is subsequently decomposed. The reaction is further divided into late reactions that undergo a process such as dehydration, oxidation, condensation, and rearrangement to be converted into advanced glycation end products (AGE). It is a phenomenon that has long been well known in the field of food science as a browning reaction that occurs during processing and storage of food.
この反応は生体内でも起こっており、ＡＧＥが加齢に依存して種々の生体組織に蓄積すること、また、糖尿病合併症、アルツハイマーや動脈硬化などの加齢関連疾患で、ＡＧＥの蓄積が有意に増加していることが報告されている。さらに、メイラード反応は、加齢に伴って生じる白内障や軟骨の弾力低下、皮膚の老化の原因となり、特に常時高血糖状態である糖尿病患者においてその進行が早いことが報告されている。 This reaction also occurs in vivo, and AGE accumulates in various biological tissues depending on aging. In addition, AGE accumulation is significant in age-related diseases such as diabetic complications, Alzheimer's disease, and atherosclerosis. Is reported to have increased. Furthermore, it has been reported that the Maillard reaction causes cataract, decrease in the elasticity of cartilage, and aging of the skin that occur with aging, and that the progress thereof is particularly rapid in diabetic patients who are constantly hyperglycemic.
このため、メイラード反応を阻害する物質は、生体内の様々な加齢関連疾患の抑制や糖尿病合併症を抑制し得ると考えられ、そのような物質を求めて種々の研究がされている。 For this reason, a substance that inhibits the Maillard reaction is considered to be capable of suppressing various aging-related diseases and diabetic complications in a living body, and various studies have been made for such a substance.
例えば、アミノグアニジンは強力なメイラード反応阻害剤として知られている（例えば、特許文献１参照）。一方でこの化合物は強い副作用を有することが知られている。また、メイラード反応阻害作用を有する植物素材がいくつか知られているが、十分満足のいく効果は得られていない（例えば、特許文献２および特許文献３参照）。 For example, aminoguanidine is known as a potent Maillard reaction inhibitor (for example, see Patent Document 1). On the other hand, this compound is known to have strong side effects. Although some plant materials having a Maillard reaction inhibitory action are known, a sufficiently satisfactory effect has not been obtained (for example, see Patent Documents 2 and 3).
平均寿命の延びや少子高齢化の進行に伴い、健康を維持しつつ長生きするために、抗加齢いわゆるアンチエイジングへの関心が高まっている中、優れたアンチエイジング効果を有し、かつ安全性の高い機能性食品や化粧品素材等の開発が切望されている。 With an increase in life expectancy and the aging of the low birth rate and the aging of the population, there is growing interest in anti-aging, or so-called anti-aging, in order to live longer while maintaining health. The development of functional foods and cosmetic materials with a high level of demand has been eagerly desired.
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤を提供することを主な目的とする。また、本発明は、当該メイラード反応阻害剤を含有する経口剤、外用剤および飲食品を提供する。 The main object of the present invention is to provide a novel Maillard reaction inhibitor containing a plant extract as an active ingredient. The present invention also provides an oral preparation, an external preparation, and a food or beverage containing the Maillard reaction inhibitor.
本発明者らは、上記課題を解決すべく鋭意検討した結果、特定の植物エキスが優れたメイラード反応阻害作用を有することを見出し、本発明を完成した。 The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that a specific plant extract has an excellent Maillard reaction inhibitory action, and completed the present invention.
本発明として、例えば下記のものを挙げることができる。
（１）ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される１種又は２種以上の植物のエキスを有効成分として含有するメイラード反応阻害剤（以下、「本発明阻害剤」という）。
（２）上記（１）のメイラード反応阻害剤を含有する経口剤（以下、「本発明経口剤」という）。
（３）上記（１）のメイラード反応阻害剤を含有する飲食品（以下、「本発明飲食品」という）。
（４）上記（１）のメイラード反応阻害剤を含有する外用剤（以下、「本発明外用剤」という）。
（５）上記（１）のメイラード反応阻害剤を含有する老化抑制用組成物（以下、「本発明組成物」という）。
（６）上記（１）のメイラード反応阻害剤を含有する、糖尿病合併症の予防又は治療用組成物。
Examples of the present invention include the following.
(1) Plants belonging to the genus Pinculus (Sterculia), plants belonging to the genus Chingerospondia (Cherospondias), plants belonging to the genus Mango (Mangifera), plants belonging to the genus Urushi (Rhus), plants belonging to the genus Fukugi (Garcinia), kuromoji Plants belonging to the genus Lindera, plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aleurites, genus Acacia A plant belonging to the genus Trapa, a plant belonging to the genus Eugenia, a plant belonging to the genus Millettia, a plant belonging to the genus Cornus (Cornus), A Maillard reaction inhibitor containing an extract of one or more plants selected from a plant group consisting of a plant belonging to the genus Areca and a plant belonging to the genus Myrica (hereinafter referred to as “the present Inventive inhibitors ").
(2) An oral preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as "the oral preparation of the present invention").
(3) Foods and drinks containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as “the present foods and drinks”).
(4) An external preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter, referred to as “external preparation of the present invention”).
(5) A composition for suppressing aging containing the Maillard reaction inhibitor of the above (1) (hereinafter, referred to as “the composition of the present invention”).
(6) A composition for preventing or treating diabetes complications, comprising the Maillard reaction inhibitor of the above (1).
本発明阻害剤は、優れたメイラード反応阻害作用を有し、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に有用である。また、本発明阻害剤は、食経験があり、副作用が少ない植物のエキスを有効成分として含有し、安全性が高いものである。 The inhibitor of the present invention has an excellent Maillard reaction inhibitory effect, and phenomena caused by aging, for example, cataract, decreased cartilage elasticity, aging of skin (decreased elasticity of skin, wrinkles and sagging of collagen It is useful for suppressing cross-linking and pigmentation that causes dull skin. In addition, the inhibitor of the present invention has a dietary experience, contains a plant extract with few side effects as an active ingredient, and is highly safe.
また、本発明阻害剤は、メイラード反応が関与することが知られている糖尿病合併症の予防又は治療用組成物として用いることもできる。 Further, the inhibitor of the present invention can also be used as a composition for preventing or treating diabetic complications that are known to be involved in the Maillard reaction.
植物エキス
本発明に係る植物エキスは、ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される植物からの抽出エキスである。
Plant extract The plant extract according to the present invention is a plant belonging to the genus Sterculia, a plant belonging to the genus Chachospondias, a plant belonging to the genus Mangofera, a plant belonging to the genus Rhus, a plant belonging to the genus Fukugi ( Garcinia), Plants belonging to the genus Lindera, plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aleurites A plant belonging to the genus Acacia, a plant belonging to the genus Trapa, a plant belonging to the genus Eugenia, a plant belonging to the genus Milletia, a genus Cornus Plants belonging to Cornus), an extract from a plant selected plants belonging to Areca genus (Areca), from a plant group consisting of plants belonging to the bayberry genus (Myrica).
