JP6064012B1 - Method for producing fine hollow projection - Google Patents

Abstract

To provide a method for producing a fine hollow projection capable of producing a fine hollow projection efficiently and continuously while suppressing an increase in cost. A method for producing a fine hollow projection 1 according to the present invention comprises contacting a convex portion 11 provided with a heating means from one surface 2D side of a base sheet 2 formed containing a thermoplastic resin, Protrusion formation that forms the protrusion 3 protruding from the other surface 2U side of the base sheet 2 while the convex part 11 is pierced into the base sheet 2 while the contact portion TP in the base sheet 2 is softened by heat A process is provided. In addition, a cooling step is provided for cooling the protruding portion 3 in a state where the protruding portion 11 is stabbed inside the protruding portion 3. Then, after the cooling step, a release step of removing the convex portion 11 from the inside of the protrusion 3 to form the fine hollow protrusion 1 is provided. [Selection] Figure 4

Description

  The present invention relates to a method for producing a fine hollow projection having a hollow inside.

  In recent years, the supply of agents using microneedles has been attracting attention for the reason that the skin is not damaged and there is little pain in spite of the performance equivalent to that of the agent supplied by a syringe. Among the microneedles, hollow microneedles, in particular, can expand the options for the agent disposed in the hollow portion.

  In general, microneedles include a self-dissolving type in which the needle itself is made of a soluble agent and a coating type in which the needle surface is coated with the agent, in addition to the hollow type. However, in both cases, the supply amount (retention amount) of the agent depends on the shape of the needle. On the other hand, the hollow mold has an advantage that a large amount of agent can be supplied without depending on the needle shape.

  The microneedle can be manufactured by, for example, a manufacturing method disclosed in Patent Document 1 or 2. Since the manufacturing method described in Patent Document 1 arranges a resin body on an elastic body, and heats the resin body from the back side of the elastic body, a fine nozzle is made to penetrate the resin body to manufacture a fine nozzle. There is no need to use a mold including fine concave portions in which the outer shape of the concave and convex portions is inverted. Therefore, it is said that the disposable fine nozzle made from resin can be manufactured.

  Patent Document 2 states that a hollow microneedle array can be manufactured using a pre-formed mold.

  Patent Document 3 discloses a method of manufacturing a microneedle by bridging a base sheet into a rod-shaped convex shape, and then heating the entire base sheet to deform it into a rod-shaped convex shape. Has been.

JP 2013-172833 A JP 2012-523270 A Japanese translation of PCT publication No. 2003-501161

  However, since the manufacturing method of the fine nozzle described in Patent Document 1 is heated from the back side of the elastic body using a hot plate or the like to warm the entire resin body arranged on the elastic body, It takes time to warm up and it is difficult to improve productivity. Moreover, since it is necessary to warm the whole resin body arrange | positioned on an elastic body, it is difficult to manufacture a fine nozzle continuously.

  Moreover, the manufacturing method of the fine through-hole molded product described in Patent Document 2 leads to an increase in cost because the mold for molding is expensive, and the degree of freedom of the shape of the microneedle and the material that can be selected is high. Low.

  Moreover, in the method of patent document 3, since the whole base material sheet is heated, it takes time to warm the whole resin body, and it is difficult to improve productivity. Further, when the fine needles are formed in an array shape, it is highly possible that parts other than the fine needle-shaped portion are subjected to thermal deformation, and it may be difficult to control the distance from the bottom of the sheet to the tip of the needle.

  Therefore, this invention is providing the manufacturing method of the fine hollow protrusion which can eliminate the fault which the prior art mentioned above has.

  The present invention is a method for producing a hollow microprojection having a hollow inside, wherein a convex portion provided with a heating means is brought into contact from one side of a base material sheet formed including a thermoplastic resin, A projecting part forming step of forming a projecting part protruding from the other surface side of the base sheet by piercing the base part sheet while softening the corresponding contact part in the base sheet by heat; and A cooling step for cooling the protruding portion with the protruding portion stabbed inside the protruding portion, and after the cooling step, the protruding portion is removed from the protruding portion to form the fine hollow protrusion. And a release process for producing a fine hollow projection.

  According to the present invention, it is possible to suppress the increase in cost and to manufacture the fine hollow protrusions efficiently and continuously.

FIG. 1 is a schematic perspective view of an example of a fine hollow protrusion manufactured by the method for manufacturing a fine hollow protrusion of the present invention. 2 is a cross-sectional view taken along line II-II shown in FIG. FIG. 3 is an explanatory view showing a method for measuring the tip diameter of the hollow projection. FIG. 4 is a diagram showing an overall configuration of the first embodiment of the manufacturing apparatus for manufacturing the fine hollow projection shown in FIG. 1. FIG. 5 is an explanatory diagram showing a method for measuring the tip angle of the convex portion. 6 (a) to 6 (c) are diagrams illustrating a process of manufacturing a fine hollow projection using the manufacturing apparatus shown in FIG. FIGS. 7A to 7C are diagrams illustrating a process of manufacturing a fine hollow protrusion using the manufacturing apparatus of the second embodiment. FIG. 8 is a schematic perspective view of another example of a fine hollow protrusion produced by the method for producing a fine hollow protrusion of the present invention. FIG. 9 is a diagram showing an overall configuration of a manufacturing apparatus according to a preferred embodiment for manufacturing the fine hollow projection shown in FIG. 8 (corresponding to FIG. 4). FIG. 10 is a diagram showing an overall configuration of a manufacturing apparatus according to another preferred embodiment for manufacturing the fine hollow projection shown in FIG. 8 (corresponding to FIG. 4).

Hereinafter, the present invention will be described based on the preferred first embodiment with reference to the drawings.
The production method of the present invention is a method for producing a fine hollow projection having a hollow inside. FIG. 1 shows a fine hollow protrusion 1 according to an embodiment manufactured by the method of manufacturing a fine hollow protrusion according to the first embodiment. The fine hollow protrusion 1 has a sheet-like base portion 2 and one conical protrusion portion 3 standing on the upper surface of the base portion 2. As shown in FIG. 2, the fine hollow projection 1 has a hollow interior. Specifically, a hollow space is formed extending through the base portion 2 and into the inside of the protrusion 3. In the fine hollow protrusion 1, the space inside the protrusion 3 is formed in a conical shape corresponding to the outer shape of the protrusion 3. In addition, although the projection part 3 is a cone shape in the fine hollow protrusion 1, in addition to a cone shape, a truncated cone shape, a column shape, a prism shape, a pyramid shape, a truncated pyramid shape, etc. may be sufficient. .

