JP5730837B2 - Melanin production inhibitor, moisturizer, whitening cosmetic, beauty food and drink - Google Patents

Description

The present invention relates to elenolic acid and / or elenolic acid glucoside represented by the following chemical structural formula (R = H in Chemical Formula 1 or Chemical Formula 2 in which a part of the functional group bonded to the pyran ring is changed). (R = Glucose in Chemical Formula 1) or at least one selected from a salt thereof. The present invention relates to a melanin production inhibitor, a moisturizing agent, a whitening cosmetic, and an application to a beauty food and drink. More specifically, a new melanin inhibitor, humectant with excellent whitening and moisturizing effects, high skin safety, and high quality stability, and a whitening makeup with excellent stability and usability using it. The present invention relates to foods and beverages that are excellent in food and beauty effects.

  Skin pigmentation is simply caused by the high accumulation of melanin pigments globally or locally in the skin as a result of the production of melanin pigments in the skin by various external factors. That is, it has been considered that skin pigmentation can be controlled by inhibiting or controlling this in vivo reaction in some form, and conventionally, for example, inhibition of melanin producing enzyme activity, Lightening due to degradation, etc., and more recently, regulation and suppression of gene expression of melanogenesis-related enzymes, suppression of intracellular or intercellular signaling that controls melanogenesis, suppression of activation of melanocytes themselves, which are melanocytes Molecular biological studies have also been studied.

And in the field of skin external preparations such as cosmetics, based on the above-mentioned knowledge, for example, ascorbic acid or its derivative, kojic acid or its derivative, cinnamic acid derivative or chromone derivative, resorcin glycoside, amine derivative, chlorogenic acid or Derivatives, unsaturated fatty acids, flavanone, catechin derivatives, arbutin, etc., legumes such as licorice, kudzu, lilyaceae plants such as Enraiso, janohige, asteraceae plants such as leopard ears, inchinko, etc. Gramineae plants, Myrtaceae plants such as clove, cucurbitaceae plants such as vines, hangeres and aloe, camellia plants such as tea, various plant extracts such as algae, and animals and microorganisms such as lactoferrin and lactoferrin degradation products Various whitening agents such as related components have been developed so far (for example, Non-Patent Document 1, Table 1).

  However, the above-mentioned whitening agents are not satisfied with the demands of consumers in actual use, such as those that are not sufficiently effective at the living body level, and that there are safety problems such as causing skin irritation.

  In addition, although it is safe and has some degree of effectiveness, it has the disadvantage that it cannot be applied unless some measure or ingenuity is applied in formulation, such as extremely poor stability, problems with odor, color tone, solubility, etc. In fact, there are only a few that can be said to be really practical active ingredients.

  In particular, ascorbic acid and ascorbic acid derivatives are often used as active ingredients in whitening agents, whitening cosmetics, beauty foods and beverages, and for the purpose of oxidation stabilizers. These ascorbic acids are known to have poor stability over time in water-based composition systems such as aqueous solutions and aqueous gels, particularly in the temperature range higher than room temperature, and the stability of these ascorbic acids Various methods for improving the efficiency have been studied. For example, a method utilizing acerola polyphenol having vitamin C stabilizing activity (Patent Document 1), a method using fumaric acid together (Patent Document 2), a method using chlorogenic acid together (Patent Document 3), an enzyme-treated isoquercitrin , Mycitrin and chlorogenic acid (Patent Document 4), a method of adjusting the pH of the composition to an acidic region (Patent Document 5), and a method of using vegetable juice together (Patent Document 6).

  However, in these methods, there are problems such as that the composition undergoes a color change over time, the generation of insoluble matter, the odor, and the taste are deteriorated, so that a sufficiently satisfactory effect cannot be obtained. However, no satisfactory solution has yet been found.

Noriyuki Omori, FRAGRANANCE JOURNAL Special Issue, No. 14, 1995, 118-126 Tetrahedron Lett, 26 (7), 865-868, 1985

JP-A-2005-154432 JP-A-4-352776 JP-A-6-9603 JP 2006-315985 JP-A-7-227256 JP2009-45030 JP 2009-114130 A

  Therefore, in the present invention, a new melanin production inhibitor that has a strong effect on the living body level and has no problems in both stability and safety, that is, has a moisturizing action and is caused by exposure to spots, buckwheat, dullness, or ultraviolet rays. It is an object of the present invention to develop an easy-to-use component having a whitening effect such as effective suppression and improvement of skin pigmentation such as skin blackening and to provide an application means thereof.

  Another object of the present invention is to provide, for example, a whitening cosmetic and a beauty food and drink having good temporal stability of ascorbic acids even in the presence of water.

  In order to solve the above-mentioned problems, the present inventors have conducted intensive studies. As a result, it has been shown that elenolic acid and / or elenolic acid glucoside, or a salt thereof, has a very excellent strong whitening effect on melanin production and moisturizing. It was found that they are effective, and evaluated that they are components that satisfy both the stability over time in the prescription system and the safety to the human body.

  Furthermore, elenolic acid and / or elenolic acid glucoside, or a salt thereof, has been found to have an effect of improving the temporal stability of ascorbic acids and the like, and when incorporated together with ascorbic acids, ascorbic acids are stabilized, whitening, The present inventors have found that the beauty effect is synergistically improved and completed the present invention.

  The present invention relates to a melanin production inhibitor containing at least one selected from elenolic acid and / or elenolic acid glucoside, or a salt thereof, a humectant, a whitening agent having a moisturizing action, a whitening cosmetic, It provides beauty foods and drinks.

  Furthermore, whitening containing at least one selected from elenolic acid and / or elenolic acid glucoside, or a salt thereof, and at least one selected from ascorbic acid, isoascorbic acid, and derivatives thereof. Provides cosmetics and beauty food and drink.

  Elenolic acid has been known to have a histamine release inhibitory effect and an antiallergic effect, and has been known to have a hay fever improving effect and an atopic dermatitis improving effect (Patent Document 7). However, no melanin production suppression (melanin biosynthesis prevention) effect or whitening effect was known at all.

  Moreover, in the system where ascorbic acids coexist, the effect of specifically improving the temporal stability of ascorbic acid has not been known at all.

  Elenolic acid and / or elenolic acid glucoside used in the present invention, or salts thereof, have excellent melanin production inhibitory action, moisturizing action, and whitening action, and this is applied to whitening cosmetics and beauty foods and drinks. As a result, it has become possible to provide a whitening effect such as effective suppression and improvement of skin pigmentation such as skin blackening caused by exposure to spots, buckwheat, dullness, or ultraviolet rays.

  In addition, the melanin production inhibitor, moisturizing agent, whitening agent having a moisturizing effect, whitening cosmetics, and beauty foods and beverages according to the present invention have good temporal stability and are extremely safe for the human body. Therefore, it can be used in a wide range in fields such as pharmaceuticals, quasi drugs and functional foods.

  Furthermore, the use of elenolic acid and / or elenolic acid glucoside, or a salt thereof in whitening cosmetics and beauty foods and drinks containing ascorbic acids can synergistically improve the temporal stability of ascorbic acids. It has become possible to provide a composition of good quality with good stability.

It is the figure which showed the melanin production inhibitory effect of elenolic acid and elenolic acid glucoside using B16 melanoma cell. It is the figure which showed the tyrosinase activity inhibitory effect of elenolic acid and its salt.

  The enolic acid and / or elenolic acid glucoside used in the present invention may be a compound in the form of a pharmacologically acceptable salt. Examples thereof include monovalent or divalent or higher inorganic salts such as sodium, potassium, calcium, magnesium and zinc, organic salts such as organic amines and basic amino acids, or salts formed by combinations thereof.

  Elenolic acid and / or elenolic acid glucoside, or salts thereof can be obtained by hydrolyzing or chemically synthesizing oleeuropein or oleeuropein aglycone using an acid or an enzyme (Non-patent Document 2). Oleuropain aglycone is obtained by allowing β-glucosidase to act on oleopane, and it can be hydrolyzed to obtain elenolic acid. When obtaining elenolic acid and / or elenolic acid glucoside from oleeuropein, it can be obtained as any / or mixture by controlling the hydrolysis conditions, but it is not always necessary to purify and can be used in the form of a mixture. it can. Moreover, the thing of the crude (coarse) state extracted from the natural product may be sufficient.

  Ascorbic acid derivatives used in the present invention include, for example, ascorbic acid sodium salt, calcium salt, potassium salt, magnesium salt, aluminum salt and the like, ascorbic acid phosphate ester or its sodium salt, calcium salt Ascorbic acid phosphates such as potassium salts, magnesium salts and aluminum salts, ascorbic acid glycosides such as 2-glucosyl ascorbate, 3-glucosyl ascorbate, 2-maltosyl ascorbate and 3-maltosyl ascorbate, palmitic Examples include ascorbic acid fatty acid esters such as ascorbyl acid, ascorbyl stearate, ascorbyl myristate, and ascorbyl oleate. These are preferably used as an additive in external preparations for skin and foods and drinks.

  The dosage form of the melanin production inhibitor, moisturizer, whitening agent, whitening cosmetic, and beauty food and drink according to the present invention is arbitrary, ampoules, capsules, powders, granules, pills, tablets, solids, A liquid, gel, foam, emulsion, cream, ointment, sheet, mousse, powder dispersion, multilayer, aerosol, and the like can be used.

  Specific whitening cosmetics (including formulations used for animals) include ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. Appropriate forms of 1) pharmaceuticals, 2) quasi drugs, 3) topical or systemic skin cosmetics (e.g. lotions, emulsions, creams, ointments, lotions, oils, packs, etc.) Facial cleanser and skin cleanser such as cosmetics, bar soap, liquid soap, hand wash, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after-shave lotion, pre-show lotion, shaving cream, Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, beauty nail preparation, beauty nail enamel, beauty nail ena 4) Medicinal or / and cosmetic preparations (eg shampoos, rinses, etc.) applied to the scalp / hair. Hair treatment agent, pre-hair treatment agent, permanent solution, hair dye, hair styling agent, hair styling agent, hair growth / hair nourishing agent, poultice agent, plaster agent, tape agent, sheet agent, aerosol agent, etc.) 5) Throw in bath water 6) In addition, odor control agents, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissue, and the like.

  Beauty foods and drinks include oral compositions (gum, candy, etc.), processed fishery products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat noodles Noodles such as udon, spaghetti, sauces, soy sauce, sauce, sugar, honey, powdered candy, water candy, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, so Vegetables, sprinkles, processed vegetables and fruits such as canned and bottled vegetables and fruits, dairy products such as cheese, butter and yogurt, miso soup, soup, fruit juice, vegetable juice, whey drink, soft drink, tea drink In addition to alcoholic beverages, beverages such as beauty and health drinks, beauty and health foods (tablets, chewable, jelly, etc.), functional foods, and general food and drinks It can also be used as a kind.

  When applying the melanin production inhibitor, moisturizer, and whitening agent containing the elenolic acid and / or elenolic acid glucoside of the present invention, or a salt thereof, in particular, when applying to whitening cosmetics, beauty foods and beverages, When elenolic acid glucoside or a salt thereof is contained in a solid content of about 0.00001 to 3% by weight, preferably about 0.0001 to 1% by weight, usability and a good melanin production inhibitory effect are obtained. It is done. Further, in the case of bath preparations, bath oils, etc., the prescription may be considered so that it is poured into 200 to 300 L of hot water and has a concentration similar to the content defined in other skin external preparations.

  In addition, the melanin production inhibitor, moisturizer, whitening agent, external preparation for skin, and beauty foods and beverages of the present invention include, in addition to the above essential components, other pigmentation inhibitors exemplified below, tyrosinase activity inhibitors, Melanocyte melanin production inhibitor, moisturizer, cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection / UV absorption promoter, astringent, anti Inflammatory agent / interleukin production inhibitor / anti-inflammatory agent, antiseborrheic agent, antibacterial agent / antiviral agent, blood flow promoter / vascular stimulant, antiandrogen agent, structural proteolytic enzyme (elastase, collagenase, keratin protease, serine Protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteogli Activity inhibitors / structural protein degradation inhibitors, structural protein synthesis promoters, mucopolysaccharides (hyaluronic acid or salts thereof, chondroitin sulfate, proteoglycans, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters , Intercellular adipogenesis promoter / intercellular lipid state improving agent, keratolytic agent / stratum exfoliation promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor, odor elimination Extracts and metabolism derived from active ingredients such as agents, plant-based materials, animal-based materials, microbial-based materials, and other natural product materials that are preferred for use in the form of whitening agents or whitening cosmetics In addition to the above-mentioned various whitening effects, various functionalities can be obtained by arbitrarily selecting and using components such as substances or various compounds as additives. It is possible to provide excellent whitening cosmetics and beauty foods and beverages having the above. The content of these various additives in the preparation is not particularly specified, but is usually used in a concentration range of 0.0001 to 50% by weight (the appropriate amount less than that in the case where there are restrictions on the amount). Is common.