本発明に係るピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物としては、特に限定されないが、例えば、ヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）、ピンポンノキ（Ｓｔｅｒｃｕｌｉａ ｎｏｂｉｌｉｓ Ｓｍｉｔｈ）、ハンタイカイ（Ｓｔｅｒｃｕｌｉａ ｓｃａｐｈｉｇｅｒａ Ｗａｌｌ．）を挙げることができ、中でもヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）が好ましい。 Examples of the plant belonging to the genus Ping-ponki (Sterculia) according to the present invention include, but are not particularly limited to, for example, Yatsudeoogiri (Sterculia foetida L.), Ping-Ponoki (Sterculia nobilis Smith), and Hunting squirrel (Sterculia scaphiragia.). Above all, preferred is A. aomori (Sterculia foetida L.).
本発明に係るチャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物としては、特に限定されないが、例えば、チャンチンモドキ（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ ａｘｉｌｌａｒｉｓ （Ｒｏｘｂ．） Ｂｕｒｔｔ ｅｔ Ｈｉｌｌ）が好ましい。 The plant belonging to the genus Chanerospondias according to the present invention is not particularly limited, but, for example, a plant belonging to the genus Choerospondias (Cherospondias axillialis (Roxb.) Burtt et Hill) is preferable.
本発明に係るマンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物としては、特に限定されないが、例えば、マンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）、ニオイマンゴー（Ｍａｎｇｉｆｅｒａ ｏｄｏｒａｔａ Ｇｒｉｆｆ．）、ビンジャイマンゴー（Ｍａｎｇｉｆｅｒａ ｃａｅｓｉａ Ｊａｃｋ．）、ウママンゴー（Ｍａｎｇｉｆｅｒａ ｆｏｅｔｉｄａ Ｌｏｕｒ．）を挙げることができ、中でもマンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）が好ましい。 Examples of the plant belonging to the genus Mangofera according to the present invention include, but are not particularly limited to, mango (Mangifera indica L.), odor mango (Mangifera odarata Griffe.), Vinjay mango (Mangifera caesia jassia jassia). Mango (Mangifera foetida Lour.) Can be mentioned, and among them, mango (Mangifera indica L.) is preferable.
本発明に係るウルシ属（Ｒｈｕｓ）に属する植物としては、特に限定されないが、例えば、ヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）、ハゼノキ（Ｒｈｕｓ ｓｕｃｃｅｄａｎｅａ Ｌ．）、ナンヨウハゼノキ（Ｒｈｕｓｔａｉｔｅｎｓｉｓ Ｇｕｉｌｌ．）、ウルシ（Ｒｈｕｓ ｖｅｒｎｉｃｉｆｌｕａ Ｓｔｏｋｅｓ）、ヤマウルシ（Ｒｈｕｓ ｔｒｉｃｈｏｃａｒｐａ Ｍｉｑ．）を挙げることができ、中でもヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）が好ましい。 Examples of the plant belonging to the genus Rhus according to the present invention include, but are not particularly limited to, nurde (Rhus javanica L.), Japanese oak (Rhus succedana L.), Japanese red oak (Rhustaitensis Guill.), And Uruushiruushi (Rhiusnihus). Stokes) and porcupine (Rhus trichocarpa Miq.), Among which Nurde (Rhus javanica L.) is preferable.
本発明に係るフクギ属（Ｇａｒｃｉｎｉａ）に属する植物としては、特に限定されないが、例えば、マンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）、ゴラカ（Ｇａｒｃｉｎｉａ ｃａｍｂｏｇｉａ Ｄｅｓｒ．）、ムムンジン（Ｇａｒｃｉｎｉａ ｄｉｏｉｃａ Ｂｌｕｍｅ）、グルグル（Ｇａｒｃｉｎｉａ ａｔｒｏｖｉｒｉｄｉｓ Ｇｒｉｆｆ． ｅｘ Ｔ． Ａｎｄｅｒｓｏｎ）、オオバノマンゴスチン（Ｇａｒｃｉｎｉａ ｄｕｌｃｉｓ （Ｒｏｘｂ．） Ｋｕｒｚ）、インドマンゴスチン（Ｇａｒｃｉｎｉａ ｉｎｄｉｃａ Ｃｈｏｉｓｙ）、フクギ（Ｇａｒｃｉｎｉａ ｓｕｂｅｌｌｉｐｔｉｃａ Ｍｅｒｒ．）、タマゴノキ（Ｇａｒｃｉｎｉａ ｘａｎｔｈｏｃｈｙｍｕｓ Ｈｏｏｋ． ｆ． ｅｘ Ｔ． Ａｎｄｅｒｓ．）を挙げることができ、中でもマンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）が好ましい。 The plant belonging to the genus Fukugi according to the present invention is not particularly limited. Ex T. Anderson, Garminia dulcis (Roxb.) Kurz, Garmonia indica Choisy, Fukugi (Garnia suberica G. ergo santiago, Gercinia kongo, G.). To name Can, inter alia mangosteen (Garcinia mangostana L.) is preferable.
本発明に係るクロモジ属（Ｌｉｎｄｅｒａ）に属する植物としては、特に限定されないが、例えば、クロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）、アメリカクロモジ（Ｌｉｎｄｅｒａ ｂｅｎｚｏｉｎ （Ｌ．）Ｂｌｕｍｅ）、テンダイウヤク（Ｌｉｎｄｅｒａ ｓｔｒｙｃｈｎｉｆｏｌｉａ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｆ． Ｖｉｌｌ．）、ヤマコウバシ（Ｌｉｎｄｅｒａ ｇｌａｕｃａ Ｂｌｕｍｅ）、ダンコウバイ（Ｌｉｎｄｅｒａ ｏｂｔｕｓｉｌｏｂａ Ｂｌｕｍｅ）、シロモジ（Ｌｉｎｄｅｒａ ｔｒｉｌｏｂａ （Ｓｉｅｂ．ｅｔ Ｚｕｃｃ．）Ｂｌｕｍｅ）を挙げることができ、中でもクロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）が好ましい。 The plant belonging to the genus Kromoji (Lindera) according to the present invention is not particularly limited, and for example, Kromoji (Lindera umbellata Thumb.), American Kromoji (Lindera benzoin (L.) Blume), and Tendaiyak (Lindera stichnefilia. Zuck.) F. Vill.), Yamabakashi (Lindera glauca Blume), Dankobai (Lindera obtusiloba Blume), Shiromoji (Lindera triloba (Sieb. Et Zucc.), And Lumbera (L. Is preferred.