  When the microscopic hollow projection 1 has a projection height H1 when it is used as a microneedle, the tip is inserted into the stratum corneum at the shallowest point and deeply into the dermis, preferably 0.01 mm or more, More preferably, it is 0.02 mm or more, preferably 10 mm or less, more preferably 5 mm or less, specifically preferably 0.01 mm or more and 10 mm or less, more preferably 0.02 mm or more. 5 mm or less. The protrusion 3 has an average thickness T1 of preferably 0.005 mm or more, more preferably 0.01 mm or more, and preferably 1.0 mm or less, more preferably 0.5 mm or less. Specifically, it is preferably 0.005 mm or more and 1.0 mm or less, and more preferably 0.01 mm or more and 0.5 mm or less. The base 2 has a thickness T2 of preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 1.0 mm or less, more preferably 0.7 mm or less. Is preferably 0.01 mm or more and 1.0 mm or less, more preferably 0.02 mm or more and 0.7 mm or less.

  The tip diameter of the fine hollow projection 1 is preferably 0.001 mm or more, more preferably 0.005 mm or more, and preferably 0.5 mm or less, more preferably 0.3 mm or less. Specifically, it is preferably 0.001 mm to 0.5 mm, and more preferably 0.005 mm to 0.3 mm. The tip diameter of the fine hollow projection 1 is measured as follows.

[Measurement of tip diameter of fine hollow projection 1]
For example, the tip of the hollow protrusion 1 is observed like a SEM image shown in FIG. 3 in a state where the tip is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope. Next, as shown in FIG. 3, the imaginary straight line ILa is extended along the straight line portion on one side 1a of the both sides 1a and 1b, and the imaginary straight line ILb is extended along the straight line portion on the other side 1b. Then, on the distal end side, a location where the one side 1a is separated from the virtual straight line ILa is obtained as the first distal point 1a1, and a location where the other side 1b is separated from the virtual straight line ILb is obtained as the second distal point 1b1. The length L of the straight line connecting the first tip point 1a1 and the second tip point 1b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is measured. Is the tip diameter of the fine hollow projection 1.

  Next, the manufacturing method of the fine hollow projection of this invention is demonstrated with reference to FIGS. 4-6 using the manufacturing method of the fine hollow projection 1 mentioned above as an example. FIG. 4 shows the overall configuration of the manufacturing apparatus 100 according to the first embodiment used for carrying out the manufacturing method according to the first embodiment. As described above, the fine hollow protrusion 1 is very small, but for convenience of explanation, the fine hollow protrusion 1 is drawn very large in FIG.

  The manufacturing apparatus 100 according to the first embodiment shown in FIG. 4 includes a protruding portion forming portion 10 that forms the protruding portion 3 on the base sheet 2A from the upstream side to the downstream side, a cooling portion 20, and a convex portion 11 described later. Are provided with a release portion 30, a cutting portion 40 for cutting into each fine hollow projection 1, and a re-pitch portion 50 for adjusting the interval between the fine hollow projections 1. In the following description, the direction in which the base sheet 2A is transported (the longitudinal direction of the base sheet 2A) is the Y direction, the direction orthogonal to the transport direction and the width direction of the transported base sheet 2A are transported in the X direction. The thickness direction of the base sheet 2 </ b> A will be described as the Z direction. In the present specification, the convex part 11 is a member provided with a convex mold 110 that is a part that pierces the substrate sheet. In this embodiment, the convex part 11 has the convex mold 110 on the disk-shaped base part. It has a structure. However, the present invention is not limited to this, and it may be a convex part composed only of the convex mold 110, or may be a convex part 11 in which a plurality of convex molds 110 are arranged on a table-like support as in the embodiment described later. There may be.

  As shown in FIG. 4, the protruding portion forming portion 10 includes a convex portion 11 having heating means (not shown). In the manufacturing apparatus 100 of the first embodiment, no heating means is provided other than the heating means (not shown) of the convex portion 11. In the present specification, “no heating means other than the heating means of the convex portion 11” not only refers to the case of excluding other heating means, but also below the softening temperature of the base sheet 2A, Or the case where a means for heating below the glass transition temperature is provided is included. However, it is preferable not to include any other heating means. The heating means (not shown) of the convex portion 11 is a heater device in the manufacturing apparatus 100 of the first embodiment. In the first embodiment, first, the belt-like base sheet 2A is fed out from the raw roll of the base sheet 2A formed by including the thermoplastic resin, and is conveyed in the Y direction. And the convex part 11 is made to contact | abut from the one surface 2D side of the strip | belt-shaped base material sheet 2A currently conveyed by the Y direction, and softens the contact part TP in the base material sheet 2A with a heat | fever. The base material sheet 2A is stabbed and the protrusion part 3 which protrudes from the other surface 2U side of the base material sheet 2A is formed (projection part formation process). Specifically, the convex portion 11 has a shape having a conical portion with a sharp tip corresponding to the outer shape of the conical protrusion 3 of the fine hollow protrusion 1 to be manufactured. In the manufacturing apparatus 100 of the first embodiment, the convex portion 11 is arranged with its tip facing upward, and is movable up and down at least in the thickness direction (Z direction). More specifically, in the manufacturing apparatus 100 of the first embodiment, the convex portion 11 can be moved up and down in the thickness direction (Z direction) by an electric actuator (not shown), and the conveying direction (Y direction). ) In parallel with the base sheet 2A. Control of the operation of the convex portion 11 is controlled by a control means (not shown) provided in the manufacturing apparatus 100 of the first embodiment. As described above, the manufacturing apparatus 100 of the first embodiment is an apparatus having the so-called box motion type projection forming part 10 that draws an endless track. Control of heating of the heating means (not shown) of the convex portion 11 is also controlled by a control means (not shown) provided in the manufacturing apparatus 100 of the first embodiment.

  The base sheet 2A is a sheet that becomes the base portion 2 of the fine hollow protrusion 1 to be manufactured, and is formed to include a thermoplastic resin. Examples of the thermoplastic resin include poly fatty acid ester, polycarbonate, polypropylene, polyethylene, polyester, polyamide, polyamideimide, polyetheretherketone, polyetherimide, polystyrene, polyethylene terephthalate, polyvinyl chloride, nylon resin, acrylic resin, etc. From the viewpoint of biodegradability, poly fatty acid esters are preferably used. Specific examples of the polyfatty acid ester include polylactic acid, polyglycolic acid, and combinations thereof. The base sheet 2A may be formed of a mixture containing hyaluronic acid, collagen, starch, cellulose and the like in addition to the thermoplastic resin. The thickness of the base material sheet 2A is equal to the thickness T2 of the base portion 2 of the fine hollow protrusion 1 to be manufactured.