(1) Pigmentation inhibitor
p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or its salts and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives (2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid Hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives , Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline phosphorus ascorbate) Acid ester, 5-O-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L- Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate Ester calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6- O-α-D-galactopyranosyl-L-ascorbic acid, 2-O-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Ester sodium salt, L-ascorbic acid sulfate sodium salt, 6-O-acyl ascorbic acid phosphate sodium salt, 6-O-acyl ascorbic acid phosphate ammonium salt, 6-O-acyl ascorbic acid phosphate isopropanol Amine salt, 3-O-isopropyl-L-ascorbic acid, 6-O-alkylascorbic acid phosphate Potassium salt, 6-O-alkylascorbic acid phosphate calcium salt, 6-O-alkylascorbic acid phosphate barium salt, 6-O-alkylascorbic acid phosphate ammonium salt, 6-O-alkylascorbic acid phosphate Acid ester monoethanolamine salt, 6-O-alkylascorbic acid phosphate diethanolamine salt, 6-O-alkylascorbic acid phosphate triethanolamine salt, 6-O-alkylascorbic acid phosphate monoisopropanolamine salt, 6-O-alkylascorbic acid phosphate diisopropanolamine salt, 6-O-alkylascorbic acid phosphate triisopropanolamine salt, 3-O-glycosyl-L-ascorbic acid, 6-O-β-D-galacto Pyranosyl-L-ascorbic acid, cholesterol ascorbyl phosphate Esters, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-O-α-D-glucosyl-L-ascorbic acid, 2-O-α-D-maltosyl-L -Ascorbic acid, 2-O-α-D-maltotriosyl-L-ascorbic acid, 3-O-α-D-glucosyl-L-ascorbic acid, 2-O-α-D-maltosyl-L-ascorbic acid , 2-O-α-D-maru Triosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-O-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-O-ascorbyl cinnamate, 2-O-ascorbyl ferrate, 2-O-ascorbyl caffeate, 2-O-ascorbyl cinna Pate, 2-O- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-toco Errol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate , Tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, D L-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl Glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-toco Ferryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfo Ethylamino) -3- (α-toco Eleyl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (Α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrieno Lurinolate, tocotrienol orotate, etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyl Oxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one Kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate , Kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baika Or salts thereof and derivatives thereof, baicalein or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin or salts thereof and Derivatives thereof, acacetin or a salt thereof and derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof Quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and These derivatives, myricetin or a salt thereof and derivatives thereof, myricitrine or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof , Pinocembrin or a salt thereof and derivatives thereof, naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromaden Dorin or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or Salts thereof and derivatives thereof, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-O-apiosyl puerarin-4′-O-glucoside, 6-O-glucosyl puerarin, 3′-hydroxy puerarin-4 '-O-glucoside, 6-O-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-O- (6'-O-apiosyl) -glucoside, maltol-3-O- (6'-O-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3 ', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond Usaponin, Ruscogenin, Celicoside, Asian Chicoside, F Deline, Senegin, Benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyraline, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide Zinc peroxide, placenta (bovine origin, pig origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, querca extract, kofuyou extract, uncaria extract , Gaijacha extract, citrus extract, licorice extract, gardenia extract, cranigean extract, clara extract, scallop (wagon) extract, wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sunflower Cucumber extract, Sanvitro extract, Sunpens extract, Silane (river cucumber) extract, Senkyu (river cucumber) extract, Senna extract, Senpukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (maehu) extract, pearl barley (yokuinin) Extract, Hamagoueki , Honey beetle extract, hamamelis extract, palm extract, parietaria extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvanojadin (bitter ginseng) extract, purple squirrel extract, white squirrels extract, moko Artemisia extract, yashajitsu extract, hongkong extract, bituminous extract, ground lily extract, citrus extract, millipede extract, etc.

(2) Tyrosinase activity inhibitor Ascorbic acid or its salts and derivatives thereof (phosphate-L-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-O-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-O-α-D-galactopyranosyl -L-ascorbic acid, 2-O-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-O-acyl ascorbic acid phosphate sodium salt, 6-O-acyl ascorbic acid phosphate ammonium salt, 6-O-acyl ascorbic acid phosphate isopropanolamine salt, 3-O-isopropyl-L -Ascorbic acid, 6-O-alkylascorbic acid potassium ester potassium salt, 6-O-alkylascorbic acid phosphate calci Umum salt, 6-O-alkylascorbic acid phosphate barium salt, 6-O-alkylascorbic acid phosphate ammonium salt, 6-O-alkylascorbic acid phosphate monoethanolamine salt, 6-O-alkylascorbine Acid phosphate ester diethanolamine salt, 6-O-alkylascorbic acid phosphate triethanolamine salt, 6-O-alkylascorbic acid phosphate monoisopropanolamine salt, 6-O-alkylascorbic acid phosphate diisopropanolamine Salt, 6-O-alkyl ascorbic acid phosphate ester triisopropanolamine salt, 3-O-glycosyl-L-ascorbic acid, 6-O-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L- Scorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-O-α-D-glucosyl-L-ascorbic acid, 2-O-α-D-maltosyl-L-ascorbic acid, 2-O-α-D-maltotriosyl -L-ascorbic acid, 3-O-α-D-glucosyl-L-ascorbic acid, 2-O-α-D-maltosyl-L-ascorbic acid, 2-O-α-D-maltotriosyl-L- Ascorbic acid, L-ascorbic acid tetraisopa Mycinate, L-ascorbate tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, L-ascorbine Acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-O-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L -Ascorbyl triphosphate, 2-O-ascorbyl cinnamate, 2-O-ascorbyl ferrate, 2-O-ascorbyl caffeate, 2-O-ascorbyl synapate, 2-O- [6-palmitoyl ascorbyl]- 4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbine Inositol-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), hydroquinone or its salts and their derivatives (hydroquinone α-D-glucose, hydroquinone) β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Carbohydrate glycosides, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose , 5-quinone sugar glycosides such as hydroquinone α-L-arabinose and hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine , Hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine and other amino sugar glycosides, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuron Acids, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid, etc. Hydroquinone glycosides such as uronic acid glycosides, hydro Quinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol) , Kojic acid or salts thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxy Til-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kouji Acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (α -Tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol ni Tinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL- γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D -β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propane -2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl- 6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or its salts and derivatives thereof (α- Tocotrienol, β-tocotrienol, γ-tocotrienol δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or its salts and derivatives thereof, glutathione or its salts and derivatives thereof, ellagic acid or its Salts and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxy Isonitrile antibiotics such as ellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobilidene Substance, orthoric acid derivative (orceric acid, orthophosphoric acid Tylester orcinol, p-geranylorceric acid, p-geranylorceric acid ethyl estergeranylorcinol, p-farnesylorselinic acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid P-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid, p -Hexadecanylorceric acid ethyl ester hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethylester undecanylorcinol, p-tridecanylorceric acid, p- Tridecanylorceric acid ethyl ester undecanylorcinol , P-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorselinic acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid P-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol , Resorcinol derivatives (4-cyclohexylresorcinol), 3-hydroxyketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyph) Nyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5 -Bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m- Methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, oleyl γ-aminobutyric acid) Esters, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, ichibi (winter position) extract, weeping birch extract, quercus (gallic) extract, chestnut extract, kamebahikokoshi extract, kurobanahikokoshi Extract, Hikikoshi (life extension grass) extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, Fujibakama (Orchid grass) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Artemisia extract, Honeysuckle extract, Yellowfin Extract, Bokudami extract, Matsuhodo extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, bay extract, hamameris extract, yamagwa extract, bellflower extract, toshishi extract Extract, dry-boiled extract, mahuang extract, senkyu extract, dokkatsu extract, psycho extract, bowfish extract, hamaboufu extract, ougon extract, peony skin extract, peonies Kiss, cranesbill extract, kudzu root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, Ali elixir extract, and the like.

(3) Melanocyte melanin production inhibitor
Lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2-nonylchromone, 2- Hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydroxy-2- (1-ethyl) Rupentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D -Maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL-N-propionyl-3- ( 1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3-methylvaleryl) -3- (1- Naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3 -(1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-Heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N- Dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl -3- (1-Naph ) Alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N- Cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3- Pentenoyl) -3- (1- Naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8 -Hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1 -Naph ) Alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (O-toluyl) -3- (1-naphthyl) alanine, DL-N- (m- Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl)- 3- (1-Naphtyl) alanine, DL-N- (4-Carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-Picolyloyl) -3- (1-naphthyl) alanine, DL- N- (3-picolineoyl) -3- (1-naphthyl) alanine, DL-N- (4-picolineoyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) Alanine, DL-N- (2-Phenylpropanoyl) -3- (1-naphth ) Alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl- 3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methyl) Valeryl) -3- (1-naphthyl) alanine-t-butyl ester), benzolactam derivatives, indolactam derivatives, cedrol, guaioles, 1- (4-hydroxyphenithio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol , 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl)- 2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2 -Methoxy-5- (3-methylhexyl) pheno , 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyl Phenyl] -1,4-pentadien-3-one, 1,5-bis [O-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or a derivative thereof, Alkylresorcinol or its derivatives (4-N-butylresorcinol, etc.), Aristolone, Caramenene (Caramenen, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenen, etc.), trans-umbellic acid, N- α-be Zoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2 -Hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2 -Cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl- 2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadiene Kind ( Amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanol, tetrahydrocoparol, tetrahydrocoparalol glucoside) , Tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiroether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, Chlorpromazine, cyclandelate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypro Ru-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2- Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane- 1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4- Acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarboni) Propyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2-hydroxy Benzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl) -1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexa (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- ( 2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3 -Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl Til-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides, etc., escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-
Cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl- Cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Dp -Hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N -Acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4 -Hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp- Hydroxyphenylglycine, N-tert-butoxy Carbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl- Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonic acid Salt, Lp-hydroxyl Nylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride , Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybocins, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene)- 1,6-Geo Oxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [ 4.5] Dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl ) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [ 4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4- Benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6- Dioxas Pyro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.4] non-3- Ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomalasmin, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4- Benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoyl) Amino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-na Futoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4 -(1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthylamino) Carbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic ester maltoside, borneol-p-hydroxycinnamic acid Stemaltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone ( 2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1- Butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- ( 2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxy Phenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxy) Phenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl)- Etanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2- Hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2 -Hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- ( 2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) ) -1-Hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'- Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecano 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decene-4-olide, 2-nonene-4-olide, 2-heptene-4-olide, 2-undecen-5-olide, 2-decene-5-olide, 2-nonene-5-olide, 2- Octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl- 5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl- 4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nona Lido, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl -4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4 -Nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide , 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- ( 2-hydroxye Toxi) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C -Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp extract, ketsumeishi extract, ogi extract Red-crowned cucumber (Calcon) extract, Onamomi (Temple) extract, Oninoyagara (Tempa) extract, Oyster extract, Ginseng extract, Uyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Ginseng extract ) Extract, black moji extract, black spider extract, sisal ) Extract, Saximarum knuckle extract, Cinnamon kaffle extract, Cinnamon ginseng (wei Sensen) extract, Oshima cherry extract, Oyama cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract Extract, ginseng extract, potato beetle extract, diamondfish extract, camellia extract, toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, dill extract, beetle extract, beetle extract Extract, human camellia (stone persimmon) extract, Higama (koi) extract, peony extract, floral blanka extract, hamula extract, sagebrush extract, convolvulus extract, Sandalwood extract, Ganoderma lucidum extract, Japanese mackerel extract (Mascus herb) extract, Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese black willow extract, Japanese willow extract, Japanese willow extract, Japanese yellow willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract Timber king willow extract, fox willow extract, dronox extract, bayberry (plum husk) extract, agave mid-autumn, Aono Agave extract, Fukurin Ryu
Turan extract, Mitsumata extract, Aonori extract, Usba aonori extract, Sugiaonori extract, Hiiraaoori extract, Bowuaonori extract, Hosoeda aonori extract, Kombu extract, Macombu extract, Resilib extract, Hosomome comb extract, Mitsuishi kombu extract, Wakame extract, Hirome extract Extracts Giraffe rhinoceros extract, juniper ginseng rhinoceros extract, tsunomata extract, ibottsu no mata extract, malvatsu nomata extract, hirakotojiki , Sugi nori extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsuba misjibu extract, Isomok extract, Nagashimamok extract, Shimomoku extract, Nemosamo extract, Nametamo extract Tatsukuri Extract, Yatsuma Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusis Mimoku Extract, Haha Moku Extract, Yoremok Extract, Sawtooth Moku Extract, Agaric Sorghum Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomkadenori Extract, Oomatsuri Extract Extract, Sponge Extract, Fushitsunagi Extract, Himefushitsunagi Extract, Hirohafutsutsugi Extract, Kurosozo Extract, Co Sozoekisu, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Tila extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, and the like.

(4) Moisturizer Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1 , 3-Butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, scylitol, laminitol, valienamine, validamine, validatol Polyhydric alcohols such as Beer rubber, benzoin rubber, danmar rubber, guaiac oil, Irish moss, Karaya rubber, tragacanth rubber, carob rubber, quinseed, agar, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose, lamina Libiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, mycarose, cladinose, accentose , Arcanose, Oribomai course, Chromose, Ebami course, Vinelose, Nogarose, Billenose, Saccharide such as biose, moenuronic acid, galosamine, cibirosamine, N-acylcansamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldogalose, blastominosine, trehalose or derivatives thereof , D-mannosamine and derivatives thereof, primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethylchitin or chitosan, and hydroxyalkyl (C2 to C4) to which alkylene (C2 to C4) oxide such as ethylene oxide is added ) Chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or Its salt, chondroitin sulfate or its salt, 1,3-β glucan, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl Water-soluble, such as alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linked polymers thereof, carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate Polymers, glycerin fatty acid pyrrolidone carboxylic acid ester Tells, glycerin fatty acid acetylamino acid esters, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D Cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl Lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-O- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- O- [β-D-glucopyranosyl-3-D-glucuronopyranosyl -Soyasapogenol B, 3-O- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapogenol, 3-O- [β-D-glucopyranosyl] -28-O- [Β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-O- [α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soya sapogenol B 3-O- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-O- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki ( Aoki) extract, Aogi extract, Kenashia Ogiri extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Amanita coconut) extract, Maruba morning glory extract, Asagao extract, Athira (Shokuyo kanna) Extract, oilseed rape extract, amachazulue Kiss, Amana extract, Ayuyu extract, Hagateto extract, Homogatetope extract, Senninoku extract, Sugimori gateto extract, Hosoa Ogretou extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippochondriax extract , Aristolomeria extract, Arcana extract, Argarovo extract, Aloe vera extract, Rabbit extract, Yew extract Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract, euglena extract ) Extract, Enokitake mushroom extract, eringi extract, pre-lotus eringi extract, Ogata Houken extract, Oogurma (civil fragrance) extract, Steller's beetle extract Extract, Onidokoro Extract, Tokoro Extract, Nagadokoro (Hikai) Extract, Ononis Extract, Yuuko Extract, Oyster Extract, Ginseng Extract, Ganohydrangea Extract, Cascara Sagrada Extract, Gypsophila Extract, Panax Ginseng Extract, Caniva Extract, Carnation Extract, Gerbera extract, camouflage (camo duck) extract, color extract, oat extract, karin extract, Kawara Psycho extract, kawajisha extract, kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (buckwheat, buckwheat) Kiss, Kantara extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory extract , Kudzu (Kudzu) extract, Ginseng (Yellow flower) extract, Kupuas extract, Gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, Gekkavidin (Monthly beautiful woman) extract, Koolen (Huoren) extract, Coconut extract, Cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (banban flower, west safflower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin carrot (37 ginseng) extract, shea (carite) extract , Cyanoki extract, shiitake extract (shiitake) extract, shiitake Di extract, Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, Oshiroi shimeji extract, Buna shimeji extract, Honjimeshi extract, Shirotamogitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (bara winter) extract, Shukukonka miso extract, Zouzan hydrangea (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki (chicken bone grass) extract, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, watermelon (Western phoenix) extract, Suzu-Psycho (Xucho cocoon) extract, subtlehille Horse tooth extract) extract, boiled extract, cherry blossom extract, Japanese apricot extract, Japanese apricot extract, Okinawa aquatic extract, Japanese apricot extract, an antelope extract, a Japanese apricot extract, a Japanese apricot extract (Bush Shukuboku) extract, mallow extract, celery extract, senshinren (Daishinren) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, Sengokushi extract, Sojutsu extract, Chankapiedra extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, Camellia extract, Clover (lacquered licorice) extract, Tonabena (river cut) extract, Corn extract, Corn hair (Southern lash) extract, Toxa (wood band) extract, Torico (crust) extract, Turkish Kyary extract, Solid bean extract, Vertical bean extract (Sword bean) extract, Jujube (Daisen) extract, Navena (interrupted) extract, Nameko extract, Nambang Karamushi (Hemp) Extract, Niosum Ville Extract, Nutzuku extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobo extract, Balata rubber extract, Haratake extract, Haratake extract, White oharatake extract , Usukimorinokasa extract, Haran extract, Pariurus (Amanita spp.) Extract, Balsamina (Spirea, bitter gourd) extract, Harindou extract, Handaikai (Yutakakai) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Himeuzu (Tenpo) extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, Fuyumushinakusatake (Cycium Cordyceps) extract, Brazilian licorice extract, hazel Extract, loofah extract, diatomaceous earth extract, nettle extract (sparkling) extract, broomweed extract, elder extract, nendo extract, scallop extract, ground scallop extract, spinach (saccharidum, acute kid, pelagic grass) extract, falcon extract Nokirinso (Keiten 37) extract, Jojoba extract, Borage (Lurichisha) extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret extract, Tamanosen Hallen extract, Kyukon Kinlenka extract, Matatabi (wooden cocoon) extract, Matsukasa extract, Matsuhodo (sardine) extract, Matico (cordon sillo) extract, quince extract, malein (browed mud squid) extract , Manzanya (Andesca Extract) ) Extract, ilex extract, cornflower extract, yacon extract, coconut extract, yab tobacco (crane gourd, tennasei) extract, malonie extract, mokka extract, lily extract, ligan extract, lime extract, rye extract, jackfruit extract, shallot (Palm-white) extract, apple extract, gentian extract, litchi (wedge, toothpick nucleus) extract, forsythia extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia ex , Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusaori extract, Aoumidro extract, Kawanoori extract, Marimo extract, Motsukihitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Aname extract, Sujime extract Extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoshikonbu extract, Ainuwakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hiemonoku extract, Tamanashimok extract, Honda wall extract, Sugi moku extract Bovine Kenori Extract, Susabiori Extract, Akebono Mozuku Extract, Cyprinus Extract, Fusanori Extract, E Banaminohana extract, Hanafnori extract, Itohnori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Saidaibara extract, Tatyibara extract, Ogonori extract, Tsurusilamo extract, Honey beetle extract, red clover extract, red ginseng extract, natto fungal culture metabolite, natto extract, loofah water, birch (white birch), red pine, or maple sap.

