JP5986394B2 - Foam forming aerosol composition - Google Patents

Description

  The present invention relates to a foam-forming aerosol composition comprising a stock solution and a propellant comprising carbon dioxide.

2. Description of the Related Art Conventionally, as a certain kind of aerosol composition, there is known an aerosol composition comprising a stock solution containing an active ingredient and a propellant made of carbon dioxide gas to form a foam-like discharge.
In a foam-forming aerosol composition using such a carbon dioxide gas as a propellant, in order to obtain good foaming properties, a surfactant is usually blended in the stock solution, and carbon dioxide gas as a propellant. In addition, liquefied petroleum gas and liquefied gas such as dimethyl ether may be used together (see, for example, Patent Document 1 and Patent Document 2). Furthermore, in order to obtain good foaming properties and suppress the occurrence of liquid sag (foam sag), that is, to obtain good adhesion in the discharged product, xanthan gum, hydroxypropylmethylcellulose (HPMC) or hydroxyethylcellulose (HEC) is added to the stock solution. )) Or the like.

However, in order to obtain good foaming properties and adhesion in a foam-forming aerosol composition using carbon dioxide as a propellant, when a surfactant or a thickener is blended in the stock solution, a liquefied gas is also used as a propellant. When using together, there is a problem that various harmful effects occur.
Specifically, in an aerosol composition containing a surfactant, depending on the type or content ratio of the surfactant used, sufficient stability of the active ingredient can be obtained by interaction with the surfactant. In particular, when used for the human body, there is a possibility that a good feeling of use cannot be obtained due to skin irritation or stickiness.
Further, in an aerosol composition in which a liquefied gas is used in combination as a propellant, skin irritation due to the liquefied gas may occur particularly when used for the human body.
In addition, in an aerosol composition containing a thickener, when the thickener is contained in a high ratio in order to fully exert its intended effect, the thickener is uniformly contained in the stock solution. It takes a lot of time to disperse, and particularly when it is used for the human body, there is a possibility that a good feeling of use cannot be obtained due to the feeling of film or stickiness.

JP 2011-93877 A Japanese Patent No. 4690863

The present invention has been made based on the above circumstances, and an object of the present invention is to provide a foam-forming aerosol composition using only carbon dioxide gas as a propellant to obtain good foam-forming properties. .
In addition, another object of the present invention is to provide a foam-forming aerosol composition that uses only carbon dioxide as a propellant to obtain a good foam-forming property and can obtain a good feeling when used on the human body. There is to do.

The foam-forming aerosol composition of the present invention consists of a stock solution and a propellant consisting only of carbon dioxide,
The stock solution comprises hydrophobized hydroxypropylmethylcellulose having a ratio of 0.1 to 1.5% by mass with respect to the entire aerosol composition and water having a ratio of 50.0 to 99.0% by mass with respect to the entire aerosol composition. Contains ,
The propellant is contained so that the internal pressure of the product at a temperature of 35 ° C. is 0.3 to 0.8 MPa .

  In the foam aerosol composition of the present invention, the stock solution preferably has a viscosity of 100 to 10,000 mPa · s at a temperature of 20 ° C.

  The foam-forming aerosol composition of the present invention is preferably for the human body.

In the foam-forming aerosol composition of the present invention, the hydrophobized hydroxypropylmethylcellulose has a high viscosity and has a large affinity (ease of familiarity) with carbon dioxide gas. Since a large foaming improvement effect and adhesion improvement effect (liquid dripping suppression action) are expressed, the discharged product can be sufficiently foamed, and the discharged product has sufficient adhesion to the application site. As a result, the occurrence of dripping can be sufficiently suppressed.
Further, in the foam-forming aerosol composition of the present invention, the amount of the hydrophobized hydroxypropylmethylcellulose is small because the hydrophobized hydroxypropylmethylcellulose exhibits a large foaming improvement effect and adhesion improvement effect (drip sag suppression action). In addition, since the hydrophobized hydroxypropylmethylcellulose has a hydrophobic group, even when the stock solution is in a high viscosity state due to its large thickening action, there is a sticky feeling at the application site on the skin. Occurrence is suppressed.
Therefore, according to the foam-forming aerosol composition of the present invention, even when only carbon dioxide gas is used as a propellant, the discharged product is sufficiently foamed by the action of hydrophobized hydroxypropylmethylcellulose. In addition, sufficient adherence to the application site can be obtained on the discharged material, so that the occurrence of liquid dripping (foam dripping) can be prevented, and thus extremely good foam forming property can be obtained, and it is applied to the human body. In some cases, a good feeling without stickiness and skin irritation can be obtained. In addition, it is not necessary to use a liquefied gas as a propellant, and it is not always necessary to contain a high-viscosity substance other than a surfactant and hydrophobized hydroxypropylmethylcellulose in the stock solution. No adverse effects such as skin irritation and stickiness due to the use of the