The shape on the front end side of the convex portion 11 only needs to be a shape corresponding to the outer shape of the protrusion 3 of the fine hollow protrusion 1 to be manufactured. The convex mold 110 of the convex mold part 11 is formed such that its height H2 is the same as or slightly higher than the height H1 of the fine hollow projection 1 to be manufactured, preferably 0.01 mm or more, more preferably 0. 0.02 mm or more, preferably 30 mm or less, more preferably 20 mm or less, specifically preferably 0.01 mm or more and 30 mm or less, more preferably 0.02 mm or more and 20 mm or less. . The convex mold 110 of the convex mold part 11 has a tip diameter D1 (see FIG. 5) of preferably 0.001 mm or more, more preferably 0.005 mm or more, and preferably 1 mm or less, more preferably It is 0.5 mm or less, specifically, preferably 0.001 mm or more and 1 mm or less, and more preferably 0.005 mm or more and 0.5 mm or less. The tip diameter D1 of the convex mold 110 of the convex mold part 11 is measured as follows.
The convex mold 110 of the convex mold section 11 has a root diameter D2 of preferably 0.1 mm or more, more preferably 0.2 mm or more, and preferably 5 mm or less, more preferably 3 mm or less. Specifically, it is preferably 0.1 mm or more and 5 mm or less, and more preferably 0.2 mm or more and 3 mm or less. The convex mold 110 of the convex mold section 11 has a tip angle α of preferably 1 degree or more, more preferably 5 degrees or more, from the viewpoint that sufficient strength can be easily obtained. The tip angle α is preferably 60 degrees or less, more preferably 45 degrees or less from the viewpoint of obtaining the protrusion 3 having an appropriate angle, and specifically, preferably 1 degree or more and 60 degrees or less. More preferably, it is 5 degrees or more and 45 degrees or less. The tip angle α of the convex portion 11 is measured as follows.

[Measurement of the tip diameter of the convex part 110 of the convex part 11]
The tip part of the convex part 110 of the convex part 11 is observed in a state of being enlarged to a predetermined magnification using a scanning electron microscope (SEM) or a microscope. Next, as shown in FIG. 5, the virtual straight line ILc is extended along the straight line portion on the one side 11a of the both sides 11a and 11b, and the virtual straight line ILd is extended along the straight line portion on the other side 11b. Then, on the distal end side, a location where the one side 11a is separated from the virtual straight line ILc is obtained as the first distal point 11a1, and a location where the other side 11b is separated from the virtual straight line ILd is obtained as the second distal point 11b1. The length D1 of the straight line connecting the first tip point 11a1 and the second tip point 11b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is measured. Is the tip diameter of the convex mold 110.

[Measurement of Tip Angle α of Convex Mold 110 of Convex Mold Part 11]
The tip part of the convex part 110 of the convex part 11 is observed as a SEM image shown in FIG. 5, for example, in a state where it is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope. Next, as shown in FIG. 5, the virtual straight line ILc is extended along the straight line portion on the one side 11a of the both sides 11a and 11b, and the virtual straight line ILd is extended along the straight line portion on the other side 11b. Then, the angle formed between the virtual straight line ILc and the virtual straight line ILd is measured using a scanning electron microscope (SEM) or a microscope, and the measured angle is determined as the tip angle α of the convex mold 110 of the convex portion 11. And

  The convex part 11 is formed of a high-strength material that is difficult to break. Examples of the material of the convex part 11 include metals such as steel, stainless steel, aluminum, aluminum alloy, nickel, nickel alloy, cobalt, cobalt alloy, copper, copper alloy, beryllium copper, and beryllium copper alloy, or ceramic. .

  In the manufacturing apparatus 100 of the first embodiment, the protruding portion forming portion 10 is a support member 12 that supports the base sheet 2A when the protruding portion 11 is pierced into the base sheet 2A as shown in FIG. have. The support member 12 is disposed on the other surface 2U side of the base sheet 2A, and serves to make the sheet base material 2A difficult to bend when the convex portion 11 is inserted from the one surface 2D side. Therefore, the support member 12 is arrange | positioned in parts other than the area | region where the convex part 11 of the base material sheet 2A is stabbed, and in the manufacturing apparatus 100 of a 1st embodiment, the conveyance direction (Y of base material sheet 2A) (Direction) is formed from a pair of plate-like members extending in parallel to the transport direction (Y direction). Each support member 12 extends from the protrusion forming part 10 to the position where the release part 30 ends through the cooling part 20.

  The material constituting the support member 12 may be the same material as the convex portion 11 or may be formed of a synthetic resin or the like.

  In the projection forming step of the first embodiment, as shown in FIG. 4, the projection is formed on the other surface 2U side (upper surface side) of the strip-shaped base sheet 2A that is fed from the raw roll and conveyed in the Y direction. The paired support members 12 and 12 support both side portions along the conveyance direction (Y direction) of the base sheet 2A. And, using the box motion type projection forming part 10, a portion of the base sheet 2A that is not supported by the support member 12, that is, a central portion between the pair of support members 12 and 12 in the base sheet 2A. The convex portion 11 is brought into contact with the surface 2D side (lower surface side). Thus, in the protrusion forming step, the other surface 2U side (upper surface side) corresponding to the contact portion TP of the base sheet 2A with which the convex portion 11 is contacted is for forming a protrusion. There is no recess or the like that fits into the convex portion 11, and it is in a floating state.

  In the first embodiment, as shown in FIG. 6 (a), in the contact portion TP, the convex part 11 is heated by the heater device, and heat is generated in the contact portion TP, so that the contact portion is formed. Softens TP. Then, while softening the contact portion TP, as shown in FIG. 6B, the convex portion 11 is moved from the one surface 2D side (lower surface side) to the other surface 2U side (upper surface side) as shown in FIG. It raises and stabs into the base material sheet 2A, and the protrusion part 3 which protrudes from the other surface 2U side (upper surface side) of the base material sheet 2A is formed.

  From the viewpoint of forming the convex part 11, the heating temperature of the base sheet 2A by the convex part 11 is preferably equal to or higher than the glass transition temperature of the base sheet 2A used and lower than the melting temperature, and in particular, melted above the softening temperature. It is preferable that the temperature is lower than the temperature. More specifically, the heating temperature is preferably 30 ° C. or higher, more preferably 40 ° C. or higher, and preferably 300 ° C. or lower, more preferably 250 ° C. or lower. It is not less than 300 ° C and more preferably not less than 40 ° C and not more than 250 ° C. In addition, what is necessary is just to adjust the heating temperature of the convex-shaped part 11 in the range mentioned above, when using a heater apparatus like 1st Embodiment. In addition, the said heating temperature is applied as a temperature range of the part of the base material sheet 2A which contacted the convex mold 110, also when heating the base material sheet 2A using an ultrasonic vibration apparatus in 1st Embodiment. . The glass transition temperature (Tg) is measured by the following method, and the softening temperature is measured according to JIS K-7196 “Softening temperature test method by thermomechanical analysis of thermoplastic film and sheet”. .