(5) Cell Activator / Metabolic Activator Vitamin A Group: Retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [[8- (3,4-Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[((8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivatives (4 -Hydroxyphenylretinamide), retinoid analogues (4-[[(5,6 -Dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl ] Benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5 -Dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4 -(E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino) benzoic acid Acid, 4-[[( 5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluoro) Phenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4- [[((5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4 -[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphth Talenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[((5, 6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] methyl] oxy] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[( 5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] Ethyl) benzoic acid, 4-[[[[ (5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6- Dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino]- 2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5 , 6-Dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3 4-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8, 10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) Mino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl) -1H-Inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or its salts and their derivatives (Carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isosexanthine, rhodoxanthine, capsanthin, crocetin), lycopene or a salt thereof and derivatives thereof, vitamin B group: thiamine or a salt thereof As well as their derivatives (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisivethiamine, thiamine monophosphate disulfide, benfotiamine, Cotyamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or salts thereof and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosyl nicotinamide pyrophosphate diester, 1-β-D-ribofuranosyl nicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (3,4-dipalmitic acid pyridoxine, 3,4 -Pyridoxine dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamin (methylcobalami) , Adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or salts thereof and derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof , Choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalci Ferrol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanol Calciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclope Ten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol and the like, dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof, Tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or Salts thereof, derivatives thereof, menaquinone or salts thereof and derivatives thereof, menadione or salts thereof and derivatives thereof, menadiol or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid Or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orot Acids or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof As well as those Conductor, adenylthiomethylpentose or salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivative thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine , Serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or a derivative thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl -β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecylo Cycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L- Amino acids such as histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid, glycol Α-hydroxy acids such as acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxy Hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylaurin Acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- ( 4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2 -(4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropane Acid, 2- (3 ', 4'-
Dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, arolic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) , Pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, pheny (Rupyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.) , Quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alloyic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or its Derivatives, allantoin, pentadecanoic acid glycerides, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof, docosahexaenoic acid or derivatives thereof, estradiol, ethenylestradiol, antialol or glycosides thereof, rioniresinol or glycosides thereof, rhodede Ndrol or its glycoside, platifironol or its glycoside, lactone compound (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β -Glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ -Lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyloic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof , 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tektrigenin 7 -Xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycan, proteo extract Lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, Mother culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete culture extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell disruption extract, Ground yellow) extract, fennel (mushroom) extract, sorghum (barley gourd) extract, barley (barley) extract, oakuri higotai (Zhengzhou leakage, indigo head) extract, komeba hypericum extract, hypericum perforatum extract, holland jelly extract , Dutch Honey Bee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawarani Ginseng (Blue Agate) Extract, Kakiran Extract, Quillaja Extract, Kinlan Extract, Ginlan Extract, Calendula Extract, Sakakanelan Extract, Sasabaginran Extract, Sawagurumi (Mountain) (Walnut) extract, shimo Pepper extract, Shajin extract, plum extract, walnut extract, cedar extract, pineapple extract, Chinese cabbage extract, Japanese cypress extract, beech extract, physalis extract, maitake (maiko) extract, misohagi ( Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (prolonged skin) extract, coconut extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract, Ogon Extract, Tonka Bean Extract, Gentiana Extract, Burdock Extract, Shikon Extract, Carrot Extract, Clam Squirrel Extract, Hop Extract, Yokuinin Extract, Odorikosou Extract, Assembly Extract, Toki Extract, Tokisenka Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Tachija Cranberry extract, rosemary extract, parsley extract, sandadagusa extract, fukurin amiji extract, guts-comb extract, oyster-comb extract, oni-konbu extract, gohei-comb extract, naga-comb extract, pea-comb extract, prickly-comb extract, rattle extract Rattle extract, Beni Mozuku extract, Hoso Beni Mozuku extract, Kagekinori extract, Ezotosaka extract, Shiramo extract, birch extract, salicylic acid or salts thereof and their derivatives (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.) , Salicyl alcohol or a salt thereof and derivatives thereof, apigenin, ament flavone, salamander extract, udo extract, shishido extract, gasho extract, potato Extract, bovine taxis extract, cuckoo thistle extract, scallion (sheep-root) extract, gymnema sylvesta extract, carrion extract, ginkgo biloba extract, konronka extract, sabrunryo extract, jasmine (matsurika) extract, hollyhock extract, gypsophila extract , Arabidopsis extract, Lily of the valley extract, Souzo extract, Deco extract, Tochu extract, Nagii Kada (Butcher bloom) extract, Teppo cucumber extract, Tokiwa mansaku extract, Nankin goby extract, Niwa urushi extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract Hemp) extract, yellow willow extract, weeping willow extract, magnolia extract, yah-so-so extract, wakame wisteria extract, leopard cauli extract, ajijigusae Kiss, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, turban shell extract, bi-extract, etc.).

(6) Antioxidants Ascorbic acid or its salts and their derivatives (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-O-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum salt, L- Scorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-O-α-D-galactopyranosyl-L-ascorbic acid 2-O-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6- O-acyl ascorbic acid phosphate sodium salt, 6-O-acyl ascorbic acid phosphate ammonium salt, 6-O-acyl ascorbic acid phosphate isopropanolamine salt, 3-O-isopropyl-L-ascorbic acid, 6 -O-alkyl ascorbic acid phosphate potassium salt, 6-O-alkyl ascorbic acid phosphate calcium salt, 6-O- Rualkylascorbic acid phosphate barium salt, 6-O-alkylascorbic acid phosphate ammonium salt, 6-O-alkylascorbic acid phosphate monoethanolamine salt, 6-O-alkylascorbic acid phosphate diethanolamine salt, 6-O-alkylascorbic acid phosphate triethanolamine salt, 6-O-alkylascorbic acid phosphate monoisopropanolamine salt, 6-O-alkylascorbic acid phosphate diisopropanolamine salt, 6-O-alkyl Ascorbic acid phosphate triisopropanolamine salt, 3-O-glycosyl-L-ascorbic acid, 6-O-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, palmitic acid L- Ascorbyl, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl myristate Ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-O-α-D -Glucosyl-L-ascorbic acid, 2-O-α-D-maltosyl-L-ascorbic acid, 2-O-α-D-maltotriosyl-L-ascorbic acid, 3-O-α-D-glucosyl- L-ascorbic acid, 2-O-α-D-maltosyl-L-ascorbic acid, 2-O-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L -Ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, le, L-ascorbic acid retinol ester , L-ascorbic acid-DL-tocopherol phosphate, L-3-O-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid Triphosphate, 2-O-ascorbyl cinnamate, 2-O-ascorbyl ferrate, 2-O-ascorbyl caffeate, 2-O-ascorbyl synapate, 2-O- [6-palmitoyl ascorbyl] -4'- Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, inositol ascorbate Derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol) , Γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate , Tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- Iroxy) propan-2-ol, 1- (carboki Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), di Dropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nor Dihydroguaselectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamol, gossypol, maritimaine, sulfretin, xanthene-2,7-diol , Caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, akebi (wood) extract, Amacha (Amacha) extract, Dutch beetle extract, Orchid extract, kumquat extract, goby extract, geno shoko (old vine) extract, sesame extract, sesame cell extract, sesame extract (genus ginseng) extract, rice bran extract, pomegranate extract, salamander extract, pear extract, daio (daio) extract , Tomato extract, Nanten extract, Noami Thistle, Daibara extract, Paprika extract, Pistachio extract, Betel wax (Large husk, coconut) extract, Buffalo extract, Bokeh extract, Hosoba Ogulma extract, Mao (mao) extract, Mimosa extract, Mebogi extract, Himekuma willow extract, Willow tree deer extract, Cotton smelt (Mitsumoni flower) extract, Chlamydomonas extract, Red-bellied extract, Red-bellied extract, Red-bellied extract, Hypericum extract Eki , White birch extract, salvia extract, nandina fruit extract, ginkgo extract, green tea extract, and the like.

(7) Reactive oxygen scavenger / radical scavenger Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and derivatives thereof, curcumin or its Salts and derivatives thereof, transferrin, ceruloplasmin, coenzyme Q, uric acid, bilirubin, metallothionein, stilbenegaloyl glycoside (3,5,4'-trihydroxystilbene 4'-O-β-D- (6 "galloyl ) Glucopyranoside, 3,5,4'-trihydroxystilbene 4'-O-β-D- (2 "galloyl) glucopyranoside), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester , Chlorogenic acid sugar ester, black Genolic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4 -[3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5- Methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole,), hydroxymatilesinol, allohydroxymatilesinol, hydantoin derivative, akaminoki (log) (Wood) extract, red-crowned wrinkle (red bud) extract, red-bellied red-brown extract, red-brown radish extract, red-brown (root) extract, hydrangea (hydrangea) extract, abemaki extract, fig extract, ginkgo biloba Kiss, Asparagus Extract, Plum (Plum Plum) Extract, Vulture Extract, Estragon Extract, Enju (Plum Blossom, Plum Blossom Rice) Extract, Kashiwa (Plum Tree, Bamboo Leaf) Extract, Gypsophila Extract, Hippopotamus Extract, Birch Extract, Kunugi (樸 Saw) extract, Oleander extract, Satsuma mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Comfrey extract, Sasa (笹) extract, Perilla extract, Aojiso extract, Chilemiso Extract, Catamenzo extract, Peony extract, Japanese oak extract, Japanese oak extract, Crape myrtle extract, Dikoppi extract, Shirakashi extract, White clover (Clover) extract, Horseradish extract, Black tea extract, Green tea extract, Azalea extract, Tencha (Japanese black tea) Extract, te Nidaiyaku Extract, Naniwaibara (Golden Cherry) Extract, Peanut (Peanut) Extract, Kei Extract, Nikkei Extract, Ceylon Nikkei Extract, Yav Nikkei Extract, Keishi Extract, Lotus Blossom Extract, Lotus (Lotus) Extract Japanese cabbage extract Mayoram (Butterfly) extract, Melon extract, Snowy willow extract, Orchid extract, Rakanka extract, Rooibos extract, Naminohana extract, Azusa extract, Basil extract, Mokko (wood scent) extract, etc.

(8) Fat metabolism promoter Phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (Β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline and Oxtriphylline, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, pear thistle extract, paddy thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (anti-self) extract, Gajuttsu (莪 朮) extract, Chrysanthemum salmon extract, Kyokyo (桔, Bellflower root) extract, kizuta extract, pepper (pepper) extract, cola acuminata extract, sageo modaka (sawabei) extract, pomelo extract, sanshuyu (yamamaki) extract, tsuba rafuji extract, otsu ヅ rafuji extract, choreimaitake (bamboo shoot) extract, Rhizoma extract, primrose extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (pure tea) extract, plum extract, boufu (windproof) extract, etc.

(9) UV protective agent / UV absorption accelerator Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- ( 4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) ) Glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinna)) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydride Roxybenzene, 1- (2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) Ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3 , 4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenze Etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, paramethoxycinnamon) Isopropyl acid, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, Dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocarbine, triazine derivatives (4,4'4 " -(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2) '-Hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1,2-distealoy Luglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'- Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoyl Glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'- Tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Ansokcho (benzoic acid) extract, Hub extract, Giant puffer extract, Assamirisiogususa extract, Kawachigusa extract, Kawatake extract, Cypridosa extract, Hassai extract, Spirulina extract, Iaciocio Extract, Funori no Ushike extract, Himegususa extract, Hytengususa extract, Oobusa extract, Chinomori extract, etc.

(10) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamellitannin, Acer Gallotannins such as tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose , Telimaglandin I, Telimaglandin II, Casuaricin, Peducraggin, Geraniin, Isoturkevin, Granatin A, Granatin B, Kevulinic acid, Keblagic acid, Casuarinin, Nufarin, Procyanidin B-2, Thiasici Elsin tannins such as cincin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, cranberry extract, tsurutsia Shrimp Extract, Teuchigurumi Extract, Tormentilla Extract, Novara Extract, Buttercup Extract, Hagoromogusa Extract, Castor Extract, Grape Extract, Prunes Extract, Veronica Extract, Bisnaga Extract, Bilberry Extract, Mansuguru Extract, Mitsugashi Extract, Myrrh Extract, Melissa Extract, Mansaku Extracts, Doroyanagi Extract, Latania (Clamelia) Extract, Lemon Extract, Daisy Extract, etc.