The foam-forming aerosol composition of the present invention is composed of a stock solution containing hydrophobized hydroxypropylmethylcellulose and water in a specific ratio and a propellant made of carbon dioxide, and is a pressure-resistant container equipped with an aerosol valve (Hereinafter, also referred to as “aerosol container”) filled in to form an aerosol product.
In addition, in the foam-forming aerosol composition of the present invention, a part of carbon dioxide gas as a propellant is dissolved in a stock solution, and foam is formed by the action of the carbon dioxide gas.
Hereinafter, the component which comprises the foam formation aerosol composition of this invention is demonstrated.

Hydrophobized hydroxypropylmethylcellulose, which is an essential component of the stock solution, acts as a thickener, exerts dripping suppression action based on its high viscosity, and has a large affinity for carbon dioxide ( In the foam-forming aerosol of the present invention using only carbon dioxide as a propellant, the foam-forming improvement effect is exhibited.
Thus, in the foam-forming aerosol composition of the present invention, the stock solution has a surfactant and a thickening other than hydrophobized hydroxypropylmethylcellulose such as xanthan gum, hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HEC), etc. Without containing a substance (thickening agent), the discharged product can be sufficiently foamed, and sufficient adherence to the applied part can be obtained on the discharged material, resulting in generation of liquid dripping (bubble dripping) Can be prevented, and thus extremely good foam-forming properties can be obtained.

As the hydrophobized hydroxypropylmethylcellulose, stearoxyhydroxypropylmethylcellulose is used.
Here, “hydrophobized hydroxypropylmethylcellulose” refers to a compound in which a hydrophobic group is introduced into hydroxypropylmethylcellulose. “Stearoxyhydroxypropylmethylcellulose” is a reaction product of stearyl glycidyl ether and hydroxypropylmethylcellulose, and stearyloxyhydroxypropoxy group is introduced into hydroxypropylmethylcellulose as a hydrophobic group.

The content ratio of the hydrophobized hydroxypropylmethylcellulose is preferably 0.1 to 1.5% by mass, more preferably 0.2 to 1.0% by mass, particularly preferably 100% by mass with respect to 100% by mass of the entire aerosol composition. Is 0.3-0.7 mass%.
When the content ratio of the hydrophobized hydroxypropylmethylcellulose is excessive, the viscosity of the stock solution increases, and there is a possibility that good jetting characteristics cannot be obtained due to the insufficient fluidity. On the other hand, when the content ratio of the hydrophobized hydroxypropylmethylcellulose is too small, sufficient adherence to the application site cannot be obtained on the discharged material, and liquid dripping (bubble dripping) may occur.

(water)
Water, which is an essential component of the stock solution, acts as a solvent for hydrophobized hydroxypropylmethylcellulose.
As water, purified water or ion exchange water is used.

  The content of water is preferably 50.0 to 99.0% by mass, more preferably 60.0 to 90.0% by mass, and particularly preferably 70.0% in 100% by mass of the entire aerosol composition. It is -80.0 mass%.

  If the water content is excessive, there may be a risk that the stock solution cannot contain other components in a sufficient ratio. On the other hand, if the water content is too small, it becomes difficult to uniformly disperse the hydrophobized hydroxypropylmethylcellulose in the stock solution to form a uniform system, and good foaming properties cannot be obtained in the discharged product. At the same time, good usability may not be obtained. In addition, a sticky feeling is generated particularly when applied to the human body, and a good feeling of use may not be obtained.

(Optional component)
In addition to the hydrophobized hydroxypropylmethylcellulose and water, which are essential components, the stock solution may contain various optional components depending on, for example, the purpose and application of the aerosol composition.
Specific examples of optional ingredients include various active ingredients in relation to the use of foam-forming aerosol compositions such as drugs, solvents for dissolving various active ingredients, moisturizers, preservatives, pH adjusters, surface activity Agents, thickeners (thickeners other than hydrophobized hydroxypropylmethylcellulose), fragrances, and the like.