The “glass transition temperature (Tg) of the base sheet” means the glass transition temperature (Tg) of the constituent resin of the base sheet, and when there are a plurality of types of the constituent resins, the plurality of types of glass transitions. When the temperatures (Tg) are different from each other, the heating temperature of the base sheet by the heating means is preferably at least the lowest glass transition temperature (Tg) among the plurality of glass transition temperatures (Tg), More preferably, the glass transition temperature (Tg) is higher than the highest glass transition temperature (Tg).
Further, the "softening temperature of the base sheet" is also the same as the glass transition temperature (Tg), that is, when there are a plurality of types of constituent resins of the base sheet, when the plurality of types of softening temperatures are different from each other, The heating temperature of the base sheet by the heating means is preferably at least the lowest softening temperature among the plurality of softening temperatures, and more preferably at least the highest softening temperature among the plurality of softening temperatures.
Moreover, when the base sheet is configured to include two or more kinds of resins having different melting points, the heating temperature of the base sheet by the heating means is preferably less than the lowest melting point among the plurality of melting points. .

[Measurement method of glass transition temperature (Tg)]
The amount of heat is measured using a DSC measuring instrument to determine the glass transition temperature. Specifically, the measuring instrument uses a differential scanning calorimeter (Diamond DSC) manufactured by Perkin Elmer. 10 mg of a test piece is collected from the base sheet. The measurement conditions are that 20 ° C. is isothermal for 5 minutes, and then the temperature is increased from 20 ° C. to 320 ° C. at a rate of 5 ° C./min to obtain a DSC curve of the horizontal axis temperature and the vertical axis calorific value. And glass transition temperature Tg is calculated | required from this DSC curve.

  The insertion speed at which the convex portion 11 is inserted into the base sheet 2A is excessively softened by heating the resin excessively, and if it is too fast, the heat softening becomes insufficient, so that the convex portion 11 can be efficiently formed. Therefore, it is preferably 0.1 mm / second or more, more preferably 1 mm / second or more, and preferably 1000 mm / second or less, more preferably 800 mm / second or less, and specifically preferably 0 mm / second or less. It is 1 mm / second or more and 1000 mm / second or less, more preferably 1 mm / second or more and 800 mm / second or less. When the heating time of the convex part 11 is stopped and the softening time, which is the time until the convex part 11 is transported to the next process (cooling process) in a state where the convex part 11 is stuck inside the protrusion 3, is too long. From the viewpoint of compensating for insufficient heating, it is preferably 0 seconds or longer, more preferably 0.1 seconds or longer, and preferably 10 seconds or shorter, more preferably 5 seconds or shorter. Specifically, it is preferably 0 second or longer and 10 seconds or shorter, and more preferably 0.1 second or longer and 5 seconds or shorter.

  From the viewpoint of efficiently forming the convex portion 11, the insertion height of the convex portion 11 that pierces the base sheet 2 </ b> A is preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably Is not more than 10 mm, more preferably not more than 5 mm, specifically preferably not less than 0.01 mm and not more than 10 mm, more preferably not less than 0.02 mm and not more than 5 mm. Here, “the insertion height” means that the apex of the convex portion 11 and the other surface 2U (upper surface) of the base sheet 2A in the state where the convex portion 11 is most inserted into the base sheet 2A. Means the distance between. Therefore, the piercing height in the protruding portion forming step means that the protruding portion 11 is deeply inserted in the protruding portion forming step and the protruding portion 11 comes out from the other surface 2U of the base sheet 2A. It is the distance from the other surface 2U to the apex of the convex portion 11 measured in the vertical direction.

  Next, in the manufacturing apparatus 100 of the first embodiment, as shown in FIG. 4, the cooling unit 20 is installed downstream of the protrusion forming unit 10. As shown in FIG. 4, the cooling unit 20 includes a cold air blowing device 21. In the first embodiment, after the protruding portion forming step, cooling is performed using the cold air blowing device 21 in a state where the protruding portion 11 is stabbed inside the protruding portion 3 (cooling step). Specifically, the cold air blowing device 21 covers the entire other surface 2U side (upper surface side) and one surface 2D side (lower surface side) of the belt-shaped base sheet 2A being conveyed. The belt-shaped base sheet 2A is conveyed in the conveyance direction (Y direction). In the tunnel of the cold air blowing device 21, an air blowing port 22 (see FIG. 6C) for blowing cold air is provided on the other surface 2U side (upper surface side) of the base sheet 2 </ b> A. It is designed to cool by spraying. Control of the cooling temperature and cooling time of the cold air blower 21 is also controlled by a control means (not shown) provided in the manufacturing apparatus 100 of the first embodiment.

  In the cooling process of the first embodiment, as shown in FIG. 4, the protruding portion 11 is inserted into the inside of the protruding portion 3 in the tunnel of the cold air blowing device 21 using the box motion type protruding portion forming portion 10. In this state, the substrate sheet 2A is conveyed in parallel with the conveyance direction (Y direction), and is arranged on the other surface 2U side (upper surface side) of the substrate sheet 2A in the tunnel as shown in FIG. Cooling air is blown from the blower opening 22, and cooling is performed while the protruding portion 11 is stuck inside the protrusion 3. When cooling, the heating of the convex portion 11 by the heater device may be continued or stopped.

  When the heating means (not shown) of the convex part 11 is a heater device as in the first embodiment, the cooling part 20 installed downstream of the protrusion part forming part 10 may be natural cooling. It is preferable to perform positive cooling, and it is preferable to provide the cold air blowing device 21.

  The temperature of the cold air to be blown is preferably −50 ° C. or higher, more preferably −40 ° C. or higher, and preferably 26 ° C. or lower, more preferably 10 ° C. or lower, from the viewpoint of forming the convex portion 11. Specifically, it is preferably −50 ° C. or higher and 26 ° C. or lower, and more preferably −40 ° C. or higher and 10 ° C. or lower. The cooling time for cooling by blowing cold air is preferably 0.01 seconds or more, more preferably 0.5 seconds or more, and preferably 60 seconds or less, from the viewpoint of compatibility between moldability and processing time. More preferably, it is 30 seconds or less, specifically, preferably 0.01 seconds or more and 60 seconds or less, more preferably 0.5 seconds or more and 30 seconds or less.