(11) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor quinolinone derivative, dibenzooxepin derivative, thiotroposin, phthalimide derivative, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivative , Carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, prometa hydrochloride , Piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or salts thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl of α-glycyrrhetinic acid, stearyl of β-glycyrrhetinic acid, pyridoxine of α-glycyrrhetinic acid, β-glycyl Pyridoxine retinoate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium cyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexa Carboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylamino) Methyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine , Trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4 '-Methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, sodium trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate) Ester, astaxanthin dipalmito oleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicin Acid ester, astaxanthin ricin Acid ester, astaxanthin parinaric acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetoric acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin Ceracholate, Astaxanthin Decenoate, Astaxanthin Steringate, Astaxanthin Dodecenoate, Astaxanthin Dioleate, Astaxanthin Distearate, Astaxanthin Dieicosapentaenoate, Astaxanthin Didocosahexaenoate, Astaxanthin Dilinoleate, Astaxanthin Dilinolenic acid es , Astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitic acid, astaxanthin lyserophosphatidylcholine palmitate, astaxanthin lyserophosphatidylcholine DHA, astaxanthin lysephrophosphati Diluinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, steviol glycoside, benzimidazole derivative (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl ) Phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) Ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H -Benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) Piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methyl Lopanic acid, etc.), alanine derivatives or salts thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L- Alanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopentyl) -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethyl) Benzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid) , Chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof, licorice extract, sicon extract, age extract, propolis, eye ( (Aiba) extract, Asenyaku (Asen Yaku) extract, Avocado extract, Amado Koro (Tamatake) extract, Amigasayuri extract, Baimo (shellfish) extract, Igakozolina (Gall head) extract, Ibukitorano extract, Turmeric (depressed gold) extract , Echinacea (Prunus japonicus) extract, Oren (Yelen) extract, Oguruma (turned over) extract, Hypericum (brutish cut grass) extract, Oniguri extract, Orange extract, Cassia extract, Kamiyatsu (weed) extract, Kawamidori extract, Kawamomogi )extract Watercress extract, Kenashi sartorini rose (Tsumago, Yamakage) extract, Gentianana extract, Koki Sekkokoku extract, Kouhon (Kakimoto, Karatsumoto) extract, Koryokyo (Kora bonsai) extract, Gosho strawberry (covered bonsai) extract, Saihailan extract, Cherry extract, Salvia (sage) extract, squirrel extract, linden extract, salamander extract, indian sea bream extract, shukushamitsu (sand seed, shredded sand) extract, juzudama extract, white minten (southern tenseed) extract, squirrel squirrel extract, natto Extract, Achillea millefolium (milfoil) extract, Hirosanega extract, Takasago Rurihigotai (Southeast indigo sashimi) extract, Takara-bi (Kashiwaji) extract, Perilla extract (Tamarika) extract, Tamasaki tsukufuji extract, Tonin extract, Chigaya Eki , Toga (winter coconut) extract, Dokudami (10 medicines) extract, Parsley (Dutch jelly) extract, Hanabishi (shitsuri, shishitsuri) extract, Hamasge (kotsuko) extract, Hishi (hijimi) extract, belude oyster extract, Fuyukazura ( (South rattan) extract, bundo (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, Hosoba Abragik (bitter jelly) extract, Mizurutennansho (Tennansei) extract, pheasant (fruit berry) extract, miracle fruit extract, mulberry extract, Peach (Peach) Extract, Cornflower Extract, Willow Willow Extract, Mistletoe (willow parasite) Extract, Yabukouji (Purple Gold Beef) Extract, Sagebrush Extract, Mugwort (Bamboo Leaf) Extract, Rosemary (Mannenrou) Extract, Japanese Yellow-bellied Extract, Yellow Jusmo Extract, Tamajuzumo extract, Mizojuzumo extract, Urushi Gusa extract, Quercus gulsa extract, Sardine beard extract, Red mushroom extract, Togemoku extract, Aqaba extract, Maruba red mushroom extract, Scallop extract, Dulse extract, Yuna extract, Belladonna extract, Hoonoki extract, Haruni extract (skin peel, white skin, maple leaf) extract, Aozuzuran Extracts, Sakaneran extract, Sasabagin orchid extract, Husambird (including varieties and origins) extract, etc.

(12) Anti-seborrheic agents Chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (Asakojin) extract, Odorikoso (continuous) ) Extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonsou extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, eucalyptus (marigold) extract, potato extract, Yamano potato extract, Nosenhalen extract, Fukitan popo (Section winter flower, Sect winter winter leaf) extract, Yabugarashi extract, Giant kelp extract, Hijirimen extract, Proboscis extract, Haius banori extract, etc.

(13) Antibacterial agent Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine Compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester, 2-keto -3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ether Inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol , Phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione , Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene Nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, chloride) Benzethonium, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof , Zinc oxide, hinokitiol, propolis, cucumber extract, agi extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, red-bellied extract, blue-headed toe Extract鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chicken Flower, Chicken Crown) ) Extract, bay bay laurel extract, Koushinbara (monthly flower) extract, copaiba balsam extract, mountain cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Extract, Sarasinashouma (Hemp) extract, Shimushi (Mikoshi) extract, white birch extract, cinnamon extract, sorrel (acid mimic) extract, dandelion extract, Nezu (Pine pine) extract, Japanese mint extract, Japanese wild mint extract, Soka ( (Grass) extract, onion extract, chicory extract, ginseng extract, tsuruna extract, tokon extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana ( Sarcophagus, vine rosacea extract, cypress extract, pimenta extract, cypress extract, white-butterfly extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, mizokakushi (half) Lotus) extract, bee extract, purple (purple) extract, moso bamboo extract, Pokeweed (commercial and commercial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, prunus nomata extract, tochaka (yahazuzumata) extract, red-bellied extract, anaaosa extract, human rush extract, hirohano Human rush extract, Ushiro rush extract, Iroro extract, Ishige extract, Alame extract, Tamai taki extract, Tambanori extract, Katanori extract, Sakuranori extract, Fujimatsumo extract, Kawamozuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi (Yoshichi) extract, etc.

(14) Blood flow promoter / vascular stimulator Tocopherol or its salt and derivatives thereof, tocotrienol or its salt and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl eugenol, ethyl Isoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ictamol, α- Borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract, aloe exhaust , Gentiana extract, Toki extract, Ashitaba (tomorrow) extract, Arnica extract, Yukiyara (Sanriku) extract, Hime wikyou extract, Citrus unshiu (Chen skin) extract, Toucan beetle (coconut) extract, Oyster extract, Kaki extract, Kina extract, Ginseng extract, pine moth (horse whip grass) extract, kubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (mountain curd) extract, syringen extract, ginger (ginger) extract, ginger (ginger)菖蒲, Sone) extract, Hawthorn extract, Seburi (Daiyaku) extract, Daidai (orange peel) extract, Tanjin (dansang) extract, Thyme extract, Chikutsutsuninjin (Takebushi ginseng) extract, Tsurudokudami (what neck 烏) extract, Tsurunjinjin (Yotei ginseng) extract, chili pepper (banban) extract, toki (tokiwa) extract, chili Mimochi extract Clover cherry tree, strawberry flower) extract, black currant extract, bodaiju (bamboo tree) extract, merirot extract, yuzu extract, wintersweet extract, bay jelly extract, hibiscus extract, rosehip extract, etc.

(15) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-prenyl Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid and the like.

(16) Activity inhibitor of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) / Structural proteolytic enzyme expression inhibitor Adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its phosphate adduct, etc. ), Carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosuma Acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11) -lanostadien- 3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin ram Nopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydro Siheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) ) Heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- ( tert-Butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6- Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4, 6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2- Droxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert -Butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid Dimethyl acid, (2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]- (2R, 6R) -2,6-Dibenzyloxy-4-hydroxy Heptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluoro Phenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4 -(4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3 -Dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidine-3- Il -Carbamate isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl]- 2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2, 2-Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl ] -N-Hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes extract Li (Banaba) extract, Omi hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, Guava extract, Shazenso extract, Rose rose extract, Hypericum perforatum extract, Octopus (breeding) extract, Hinata tadpole (cow knee) Extract, Honoki (Japanese Kobak, Park) Extract, American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ogon Extract, Hypericum Extract, Clara Extract, Mulberry Extract, Keihi Extract, Genpachi Extract, Comfrey extract, salvia extract, elderberry extract, bodaiju extract, button pi extract, Aozulan extract, sakaneran extract, sasabagin orchid extract, swanbird (including varieties and origins) extract, etc.

(17) Structural protein synthesis promoter Ethanolamine derivative, pentoxyphyllin, serine derivative, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5, 5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-oct Methyl tenenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- ( 3,5,5-Trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate 2-methyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) ) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2- Hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy)- 2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy)- 2-hydroxybenzoic acid, 4-N-hexyloxy-2-hydride Roxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyl) Sodium oxy) -2-hydroxybenzoate, methyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 4-{(2E) -3,7 Ethyl 3-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, ethyl 5-{(2E) -3,7 dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3 -{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3-{(2E) -3,7-dimethyl Ethyl 2,6-octadienyloxy} -5-hydroxybenzoate, ethyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoate, 4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxybenzoic acid methyl 4-{(2E) -3,7-dimethyl-2, 6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy } -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl- 2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadi Nyloxy} -3-methoxybenzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4- { (2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2- Hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy}- 2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) Benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) Benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy ] Benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy) benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl- 9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7 , 8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl- 2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyl Oxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadi Nyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, tokamodoki extract, ikanoashi extract, hosoivo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Extracts, Sasabayanaginori extract, Wasabi extract, etc.

(18) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors Anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienyl) Salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadeca Trienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde propyl Ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-penta Decatrienyl cinnamic acid, 2-butyl ether-6-pentadecatrienyl cinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol , 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Indoka) ) Extract, Narco lily extract, scallop extract, yellow orchid extract, Oshida extract, Onji extract, Spruce extract, crow birch extract (half summer) extract, pheasant extract, wolfberry ) Extract, Goshuyu (Kurei) Extract, Senega Extract, Sendan Extract, Indian Sendan Extract, Tamarind Extract, Tarragon Extract, Kendaku Daio (Dai Yellow) Extract, Hachiku (Bamboo Bamboo) Extract, Daisies (Daisy) Extract, Milobaran Extract, Hime Bear Willow Extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Rueto Keana Extract, Hilacsa Extract, Pterosa Extract, Kata Beak Extract, Yatabegusa Extract , Ezotsu no Mata Extract, Toget No Mata Extract, Fusaikawa Ivy Extract, Hanemo Extract, Mill Extract, Chromil Extract, Sakibuchimil Extract, Nagar Mill Extract, Hiramil Extract, Matsumo Extract, Okinawa Mozuku Extract, Mozuku Extract, Fukuronori Extract, Kajime Extract, Fukuronori Extract, Mafunori Extract etc.

(19) Mucopolysaccharide synthesis promoter Stilbene derivative or salt thereof, morgin or salt thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, banana extract, bread extract, flounder extract, koto Gitznomata extract, Yaleus banori extract, Kagios banori extract, Susius banori extract, Amiaosa extract, Nagaaosa extract, Hosobanosasakamodoki extract, Hirohatosakamodoki extract, Yatsudegatatosakamodoki extract, Kurotosakamodoki extract, Nezushinosakamodoki extract, Yusora extract, Etsukinosakamodoki extract, Nankaisakamodoki extract, Himetosakamodoki extract, etc.

(20) intercellular adipogenesis promoter / intercellular lipid state improving agent phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, Diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2-azela Oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosylceramide, Lactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, sphingo Myelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydroergo Sterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocore Terol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, gangliatetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide Derivatives, Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Oni lily extract, Sasa lily extract, Hakata lily Kiss, poppy extract, and the like.

(21) Keratolytic agent / stratum corneum exfoliation accelerator Tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract, chickpea Extract, mungbean extract, etc.

(22) Plasminogen activator antagonist inhibitor Rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(23) Maillard reaction inhibitor Aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, tannic acid tannin, Tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl quinic acid), 2- Hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6 -Trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), gypsum extract, sandalwood extract, etc. .

(24) Testosterone 5α reductase activity inhibitor γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid) Propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ- Amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid Ethyl glycol ester, γ-amino-β-hydroxybutyric acid sorbitol ester, γ-amino-β-hydride Loxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyldimethylamine oxide, stearyldimethylamine oxide, palmityldimethylamine oxide, myristyldimethylamine oxide, lauryldimethylamine oxide) Dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethyl amine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amide propyl betaine, Laurylhydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), Midine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino- 4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1 -Hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1- Oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-ethyl-6 -Morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino-4-methyl-6-piperidinopi Limidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrosinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine -3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1-pyrosinyl) pyrimidine-3-oxide, 2 -Methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino -5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2-acetylamino-4-methyl-6- Piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-6- (2 , 4,6-Trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro- 6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5- Triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane- 3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-ON-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. glyceride sulfate, monopentadecyl Glyceryl ether sulfate, 1-O-hexadecyl-2-O-methylglycerol, 1-O-octadecyl -2-O-methylglycerol, 1-O-oleyl-2-O-methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives , Proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1 etc.), aracaci extract , Angelica extract, Anse extract, Honzu extract, Ichiyakuso Cormorant (one medicinal herb) extract, licorice extract, psyllium (carlet child, carve herb) extract, psyllium shabushi extract, olive extract, giant dogfowl extract, seisei extract, calla cucumber extract, cinnamon crocodile extract Extract, Catalpa extract, Kukui nut extract, Camphor tree extract, Kubaba extract, Black-bellied red extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, Mokuren extract, Sanekazu extract , Colombo extract, Conslango extract, Sasanqua extract, Sweet potato extract, Sanebuto jujube (acid soy sauce) extract, Sandscon (Yamazu root) extract, Potato extract, Shishigashira extract, Nashishi extract, coriander extract, stevia extract, Takatodai extract (Otsuka) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, taranoki extract, nigaki (Nakiki) extract, Nurde (penta) extract, hakama Urabosi (bone crush) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, sorghum grass extract, cicada carrot (participant) extract, mangosteen extract, ginger extract, melaleuca extract, yachabushi extract, himeya shabushi Extract, Oobaya Shabushi Extract, Yakumosou Extract, Yamahanoki (Yamatake) Extract, Longan (Yongan) Extract, Locon (Yoshi, Sone) Extract, Logwood Extract, Lantana Extract, Phthradinones, Benzoxazinones, Phosphonic Acid Derivatives , Cyproterone, 5α-androstene- 3α, 17β-diol, medroxyprogesterone, norethisterone, mestanolone, ichihatsu (primary) extract, katsu extract, kanto extract, sanjiko extract, shiramo extract, prunus extract, scabbard licorice extract, fritillary extract, cypress extract, seaweed extract, Yoremoku extract.