The content ratio of the optional component varies depending on the type of the optional component, but is preferably 0.1 to 50.0% by mass, more preferably 5.0 to 40.0% in 100% by mass of the entire aerosol composition. It is mass%, Most preferably, it is 10.0-30.0 mass%.
When the content ratio of the optional component is excessive, there is a possibility that the essential component cannot be contained in a required ratio. On the other hand, when the content ratio of the arbitrary component is too small, there is a possibility that the intended effect cannot be obtained sufficiently.

  The stock solution composed of the above essential components and optional components preferably has a viscosity at a temperature of 20 ° C. of 100 to 10,000 mPa · s, more preferably 400 to 4000 mPa · s, and particularly preferably 1000 to 3000 mPa · s. -S.

  When the viscosity of the stock solution is excessive, it becomes impossible to obtain a good injection state, specifically, it becomes impossible to perform the injection itself, or it becomes impossible to obtain a desired amount of discharged matter. In addition, there is a risk of stickiness when applied to the human body, and good usability may not be obtained. On the other hand, when the viscosity of the undiluted solution is too low, sufficient adherence to the application site cannot be obtained on the discharged material, and there is a possibility that liquid dripping (bubble dripping) may occur.

Carbon dioxide gas is used as a propellant constituting the foam-forming aerosol composition of the present invention.
In the foam-forming aerosol composition of the present invention, carbon dioxide gas is soluble in water and thus dissolved in the stock solution, thereby exhibiting a foam-forming action.

The above foam-forming aerosol composition is filled into an aerosol container to obtain an aerosol product, and a propellant may be included so that the product internal pressure of the aerosol container is 0.8 MPa or less at a temperature of 35 ° C. preferable. Further, the product internal pressure of the aerosol container at a temperature of 35 ° C. is more preferably 0.3 to 0.7 MPa.
When the internal pressure of the product is excessive, there is a possibility that sufficient safety cannot be obtained due to excessive increase in the filling pressure of the propellant.
Further, when the product internal pressure at a temperature of 35 ° C. of the aerosol container is 0.3 to 0.7 MPa, sufficient safety can be obtained for the aerosol product and good foaming property can be obtained for the discharged product.

In such a foam-forming aerosol composition of the present invention, the hydrophobized hydroxypropylmethylcellulose has a high viscosity and a large affinity (easiness to adapt) to carbon dioxide gas. Since propylmethylcellulose exhibits a large foaming improvement effect and adhesion improvement action (drip sag suppressing action), the discharged product can be sufficiently foamed, and sufficient for the application location on the discharged product. Adhesiveness is obtained and the occurrence of liquid sag (foam sag) can be sufficiently suppressed. The foam-like discharge formed by the foam-forming aerosol composition of the present invention can provide sufficient adhesion to the application site even in a state where the foam is crushed and spread. Therefore, liquid dripping does not occur, and therefore, the ejected material in a spread state exists at the application site for a relatively long time, so that the effect of the components contained in the stock solution is continuously acted.
Further, in the foam-forming aerosol composition of the present invention, the amount of the hydrophobized hydroxypropylmethylcellulose is small because the hydrophobized hydroxypropylmethylcellulose exhibits a large foaming improvement effect and adhesion improvement effect (drip sag suppression action). In addition, since the hydrophobized hydroxypropylmethylcellulose has a hydrophobic group, even when the stock solution is in a state of high viscosity due to its large thickening action, the application site on the skin is not sticky. I don't feel it.
Therefore, according to the foam-forming aerosol composition of the present invention, even when only carbon dioxide gas is used as a propellant, the discharged product can be sufficiently foamed and applied to the discharged product. Adhesiveness to the liquid can be obtained and the occurrence of liquid sag (foam sag) can be prevented, and thus extremely good foam-forming properties can be obtained. Moreover, when applied to the human body, it is possible to obtain a feeling of stickiness and good use without skin irritation. Further, it is not necessary to use a liquefied gas as a propellant, and it is also necessary to contain a high-viscosity substance (thickener) other than a surfactant and hydrophobized hydroxypropylmethylcellulose in a high ratio. Therefore, there are no adverse effects such as skin irritation and stickiness caused by using them.