  Next, in the manufacturing apparatus 100 of the first embodiment, as shown in FIG. 4, the release unit 30 is installed downstream of the cooling unit 20. In the first embodiment, after the cooling step, using the box motion type projection forming portion 10, the convex portion 11 is removed from the inside of the projection 3 to form the precursor 1 </ b> A of the fine hollow projection 1. (Release process). Specifically, in the release process of the first embodiment, as shown in FIG. 6 (d), using the box motion type projection forming part 10, from one surface 2D side (lower surface side) of the base sheet 2 </ b> A. From the state where the convex part 11 is lowered and the convex part 11 is stabbed inside the projecting part 3, the convex part 11 is removed, and the fine hollow projecting object 1 is formed into a hollow fine hollow projecting object 1 inside. 1A is formed.

  Next, in the manufacturing apparatus 100 of the first embodiment, as shown in FIG. 4, a cutting part 40 is installed downstream of the release part 30. In the manufacturing apparatus 100 of the first embodiment, the cutting part 40 includes a cutter part 41 having a cutter blade at the tip and an anvil part 42. The cutter blade of the cutter unit 41 is formed wider than the entire width (length in the X direction) of the belt-shaped fine hollow projection precursor 1A. In the first embodiment, after the release step, the belt-shaped fine hollow projection precursor 1A is transported between the pair of cutter parts 41 and the anvil part 42 and is adjacent to the transport direction (Y direction). The fine hollow protrusion 1 of a single wafer is continuously manufactured by cutting with a cutter blade of the cutter part 41 between the protrusions 3 and 3.

  The cutting of the precursor 1A of the band-shaped fine hollow protrusions only needs to be performed so as to extend in the width direction of each fine hollow protrusion 1, and can be performed linearly across the width direction of each fine hollow protrusion 1, for example. . Or it can cut so that a cutting line may draw a curve. In any case, it is preferable to employ a cutting pattern that does not cause trimming by cutting.

  Next, in the manufacturing apparatus 100 of the first embodiment, as shown in FIG. 4, the re-pitch part 50 is installed downstream of the cutting part 40. In the manufacturing apparatus 100 according to the first embodiment, the re-pitch unit 50 includes a plurality of rollers 51 that are arranged so that their rotation axes are parallel to each other, and an endless conveyance belt 52 that is spanned between the rollers 51. have. Further, a suction box 53 is provided inside the conveyor belt 52. The conveyor belt 52 is provided with a plurality of through holes (not shown) for sucking air from the outside to the inside of the circuit track by starting the suction box 53. In addition, the conveyance speed of the conveyance belt 52 is faster than the conveyance speed of the base sheet 2 </ b> A up to the cutting unit 40.

  In the first embodiment, the heating elements 2 of each leaf are continuously placed on the conveying belt 52 while being sucked by the suction box 53 through a through hole (not shown), and the conveying direction ( In the Y direction), the distance between the fine hollow protrusions 1 and 1 adjacent to each other in the front and rear directions is increased, and the fine hollow protrusions 1 are rearranged at a predetermined distance.

  As explained above, according to the manufacturing method of the first embodiment for manufacturing the fine hollow protrusion 1 using the manufacturing apparatus 100 of the first embodiment, the fine hollow protrusion 1 is manufactured by only a simple process. Therefore, the cost increase can be suppressed, and the fine hollow projection 1 can be manufactured efficiently and continuously.

  Further, as described above, in the first embodiment, as shown in FIG. 6A, only the contact portion TP of the base sheet 2A with which the convex portion 11 is in contact is projected by the heater device. Since the mold part 11 is heated and the contact part TP is softened, the fine hollow projection 1 can be manufactured continuously and efficiently with energy saving. On the other hand, if the entire resin is heated to the same temperature as the convex part, not only is the energy efficiency poor, but the entire sheet is softened, resulting in the occurrence of pitch deviation of the protrusions, the sheet This increases the risk of occurrence of problems such as generation of distortion and difficulty in continuous sheet conveyance. In the present invention, the heat due to the heating of the convex portion 11 is efficiently transmitted to the contact portion TP, and the surrounding portion becomes an environment where only the desired heating can be applied, so only the processing (contact) portion is heated. There is an advantage that these problems do not occur.

  In addition, as described above, the manufacturing apparatus 100 according to the first embodiment uses the control unit (not illustrated) to operate the convex portion 11, the heating condition of the heating unit (not illustrated) provided in the convex portion 11, and the cold air blowing. The cooling temperature and cooling time of the device 21 are controlled. Therefore, the amount of insertion of the convex portion 11 into the base sheet 2A can be easily changed by controlling the insertion height of the convex portion 11 in the protrusion forming step, for example, by a control means (not shown). The protrusion height H1 of the fine hollow protrusion 1 to be manufactured can be controlled. Moreover, if at least any one of the heating conditions of the convex part 11, the softening time of the contact portion TP of the base sheet 2 </ b> A, and the insertion speed of the convex part 11 into the base sheet 2 </ b> A is controlled, the fine The thickness T1 and the like of the protrusion 3 constituting the hollow protrusion 1 can be freely controlled. That is, the conditions of the heating means (not shown) with which the convex part 11 is provided, the insertion height of the convex part 11 into the base sheet 2A in the projection forming step, the softening time of the contact part TP of the base sheet 2A The shape of the fine hollow projection 1 can be freely controlled by controlling at least one of the insertion speed of the convex portion 11 into the base sheet 2A, the shape of the convex portion 11 and the cooling condition in the cooling step. can do.

  In addition, as described above, in the first embodiment, as shown in FIG. 4, a pair of support members 12 and 12 arranged on the other surface 2U side (upper surface side) of the base sheet 2A is used. Supports both side portions along the conveyance direction (Y direction) of the material sheet 2A, and floats between the pair of support members 12 and 12 in the base sheet 2A (non-supported by the pair of support members 12 and 12) The protruding portion 11 is brought into contact with one surface 2D side (lower surface side) of the central portion in the support state, and the contact portion TP is softened by heat to form the protruding portion 3. Thus, since the recessed part etc. which fit in the convex-shaped part 11 for forming a protrusion part are unnecessary, a cost increase can be suppressed and the protrusion part 3 with which the fine hollow protrusion 1 manufactured is manufactured efficiently Can be formed with high accuracy.

Next, the present invention will be described based on the second embodiment with reference to FIG. In this description, differences from the above-described first embodiment will be mainly described.
In the manufacturing apparatus 100 of the first embodiment used in the first embodiment, the heating means (not shown) of the convex portion 11 is a heater device, but the heating apparatus of the second embodiment used in the second embodiment. Instead of this, the manufacturing apparatus 100 uses an ultrasonic vibration device.