(25) Odor-eliminating agent: Inond extract, Elemi extract, Danmar extract, vanilla bins extract, pine extract and the like.

(26) Ingredients derived from plant-based materials used as additives Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Akinire (crust) extract, Aguay guassu extract, Abiu extract, Abiurana extract, Yellow support extract , Ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, crab extract , Karaya extract, Galyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidney pepper extract, Kimenka extract, Cabbage extract, Kiraja saponaria extract, Ginseng extract, Kimbusen extract, Guapepa ve Rumella extract, Kugenumaran extract, Coosberry extract, Kutiti River extract, Curkurigo latifolia extract, Kuroganemochi (rescue) extract, Kourian extract, Sapotea mariyo extract, Salmon berry extract, Saranchito (sand indigo sashimi) extract , Cactus cactus extract, Cranberry extract, Shunran extract, Shozuk extract, Shirobanatsuta extract, Cinchona sill bra extract, Swimberry extract, Star apple extract, Sulgaran extract Extract, mistletoe extract, sennin cactus extract, senboku extract, elephant spinach extract, prunus extract, some mono-potato extract, dark sweet cherry extract, tongue Citrus extract, Chocostaye extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract (Duckweed) extract, Duberry extract, Clover extract, Tragacanth extract, Triacanthus extract, Neiseria berry extract, Rapeseed Extract, Panther Extract, Paw Dorse Extract, Hakkayumatou Extract, Hakuru Berry Extract, Batata Extract, Hamakakiran Extract, Balata Extract, Harcanlan Extract, Pecan Nuts Extract, Chicknut Extract, Himemulan Extract, Brazil Carrot Extract , Branjen extract, Fruceria extract, Blond psyllium extract, Hetsukaran extract, Heneken extract, Berry extract, Persair extract, Pervianburg extract, Pereschia grandiff Rear extract, Boysenberry extract, Hosairan extract, Pouteria zapota extract, Pouteria rukuma extract, Hosobabarengiku extract, White berry extract, Mazaran uba extract, Masaransuba de Cearer extract, Masheira de Boyi extract, Matta auryo extract , Mulberry Extract, Green Zapote Extract, Murasaki Corn Extract, Megacansa Opuntica Extract, Mokukirin Extract, Momijidaio Extract, Morello Cherry Extract, Yakawa Murasakiimo Extract, Cornflower Extract, Ruritama Thisami Head) extracts, red currant extract, red pitaya extract, lemongrass extract, wax palm extract, logan berry extract and other plant extracts.

(27) Ingredients derived from plant-based materials used as additives Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Anemone swan extract, Volbox genus genus extract, Volbox genus Volbox extract, Palmera extract, Jupiter essence extract , Tsurugidomiro extract, Hibidomylo spp. Black croaker extract, Casanori genus Casanori extract, Mika moth extract, Collecaete extract, Tsutsumi biloba extract, Chrysanthemum genus Duckweed extract, Sayamidro extract, Kunshi Green algae extracts such as spider extract, Sumiremo violet reed, Hosimidro extract, Fuchinashimidoru extract, Cyanobacteria genus Suizinori extract, Blue-green algae extract such as Aoko extract, Yuremo extract, Piraella piella extract, Shiomidomo Nagamisiomidro extract, Isovine genus isovine extract , Isogawala genus Isogawara extract, Black moth genus Black moth moth extract, Kashirazaki genus Kashirazaki essence, Muchimo genus Muchimo extract, Muchimo genus Hiramachimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus genus Common genus extract, Jigamigusa genus digigagus Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navarimo genus Navarimo extract, Chasommen genus Mocha-chaumen extract , Nagamatsu spp. Composita spp. Kojimari extract, Calyx genus Camono mono extract, Fennel genus Falcon extract, Cultiva turmeric extract, Cicaria chrome extract, Chrysanthemum genus Chrysanthemum extract, Nerecomb genus Nerecomb extract, Uchimo genus Oukimo extract, Burukimo genus Burukimo extract, Brown algae extract such as mosquito genus mosquito extract, Amanori genus Uprinori extract, Amanori genus Onianori extract, Amanori genus Tasa extract, Amanori firitasa extract, Amanori Benitasa extract, Rhodocorton milnobeni extract, Konahada spp. L. pine extract, Nisefusanori genus Fusanori extract, Sodegara genus Sodegarami extract, Hirohataidai genus Hirohatamitaki extract, Amanita Nambugusa extract Tengusa spp. Mon extract, Nisekarekigusa Nisekarekigusa extract, Okitsubara Oobakutara extract, Sangomomoda Ragaradoki extract, Shiogusagoromo Shiogusagoromo extract, Iwanokawa Etsukiiwanokawa extract, Kinokawa Coral extract, Centipede spruce extract, Centipede spruce extract, Centacum spruce extract, Centacum spp. Extract, Centipede vine extract, Centipede genus Fudarak extract, Centipede genus Marbahudarak extract, Cyprinus genus Pleurotus extract, Tricholoma terrestris extract, Quercus genus Chabokintoki extract, Quintelli genus Kintoki extract, Kintoki genus extract Genus Pinus extract, Kintoxia fushikintoki extract, Kintoki tsunomukade extract, Kintoki nagakintoki extract, Kintoki sujikadeki extract, Kakateto Obakintoki extract, Nagaobane genus Nagaobane extract, Karekigusa genus Kakukigusa extract Genus Encarinum genus extract, Tuscania genus Otsukasanori extract, tsukasanori Hanagakarimenia extract, Hoonoo genus Hounoo extract , Genus genus genus extract, genus genus genus usuginu, genus genus urchinus extract, venus genus venus nago extract, sukabeni genus sukabebeni extract, okaramusa genus genus extract, isomocca genus isomokka extract, genus genus Root extract, Atsubanori genus Azobanori extract, Ogonori genus Mizo-Okonori extract, Ogonori genus Beniogonori extract, Ogonori genus Fucresinori extract, Ogonori genus purple birch extract, Ogonori shinkaibanori extract, Ogonori genus Togekabanori extract Genus Katagogonori extract, Ogonori genus Ryukyu Ogonori extract, Ogonori genus Ogonori extract, Ogonori genus Hitsuginu extract, Ogonori genus Utagata ogonori extract Ogonori Kubireogonori Extract, Ogonori Mosaogonori Extract, Ogonori Kinubanabori Extract, Fushikenori Fushikenori Extract, Namiiwatake Namiiwatake Extract, Saimi Itamigusa Extract, Saimi Genus Extract, Hajijigusa Hagisagi Nangusa Saw extract, Rhizobium spp. Extract, slatted goat extract, dallus scorpion extract, dals anadalus extract, weebusa genus extract, benifuku Nori spp., Villus spp. Extract, Suzushironori Extract, Usbeni Genus Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonono Hanori Nagakonohanori Extract, Sugiginus Sugiginu Extract, Sugiginus Atsubasuginu Extract, Hius Banori Genius Cageus Banori Extract, Haius Banori Genius Heusius Bavaria Usubanori Extract, Hausubanori Genus Huisubanori Extract, Usubanorimodoki Genus Usubanorimodoki Extract, Ayanishiki Ayanishiki Extract, Ayaginu Ayaginue Kisses, Dadia Enasidia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodoki Daijimodoki Extract, Makuri Makuri Extract, Hanegusa Hanegusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Cozaemone Extract, Chrysanthemum extract, Himego-genus Himego-keki extract, Himego-keki-Kuro-himegome extract, Hyodosigki chrysanthemum extract, Hyodosigus hyodosigusa extract, Hyodosigus genus Usobahiodosi extract, Isomegusa isomegusa extract, Suzynagusa spp. Red Algae Extracts, Shajikumo, such as the genus Isobasho Extract, Ideukogome Ideukogome Extract, Ochimomoku Okichimozuku Extract, Chisujinori Chisujinori Extract Kiss, white ball mode extract, Hoshitsurimo genus Hoshitsurimoekisu, Riku Roh Tam Taunus extract, Furasukomo genus Princess flask model extract, bantams flask model extract, axle algae extract such as Toriperaekisu, yellow algae extract such as Chromophyton rosanoffii genus Chromophyton rosanoffii extract.

(28) Components derived from animal materials used as active ingredients or additives Chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation product thereof, cow or pig Brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and its degradation product Or derivatives thereof, porcine or bovine blood cell protein degradation product (globin peptide), cattle or porcine hemoglobin degradation product (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof Skim milk powder and its degradation products or derivatives thereof, lactoferrin or its degradation products, egg component, fish degradation product, nucleus Related substances (ribonucleic acid, deoxyribonucleic acid), and the like.

(29) Components derived from microbial raw materials used as active ingredients or additives Yeast metabolites, yeast extract, bacterial metabolites, bacterial extracts, metabolites such as fungi or mushrooms, actinomycete metabolites, fungi or mushrooms, etc. Extracts, actinomycetes extract, natto bacteria metabolite, natto extract, rice fermented extract, rice bran (red koji, birch) fermented extract, euglena extract or decomposed products thereof, or their water-soluble derivatives, lactic acid in raw milk or skim milk powder Fermented products, trehalose or derivatives thereof.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

(30) Ingredients of natural products used as active ingredients or additives Seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea mineral salts (sodium chloride, magnesium chloride, (Potassium chloride, etc.), sea mud or mud (Fango), for example, Italian mud, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide) , Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc. Marine components etc.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohols such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohols, acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, Various organic solvents such as silene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, water, etc.) prepared as appropriate. It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the point of stability of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, within the range of the raw material: solvent 4: 1 to 1: 200, and the weight ratio of 1: 1 to 1:10 is particularly preferable.