本発明に係るイヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物としては、特に限定されないが、例えば、アイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）、ヤナギタデ（Ｐｅｒｓｉｃａｒｉａ ｈｙｄｒｏｐｉｐｅｒ （Ｌ．） Ｓｐａｃｈ）、オオイヌタデ（Ｐｅｒｓｉｃａｒｉａ ｌａｐａｔｈｉｆｏｌｉａ （Ｌ．） Ｓ． Ｆ． Ｇｒａｙ）、オオケタデ（Ｐｅｒｓｉｃａｒｉａ ｏｒｉｅｎｔａｌｉｓ （Ｌ．） Ａｓｓｅｎｏｖ）、ツルソバ（Ｐｅｒｓｉｃａｒｉａ ｃｈｉｎｅｎｓｉｓ （Ｌ．） Ｎａｋａｉ）、ミゾソバ（Ｐｅｒｓｉｃａｒｉａ ｔｈｕｎｂｅｒｇｉｉ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｈ． Ｇｒｏｓｓ）を挙げることができ、中でもアイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）が好ましい。 As plants belonging to the persicaria (persicaria) according to the present invention is not particularly limited, for example, the eye (Persicaria tinctoria (Lour.) H. Gross), Polygonum hydropiper (Persicaria hydropiper (L.) Spach), Ooinutade (Persicaria lapathifolia (L.) SF Gray, Pokémon (Persicaria orientalis (L.) Assenov), Persicaria chinensis (L.) Nakai, Mizosoba (Persicaria thunberg. Can be, among others, the eye (Persicaria tinctoria) (Lour.) H. Gross) is preferred.
本発明に係るギシギシ属（Ｒｕｍｅｘ）に属する植物としては、特に限定されないが、例えば、キブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）、スイバ（Ｒｕｍｅｘ ａｃｅｔｏｓａ Ｌ．）、ヒメスイバ（Ｒｕｍｅｘ ａｃｅｔｏｓｅｌｌａ Ｌ．）、ギシギシ（Ｒｕｍｅｘ ｊａｐｏｎｉｃｕｓ Ｈｏｕｔｔ．）、ナガバギシギシ（Ｒｕｍｅｘ ｃｒｉｓｐｕｓ Ｌ．）を挙げることができ、中でもキブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）が好ましい。 Examples of the plant belonging to the genus Rumex according to the present invention include, but are not particularly limited to, Rumex nepalensis Spreng., Sorrel (Rumex acetosa L.), shimejiba (Rumex acetosella L.), and G. jap. Hout.) And Rumex crispus L. (Rumex crispus L.). Above all, Rumex nepalensis Spreng. Is preferable.
本発明に係るミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物としては、特に限定されないが、例えば、ミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）、シンミズヒキ（Ａｎｔｅｎｏｒｏｎ ｎｅｏｆｉｌｉｆｏｒｍｅ （Ｎａｋａｉ） Ｈａｒａ）を挙げることができ、中でもミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）が好ましい。 Examples of the plant belonging to the genus Amaranthus (Antenoron) according to the present invention include, but are not particularly limited to, for example, Mizuhiki (Antenoron filiforme (Thunb.) Roberty et Vautier), and Shinmizuki (Antenoron neofiliforme (Nakaiar). Above all, Mizuhiki (Antenoron filiforme (Thunb.) Roberty et Vautier) is preferable.
本発明に係るアブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物としては、特に限定されないが、例えば、ククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）、アブラギリ（Ａｌｅｕｒｉｔｅｓ ｃｏｒｄａｔａ （Ｔｈｕｎｂ） Ｒ．Ｂｒ． ｅｘ Ｓｔｅｕｄ．）、シナアブラギリ（Ａｌｅｕｒｉｔｅｓ ｆｏｒｄｉｉ Ｈｅｍｓｌ．）、カントンアブラギリ（Ａｌｅｕｒｉｔｅｓ ｍｏｎｔａｎａ （Ｌｏｕｒ．） Ｗｉｌｓ．）を挙げることができ、中でもククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）が好ましい。 Examples of the plant belonging to the genus Aleurites according to the present invention include, but are not particularly limited to, Japanese cypress (Aleuretes moluccana (L.) Willd.), Abragiri (Aleuretes cordata (Thumb) R. Br. Ex Steud.), Aleuritis fordii Hemsl. And Canton abragiri (Aleuretes montana (Lour.) Wils.) Can be mentioned, and among them, cucumber (Aleurites moluccana (L.) Willd.) Is preferable.
本発明に係るアカシア属（Ａｃａｃｉａ）に属する植物としては、特に限定されないが、例えば、アセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）、ミモサアカシア（Ａｃａｃｉａ ｄｅｃｕｒｒｅｎｓ Ｗｉｌｌｄ．）、モリシマアカシア（Ａｃａｃｉａ ｍｅａｒｎｓｉｉ Ｄｅ Ｗｉｌｄ．）、アラビアゴムノキ（Ａｃａｃｉａ ｓｅｎｅｇａｌ （Ｌ．） Ｗｉｌｌｄ．）を挙げることができ、中でもアセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）が好ましい。 Examples of the plant belonging to the genus Acacia according to the present invention include, but are not particularly limited to, Acacia catechu Willd., Acacia leucophloea Willd., And Mimosa academia duc. , Acacia meansiii De Wild., Gum acacia (Acacia senegal (L.) Willd.), And among them, Acacia catechu Willd., And Ricocoae acacia (Aacophile Aacophile). preferable.
本発明に係るヒシ属（Ｔｒａｐａ）に属する植物としては、特に限定されないが、例えば、ツノナシビシ（Ｔｒａｐａ ａｃｏｒｎｉｓ Ｎａｋａｎｏ）、ヒメビシ（Ｔｒａｐａ ｉｎｃｉｓａ Ｓｉｅｂ. ｅｔ Ｚｕｃ.）、ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、トラパ・ナタンス（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）を挙げることができ、中でもヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）が好ましい。 Examples of the plant belonging to the genus Hishi (Trapa) according to the present invention include, but are not particularly limited to, tsunanashibishi (Trapa acornis Nakano), Himebishi (Trapa incisa Sieb. Et Zuc.), Hishi (Trapa japonica Trevi), bispinosa Roxb., Trapana natans L., and Onibishi (Trapana natans L. var. japonica Nakai). Above all, Hishi (Trapa japonica Ferov), Obi (pob. Trapa natans L. var. Japonica Nakai) is preferred.
本発明に係るエウゲニア属（Ｅｕｇｅｎｉａ）に属する植物としては、特に限定されないが、例えば、ピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）、タイワンアデク（Ｅｕｇｅｎｉａ ｆｏｒｍｏｓａｎａ Ｈａｙａｔａ），セイロンアデク（Ｅｕｇｅｎｉａ ｓｐｉｃａｔａ Ｌａｍ．）を挙げることができ、中でもピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）が好ましい。 Examples of the plant belonging to the genus Eugenia according to the present invention include, but are not particularly limited to, pitanga (Eugenia uniflora L.), Taiwan adek (Eugenia formosana Hayata), and Ceylon adek (Eugania spicata). Among them, pitanga (Eugenia uniflora L.) is preferable.