  When the heating means (not shown) of the convex portion 11 is an ultrasonic vibration device as in the manufacturing apparatus 100 of the second embodiment, as shown in FIG. The convex part 11 is ultrasonically vibrated by the vibration device to generate heat due to friction at the contact part TP to soften the contact part TP. Then, while softening the contact part TP, as shown in FIG. 7B, the convex part 11 is moved from the one surface 2D side (lower surface side) to the other surface 2U side (upper surface side) as shown in FIG. It raises and stabs into the base material sheet 2A, and the protrusion part 3 which protrudes from the other surface 2U side (upper surface side) of the base material sheet 2A is formed. When the protruding portion 3 protrudes to the set height, the rising of the protruding portion 11 is stopped, and the protruding portion 11 is transported to the next process while being stuck in the protruding portion 3. The ultrasonic vibration of the convex portion 11 by the wave vibration device is performed from immediately before the convex portion 11 comes into contact with the base sheet 2A to immediately before reaching the cooling portion 20 in the next step (cooling step).

  Regarding the ultrasonic vibration by the wave vibration device of the convex part 11, the frequency is preferably 10 kHz or more, more preferably 15 kHz or more, and preferably 50 kHz or less from the viewpoint of formation of the convex part 11, More preferably, it is 40 kHz or less, specifically, preferably 10 kHz or more and 50 kHz or less, more preferably 15 kHz or more and 40 kHz or less. Further, regarding the ultrasonic vibration of the convex portion 11 by the wave vibration device, the amplitude is preferably 1 μm or more, more preferably 5 μm or more, and preferably 60 μm or less from the viewpoint of forming the convex portion 11. Yes, more preferably 50 μm or less, specifically preferably 1 μm or more and 60 μm or less, and more preferably 5 μm or more and 50 μm or less.

  As described above, in the manufacturing apparatus 100 according to the second embodiment, the cooling unit 20 is provided with the cold air blowing device 21 in order to perform positive cooling, but the heating unit (not shown) of the convex portion 11 is provided. Since it is an ultrasonic vibration device, it is not always necessary to provide the cold air blowing device 21, and cooling can also be performed by cutting the vibration of the ultrasonic vibration device. In this respect, it is preferable to use ultrasonic vibration as a heating means because it simplifies the apparatus and facilitates the production of fine hollow projections at high speed. Further, in the portion of the base sheet 2A that is not in contact with the convex portion 11, heat is more difficult to be transmitted, and since cooling is efficiently performed by turning off the application of ultrasonic vibration, deformation other than the molded portion occurs. There is an advantage that it is difficult.

  As mentioned above, although this invention was demonstrated based on the preferable 1st embodiment and 2nd embodiment, this invention is not restrict | limited to the said embodiment, It can change suitably.

  For example, the fine hollow protrusion 1 manufactured by the manufacturing method of the fine hollow protrusion of the first embodiment using the manufacturing apparatus 100 of the first embodiment or the second embodiment using the manufacturing apparatus 100 of the second embodiment. 1 has one projection 3 on the upper surface of the sheet-like base 2, but may have a plurality of projections 3 in an array as shown in FIG. Here, having the protrusions 3 in the form of an array means having a plurality of protrusions 3 on the upper surface of the sheet-like base 2, and in particular, the plurality of protrusions 3 are It is preferable that the upper surface of the sheet-like base portion 2 is arranged in a matrix having a plurality of rows and a plurality of columns. When manufacturing the micro hollow projection 1 (1M) which has the some projection part 3 in the array form, it is possible to use an apparatus as shown in FIG. In the apparatus shown in FIG. 9, the protruding portion forming section 10 includes a protruding portion 11 having a plurality of protruding molds 110 corresponding to the number and arrangement of the protruding portions 3 and the outer shape of each protruding portion 3. ing. Alternatively, the fine hollow protrusion 1 having a plurality of protrusions 3 may be manufactured by inserting one convex portion 11 into the base sheet 2A a plurality of times. In addition, in the manufacturing apparatus 100 shown in FIG. 9, the same number is attached | subjected to the same site | part as the manufacturing apparatus 100 shown in FIG.

  In addition, when the sheet conveying system is operated intermittently, a projection forming unit 10 that can move only in the thickness direction (Z direction) is used instead of the box motion type projection forming unit 10 that draws an endless track. Thus, the projection can be formed.

  Moreover, the manufacturing apparatus 100 of the said 1st Embodiment or 2nd Embodiment is a pair of board which supports base material sheet 2A, when projecting the convex part 11 in base material sheet 2A, as shown in FIG. The support members 12 and 12 are in the form of a plate, but other than the pair of plate-like support members 12 and 12 as long as they support the base sheet 2A by being arranged on the other surface 2U side of the base sheet 2A. It may be a thing. For example, instead of the pair of plate-like support members 12 and 12, a punching plate 12A, which is an example of an opening plate having an opening 121 at a position corresponding to the contact portion TP, as shown in FIG. You may distribute | arrange to the other surface 2U side of 2 A of material sheets, and may support the base material sheet 2A, when piercing the convex-shaped part 11 in the base material sheet 2A. The opening plate is a plate having an opening part into which the convex mold 110 of the convex part 11 can be inserted. In the present embodiment, the opening is a through hole, but it may be non-through. In addition, when using an opening plate, it can be said that the part which opposes the opening part of 2 A of base materials is not supported by the opening plate. In the manufacturing apparatus 100 shown in FIG. 10, the protruding portion forming section 10 includes a protruding portion 11 having a plurality of protruding molds 110 corresponding to the number and arrangement of the protruding portions 3 and the outer shape of each protruding portion 3. I am doing so. Moreover, in the manufacturing apparatus 100 shown in FIG. 10, the opening plate 12A is arranged so that the other surface 2U side of the base sheet 2A is in contact with each other. In addition, in the manufacturing apparatus 100 shown in FIG. 10, the same number is attached | subjected to the same site | part as the manufacturing apparatus 100 shown in FIG.

  In the manufacturing apparatus 100 shown in FIG. 10, the base sheet 2A is sandwiched between the convex portion 11 and the opening plate 12A. In the manufacturing apparatus 100 shown in FIG. 10, the opening plate 12 </ b> A has one through-hole 121 arranged at a position corresponding to the contact portion TP of one convex mold 110 of the convex mold part 11 in the base sheet 2. However, one through-hole 121 may be arranged at a position corresponding to the contact portion TP of the plurality of convex molds 110. The through-hole 121 is formed in a circular shape in the manufacturing apparatus 100 shown in FIG. 10, although the shape of the opening plate 12A is not particularly limited when the opening plate 12A is viewed from the upper surface side.