(31) Other examples of plant-based raw materials used as active ingredients or additives Almond (Tempo), Ai (Aiba), Aokazura (Seifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Rafuji (wood protection)巳), Aotenma, Acacia, Akashouma (Red Cannabis), Akasuguri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Akamegashiwa (Red bud), Akamino Akane or Akane or Akane ), Agi (Atsu), Aki larch, Akinire (crust), Aguay Guassu, Aguahe (Omiten palm), Akebi (Kitsu), Asa (Asako Jin), Maruba morning glory or morning glory (Check cow), Hydrangea (hydrangea) ), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asen Yaku), Athira (Shokuyo Kanna), Anise, Abi U, Abiurana, Rape, Abemaki `` Fruits '', Avocado, Ama, Achacha (Amacha), Achacharu, Amadokoro (Jade), Amaranth (Amaranthus) Haribiyu, Aozzuran, Amaranthus hypochondriax), Amigasayuri or Baymo (shellfish), Aristolomeria (Yurizuisen), Arcana (alcanna), Algarrobo (cabbe), Altea, Arnica, Alpinia or Katsudai (Suzukuku), Aloe (エ) ), Aloe vera, angelica, apricot or hon-anzu (Anzujin), Ansokkou (benzoic incense), yellow sapote, igakozorina (geogallbladder), licorice or gecko licorice (indian octopus), rush (light heart), itadori (tiger cane root), yew ( ), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one herb), ginkgo (Ginkgo `` seed, leaves ''), Itohimehagi (distant), carob , Inunazuna (Taileki), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki Sawweed, Nettle, Ylang Ylang, Iwa Tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), common bean, oolong tea, fennel (Rose), Wheat (Chibusanoki), Ukiyagara (Sanryo), Uguisukagura `` Fruit '', Himeuki Kyo, Turmeric (Golden), Duckweed (Floating), Usba Saishin or Keirin Saishin or Oshusaishin (Spicy), Usbunia Oy , Usbenitachaoi, phalaenopsis, peony (summer hay), udo or shishiudo (growth, independence, tangoku), unyadegato Nkaria, Cat's Claw), Uba tea, Ume (Japanese apricot `` seed, pulp ''), Japanese white beetle, Uwaurushi (Kusako-kemomo), Unshimikan (Chen), Unboku, Estragon, Ezokogi (Tomogoka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car front grass), large thistle (Zhengzhou leakage, bald eagle), Hazel (lion), Toucan cactus, Ovana okera or Okera (white moth), Osara bursberg (Banaba), Obayaya shabushi "fruit", Steller's beetle (cereal sperm), Omia catechu, Hawthorn or Hawthorn (Mountain) Barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturn), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Pterotus pertussis or Hypericum perforatum (Brother cut grass), Odorikosou (continuous), Onamomi (Circle ear), Onigomi, Onikoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut楡), Ominae (losing sauce), Yuuko, Dutch mustard (watercress) Dutch jellies, Dutch biloba, Dutch honey bees, olives `` fruits, seeds, leaves '', oregano, orange `` fruits, peels '', silkworms (ripening yellow), cacao `` fruits, peels, seeds '', oysters (bamboo `` leaves '') , Kagikazura (Katsufuji 鈎), Kakidooshi or Kantorisou (lotus), Kakiran, Gaku hydrangea, Cassia, Cassilla (fruit berries), Gadju (莪 朮), Kashiwa (Kashiwagi, 槲 葉), Cascarilla, Kasari Scala Sagrada, Gypsophila, Gypsophila, Crab (Kinshato), Kaniwa, Carnation, Valerian (Valentine Root), Hippopotamus, Birch or Fern birch (Bird), Gerbera, Pumpkin, Kapokoki `` Seeds '', Kahoku Salamander (Garden), Gama (蒲 Yellow), chamomile or Roman chamomile, chamomile (weed), cam cam (camo duck), color, chrysanthemum, crow cucumber, or cinnamon crow (Wang Song), Crow Bishaku (Half Summer), Oats, Garana `` Seeds '', Karaho (Koh-Pak), Karaya, Garyu, Karin (Kiso), Garcinia, Kawamidori, Kawara Psycho (Koryocho), Kawajisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (buckwheat, buckwheat), Kawaraninjin (blue potato), Chinese mugwort (bamboo chin mackerel), Kansui (licorice), licorice (licorice), Kantaraasa, candelilla, kanto, canna, kanran , Raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, navashiro strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', kikarasuuri (guro-root), kyo-kyo (kikyo, bellflower root), chrysanthemum (chrysanthemum, zebra daisy, ginkgo biloba) , Kikutaniku, Kisage (fruit), Shigegi (sheep), pheasant (fruit), Kizuta, Kidachi Aloe, Kidachi Peppermint, quina, linden tree (shinkona, red linden tree), quinoa (quinoa), yellowfin (yellow twilight), yellow bean, gymnema sylvester, Kimenkaku, cabbage, cabbage `` Immature fruit '', caraway, cucumber, gyory (Nishikawa willow, tail willow) , Kiraja saponaria, Kiraya, Kiransou (golden grass), Kumquat `` fruit '', Kinkiju, Ginseikai, Kimbusen, Kinma, Kinshuhiki (Sentsukakusa), Kinran, Ginlan, Kinryohen, Guapeba Vermela, Guava `` Fruit '', Guayule, Quercus infectria, cucumber nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, cruciform skin), squirrel katsura (Tenmon winter), kudu (kudzu), camphor, gooseberry `` fruit '', xanthines (yellow flowers)蒿), Kutiti River, Gardenia (Yamako), Kunigi (Kin Saw) Kupuas, Kubeba, Kumazasa, Kumatsutsura (horse whip grass), Clara (bitter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curcumillo latifolia `` fruit '', grapefruit `` fruit and leaf '', buckthorn, kuroganemochi ( Rescue), Kamehiba Kokoshi or Kurobana Hikikoshi or Hikiokoshi (prolonging grass), Clove (clove, clove), Gumbai Tuna (Sekimei, Sekimeishi), Keigai (Kashiwa, Hakuho), Celosia (Chicken flower, Chicken crown), Gekkavidin, Gecko (Laurel Tree), Kenashi Sartoribaira (Dogo, Mountain Return), Gentiana, Gennoshouko (Old Grass), Kemponashi (Kigushi), Kokisekoku, Kishimizukan (Koji, Tachibana, Obenimikan, Fukurimikan, Sagamikouji, Ponkan, Santara Skin) ), Koshinbara (moon flower), Kousuihakka, Ko Zo `` fruit '', kocha (tea), kohone (riverbone), kohon (Kakimoto, Karamoto), Koryang, Koryokyo (Kora), cilantro `` fruit '', Kouren (Huo Ren), Koganebana (Yellow Gon), cowberry (Etsutachibana), coconut `` fruit '', goshyu (gyu), gosho strawberry (covered bonsai), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot pepper), burdock (beef bowl, Beef eggplant), coconut mulberry, sesame seeds, sesame seeds (genus ginseng), trash beetle (gomi), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran `` red rice cake, white birch '', rice oil, cola acminata `` Seeds ", Cola Bella" Seeds ", Colonyella, Koroha" Fruits ", Colombo, Conzurango, Kombu, Konjac, Comfrey (Changzhou), Sisal (Sisal Asa), Saiha Orchid, Sakaneran (Ezosakaneran), Sasima button eel or cinnamon pod or Chinese plover (weiken), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashi, Bean cherry, Miyazakura, Yoshino cherry, Takanezakura, Kazumizakura, Kozakura, Kokura, Leaf Flowers, fruit, bark (cherry bark) ''), cherries, pomegranate, Sasa, Sasabagin orchid, sasanqua, Sadamodaka (Sawaka), sweet potato, sugar cane, sugar beet, sunflower jujube, saffron (bancho flower, west safflower), sapodilla , Sapotea mariyo, pomelo `` fruit '', savonso, salmon berry `` fruit '', salamander (sasma), salamander (sand sashimi), salvia (sage), ragweed (bamboo rape), sawagurumi (wild walnuts), sankaku cactus , Sangredeg (Croton), salamander, sanchinin carrot (37 ginseng), sanshuyu (sanroku), sanctuary (sanroku), sanzukon (yamadone), shea (karite), cyano (fruit), shiitake mushroom (shiitake) ), Zion (Purple moth), Pika bear, Dikitaris, Sikkunshi (Amiko), Perilla or Aojiso or Chilemenzo or Katamenjiso (Shiyoha, Shisoko), Rosewood, Linden, Sinah onion, Synergic gill (ream), Shimeji (Himushiji, Shakashimeji), Hatake shimeji, oshiroi shimeji, beech shimeji, honjimeshi, shirotamogitake, shimokuren (spicy potato), shimotsukeso, potato, peonies (glaze), shajin (shasan), jasmine (matsurika), janohige (barley winter), shrimp Gypsophila, Shukushamitsu (sand seed, shredded sand), Juzdama, Shuro "fruit", Shunlan Zououashi, Ginger (Ginger), Zouzan Hydrangea (Tsuneyama), Shobu (Koji, Sone), Shozu `` Fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), Shirogori `` Seeds '', White clover (Clover), White-headed azuki (chicken) Bone grass), White squirrels (Nioiris), Shirobanatsuta "flowers", Shirobana rupin, Shirominanten (Nan Tenshin), Cinchona sylbula, Ginkgo biloba (Mizuka, Mizuka flower, Shencho flower), Cinnamon, Cinnamum cassia (cinnamon), watermelon (Saijo), Honeysuckle (Silver flower, Shinobu), Sorrel (Acami), Swimberry `` Fruit '', Star Apple, Stevia, Strawberry `` Fruit '', Suzu-Psycho (Xucho), Sugina (Question), Suburihiyu (Horse tooth soap, (Horse tendon), plum "fruit", sulgaran (oran), Japanese red pine "ball cone", Japanese larch Kizuta, Prunus, Hawthorn, Sunflower, Dandelion, Horse Chestnut (Maroni), Pear `` Fruit '', Papaver, Elder, Prunus (Juniper, Juniper), Yarrow, Millefoil Rose, pearl butterfly, mistletoe, yellow mint or wild mint ) (Dendrobium, sarcophagus), Cedron (Boushuboku), Zeniaoi, Hiroha Senega, Senega, Seri, Celery, Senkyu (river cucumber), Senshinren (Bentling ream), Sender , Sennin cactus, senna `` fruit, leaf '', sennin (Daisen), senburi (drug), senboku, soka (grass), elephant shoots, soshin waxy, buckwheat `` seed '', potato monodrum, broad bean, daiou (daihuang), Daikon radish, soybean, Daidai (orange peel, fruit), Takasago Gurihigotai (Southeast indigo sashimi), Takasaburo (Cirrus), Takatodai (daikon), Takaharabi (Kashiwaji), dark sweet cherry `` fruit '', hollyhock, Tachi musk (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (hot pepper), taranoki `` fruit, leaves, root bark '', tarayou (large leaf winter blue, one leaf tea, bitter tea, bitterness (Tea), Dahlia (Tenjiku button), Tarwi, Tankimi, Tanshichiwa, Tanjin, Dandelion, Shirobana Dandelion or Mouko Dandelion, Nmaru, cherry `` fruit '', chigaya `` fruit, root, bud '', chixetsu carrot (bamboo ginseng), chicory, chankapiedra (Kidachi Kamikanso), tulip, choco no stay, datura (artichoke), ginkgo biloba (large yellow) , Korean senile (蕪 夷), Korean mugwort (艾艾), Choreimaitake (猪苓), Chorogi, camellia, tsukushikaneran, Tsukutake (mushroom), azalea, camellia, camellia, clover (lacquered grass), camellia (duck moth) Grass), Tsuzuki Azuki (Red Azuki), Tsurutsuchiakebi, Tsurudokudami (What's Noodles), Tsuruna (Apricot), Tsuruninjin (Yoba Ginseng), Tsurume, Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruits '', Tengusa, Tencha (Matsucha), Tendai Yaku ( Glaze), chili (winter coconut), chirped wig, chili pepper (banban), tow Ki (Today), Tokin-Senka (Marigold), Tosykachichi, Tounabena (river cut), Corn or Maize hair (Minami Kashiwa), Toshiko-mochi (Sadako), Torindo or Chosen-Lindou (Ryuboku), Toksa (Tits) , Dokudami (ten drugs), tokon (root), toshishi or bean pod or pear root, eucommia (Tatsunaka `` bark, leaf, root ''), ash (skin), tomato, tragacanth, triacanthus `` seed '', Turkish Kyo, Torumentilla, Doronoki, Toro-aoi, Tonkame, Niseria berry `` fruit '', Chinese yam or wild yam (Yakuyaku), Nagii Kada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsume or Vertical oyster (Sword bean), Natsumikan, Jujube Naniwaibara (Kanasakurako), Navena (continuous), Nameko, peanut (peanut), Nanten (Minami Tenmi) Namban Karamushi (Sesame), Niosumire, Nigaki (Nakiki), Nigamugigi (Anniversary), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabu Nikkei (Cinnamon Bark) or Keishi (Katsura Branch), Nyo-bachidori, Nira (Chicken), Elderberry (Bone graft `` fruits, flowers, stems, leaves ''), garlic (large coral), nurde (penta), leek, nemkin or nebu or nebi or nemlinoki or zigokubana (community), noami (large cormorant), Neubara (fruit), Nousenkazura (Lingen Flower), Nogateto, Yarrow, Nodake (Apricot), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Bussouge, Furibususouge, Roselle), Hirindou, Houtiwa, Pau Douse, Hakamarabosi Hakkayumatou, Chinese cabbage, hakusen (white tinea), hakuberry (fruit), hakobe (breeding), hazel (palm), hashi Skull (roth root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellied), hadakamugi, batata, bee or madake (bamboo shoots), patchouli, mint (thin load, light load leaf), yellow bean, pearl barley ( (Yokuinin), Hanasuge (knowing mother), banana, Hanahaku, Hanabishi (Sitoshi, Shishitsuri), vanilla bins, papaya, scallops, Pahalobo, hub "whole grass, stem, leaf", paprika, Hamakakiran, Hamago or Mitsuba Hamago (Vulgaris), Hamasuge (Katsukiko), Habibishi (Shitsuko), Hamanasu (Maikai Flower), Hamaboufu (Hamaboshi), Hamamelis, Palm, Rose (Rose), Balata, Balata Rubber, Agaric, Agaric ), Haran, Pariurus (Hanajutsu), Parietalia, Harkanran, Balsamina (Turureishi) , Bitter gourd), barbisco, harlindough, handdai kai (sea bream), breadfruit, giant eagle (shooting dry), lizard carrot (participant), pecan nuts, ganbanana (stone carp, vine) Zhushahua), Higurmadaria, Higotai, Hishitai, Pistachio, Beet, Hitsuba (Ishizuchi), Hitsubei Nishida, Daisies (Daisy), Hinata Taikozuchi (cow knee), Japanese chicks, Cypress, Hiba, Castor, Sunflower , Peppers, himeuzu (tengu), himega (incense), himematsutake (kawariharatake, hiromatsutake), himemeyoran, pimenta `` fruit '', juniper, beakkyu, hiyu `` fruit '', chickpea, lentil, belude oyster, hirohao ), Loquat "fruits, leaves, stems", betel wax (large clothes skin, coconut), puer tea (general tea), sweet pepper (south) Rattan), Japanese cypress, Japanese cypress poppy (Japanese winter flowers, Japanese winter leaf), Japanese scallops (Orchid), Japanese bean (Japanese peas), Japanese white cherry (Chrysanthemum sakura, Japanese cypress), Grapes `` Fruits, pericarps, seeds, leaves '', beech, Japanese cypress bamboo ( Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, black currant `` fruit '', blackberry, brunnen, plum `` fruit '', full celaria, blueberry (Prunus japonica), prunes, floral blanka, blond psyllium , Bundo (mung bean), hazelnut, loofah, hetsukaran, safflower (safflower), heneken, belladonna, berry `` fruit '', persair, pervianburg, pereschia grandifolia, benze or squirrel (jingten), boysenberry `` fruit '', Broom or sardine or nendo U or Hahagigi ・ Kokia (Gerfum), Hausairan, Hempenka (Akansen, Acute pupa, Pseudograss), Powteria sapota, Powteria rukuma, Binoki, Bowfu (Windbreak), Spinach, Physalis (Torune), Honoki ( Japanese Koshoku, Park), Bokeh (Kiso), Hosoba Aburagiku (Sweet Yoku), Hosobao Guruma, Hosobana Okera (蒼朮), Hosoba Kirinso (Keiten Sanshichi), Hosobabarengiku, Bodaiju (Bamboo Tree), Button (peony `` flower, `` Leaf, stem, bark ''), button pi (peony skin), hop, jojoba, borage (Lulichisha), Bordeaux, white berry `` fruit '', hononiku (meat juju, large art), honsekkok (iron skin stone wall, sparrow mountain) Sarcophagus), Mizurutennansho (Tennansei), Maitake (Maiko), Maou (mao), Maca, Macadamia nut, Margaret (Mokushungiku), Macri (Seaman grass), Magwa (Mulberry white bark `` Tree '' , Leaves ''), magnolia sprengueli, masaran uba, masalan zuba de sear, masheira de boi, mashua (tamano sen haren, kyukonkinrenka), matatabi (wood tengu), matsukasa, pine `` leaves, bark, root '', Matta Orillo, Matsuhodo (茯苓), Matico (Cordon Sillo), Mayoram (Hanahakka), Malvano Jazine (Bitter), Mulberry `` Fruit '', Quince, Malene (Bilaud Muzuka), Mango, Mangosteen, Manzanya (Andesca Mitsule) ), Manshugurumi, Mandarin `` fruit '', Mannentake (reishi), pheasant (fruit `` fruit ''), Mishima Psycho (Shibahu), Psyllium serrata (Dragongrass), Mizokakushi (half-sided lotus), Misohagi (Chikuma) Rape), green willow or elder willow (hen stock), honey bee, honey bee, green potato, green Liquor, mimosa, myoga, miracle fruit `` fruit '', myrrh, milobaran, wheat straw, mugwort (mushroom), mugwort, mukuroji (life-prolonging skin), munya, murasaki (purple root), murasakikib or oomurasakikib (purple pearl), murasaki corn , Murasaki Kinafuji (Kunming chicken blood wisteria), Megakansa Opuntica, Mehajiki (beneficial herb), Mebogi, Melaroika, Melissa, Melilot, Melon `` fruit '', Moukomugi, Mosouchiku, Mokkirin, Mogi (Pepper), Mochinoki, Mokkoki Incense), Japanese maple peach, Peach (peach `` leaves, seeds, flowers, fruit ''), coconut palm, Morello cherry `` fruit '', Morohaya (burlap), Yakawamuraimo, Yakuchi (Michichi), cornflower (cornflower), Cornflower mint, yacon, Yashabushi (arrow wheel), Himeya Sabushi or Obayashi Bushi `` fruit, pericarp, fruit ear '', willow willow, starfish (octagonal gold plate), mistletoe (willow infestation), willow (kawa willow, twill willow, weeping willow, red willow, cat willow, incolyana, kinuyanagi, koryanagi, willow, willow, willow, willow, willow ), Willow tree, leaves, stalk, yabgarashi, yabukouji (purple gold beef), yab tobacco (crane tsumugi, Tenmeisei), pokeweed (shoku land), yamahanoki (yamabe), yam (Plum), wormwood, eucalyptus, Yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, crocodile, mugwort (lily leaf), ligan (Raimaru), lime `` fruit '', rye, rakanka `` fruit ”, Raspberry“ leaves, fruit ”, latania (chlamellia), raccoon or eschar White, lavender, longan (long-eyed), agave (Aonus agave, fuchlin agave), ryokucha (green tea), apples `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cool), rulitama thistle (urajiro) (Higotai, Xinjiang indigo sashimi), Ganoderma (ricepick, toothpick core), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (ream), forsythia, wintersweet (Waume), wax palm, locon (yoshi, sone), Logan berry `` fruit '', rosemary (mannenrou), rose hip (nobara), wasabi, staghorn (mongdang flower), walmocow (butterfly), etc. It is done.