本発明に係るナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物としては、特に限定されないが、例えば、ムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）、ミレッティア・ニティダ（Ｍｉｌｌｅｔｔｉａ ｎｉｔｉｄａ Ｂｅｎｔｈ．）を挙げることができ、中でもムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）が好ましい。 Examples of plants belonging to the genus Nuffetia (Millettia) according to the present invention include, but are not particularly limited to, for example, Natsufuji natsufuji (Milletia reticulata Benth.) And Milletia nitida (Milletia nitrida Benth.). Fuji (Milletia reticulata Benth.) Is preferred.
本発明に係るミズキ属（Ｃｏｒｎｕｓ）に属する植物としては、特に限定されないが、例えば、サンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、セイヨウサンシュユ（Ｃｏｒｎｕｓ ｍａｓ Ｌ．）、ヤマボウシ（Ｃｏｒｎｕｓｋｏｕｓａ Ｂｕｅｒｇ． ｅｘ Ｈａｎｃｅ）、ミズキ（Ｃｏｒｎｕｓｃｏｎｔｒｏｖｅｒｓａ Ｈｅｍｓｌ．）を挙げることができ、中でもサンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）が好ましい。 Examples of the plant belonging to the genus Cornus of the present invention include, but are not limited to, Sanshu (Cornus officinalis Sieb. Et Zucc.), Sanshuyu (Cornus mas L.), and yamaboushi (Cornuskous Häger.ex). And Cornus (Cornuscontroversa Hemsl.). Among them, Sanshu (Cornus officinalis Sieb. Et Zucc.) Is preferable.
本発明に係るビンロウ属（Ａｒｅｃａ）に属する植物としては、特に限定されないが、例えば、ビンロウジュ（Ａｒｅｃａ ｃａｔｅｃｈｕ Ｌ．）が好ましい。 The plant belonging to the genus Areca (Areca) according to the present invention is not particularly limited, but is preferably, for example, areca (Areca catechu L.).
本発明に係るヤマモモ属（Ｍｙｒｉｃａ）に属する植物としては、特に限定されないが、例えば、シロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）、ヤマモモ（Ｍｙｒｉｃａ ｒｕｂｒａ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、カロライナヤマモモ（Ｍｙｒｉｃａ ｃａｒｏｌｉｎｅｎｓｉｓ Ｍｉｌｌ．）を挙げることができ、中でもシロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）が好ましい。 The plant belonging to the genus Myrica according to the present invention is not particularly limited, but, for example, white peach (Myrica cerifera L.), bayberry (Myrica rubra Sieb. Et Zucc.), And Carolina bayberry (Myolica circa). Among them, whiteberry (Myrica cerifera L.) is preferable.
上記の植物の中で、ヤツデアオギリ、チャンチンモドキ、マンゴー、ヌルデ、マンゴスチン、クロモジ、アイ、キブネダイオウ、ミズヒキ、ククイノキ、アセンヤクノキ、リウコフロエアアカシア、ヒシ、ピタンガ、ムラサキナツフジ、サンシュユ、ビンロウジュ、シロコヤマモモからなる植物群から選ばれる植物からの抽出エキスが特に好ましい。
植物エキスの製造方法
本発明に係る植物エキスの製造には、上記植物の各部位、例えば、花、花穂、果皮、果実、果肉、茎、葉、枝、枝葉、幹、樹皮、根茎、根皮、根、種子、虫えい、心材、地上部、地下部又は全草を用いることができる。
Among the above plants, Yatsudeoagiri, Chanchinmodoki, Mango, Nurde, Mangosteen, Kromoji, Ai, Kibunedaiou, Mizuhiki, Kukuinoki, Aseniyakunoki, Ryukofuroacacia, Hishi, Pitanga, Murasaki Natsuji, Sanshuyu, Shiroko, Shiroko Extracts from plants selected from the plant group consisting of the bayberry are particularly preferred.
Method for producing plant extract In producing the plant extract according to the present invention, each part of the plant, for example, flowers, spikes, pericarp, fruits, pulp, stems, leaves, branches, branches and leaves, stems, bark, Rhizomes, root bark, roots, seeds, worms, heartwood, above ground, below ground or whole plants can be used.
本発明に係る植物エキスの製造方法は、特に限定されず、例えば、通常用いられる方法により製造することができる。具体的には、植物の各部位をそのまま又は適当な大きさに切断し、搾汁又は溶媒で抽出することにより製造することができる。抽出溶媒としては、例えば、水、各種有機溶媒、あるいはそれらの混合溶媒を用いることができる。抽出のための有機溶媒としては、例えば、低級アルコール（例えば、メタノール、エタノール）、クロロホルム、酢酸エチル、ｎ−ヘキサンを挙げることができる。抽出溶媒の中で、特に水、メタノール、エタノールが好ましい。また、これらの溶媒を一種又は二種以上混合して用いることもできる。 The method for producing the plant extract according to the present invention is not particularly limited, and for example, it can be produced by a commonly used method. Specifically, it can be produced by cutting each part of a plant as it is or by cutting it to an appropriate size, and extracting it with juice or a solvent. As the extraction solvent, for example, water, various organic solvents, or a mixed solvent thereof can be used. Examples of the organic solvent for extraction include lower alcohols (for example, methanol and ethanol), chloroform, ethyl acetate, and n-hexane. Among the extraction solvents, water, methanol and ethanol are particularly preferred. These solvents can be used alone or in combination of two or more.
抽出溶媒の使用量は、用いる植物原料や抽出溶媒等により異なるが、重量比で、１：２〜１：３０（植物原料：抽出溶媒）の範囲内が適当であり、１：３〜１：２０の範囲内が好ましく、１：５〜１：１０の範囲内がより好ましい。抽出時間は、1時間〜１５日の範囲内が適当である。抽出温度は、５〜１００℃の範囲内が適当である。抽出方法については特に制限されず、バッチ抽出、カラムを用いた連続抽出等、任意の方法を適用することができる。 The amount of the extraction solvent used varies depending on the plant material used, the extraction solvent, and the like. It is preferably in the range of 20 and more preferably in the range of 1: 5 to 1:10. The extraction time is suitably in the range of 1 hour to 15 days. The extraction temperature is suitably in the range of 5 to 100 ° C. The extraction method is not particularly limited, and any method such as batch extraction and continuous extraction using a column can be applied.