  The shape of the opening plate 12A is not particularly limited, but is formed in a plate shape in the manufacturing apparatus 100 shown in FIG. The length of the plate-shaped opening plate 12A in the Y direction is substantially the same as the length of the convex portion 11 in the Y direction, and the length of the X direction is substantially the same as the length of the convex portion 11 in the X direction. The same. In the manufacturing apparatus 100 shown in FIG. 10, such a plate-shaped opening plate 12 </ b> A sandwiches the base material sheet 2 </ b> A conveyed in the Y direction, and the operation of the box motion type convex portion 11 and the target operation. It is designed to draw an endless track with a box motion formula. The box motion type opening plate 12A is arranged adjacent to the upper surface in the thickness direction (Z direction) from the other surface 2U of the base sheet 2A, and runs parallel to the base sheet 2A in the transport direction (Y direction). It is possible. The movement speed of the opening plate 12A in the conveyance direction (Y direction) corresponds to the movement speed of the convex portion 11 in the conveyance direction (Y direction), and is provided in the manufacturing apparatus 100 shown in FIG. It is controlled by means (not shown).

  Moreover, as shown in FIG. 4, the manufacturing apparatus 100 of the said 1st Embodiment or 2nd Embodiment inserts the base material sheet 2A in the downward direction upwards, but the base material 2A is shown in FIG. The positional relationship between the convex portion and the support member with respect to the sheet and the insertion direction are not limited to this, and the fine hollow protrusions may be formed from the top to the bottom.

In relation to the above-described embodiments, the present invention further discloses the following method for producing fine hollow protrusions. <1> A method for producing a hollow microprojection having a hollow inside, wherein a convex portion provided with a heating means is brought into contact with one side of a base sheet formed by including a thermoplastic resin. A protrusion forming step of forming a protrusion protruding from the other surface side of the base sheet by piercing the base portion into the base sheet while softening the corresponding contact portion of the material sheet by heat; A cooling step of cooling the protruding portion in a state where the protruding portion is stabbed inside the portion, and after the cooling step, the protruding portion is removed from the inside of the protruding portion to form the fine hollow protrusion. A manufacturing method of a fine hollow projection provided with a release process.
<2> The projecting portion forming step is performed using a support member that supports the base sheet when the convex portion is stabbed into the base sheet, and the support member is a member other than the base sheet. The fine hollow according to <1>, wherein the protruding portion is formed by bringing the convex portion into contact with one surface side of a portion of the base sheet that is disposed on the surface side and not supported by the support member. Protrusion manufacturing method.
<3> The method for producing a fine hollow projection according to <2>, wherein an opening plate having an opening into which the convex shape in the convex portion can be inserted is used as the support member.
<4> The method for producing a fine hollow projection according to <3>, wherein the opening plate includes a plurality of the openings.
<5> The method for producing a fine hollow protrusion according to <3> or <4>, wherein one convex mold is inserted into one opening of the opening plate.
<6> The method for producing a fine hollow projection according to <3> or <4>, wherein the plurality of convex molds are inserted into the opening of the opening plate.
<7> In the heating condition of the convex part in the protrusion part forming step, the softening time of the contact portion of the base sheet, the insertion speed of the convex part into the base sheet, and the cooling step The method for producing a fine hollow projection according to any one of <1> to <6>, wherein any one of the cooling conditions is controlled to control the shape of the fine hollow projection.
<8> Any of the above <1> to <7>, wherein a band-shaped substrate sheet is used as the substrate sheet, and the fine hollow protrusions are continuously formed on the other surface side of the band-shaped substrate sheet. A method for producing the fine hollow projection according to claim 1.
<9> The fine hollow according to any one of <1> to <8>, wherein the heating temperature of the base sheet by heating the convex part is not less than the glass transition temperature of the base sheet and less than the melting temperature. Protrusion manufacturing method.
<10> The production of the fine hollow projection according to any one of <1> to <9>, wherein the heating temperature of the base sheet by heating the convex portion is not less than the softening temperature of the base sheet and less than the melting temperature. Method.
<11> The method for producing a fine hollow projection according to <9> or <10>, wherein the heating temperature is 30 ° C. or higher and 300 ° C. or lower.
<12> The method for producing a fine hollow projection according to any one of <1> to <11>, wherein the heating unit included in the convex portion is a heater device.
<13> The heating means provided in the convex portion is an ultrasonic vibration device, and the ultrasonic vibration device is used to ultrasonically vibrate the convex portion to generate heat due to friction at the contact portion. The manufacturing method of the fine hollow protrusion of any one of said <1>-<11> which softens a part.
<14> The method for producing a fine hollow projection according to <13>, wherein the frequency of the ultrasonic vibration is 10 kHz to 50 kHz, and more preferably 15 kHz to 40 kHz.
<15> The method for producing a fine hollow projection according to <13> or <14>, wherein the amplitude of the ultrasonic vibration is 1 μm or more and 60 μm or less, more preferably 5 μm or more and 50 μm or less.
<16> The method for producing a fine hollow projection according to any one of <1> to <15>, wherein in the protrusion formation step, no heating means is provided other than the heating means of the convex portion.
<17> A temperature equal to or higher than the softening temperature of the base sheet is applied only to the portion of the base sheet into which the convex portion is inserted and a region in the vicinity thereof. The method for producing fine hollow projections according to any one of <1> to <16>, wherein only a temperature rise of 1 can be applied.
<18> The fine hollow according to any one of <1> to <17>, wherein the height of the convex portion is the same as or slightly higher than the height of the fine hollow protrusion to be produced. Protrusion manufacturing method.
<19> The height of the convex portion is 0.01 mm or more and 30 mm or less, more preferably 0.02 mm or more and 20 mm or less, and the fineness according to any one of <1> to <18>. Manufacturing method of hollow protrusion.
<20> The convex portion has a tip diameter of 0.001 mm to 1 mm, and more preferably 0.005 mm to 0.5 mm, in any one of the above <1> to <19>. The manufacturing method of the fine hollow protrusion of description.
<21> The convex portion has a root diameter of 0.1 mm to 5 mm, and more preferably 0.2 mm to 3 mm, according to any one of the above <1> to <20>. Manufacturing method of fine hollow protrusion.
<22> The convex portion has a tip angle of not less than 1 degree and not more than 60 degrees, more preferably not less than 5 degrees and not more than 45 degrees, according to any one of the above <1> to <21>. Manufacturing method of fine hollow protrusions.
<23> The fine hollow projection according to any one of <1> to <22>, wherein in the cooling step, cooling is performed by a cold air blower in a state where the projection is stabbed inside the projection. Manufacturing method.
<24> The method for producing fine hollow projections according to <23>, wherein the temperature of the cold air is −50 ° C. or higher and 26 ° C. or lower, preferably −40 ° C. or higher and 10 ° C. or lower.
<25> The fine hollow projection according to <23> or <24>, wherein the cooling time for cooling by blowing the cold air is 0 second to 60 seconds, and more preferably 0.5 seconds to 30 seconds. Manufacturing method.
<26> The method for producing a fine hollow projection according to any one of <1> to <25>, wherein in the cooling step, natural cooling is performed without performing cooling by a cold air blower.
<27> In the protrusion formation step, the convex portion has a plurality of protrusions that form a plurality of protrusions by being inserted into different positions of the base sheet <1> to <26>. The manufacturing method of the fine hollow protrusion as described in any one of these.
<28> In the projection forming step, a plurality of convex portions arranged in an array are inserted into the base sheet to form a fine hollow projection having a plurality of projections in an array. 27> The manufacturing method of the fine hollow protrusion as described in any one of 27>.
<29> The method for producing a fine hollow protrusion having a through hole according to any one of <1> to <28>, wherein the protrusion is a microneedle.
<30> The method for producing a fine hollow protrusion according to <29>, wherein the fine hollow protrusion is a microneedle array in which a plurality of protrusions are arranged on a base sheet.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited to such examples.