(32) Other examples of seaweed-based raw materials Seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Sugiaonori, Hiraaoori, Bouaoonori, Hosoeda Aonori), Anaaoosa (seaweed)] [Brown algae: Kombu (Macombu, Risilibu, Hosome Kombu, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrifolia, Neocitus Luetkeana), Hijiki, Hibamata, Umiuchiwa, Usuba Umiuchiwa, Kirebanoumiuchiwa, Akaba Umiuchiwa, Konaumi Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsuuki Uchiwa], seaweed [Red Algae: Red Lime, Maca (Tengusa), Hiluxa, Cypress, Oba Rabbit, Kata-bucka, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Tokikininsai, Amakusakirinsai, Kirinsai, Binkishininsai, Tsunomata, Obatsunomata, Tocha-no-no-no-mata, Hitsunotakata, Togetokota , Kainori, Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamominori] and the like.

  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimegasa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).

  Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haeshinosakiba, Kawamoku : Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okimozu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  As these materials derived from plant-based or animal-based materials, any sites, cells, tissues, organs, metabolites, etc. derived from genetically modified organisms or cell fusions can also be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

  Degradation in processing mainly includes decomposition by acid, decomposition by alkali, decomposition by enzyme, decomposition by high temperature and high pressure, and the like. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and pralanase, hen egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, gluco Examples include cell wall lytic enzymes such as uronidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Derchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Graphnoola, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, a filter aid, and the like, centrifugal separation, and fractional precipitation, which is an application thereof, and density gradient separation methods such as a red zone centrifugal separation method and a density gradient sedimentation equilibrium method.

(33) Other compounds used as additives Silica, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, Inorganic pigments such as yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, Sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride peroxide Hydrogen oxide adduct, β- Losinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, thioglycol Redox agents such as magnesium acid and strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3, 3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride , Metaphenylenediamine , Orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine , Nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino- 1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-sulfate Nitrophenol, orthoaminophenol sulfate, orthochloroparaphenylene sulfate Amine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylene sulfate Diamine, Sulfated paraphenylenediamine, Sulfated paramethylaminophenol, Sulfated metaaminophenol, Sulfated metaphenylenediamine, Catechol, Diphenylamine, α-Naphthol, Hydroquinone, Phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diamino Dye agents such as sodium azobenzene-5'-sulfonate, hematein, natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, oren Essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, Gingergrass essential oil, cedar essential oil, spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, trough balsam essential oil, batchuri essential oil, rose essential oil, palmarosa essential oil, coconut essential oil, hiba essential oil , Sandalwood essential oil, petit glen essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boad rose essential oil, mellow essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, low Perfumes such as Zumaree essential oil, Japanese mint mint essential oil, other synthetic fragrances, 5-amino-O-cresol, O-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxyethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine , P-nitro-O-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene / sodium sulfate, toluene -2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-O-cresol Sulfate, p-aminophenol, sulfate, O-chloro-p-phenylenediamine, sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene, sulfate, 4,4'-diaminodiphenylamine, Sulfate, p-methylaminophenol / sulfate, p-phenylenediamine / sulfate, m-phenylenediamine / sulfate, toluene-2,5-diamine / sulfate, 2,4-diaminophenoxyethanol / hydrochloride, toluene -2,5-diamine / hydrochloride, m-phenylenediamine / hydrochloride, 2,4-diaminophenol / hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine / hydrochloride, N-phenyl-p -Phenylenediamine / hydrochloride, N-phenyl-p-phenylenediamine / acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-amino Phenyl) -2,5-diamino-1,4-quinonedi Min, O-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino- 4-Methylaminoanthraquinone, nitro-p-phenylenediamine / hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino-5-nitrophenol / sulfate, resorcinol , Nitro-p-phenylenediamine / sulfate, p-nitro-O-phenylenediamine / sulfate, p-nitro-m-phenylenediamine / sulfate, Red No. 2, Red No. 3, Red No. 102, Red No. 104 (1), Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Color 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 No. (1), yellow 406, yellow 407, orange 205, orange 207, orange 402, green 3, green 204, green 205, green 401, green 402, brown 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye , Krill pigment, Amber pigment, Caramel, Gold, Silver, Gardenia pigment, Corn pigment, Onion pigment, Tamarind pigment, Spirulina pigment, Buckwheat whole plant pigment, Cherry pigment, Nori pigment, Hibiscus pigment, Grape juice Dyes, marigold dyes, purple potato dyes, purple yam dyes, lac dyes, rutin and other pigments and colorants, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter , Chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, Oils and fats such as turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, beef tallow, pork fat or hydrogenated products of these oils (hardened oil etc.), beeswax, carnauba wax, whale wax, Lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax Waxes such as squalene, squalane, pristane, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, Natural fatty acids such as linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2 -Fatty acids such as synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid, ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytostero , Natural alcohols such as phenoxyethanol, alcohols such as 2-hexyldecanol, isostearyl alcohol, synthetic alcohols such as 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, olein Oleyl acid, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, diisobutyl adipate, 2-hexyl decyl adipate, diheptyl undecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, triisostearic acid Trimethylolpropane, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, cetyl 2-ethyl hexanoate Trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, Esters such as propylene glycol dioleate, metal soaps such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants ( Alkyl carboxylates, alkyl sulfonates, alkyl sulfates, alkyl phosphates), cationic surfactants (alkyl amines) Mineral salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type Amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic Surfactants), other surfactants (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants), etc. Agents etc.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

(Preparation 1) Preparation of elenolic acid and elenolic acid glucoside 1N-sulfuric acid (500 mL) was added to oleeuropein (2 g) or crude oleeuropein, and after hydrolysis at 60 to 90 ° C. for about 1 to 2 hours, After cooling to room temperature, 5N-sodium hydroxide solution was added dropwise thereto, and the pH was adjusted to 2 to 2.5 to obtain a hydrolyzed solution. Subsequently, ethyl acetate was added thereto, followed by extraction several times, and the recovered ethyl acetate layer was dried under reduced pressure to obtain an oily decomposition product. Next, this oily decomposition product was fractionated and purified with octadecylated silica gel, and the recovered products were concentrated and freeze-dried to obtain elenolic acid (about 430 mg) and elenolic acid glucoside (about 150 mg).

(Adjustment 2) Preparation of oleeuropein aglycone 2% β-glucosidase solution (1/10 amount) in 1% -0.1M sodium acetate buffer solution (pH 4.1) of oleeuropein or crude oleeuropein In addition, the mixture was incubated at 32 ° C. for 16 hours for deglycosylation. Ole europain aglycone was extracted with chloroform from this decomposition solution.

(Adjustment 3) Preparation of elenolic acid 1N-hydrochloric acid (500 mL) was added to oleeuropein aglycone (2 g), hydrolyzed at 60 ° C. for about 4 hours, cooled to room temperature, and then 1N-hydroxylated A sodium solution was added to adjust the pH to 2 to 2.5 to obtain a hydrolysis solution. Subsequently, ethyl acetate was added thereto, followed by extraction several times. The recovered ethyl acetate layer was dried under reduced pressure to obtain an oily decomposition product. This oily decomposed product was subjected to alkaline resin column, water-methanol mixture was gradually increased in methanol concentration to elute hydroxytyrosol-containing fraction, and elenolic acid-containing fraction was eluted and purified. Elenolic acid (about 870 mg) was obtained.

(Analysis) Thin layer chromatography (1) Oleuropain aglycone silica gel 60 (F ₂₅₄ ) plate, developing solvent (benzene / methanol / acetic acid = 45: 8: 1)
Rf = 0.35
(2) Elenolic acid silica gel 60 (F ₂₅₄ ) plate, developing solvent (chloroform / methanol = 8: 2)
Rf = 0.57, and Rf = 0.5

(Analysis) 1H-NMR: Elenolic acid (Rf = 0.57)
1H-NMR (270 MHz, CDCl ₃ , TMS): δ 9.92 (1H, brs), 9.60 (1H, d, J = 2 Hz), 7.70 (1H, d), 7.63 (1H, s), 4.28 (1H, dq, J = 2.5 Hz), 3.75 (3H, s), 3.40 (1H, dd, J = 2.5 Hz), 2.90 (1H, dd, J = 16.5 Hz), 2.72 (1 H, m), 2.35 (1 H, dd, J = 16.5, 11 Hz), 1.50 (3 H, d, J = 7 Hz)

(Analysis) 1H-NMR: Elenolic acid (Rf = 0.5)
1H-NMR (270 MHz, CDCl ₃ , TMS): δ 9.92 (1H, brs), 9.63 (1H, d, J = 2 Hz), 7.70 (1H, d), 7.62 (1H, s), 4.48 (1H, dq, J = 2.5 Hz), 3.75 (3H, s), 3.40 (1H, dd, J = 2.5 Hz), 2.94 (1H, dd, J = 16.5 Hz), 2.72 (1 H, m), 2.37 (1 H, dd, J = 16.5, 11 Hz), 1.43 (3 H, d, J = 7 Hz)

(Analysis) 1H-NMR: Elenolic acid glucoside 1H-NMR (270 MHz, CDCl ₃ , TMS): δ 9.92 (1H, brs), 9.63 (1H, d, J = 2 Hz), 7.70 (1H , D), 7.63 (1H, s), 4.48 (1H, dq, J = 2.5 Hz), 3.4-4.8 (7H, m), 3.40 (1H, dd, J = 2.5 Hz), 2.95 (1 H, dd, J = 16.5 Hz), 2.72 (1 H, m), 2.37 (1 H, dd, J = 16.5, 11 Hz), 1.43 (3H, d, J = 7Hz)

(Preparation 3) Preparation of salt of elenolic acid and / or elenolic acid glucoside Ammonia water, or 0.7% of purified water (50 mL) dissolved in elenolic acid, elenolic acid glucoside, or a mixture thereof (30 mg). Add sodium hydroxide solution, potassium hydroxide solution, calcium hydroxide solution, magnesium hydroxide solution adjusted to 1N, respectively, freeze-dried, respectively, ammonium salt and sodium salt of elenolic acid and / or elenolic acid glucoside Each of potassium salt, calcium salt and magnesium salt was prepared. These can be purified by recrystallization from water if necessary.

(Test 1) Test for inhibiting melanin production B16 melanoma cells are mouse-derived melanin-producing cells, and a drug that suppresses the melanin production of these cells can be expected to lighten the skin color, that is, to whiten.
[Test Method and Evaluation Method] B16 melanoma cells were cultured for 24 hours, and this culture solution was replaced with a culture solution to which a sample was added. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured to obtain the amount of melanin. At the same time, the number of cells was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983) reference), and it was confirmed that there was no difference in the number of viable cells between the blank group and the sample addition group.
[Sample] Elenolic acid and elenolic acid glucoside were dissolved in DMSO so as to have final solid content concentrations of 0.1 ppm, 1 ppm, 10 ppm, and 20 ppm, and used for the test. A DMSO solution was used as a blank. In addition, a DMSO solution of arbutin (manufactured by Sigma) was used as a comparative control.
[Test Results] As shown in FIG. 1, it was confirmed that elenolic acid and elenolic acid glucoside both have a strong melanin production inhibitory effect over arbutin and can be used as a highly effective melanin production inhibitor. In addition, the melanocyte cytotoxicity was not recognized by the sample.

(Test 2) Tyrosinase activity inhibition test [Sample] A solution prepared by dissolving elenolic acid and elenolate in a 30% DMSO solution was prepared. In addition, a DMSO solution of arbutin (manufactured by Sigma) was used as a comparative control.
[Test Method and Evaluation Method] A tyrosine solution (L-tyrosine 0.3 mg / mL) 1.0 mL, mucklevine buffer (pH 6.5, 1.0 mL) and each sample (0.1 mL) were mixed, and 37 After standing for about 10 minutes in a constant temperature bath, a tyrosinase solution (mushroom-derived 2500 units / mL, 0.1 mL) was added thereto, and then the absorbance at 475 nm was measured. did. Thereafter, this reaction solution was allowed to stand in a 37 ° C. constant temperature bath for 20 minutes, and the absorbance at 475 nm was measured in the same manner. The absorbance value at this time was defined as A ′. At the same time, as a blank, the absorbance was measured in the same manner using a 30% DMSO solution instead of the sample, and the absorbance values at this time were defined as B and B ′. From these values, the tyrosinase activity inhibition rate was determined by the following equation [Formula 1]. The results are shown in FIG.
[Equation 1] Tyrosinase activity inhibition rate (%) = [(B′−B) − (A′−A)] / (B′−B) × 100
[Test Results] As a result of testing the tyrosinase activity inhibitory action of each sample, elenolic acid and its salt showed almost the same concentration-dependent enzyme activity inhibitory action. Moreover, the inhibitory rate of activity was remarkably high as compared with the case of using the same concentration of arbutin. Therefore, it was found that elenolic acid and its salts have an excellent tyrosinase activity inhibitory action.

(Test 3) Stability test In order to evaluate the stability of elenolic acid and / or elenolic acid glucoside and elenolic acid salt, the sample was allowed to stand in a 60 ° C environment for a certain period of time, and color change, occurrence of starch, etc. were confirmed.
[Sample] Prepare a DMSO solution so that elenolic acid and / or elenolic acid glucoside, elenolic acid sodium salt, elenolic acid potassium salt, elenolic acid calcium salt, and elenolic acid magnesium salt become 0.1%, and use a thermostatic bath. It was stored at 60 ° C., and the change with time was observed for one month.
[Test Results] All the samples were confirmed to be stable with no change in color tone, occurrence of starch, and odor change during the course of one month.

(Test 4) Safety test (1) Primary skin irritation test A solution of elenolic acid, elenolic acid glucoside and elenolic acid sodium salt was prepared so as to be about 0.1% each, and this was Hartley shaved on the back. 0.03 mL was applied to each animal per 2 × 2 cm ² of skin of female guinea pigs (female, 3 animals per group, body weight around 330 g). Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all animals, no erythema and edema were observed, and it was judged negative.