得られた植物エキスは、そのままの状態で用いることもできるが、必要に応じ、その活性に影響のない範囲内で更に精製処理を加えてもよい。このような精製処理は、通常の方法によって行えばよく、例えば、植物エキスを常法によりろ過することにより行うことができる。その後、得られたろ液を減圧濃縮、凍結乾燥して、本発明に係る植物エキスとすることができる。
本発明阻害剤、本発明組成物
本発明阻害剤は、上記のようにして得られた植物エキスを1種又は2種以上含有するものである。本発明阻害剤は、例えば、上記のようにして得られた植物エキスを、そのまま又は担体として使用することのできる素材と混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。
The obtained plant extract can be used as it is, but if necessary, may be further purified within a range that does not affect its activity. Such a purification treatment may be performed by a usual method, for example, by filtering a plant extract by a conventional method. Thereafter, the obtained filtrate is concentrated under reduced pressure and freeze-dried to obtain a plant extract according to the present invention.
The inhibitor of the present invention and the composition of the present invention The inhibitor of the present invention contains one or more plant extracts obtained as described above. The inhibitor of the present invention is, for example, a plant extract obtained as described above, as it is or mixed with a material that can be used as a carrier, and then powdered, lump, or various forms such as liquid by a conventional method. It can be manufactured by processing.
本発明組成物は、本発明阻害剤を含有するものである。本発明組成物は、例えば、本発明阻害剤をそのまま用いることもできるし、又は、本発明阻害剤と、担体として使用することのできる素材とを混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。 The composition of the present invention contains the inhibitor of the present invention. The composition of the present invention can be, for example, the inhibitor of the present invention as it is, or a mixture of the inhibitor of the present invention and a material that can be used as a carrier, and then powdered or aggregated by a conventional method. And can be manufactured by processing into various forms such as liquid.
本発明阻害剤及び本発明組成物には、任意に医薬上又は食品上許容される添加物を配合することができる。かかる添加剤としては、例えば、結合剤、崩壊剤、滑沢剤、分散剤、懸濁剤、乳化剤、緩衝剤、酸化防止剤、賦形剤、界面活性剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、防腐剤、抗菌剤、保湿剤、色素を挙げることができ、これらの１種又は２種以上を適当量使用することができる。 The inhibitor of the present invention and the composition of the present invention may optionally contain pharmaceutically or food acceptable additives. Such additives include, for example, binders, disintegrants, lubricants, dispersants, suspending agents, emulsifiers, buffers, antioxidants, excipients, surfactants, UV inhibitors, sequestering agents , A thickener, a preservative, an antibacterial agent, a humectant, and a pigment, and one or more of these can be used in an appropriate amount.
本発明阻害剤及び本発明組成物における植物エキスの配合量は、特に限定されず、０．０１重量％（以下、単に「％」という）以上、好ましくは、０．０５〜５０％である。
本発明阻害剤及び本発明組成物は、常法により、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ錠、トニック、ローション、軟膏、クリーム等の剤型に適宜調製することができる。
The blending amount of the plant extract in the inhibitor of the present invention and the composition of the present invention is not particularly limited, and is 0.01% by weight (hereinafter, simply referred to as “%”) or more, preferably 0.05 to 50%.
The inhibitor of the present invention and the composition of the present invention can be appropriately prepared into tablets, powders, granules, capsules, liquids, syrups, drop tablets, tonics, lotions, ointments, creams, and the like by ordinary methods. it can.
本発明阻害剤及び本発明組成物の摂取量は、含有されている植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。 The inhibitor of the present invention and the intake amount of the composition of the present invention vary depending on the type of plant extract contained therein, the dosage form, the age of the subject to be administered, the body weight, etc. It is appropriate to be in the range of 0.1 to 100 g, preferably in the range of 1 to 60 g, but is not necessarily limited to this range. Such daily intake may be taken once, or may be taken in 2 to 4 divided doses.
本発明阻害剤及び本発明組成物は、優れたメイラード反応阻害作用を有するため、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に用いることができる。また、本発明阻害剤は、メイラード反応が関与することが知られている、糖尿病合併症（例えば、心筋梗塞、糖尿病性腎症、糖尿病性網膜症、糖尿病性神経症）の予防又は治療に用いることもできる。
経口剤
本発明経口剤は、本発明阻害剤を含有する、経口摂取が可能な組成物を意味する。本発明経口剤は、本発明阻害剤をそのまま又は必要に応じて、経口剤を製造する際に用いられる医薬上又は食品上許容される添加剤とを適量配合したものを、常法により製剤化することにより得ることができる。かかる添加剤としては、賦形剤、充填剤、増量剤、結合剤、崩壊剤、界面活性剤、調味料、香料、滑沢剤等を挙げることができる。
Since the inhibitor of the present invention and the composition of the present invention have an excellent Maillard reaction inhibitory action, phenomena caused by aging, for example, cataract, decreased cartilage elasticity, aging of skin (decreased elasticity of skin, wrinkles and sagging) It can be used to suppress the formation of collagen cross-links that cause causation and pigmentation that causes dullness of the skin. Further, the inhibitor of the present invention is used for the prevention or treatment of diabetic complications (eg, myocardial infarction, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy) that are known to be involved in the Maillard reaction. You can also.
Oral agent The oral agent of the present invention means a composition containing the inhibitor of the present invention, which can be taken orally. The oral preparation of the present invention is prepared by mixing the inhibitor of the present invention as it is or as necessary, and an appropriate amount of a pharmaceutically or food acceptable additive used in the production of an oral preparation by an ordinary method. Can be obtained. Such additives include excipients, fillers, extenders, binders, disintegrants, surfactants, seasonings, fragrances, lubricants and the like.
本発明経口剤の製剤化に際して、他の生理機能を有する素材を配合することもできる。本発明経口剤の剤型は特に限定されず、例えば、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ剤を挙げることができる。 In formulating the oral preparation of the present invention, a material having another physiological function may be blended. The dosage form of the oral preparation of the present invention is not particularly limited, and examples thereof include tablets, powders, granules, capsules, solutions, syrups, and drops.
本発明経口剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、本発明阻害剤を固形分換算で、０．５〜６０％、好ましくは３〜５０％、特に好ましくは５〜１０％の範囲内で配合すれば良い。 The content of the inhibitor of the present invention in the oral preparation of the present invention may be appropriately adjusted according to the type of the plant extract according to the present invention contained therein, the dosage form, and the like. The agent may be blended in a range of 0.5 to 60%, preferably 3 to 50%, particularly preferably 5 to 10% in terms of solid content.
本発明経口剤の摂取量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。
外用剤
本発明外用剤は、本発明阻害剤を含有する、外用で使用することが可能な組成物を意味する。
The intake of the oral preparation of the present invention varies depending on the type, dosage form, age, body weight, etc. of the plant extract of the present invention contained therein. The weight is suitably in the range of 0.1 to 100 g, preferably in the range of 1 to 60 g, but is not necessarily limited to this range. Such daily intake may be taken once, or may be taken in 2 to 4 divided doses.