Preparation of Convex Type Part 11 Provided in Manufacturing Apparatus The convex part 11 is made of SUS304, which is made of stainless steel, and has a conical tip. The convex part 11 had a height (taper part height) H2 of 2.5 mm, a tip diameter D1 of 15 μm, and a root diameter D2 of 0.5 mm.

Preparation of Base Material Sheet 2A As the base material sheet 2A, a strip-like sheet having a thickness of 0.3 mm formed of polylactic acid (PLA) was prepared.

[Example 1]
A fine hollow projection 1 was produced according to the procedure shown in FIG. Specifically, the heating means of the convex portion 11 was a heater device. As the manufacturing conditions, as shown in Table 1, the heating temperature is 140 ° C., the insertion height is 1.0 mm, the insertion speed is 1 mm / second, the softening time is 10 seconds, cooling Time was 10 seconds.

[Example 2]
A fine hollow projection 1 was produced according to the procedure shown in FIG. Specifically, the heating means of the convex part 11 was an ultrasonic vibration device. As shown in Table 1, the manufacturing conditions are as follows: the frequency of ultrasonic vibration is 20 kHz, the amplitude of ultrasonic vibration is 40 μm, the insertion height is 1.0 mm, and the insertion speed is 10 mm / second. The softening time was 0.5 seconds and the cooling time was 2 seconds.

[Performance evaluation]
About the fine hollow protrusion of Examples 1-2, the tip diameter of the fine hollow protrusion was measured according to the method mentioned above, and the fundamental diameter of the fine hollow protrusion was measured. The results are shown in Table 1 below. Moreover, the photograph of the fine hollow protrusion of manufactured Examples 1-2 is also shown collectively.

  As is clear from the results shown in Table 1, the fine hollow protrusions of Examples 1 and 2 had good shape accuracy. Therefore, according to the manufacturing method which manufactures the fine hollow protrusion of Examples 1-2, it can be anticipated that the fine hollow protrusion with favorable shape precision can be manufactured efficiently and continuously.

DESCRIPTION OF SYMBOLS 1 Fine hollow projection 2 Base part 3 Projection part 10 Projection part formation part 11 Convex part 12 Support member 12A Opening plate (punching plate)
DESCRIPTION OF SYMBOLS 20 Cooling part 21 Cold air blower 22 Air blower 30 Release part 40 Cutting part 41 Cutter part 42 Anvil part 50 Re-pitch part 51 Roller 52 Conveyor belt 53 Suction box 100 Manufacturing apparatus

Claims (11)

A method for producing a fine hollow projection having a hollow inside,
From one surface side of the base sheet formed by including a thermoplastic resin, the convex portion provided with heating means is brought into contact, and the corresponding contact portion in the base sheet is softened by heat. A protrusion forming step of piercing the base sheet and forming a protrusion protruding from the other side of the base sheet;
A cooling step of cooling the protruding portion in a state where the protruding portion is stabbed inside the protruding portion;
After the cooling step, including a release step of removing the convex portion from the inside of the protrusion to form the fine hollow protrusion ,
A method for producing a fine hollow projection, wherein the heating means is an ultrasonic vibration device . The protruding portion forming step is performed using a support member that supports a region other than the region where the protruding portion is formed in the base sheet when the convex portion is stabbed into the base sheet.
The support member is disposed on the other surface side of the base sheet,
The manufacturing method of the fine hollow protrusion of Claim 1 which makes the said convex part contact | abut from the one surface side of the part which is not supported by the said supporting member in the said base material sheet, and forms the said projection part.   The manufacturing method of the fine hollow protrusion of Claim 2 using the opening plate which has an opening part which can insert the convex in the said convex part as the said supporting member.   The manufacturing method of the fine hollow protrusion of Claim 3 with which the said opening plate is provided with the said some opening part.   The manufacturing method of the fine hollow protrusion of Claim 3 or 4 with which one said convex type | mold is inserted with respect to the said one opening part of the said opening plate.   In the projection forming step, the condition of the heating means provided in the convex part, the insertion height of the convex part into the base sheet, the softening time of the contact portion of the base sheet, the convex The shape of the fine hollow protrusions is controlled by controlling at least one of the insertion speed of the mold part into the base sheet, the shape of the convex mold part, and the cooling conditions in the cooling step. The manufacturing method of the fine hollow protrusion of any one of Claims 1.   The belt-like base material sheet is used as the base material sheet, and the fine hollow protrusions are continuously formed on the other surface side of the belt-like base material sheet. Manufacturing method of fine hollow protrusion.   The method for producing a fine hollow projection according to any one of claims 1 to 7, wherein a heating temperature of the base sheet by heating the convex part is not less than a glass transition temperature of the base sheet and less than a melting temperature. .   The method for producing a fine hollow projection according to any one of claims 1 to 8, wherein a heating temperature of the base sheet by heating the convex portion is not less than a softening point of the base sheet and less than a melting temperature.   The method for producing a fine hollow projection according to any one of claims 1 to 9, wherein, in the projection forming step, no heating means is provided other than the heating means of the convex portion. The protrusion forming step, by using a plurality of convex portions, to form a fine hollow projections having a plurality of protrusions in an array, microporous according to any one of claims 1-10 Protrusion manufacturing method.