(2) Cumulative skin irritation test Hartley guinea pigs (female, 1) were prepared by preparing solutions of elenolic acid, elenolic acid glucoside, and sodium enolic acid salt at about 0.1%, and shaving the flank. 0.03 mL was applied to each animal once a day, 5 times a week, per 2 × 2 cm ² of skin (3 groups, body weight around 330 g). Application was performed over 2 weeks, and the shaving was performed in a timely manner. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged negative.

(3) Single-dose toxicity test Ddy mice (male and female, 1 group) in which elenolic acid glucoside and elenolic acid sodium salt were fasted at a dose of 2,000 mg / kg (body weight) per animal for 16 hours before the test. 5 animals, 5 weeks of age) were orally administered, and the onset and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and as a result of dissection, it was confirmed that there was no abnormality.

(Test 5) Moisturizing effect test In order to evaluate the moisturizing effect by external application of the elenoleic acid sodium salt solution, the transepidermal water loss (TEWL) by a monitor was measured.
[Sample] Purified water, 0.01% sodium elenoate aqueous solution [Measurement instrument] TEWAMETER TM210; COURAGE + KHAZAKA Electronic Gmbh [Method] Apply a sample (1 mL) three times a day to the left and right forearm flexion side of the monitor. The above is performed continuously for 3 days, and after applying for the third time throughout the day, it is stabilized in a constant temperature and humidity chamber (24 ° C., 50% RH) for 1 hour, and then the amount of transepidermal water loss is measured using a measuring instrument. went. The measurement is performed at intervals of 2 seconds for 3 minutes, and the average value of all the numerical values is taken as the TEWL value of the test site. The results are shown in Table 2.
[Results] As shown in Table 2, the sodium elenoate solution significantly suppressed the amount of transepidermal water evaporation and showed an excellent moisturizing action. This proved to be useful as an active ingredient of a humectant.

(Test 6) Stability over time of ascorbic acid A composition containing ascorbic acid or a derivative thereof was prepared with the formulation shown in Tables 3-4. In addition, pH of the composition adjusted the initial value between 3.7-3.9. After preparation, in order to make a temporal stability test sample, about 100 mL of the composition was filled in a 100 mL transparent glass bottle, and sterilized by heating at 65 ° C. for 15 minutes. The content of ascorbic acid in each composition immediately after the sterilization treatment was quantified and used as the initial value (A) of each ascorbic acid content. The standing was carried out under conditions of 55 ° C. and 7 days, and the ascorbic acid content (B) immediately after being left was determined and determined. The stability of ascorbic acid was evaluated by calculating the residual rate (%) of ascorbic acid before and after standing. That is, the relative value of the ascorbic acid content (B) immediately after being left when the initial value (A) of each sample was 100 was determined. Ascorbic acid was quantified by using an indophenol titration method to measure the amount of reduced ascorbic acid. The evaluation results are shown in Tables 2-3.
[Results] As shown in Tables 3-4, the composition containing elenoate and elenolic acid glucoside salt has a high residual rate of ascorbic acid after standing at 55 ° C. for 7 days, compared to the respective comparative compositions, Good results were shown.

(Manufacture of various preparations)
Cosmetics, bathing agents, and foods and drinks were manufactured using the melanin production inhibitor, moisturizer, and whitening agent according to the present invention. The prescription example is as follows. Ethanol is abbreviated as EtOH, and 1,3-butylene glycol is abbreviated as 1,3-BG.

1) Manufacturing lotion
weight%
1. Sorbit 2
2.1,3-BG 2
3. Polyoxyethylene oleyl ether (25 EO adduct) 2
4). EtOH 20
5. Ascorbic acid 2-glucoside 0.2
6). Green tea 30% EtOH extract 0.01
7). Chamomile 30% EtOH extract 1.0
8). Artichoke leaf 50% 1,3-BG extract 1.0
9. Elenolic acid glucoside sodium 0.0001
10. pH adjuster appropriate amount11. Phenoxyethanol appropriate amount 12. Residue with 100 purified water

2) Production of emulsion
weight%
1. Squalane 3
2. Vaseline 1
3. Stearyl alcohol 0.3
4). Sorbitan monostearate 1.5
5. Polyoxyethylene (20) sorbitan monooleate 3
6.1,3-BG 10
7). Crude elenolic acid and elenolic acid glucoside 0.0001
8). Ascorbic acid phosphate magnesium salt 0.1
9. Acerola 30% 1,3-BG extract 1.0
10. Scarlet root 30% 1,3-BG extract 1.0
11. Sodium hyaluronate 0.005
12 Nasal cartilage extract (containing proteoglycan) 0.2
13. Preservative (paraoxybenzoic acid ester) Residue with 100 purified water

3) Production of emulsion
weight%
1. Squalane 8.0
2. Jojoba oil 7.0
3. Maltose 3.0
4). Crude calcium elenoate 0.0001
5. Ascorbic acid phosphate magnesium salt 0.1
6). Cetyl alcohol 1.5
7). Glycerol monostearate 2.0
8). Polyoxyethylene (20) cetyl ether 3.0
9. Polyoxyethylene (20) sorbitan monooleate 2.0
10. Yuzu 50% 1,3-BG extract (containing Yuzuceramide) 1.0
11. Porcine placenta extract 0.1
12.1, 3-BG 1.0
13. Glycerin 2.0
14 Sodium hyaluronate 0.01
15. Susavinori hot water extract (containing porphyran) 0.5
16. Preservative (paraoxybenzoic acid ester) Residue with 100 purified water

4) Manufacture of cosmetic oil
mass%
1. Liquid paraffin 30.0
2. Squalane 20.0
3. Olive oil 20.0
4). Isopropyl palmitate 10.0
5. Elenolic acid 0.0001
6). Olive oil 1.0
7). Shea fat 1.0
8). Butylhydroxyanisole 0.1
9. DL-α-tocopherol derivative 0.1
10. Ascorbic acid phosphate magnesium salt 0.1
11. Bilberry 30% 1,3-BG extract 1.0
12 Indigo Luros 30% 1,3-BG extract 1.0
13. Preservative (paraoxybenzoic acid ester) Perfume appropriate amount 15. Residue with 100 purified water

5) Manufacture of 2-layer whitening lotion
mass%
1. Squalane 8.0
2. POE sorbitan tetraoleate 0.3
3. Sorbit 1.0
4). EtOH 15.0
5. Neem leaf 30% EtOH extract 2.0
6). Sage Whole 30% EtOH Extract 2.0
7). Chamomile flower head 30% EtOH extract 1.0
8). Artichoke leaf 30% EtOH extract 1.0
9. Ascorbic acid 2-glucoside 0.1
10. Lemongrass 50% 1,3-BG extract 1.0
11. Astringent 0.1
12 Potassium elenoate 0.0001
13.2-Phenoxyethanol Suitable amount Residue with 100 purified water

6) Pack production
mass%
1. Polyvinyl alcohol 15.0
2. Sodium carboxymethylcellulose 5.0
3. Propylene glycol 3.0
4). EtOH 10.0
5. Magnesium elenoate 0.0001
6). Isomaltitol 1.0
7). Ascorbic acid 2-glucoside 0.2
8). Preservative (paraoxybenzoic acid ester) Perfume appropriate amount10. Residue with 100 purified water

7) Production of cream
mass%
1. Sara honey bees 11.0
2. Liquid paraffin 22.0
3. Lanolin 10.0
4). Olive oil 5.0
5. Chamomile oil 5.0
6). Palm oil 5.0
7). Oat bark 30% 1,3-BG extract 2.0
8). Water-soluble collagen solution 3.0
9. Crude sodium elenoate 0.0001
10. Porcine placenta extract 0.1
11. Ascorbic acid phosphate magnesium salt 0.1
12 Liquid shea fat 1.0
13. Hydroxypropyl cellulose 2.0
14 Residue with 100 purified water

8) Manufacture of face-wash cream
mass%
1. Stearic acid 10.0
2. Palmitic acid 10.0
3. Myristic acid 12.0
4). Lauric acid 4.0
5. Oleyl alcohol 1.5
6). Lanolin derivative (EO adduct) 1.0
7). Glycerin 18.0
8). Potassium hydroxide 6.0
9. Elenolic acid glucoside 0.0001
10. Glycyrrhizic acid 2-potassium 1.0
11. Soap nut (Rita) extracted saponin 0.1
12 Perfume appropriate amount13. Residue with 100 purified water

9) Manufacture of body soap
mass%
1. Potassium laurate 15.0
2. Potassium myristate 5.0
3. Propylene glycol 5.0
4). Maltose 3.0
5. Potassium Elenolate 2.0
6). Polyethylene powder 0.5
7.4% -Hydroxypropylchitosan aqueous solution 4.0
8). Amino acid mixture 0.5
9. Grapefruit 50% 1,3-BG extract 2.0
10. Sakura leaf 50% 1,3-BG extract 2.0
11. Polyoxyethylene (20) sorbitan monooleate 3
12 pH adjuster appropriate amount13. Perfume appropriate amount14. Residue with 100 purified water

10) Manufacture of cream foundation
mass%
1. Stearic acid 4.0
2. Glycerol monostearate 3.0
3. Cetanol 1.5
4). Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6). Sara honey bee 3.0
7). Triethanolamine 1.5
8). Glycerin 3.0
9. Bentonite 1.0
10. Titanium oxide 8.0
11.2,4-dihydroxybenzophenone 8.0
12 Kaolin 3.0
13. Talc 3.0
14 Coloring pigment (yellow iron oxide) 1.0
15. Elenolic acid glucoside 0.00001
16. Trehalose 0.5
17.2-Phenoxyethanol appropriate amount 18. Perfume proper amount19. Residue with 100 purified water

11) Manufacture of bath preparation
mass%
1. Refined jojoba oil 5.0
2. Poloxyethylene sorbitan monolaurate 20.0
3. Glycerol monostearate 5.0
4). Liquid paraffin 2.0
5. Lauric acid diethanolamide 3.0
6). Glycerin 5.0
7). Crude elenoic acid sodium glucoside 0.01
8). Himefuuro 50% 1,3-BG extract 2.0
9. Peppermint 20% 1,3-BG extract 2.0
10. Loquat 50% 1,3-BG extract 2.0
11. Residue with 100 purified water

12) Tablets for tablets for beauty and health
The composition containing the following additives was compressed into tablets. weight%
1. Guarana 50% EtOH extraction powder 5
2. Walnut hot water extraction powder 5
3. Calcium elenoate, sodium elenoate 5
4). Royal jelly powder 5
5. Sodium ascorbate 1
5. Collagen powder 5
6). Lactose 35
7). Corn starch 25
8). Hydroxypropyl cellulose 4
9. Magnesium stearate 1
10. Salmon nasal cartilage extraction powder (containing proteoglycan) 1
11. N-acetylglucosamine 5
12 Chondroitin sodium sulfate 1
13. Dextrin 2

13) Beauty food (granule)
Granules (single package) containing the following additives were produced. Weight g
1. Collagen powder 1.5
2. Collagen tripeptide 1.0
3. Pig placenta water extraction powder (50% dextrin) 0.1
4). Royal Jelly Peptide 0.2
5. Artichoke leaf extraction powder 0.1
6). Soy peptide 0.05
7). Sodium ascorbate 0.03
8). Crude elenolic acid and crude elenolic acid glucoside 0.02

14) Beauty and health supplements (granule)
Granules (4 packs) containing the following additives were produced. Weight g
1. Collagen powder 5
2. Fat content 0.024
3. Sodium aspartate 0.01
4). Vitamin A 0.002
5. Vitamin B1 0.003
6). Vitamin B2 0.004
7). Vitamin B6 0.004
8). Vitamin B12 0.0006
9. Sodium ascorbate 0.03
10. Vitamin E 0.002
11. Niacin 0.004
12 Pantothenic acid 0.001
13. Arginine 0.6
14 Leucine 0.6
15. Valine 0.4
16. Eggshell calcium 0.01
17. Hydroxypropyl cellulose 2
18. Crude elenolic acid and crude elenolic acid glucoside 0.01
19. N-acetylglucosamine 5
20. Chondroitin sodium sulfate 1
21. Hydrolyzed silk powder 0.2

22. Dextrin 2

15) Beverages for beauty
weight%
1. Pomegranate water extract 20
2. Rose Hot Water Extract 20
3. Sodium ascorbate 0.1
4). Potassium elenoate 0.002
5. Porcine placental water extract 0.02
6). Honey 5
7). Citric acid 0.1
8). Water-soluble collagen 2
9. dl-malic acid 0.1
10. D-sorbitol solution (70%) 10
11. Sodium benzoate 0.03
12 Perfume appropriate amount13. Residue with 100 purified water

16) Lactic acid bacteria fermented beverage for beauty
weight%
1. Carrot juice lactic acid bacteria fermentation 40
2. Orange concentrated reduced juice 10
3. Sodium ascorbate 0.2
4). Lactulose syrup 1
5. Crude elenoate 0.002
6). Citric acid 0.1
7). Water-soluble collagen 2
8). Perfume appropriate amount 9. Residue with 100 purified water

  The present invention has a moisturizing action and also has a whitening effect such as effective suppression and improvement of skin pigmentation such as skin darkening due to exposure to spots, buckwheat, dullness or ultraviolet rays, both in stability and safety. A novel novel melanin inhibitor and its application means are provided.

  The melanin production inhibitor according to the present invention is excellent in its action and effect and also has a moisturizing action. Since it is safe and has excellent stability over time, it is very suitable for use in whitening cosmetics, beauty foods and beverages. In addition, it functions as a time-stabilization of ascorbic acids widely used as an active ingredient and for the purpose of an oxidation stabilizer in whitening cosmetics, beauty foods and beverages, and the like. Therefore, the use in whitening cosmetics, beauty foods and drinks containing ascorbic acids is particularly suitable because it can enhance the whitening and beauty effects and contribute to the stabilization of the composition.

Claims (5)

  Melanin production inhibitor containing elenolic acid and / or elenolic acid glucoside, or a salt thereof as an active ingredient   Moisturizer containing elenolic acid and / or elenolic acid glucoside, or a salt thereof as an active ingredient   A whitening agent containing elenolic acid and / or elenolic acid glucoside, or a salt thereof as an active ingredient.   Whitening cosmetics containing elenolic acid and / or elenolic acid glucoside, or a salt thereof as an active ingredient.   It contains at least one selected from elenolic acid and / or elenolic acid glucoside, or a salt thereof, and at least one selected from ascorbic acid, isoascorbic acid, and derivatives thereof, Whitening cosmetics.

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