In addition, the foam-forming aerosol composition of the present invention can be used for, for example, the human body or other various applications, but it can provide a good feeling without stickiness and skin irritation, and only carbon dioxide as a propellant. Since the foam is formed by carbon dioxide gas, an effect of promoting blood circulation by carbon dioxide gas can be obtained, so that it can be suitably used especially for the human body.
Specifically, beauty agent, cooling agent, sunscreen agent, hair styling agent, hair wax agent, hair treatment agent, hair dye, shampoo agent, conditioner agent, hair restorer, massage agent, facial cleanser, cleansing agent, It can be used as a shaving agent, cosmetic base agent, skin protective agent, moisturizer, hair remover, hand soap, body soap, athlete's foot drug, muscle anti-inflammatory agent, alcohol sanitizer and the like.

  Examples of the present invention will be described below, but the present invention is not limited thereto.

[Examples 1 to 10 and Comparative Examples 1 to 7]
First, in accordance with the formulation shown in Tables 1 and 2, the raw material raw materials were charged into a glass beaker and stirred using a propeller stirrer to prepare the stock solution. Thereafter, the obtained stock solution was filled into a transparent pressure-resistant glass bottle having a volume of 100 ml, an aerosol valve was attached to the pressure-resistant glass bottle, and then the propellant made of carbon dioxide gas was filled into the pressure-resistant glass bottle. And the aerosol product was produced by shaking the pressure-resistant glass bottle with which the valve | bulb for aerosols was mounted | worn up and down 20 times.
Here, in particular, Example 8 is an example when used as a beauty agent (beauty whitening liquid foam), Example 9 is an example when used as a coolant (cooling foam), and Example 10 is a tan. It is an example in the case of using as a stop agent (sunscreen foam).
Comparative Example 1 is an example in which no hydrophobized hydroxypropylmethylcellulose is contained, and Comparative Example 2 and Comparative Example 3 do not contain hydrophobized hydroxypropylmethylcellulose. Instead, it is an example in which another thickener is contained, Comparative Example 4 is an example in which the content of hydrophobized hydroxypropylmethylcellulose is too small, and Comparative Example 5 is hydrophobized hydroxypropyl. This is an example in which the content ratio of methylcellulose is excessive, Comparative Example 6 is an example in which the content ratio of water is excessively small, and Comparative Example 7 does not contain hydrophobized hydroxypropylmethylcellulose. , Nonionic surfactant (polysorbate 80 (polyoxyethylene sorbitan monooleate)) Is an example of the case being closed.

<Evaluation test>
About each of the aerosol products produced by said Examples 1-10 and Comparative Examples 1-7, it is formed in the foam container by the following method in the foaming property in a discharge material, the liquid dripping suppression property in a discharge material, and an aerosol container. The fluidity of the liquid content (hereinafter also referred to as “fluidity of the content”) and the presence or absence of stickiness were evaluated. The results are shown in Tables 1 and 2.

(Foamability in discharged material)
After immersing the aerosol product produced by each of the examples and comparative examples in a constant temperature water bath set at 25 ° C. for 30 minutes, 3 g of the contents of each aerosol product was injected into a glass beaker having a volume of 20 ml, immediately after injection. Measure the volume of the discharged material in the glass beaker, and if the volume is 10 ml or more, the foaming property is “A”, and the volume is 5 ml or more and less than 10 ml. Was evaluated as “B”, and when the volume was less than 5 ml, “C” was evaluated as insufficient foaming property.

(Liquid sag suppression in discharged material)
After immersing the aerosol product produced by each of the examples and comparative examples in a constant temperature water bath set at 25 ° C. for 30 minutes, 1 g of the contents of each aerosol product was sprayed onto a glass plate horizontal to the floor, In particular, if the discharged material is in the form of foam, after spreading the discharged material so as to crush the bubbles, the glass plate is tilted so as to be perpendicular to the floor and visually checked for the presence of liquid dripping. In the case where no dripping occurred at all, “A” is assumed that the dripping suppression property is very good, but when there is no problem in practical use although the slight dripping occurs, “ “B”, when dripping occurred and there was a problem in practical use, it was evaluated as “C” because the dripping suppression property was insufficient.