External preparation The external preparation of the present invention means a composition containing the inhibitor of the present invention and which can be used externally.
本発明外用剤は、本発明阻害剤をそのまま又は必要に応じて、外用剤を製造する際に用いられる医薬上、化粧上又は食品上許容される添加剤とを適量配合したものを常法により製剤化することにより得ることができる。かかる添加剤としては、軟膏用基材、アルコール、多価アルコール、水溶性高分子、酸化防止剤、ｐH調整剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、界面活性剤、精製水、防腐剤、抗菌剤、油剤、高級脂肪酸、脂肪酸エステル、保湿剤、色素、ビタミン類、アミノ酸類等を挙げることができる。 The external preparation of the present invention is prepared by mixing the inhibitor of the present invention as it is or as necessary, and a medicinal, cosmetic or food acceptable additive used in the production of the external preparation and an appropriate amount thereof mixed by an ordinary method. It can be obtained by formulating. Such additives include ointment base materials, alcohols, polyhydric alcohols, water-soluble polymers, antioxidants, pH adjusters, UV inhibitors, sequestering agents, thickeners, surfactants, purified water, Examples include preservatives, antibacterial agents, oils, higher fatty acids, fatty acid esters, humectants, pigments, vitamins, amino acids and the like.
さらに、本発明阻害剤を、公知の医薬部外品、化粧品に配合して本発明外用剤として用いることもできる。 Furthermore, the inhibitor of the present invention can be used as an external preparation of the present invention by blending it in known quasi-drugs and cosmetics.
本発明外用剤には、本発明阻害剤のほか、老化抑制効果を高めるための成分を更に配合したり、他の生理機能を有する素材を配合することもできる。かかる成分としては、例えば、紫外線防止剤、酸化防止剤、保湿剤、細胞賦活剤、血流促進剤を挙げることができる。これらの1種又は２種以上を適当量使用することができる。 The external preparation of the present invention may further contain, in addition to the inhibitor of the present invention, a component for enhancing the effect of suppressing aging, and may further contain a material having another physiological function. Such components include, for example, UV inhibitors, antioxidants, humectants, cell activators, and blood flow enhancers. One or more of these can be used in an appropriate amount.
本発明外用剤の具体的な使用態様としては、特に限定されず、例えば、化粧水、乳液、クリーム、軟膏、ローション、オイル、パックを挙げることができる。 Specific usage of the external preparation of the present invention is not particularly limited, and examples thereof include a lotion, an emulsion, a cream, an ointment, a lotion, an oil, and a pack.
本発明外用剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、固形分換算で、０．０００１〜３０％、好ましくは０．００１〜２５％、特に好ましくは０．５〜２０％の範囲で配合すればよい。 The content of the inhibitor of the present invention in the external preparation of the present invention may be appropriately adjusted according to the type of the plant extract according to the present invention contained therein, the dosage form, and the like. The amount may be 0.0001 to 30%, preferably 0.001 to 25%, particularly preferably 0.5 to 20%.
本発明外用剤の使用量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。
飲食品
本発明飲食品は、本発明阻害剤と公知の食材又は飲食品とを混合して、常法により、食品に加工することにより得ることができる。
The amount of the external preparation of the present invention varies depending on the type, dosage form, age, weight, etc. of the plant extract according to the present invention contained therein. It is suitable to be within a range of 0.1 to 100 g, preferably within a range of 1 to 60 g, but is not necessarily limited to this range. Such a daily use amount may be used once or may be used by dividing into two to four times.
Food and drink The food and drink of the present invention can be obtained by mixing the inhibitor of the present invention with a known food or food and drink, and processing the mixture into a food by a conventional method.
本発明飲食品の形態は特に限定されず、例えば、粉末状、塊状、液状、シロップ状、ゼリー状を挙げることができる。 The form of the food and drink of the present invention is not particularly limited, and examples thereof include powder, lump, liquid, syrup, and jelly.
本発明飲食品には、食品上許容される他の成分を配合することができる。かかる成分としては、例えば、栄養素、賦形剤、増量剤、甘味料、香味剤、着色剤、防腐剤、乳化剤、可溶化剤、多価アルコール、有機酸、無機酸、水溶性高分子を挙げることができる。これらの1種又は2種以上を適当量使用することができる。 The food or drink of the present invention may contain other food-acceptable components. Examples of such components include nutrients, excipients, bulking agents, sweeteners, flavoring agents, coloring agents, preservatives, emulsifiers, solubilizers, polyhydric alcohols, organic acids, inorganic acids, and water-soluble polymers. be able to. One or more of these can be used in an appropriate amount.
本発明飲食品の種類としては、例えば、飲料（清涼飲料、乳飲料、ジュース、茶類等）、粉末飲料（粉末ジュース、粉末スープ等）、練製品（畜肉ソーセージ、魚肉ソーセージ、かまぼこ、竹輪等）、惣菜（オムレツ、卵焼、ハンバーグ、コロッケ、ミーとボール、酢の物、酢豚、サラダ、餃子、しゅうまい、ロールキャベツ、豆腐、筑前煮、煮豆、ひじき煮、唐揚、天ぷら、フライ、茶碗蒸、胡麻和え、サラダ、カレー、シチュー、スープ、チャーハン、おにぎり、餅、ふりかけ、味噌汁等）、麺類（うどん、そうめん、そば、スパゲッティ、マカロニ、ラーメン等）、調理パン（ハンバーガー、ホットドッグ、サンドイッチ等）、パン（食パン、フランスパン等）、菓子（ケーキ、クッキー、ウエハース、クレープ、ヨーグルト、プリン、キャンディー、ガム、アイスクリーム、キャラメル、チョコレート、ドーナツ、せんべい、ようかん、ういろう、もなか、まんじゅう、大福餅、おはぎ、団子、甘納豆、中華まん等）を挙げることができる。この他、マヨネーズ、サラダドレッシング等も挙げることができる。 Examples of the food and drink of the present invention include drinks (soft drinks, milk drinks, juices, teas, etc.), powdered drinks (powder juices, powdered soups, etc.), kneaded products (livestock sausages, fish sausages, kamaboko, bamboo rings, etc.). ), Side dishes (omelet, egg fried, hamburger, croquette, meat and balls, vinegar, vinegar pork, salad, gyoza, sweet potato, roll cabbage, tofu, chikuzeni, boiled beans, hijiki, fried chicken, tempura, fried, chawanmushi, sesame sauce , Salad, curry, stew, soup, fried rice, rice ball, mochi, sprinkle, miso soup, noodles (udon, somen, soba, spaghetti, macaroni, ramen, etc.), cooking bread (hamburger, hot dog, sandwich, etc.), bread (Bread, French bread, etc.), confectionery (cake, cookies, wafers, crepes, yogurt, pudding) Candy, can be gum, ice cream, caramel, chocolate, donuts, crackers, jelly, Uiro, during, buns, Daifukumochi, Ohagi, dumpling, amanattō, be given the Chinese steamed buns, etc.). Other examples include mayonnaise and salad dressing.