(Fluidity of contents)
An aerosol composition 50 g according to each of the examples and comparative examples was filled in a transparent pressure-resistant glass bottle, and the glass bottle was left in a state where the bottle bottom was upside (upside down state). After the total amount of the liquid content in the bottle is moved to the bottle mouth side of the pressure-resistant glass bottle (the lower side of the upside-down pressure-resistant glass bottle), the total amount of the liquid content is dropped, that is, the bottom of the bottle is down, that is, Check the time required for the entire amount of the liquid contents to move from the bottle mouth side to the bottle bottom side of the pressure-resistant glass bottle (hereinafter also referred to as “total amount drop time”), and if the total amount drop time is within 5 seconds “A” when the fluidity of the contents is extremely good, and “B” when the total amount falling time is less than 11 seconds exceeding 5 seconds and “B” when the total amount falling time is 11 More than seconds A certain case the fluidity of the contents was evaluated as "C" as being insufficient.

(With or without stickiness)
After the aerosol products produced in each of the examples and comparative examples were immersed in a constant temperature water bath set at 25 ° C. for 30 minutes, 1 g of the contents of each aerosol product was placed on the palm in a state of being horizontal on the floor and facing upward. When sprayed upwards, especially when the discharge is foamy, spread the discharge on the palm of the hand as if crushing the bubbles, and perform a sensory test to check for the presence of a sticky feeling, when there is no sticky feeling at all "A", because there is no stickiness, but feels a little sticky, but "B", where there is almost no stickiness when there is no practical problem, "B", when there is a practical problem It was evaluated as “C”.

In Tables 1 and 2, “stock solution viscosity” is the viscosity of the stock solution at a temperature of 20 ° C., and the product internal pressure is an internal pressure of the aerosol product at a temperature of 35 ° C.
In the same table, “hydrophobized hydroxypropylmethylcellulose” is stearoxyhydroxypropylmethylcellulose “Sangelose 60L” (manufactured by Daido Kasei Kogyo Co., Ltd.), and hydroxyethylcellulose is “HEC SE900” (Daicel Finechem Co., Ltd.). "Xanthan gum" is "Echo gum T" (manufactured by DSP Gokyo Food & Chemical Co., Ltd.).

From the results shown in Table 1, the aerosol compositions according to Examples 1 to 10 have sufficient fluidity and a foamy discharge, and the discharge is sufficiently foamed. It was confirmed that there was no occurrence of the occurrence of stickiness, and that no sticky feeling was generated.
On the other hand, since the aerosol composition according to Comparative Example 1 does not contain hydrophobized hydroxypropylmethylcellulose in the stock solution, the discharged product is not sufficiently foamed, and dripping occurs. The aerosol composition according to Comparative Example 3 contains a thickener in place of the hydrophobized hydroxypropylmethylcellulose in the stock solution, so that a sticky feeling is generated and a good feeling of use cannot be obtained, and the discharge product Was not sufficiently foamed, or dripping occurred. In the aerosol composition according to Comparative Example 4, since the content ratio of the hydrophobized hydroxypropyl methylcellulose is too small, dripping occurs, and the aerosol composition according to Comparative Example 5 has an excessive content ratio of the hydrophobized hydroxypropylmethylcellulose Therefore, sufficient fluidity could not be obtained. Moreover, since the content rate of water was too small, the aerosol composition which concerns on the comparative example 6 produced a sticky feeling, and the favorable usability | use_condition was not obtained. The aerosol composition according to Comparative Example 7 contains a surfactant instead of hydrophobized hydroxypropylmethylcellulose in the stock solution, so that the discharged product foams sufficiently, but liquid sag occurs and a sticky feeling is produced. As a result, a good feeling of use was not obtained.

Claims (3)

Consists of undiluted solution and propellant consisting only of carbon dioxide,
The stock solution comprises hydrophobized hydroxypropylmethylcellulose having a ratio of 0.1 to 1.5% by mass with respect to the entire aerosol composition and water having a ratio of 50.0 to 99.0% by mass with respect to the entire aerosol composition. Contains ,
A foam-forming aerosol composition, wherein the propellant is contained so that the internal pressure of the product at a temperature of 35 ° C. is 0.3 to 0.8 MPa .   The foam-forming aerosol composition according to claim 1, wherein the stock solution has a viscosity of 100 to 10,000 mPa · s at a temperature of 20 ° C.   The foam-forming aerosol composition according to claim 1 or 2, wherein the foam-forming aerosol composition is used for a human body.