本発明飲食品への本発明阻害剤の添加量は、添加剤の有無や食品の種類等により異なるが、含有されている本発明に係る植物エキスの固形分換算で０．０１〜５０％の範囲内とするのが適当であり、０．１〜３０％の範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。 The amount of the inhibitor of the present invention added to the food or drink of the present invention varies depending on the presence or absence of the additive or the type of the food, but is 0.01 to 50% in terms of the solid content of the plant extract according to the present invention contained. It is appropriately within the range, preferably within the range of 0.1 to 30%, but is not necessarily limited to this range.
本発明飲食品の摂取量は、摂取者の性別、年齢、体重等によって異なる。かかる摂取量は、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。 The amount of the food and drink of the present invention varies depending on the sex, age, weight, and the like of the user. The amount of such intake is suitably in the range of 0.1 to 100 g, and preferably in the range of 1 to 60 g, as the weight of the plant extract according to the present invention per adult day. It is not limited to the range. Such a daily use amount may be used once or may be used by dividing into two to four times.
以下に参考例、抽出例、試験例、実施例を掲げて本発明をさらに詳述する。但し、本発明が下記実施例に限定されないことは言うまでもない。
参考例１ ケイシエキス（５０％エタノール抽出）の製造
ケイシ粉末（前忠株式会社製）５ｇを５０％エタノール１００mLに浸漬し、常温で５日間静置した後、濃縮、凍結乾燥し、ケイシエキスを得た。
抽出例１ 各植物エキス（メタノール抽出）の製造
表１に記載の番号１〜１９の各植物を風乾後、６０℃で一晩乾燥させた。ブレンダーにて粉砕後、得られた粉砕物 １００ｇをメタノール５００ｍLに浸漬し、常温で一週間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターでメタノールを留去して乾固し、番号１〜１９の各植物エキスを得た。
Hereinafter, the present invention will be described in more detail with reference to reference examples, extraction examples, test examples, and examples. However, it goes without saying that the present invention is not limited to the following examples.
Reference Example 1 Production of keissi extract (50% ethanol extraction) 5 g of keissi powder (manufactured by Maechu Corporation) was immersed in 100 mL of 50% ethanol, allowed to stand at room temperature for 5 days, concentrated and freeze-dried to obtain a keissi extract .
Extraction Example 1 Production of Each Plant Extract (Methanol Extraction) Each plant of Nos. 1 to 19 described in Table 1 was air-dried and then dried at 60 ° C. overnight. After pulverizing with a blender, 100 g of the obtained pulverized product was immersed in 500 mL of methanol and allowed to stand at room temperature for one week. The filtrate obtained by filtering the obtained extract was distilled off methanol with a rotary evaporator and dried to obtain plant extracts Nos. 1 to 19.
試験例１ メイラード反応阻害活性の測定
参考例１、抽出例１で得られた各植物エキスはジメチルスルホキシド（ＤＭＳＯ）に３０ｍｇ／ｍＬとなるように溶解した。なお、参考例１のケイシエキスを陽性対照として用いた。また、陰性対照には、検体の代わりにＤＭＳＯを用いた。
Test Example 1 Measurement of Maillard Reaction Inhibitory Activity Each plant extract obtained in Reference Example 1 and Extraction Example 1 was dissolved in dimethylsulfoxide (DMSO) so as to be 30 mg / mL. In addition, the poppy extract of Reference Example 1 was used as a positive control. As a negative control, DMSO was used instead of the sample.
各検体はＤＭＳＯで、試験溶液中の植物エキスの最終濃度が１０、５、２．５、１．２５、０．６２５μｇ／ｍＬとなるように調製した。各検体２０μＬ、１００ｍＭリン酸バッファー５００μＬ、蒸留水１８０μＬ、２Ｍグルコース溶液１００μＬ、４ｍｇ／ｍＬ ＢＳＡ溶液２００μＬを１．５ｍLマイクロテストチューブ（アズワン社製）に入れて混合し、試験溶液とした。その後、試験溶液及び陰性対照を６０℃下３０時間インキュベートした。 Each sample was prepared in DMSO so that the final concentration of the plant extract in the test solution was 10, 5, 2.5, 1.25, 0.625 μg / mL. 20 μL of each sample, 500 μL of 100 mM phosphate buffer, 180 μL of distilled water, 100 μL of a 2 M glucose solution, and 200 μL of a 4 mg / mL BSA solution were placed in a 1.5 mL micro test tube (manufactured by As One Corporation) and mixed to prepare a test solution. Thereafter, the test solution and the negative control were incubated at 60 ° C. for 30 hours.
次に、この反応液１ｍＬへトリクロロ酢酸（ＴＣＡ）１００ｍＬを添加し、４℃下、１５０００ｒｐｍで４分間遠心分離した。上清を除去後、残った沈殿物を０．２５Ｎ 水酸化ナトリウム−ＰＢＳ溶液１ｍＬにて溶解した。得られた試験溶液を、蛍光プレートリーダー（インフィニットＭ２００ＦＡＬ、５５２−８２６３１、ＴＥＣＡＮ社製）を用いて、励起波長３６０ｎｍ、蛍光波長４４０ｎｍにて蛍光測定した。 Next, 100 mL of trichloroacetic acid (TCA) was added to 1 mL of the reaction solution, and centrifuged at 15,000 rpm for 4 minutes at 4 ° C. After removing the supernatant, the remaining precipitate was dissolved in 1 mL of a 0.25N sodium hydroxide-PBS solution. The fluorescence of the obtained test solution was measured at an excitation wavelength of 360 nm and a fluorescence wavelength of 440 nm using a fluorescent plate reader (Infinite M200FAL, 552-82631, manufactured by TECAN).
ブランク１として、陰性対照と同組成の溶液であって、インキュベートしていないものを用いた。また、試験溶液と同組成の溶液であって、インキュベートしていないものをブランク２とした。 As Blank 1, a solution having the same composition as that of the negative control and not incubated was used. A solution having the same composition as the test solution but not incubated was used as blank 2.
メイラード反応阻害活性（％）は、以下の数式に従い算出した。 The Maillard reaction inhibitory activity (%) was calculated according to the following formula.
横軸に試料の濃度（ｍｇ／ｍＬ）、縦軸にメイラード反応阻害活性（％）をとった対数グラフを作成し、５０％阻害活性を示す濃度（ＩＣ50）を算出した。その結果を表２に示す。 A logarithmic graph was prepared in which the concentration of the sample (mg / mL) was plotted on the horizontal axis and the Maillard reaction inhibitory activity (%) was plotted on the vertical axis, and the concentration (IC 50 ) showing 50% inhibitory activity was calculated. Table 2 shows the results.
表２に示したとおり、本発明に係る植物エキスは、強力なメイラード反応阻害作用が報告されているケイシのＩＣ50と同等またはそれ以上の阻害活性を示し、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 2, the plant extract according to the present invention exhibit strong Maillard equivalent IC 50 of twig reaction inhibitory activity has been reported or more inhibitory activity, have excellent Maillard reaction inhibitory effect It has been shown.
抽出例２ アセンヤクノキおよびヌルデの植物エキスの製造
表１および２に記載の番号４（ヌルデ、虫えい）および番号１２（アセンヤクノキ、心材）について、各植物を風乾後、６０℃で一晩乾燥させ、ブレンダーにて粉砕した。得られた粉砕物 ２ｇおよび３０ｍLの各抽出溶媒（９９．５％エタノール、７０％含水エタノールまたは水）を５０ｍL容のスクリューキャップ付試験管に入れて攪拌した後、８０℃で３０分間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターで濃縮乾固し、表３に記載の番号２０〜２５の各植物エキスを得た。
試験例２ メイラード反応阻害活性の測定
抽出例２で得られた各植物エキスは、試験例１の方法に従って、メイラード反応阻害活性を測定した。ただし、各植物エキスはＤＭＳＯの代わりに各抽出溶媒に溶解し、検体調製には、ＤＭＳＯの代わりに各抽出溶媒を用いた。試料溶液中の植物エキスの最終濃度は１０、５、２、０.２、０.１μｇ／ｍＬとなるよう調製した。また、陽性対照として、アセンヤクノキ（心材）およびヌルデ（虫えい）のメタノール抽出エキスを用い、陰性対照として、検体の代わりに抽出溶媒を用いた。
Extraction Example 2 Production of plant extracts of Acacia catechu and Nurde For No. 4 (Nurude, Insect) and No. 12 (Acacia catechu, heartwood) described in Tables 1 and 2, each plant was air-dried and then dried at 60 ° C. overnight. Crushed in a blender. 2 g of the obtained crushed product and 30 mL of each extraction solvent (99.5% ethanol, 70% aqueous ethanol or water) were placed in a 50 mL test tube with a screw cap, stirred, and allowed to stand at 80 ° C. for 30 minutes. . The filtrate obtained by filtering the obtained extract was concentrated to dryness with a rotary evaporator to obtain each plant extract of Nos. 20 to 25 shown in Table 3.
Test Example 2 Measurement of Maillard Reaction Inhibitory Activity For each plant extract obtained in Extraction Example 2, the Maillard reaction inhibitory activity was measured according to the method of Test Example 1. However, each plant extract was dissolved in each extraction solvent instead of DMSO, and each extraction solvent was used instead of DMSO for sample preparation. The final concentration of the plant extract in the sample solution was adjusted to be 10, 5, 2, 0.2, 0.1 μg / mL. As a positive control, a methanol extract of Acacia catechu (heartwood) and Nurde (Mushii) was used, and as a negative control, an extraction solvent was used instead of the sample.
その結果を表３に示す。 Table 3 shows the results.
表３に示したとおり、本発明に係る植物エキスは、試験例２で用いたいずれの溶媒で抽出したエキスであっても、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 3, it was shown that the plant extract according to the present invention had an excellent Maillard reaction inhibitory activity even when extracted with any of the solvents used in Test Example 2.
抽出例３ ヒシ属の植物エキスの製造
ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）の果実、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）の果実および果皮、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）の果実および果皮について、抽出例２と同様の方法に従って植物エキスの製造を行い、各植物エキスを得た。
試験例３ メイラード反応阻害活性の測定
試験例２と同様の方法に従って、表４に記載の番号２６〜３７の各植物エキスについてメイラード反応阻害活性の測定を行った。ただし、陽性対照として、ヒシ（果実）のメタノール抽出エキスを用いた。
Extraction Example 3 Production of a plant extract of the genus Russula fruit of Trapa japonica Flerov, fruits and pericarp of Trapa bispinosa Roxb., Extract of Trapa natans L. var. A plant extract was produced in the same manner as in Example 2 to obtain each plant extract.
Test Example 3 Measurement of Maillard Reaction Inhibitory Activity According to the same method as in Test Example 2, the measurement of Maillard reaction inhibitory activity was performed on each of plant extracts Nos. 26 to 37 shown in Table 4. However, as a positive control, a methanol extract of a Japanese wild boar (fruit) was used.
その結果を表４に示す。 Table 4 shows the results.
表４に示したとおり、本発明に係る植物エキスは、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 4, it was shown that the plant extract according to the present invention has an excellent Maillard reaction inhibitory action.
次に、本発明阻害剤を含有する経口剤、外用剤、飲食品の実施例を示す。
実施例１ 経口剤（錠剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って錠剤を製造する。
Next, examples of oral preparations, external preparations, and foods and beverages containing the inhibitor of the present invention will be described.
Example 1 Preparation of oral preparation (tablet) Each component is mixed in accordance with the following mixing ratio to produce a tablet according to a conventional method.
実施例２ 経口剤（顆粒剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って顆粒剤を製造する。
Example 2 Preparation of oral preparation (granule) Each component is mixed according to the following mixing ratio, and a granule is produced according to a conventional method.
実施例３ 経口剤（ソフトカプセル剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってソフトカプセル剤を製造する。
Example 3 Preparation of Oral Preparation (Soft Capsule) Each component is mixed in accordance with the following mixing ratio, and a soft capsule is produced according to a conventional method.
実施例４ 外用剤（クリーム）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってクリームを製造する。
Example 4 Preparation of external preparation (cream) A cream is produced by mixing each component according to the following mixing ratio and according to a conventional method.
実施例５ 外用剤（化粧水）の調製
以下の配合割合に従い、各成分を混合して、常法に従って化粧水を製造する。
Example 5 Preparation of external preparation (lotion) Each component is mixed according to the following mixing ratio, and a lotion is produced according to a conventional method.
実施例６ 飲食品（飲料）の調製
以下の配合割合に従い、各成分を混合して、常法に従って飲料を製造する。
Example 6 Preparation of Food and Beverage (Beverage) Each component is mixed according to the following mixing ratio, and a beverage is manufactured according to a conventional method.
実施例７ 飲食品（キャンデー）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってキャンディーを製造する。
Example 7 Preparation of Food and Beverage (Candy) Each component is mixed according to the following compounding ratio, and a candy is manufactured according to a conventional method.
Claims (7)
The oral preparation or food or drink according to any one of claims 1 to 4, which is used for suppressing a decrease in elasticity of cartilage.
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