JP5493730B2 - Dentifrice composition - Google Patents

Description

  The present invention exhibits high bactericidal action on oral biofilms derived from isopropylmethylphenol, has low irritation to oral mucosal irritation, suppresses taste nuisance, has an excellent feeling of use, and also has good foaming during dentifrice brushing It is related with the dentifrice composition which is.

  It is known that the cause of two major oral diseases, caries and periodontal disease, is an infection caused by a biofilm formed in the oral cavity. A biofilm is a community of microorganisms formed by attaching bacteria to the surface of a substance, and is characterized by being protected against the external environment by being covered with organic substances such as extracellular polysaccharides in addition to bacteria. Have. Oral biofilms have different pathogenic bacterial species depending on the site where they form, for example, streptococci such as S. mutans for caries, and Porphyromonas gingivalis for periodontal disease. It has been found that bacteria mainly composed of obligate anaerobic gram-negative bacilli such as (P. gingivalis) and oral bacteria such as Fusobacterium nucleatum are involved as the cause of bad breath. Therefore, as an effective means for prevention and improvement of oral diseases, do not form oral biofilms, keep the number of pathogenic bacteria in the biofilm at a low level, and count the number of pathogenic bacteria as a whole in the oral cavity. It is said that it is useful to control.

Pathogenic bacteria in the oral cavity are resident as floating bacteria in the formed biofilm and in saliva. To reduce the number of pathogenic bacteria, water-insoluble fungicides such as triclosan and chloride It is effective to use a cationic fungicide such as cetylpyridinium and other anionic fungicides. In particular, isopropylmethylphenol, which is a poorly water-soluble fungicide, is suitably used for bacteria present in biofilms (Patent Documents 1 to 4).

  Isopropyl methylphenol, which is considered to be suitable for pathogenic bacteria inside the biofilm, is known to have better penetrability into the biofilm than other bactericidal components. However, the composition containing isopropylmethylphenol has a disadvantage that the feeling of use is remarkably impaired because it has a peculiar taste, and improvement of this point has been demanded.

  In response to this problem, for example, a technique for reducing the off-flavor of antibacterial components by combining a specific acyl sarcosine salt in combination with a specific mixing ratio with respect to phenoxyethanol (Patent Document 5), l-menthol and sodium chloride with isopropylmethylphenol On the other hand, a technique (Patent Document 6) for reducing off-flavors and off-flavors by blending at a specific mass ratio is proposed. However, when a large amount of acyl sarcosine salt is added, oral mucosal irritation considered to be derived from the acyl sarcosine salt occurs, and when sodium chloride is added, the flavor type may be limited depending on the salty taste. There was a problem and it was difficult to say that it was satisfactory.

  In addition, there is a method of reducing the taste by masking with a sweetener such as saccharin. However, in this case, the taste of the sweetener is emphasized too much and it cannot always be said that the taste can be suppressed. Therefore, a new technique for reducing the tasting taste derived from isopropylmethylphenol has been demanded.

  In addition, since bacteria in biofilms are covered with a film (extracellular matrix), isopropylmethylphenol is highly resistant to antibacterial substances and has an excellent bactericidal effect on biofilms compared to other antibacterial components. Therefore, there has been a demand for a technique for enhancing the sterilizing effect.

By the way, when suffering from periodontal disease, a strong inflammatory reaction often occurs in the gums, and the gums may be sensitive to physical and chemical stimuli, and you feel subjective symptoms such as pain and bleeding when brushing your teeth. In this case, it is desirable to increase the preventive effect of periodontal disease without causing an inflammatory reaction.
On the other hand, in order to sterilize the bacteria in the biofilm, it is necessary to make the medicinal component reach the inside by destroying or permeating the covered film. However, when these are blended, the oral mucosa often gives a sense of irritation, and therefore there has been a demand for a dentifrice composition that is not irritated or very little.

  In addition, the toothpaste composition is also required to have a feeling of cleaning, and one of the textures that provides a satisfactory feeling of cleaning is foaming when brushing. However, when the amount of the anionic surfactant is increased in order to improve foaming during tooth brushing, there is a concern that irritation in the oral cavity becomes stronger, and there is also room for improvement in this respect.

  On the other hand, since condensed phosphate has a chelating action on metal ions, it is used as an effective ingredient for suppressing tartar, a component for obtaining a whitening effect on teeth, etc. in oral compositions (Patent Document 7). -10). However, the condensed phosphate has an effect on the oral mucosa due to its action mechanism, and there is a problem that irritation to the oral mucosa occurs depending on the type of surfactant to be blended in the dentifrice composition. In this case, if the amount of the anionic surfactant is decreased, the irritation tends to be weakened, but another problem has arisen in that foaming during dentifrice is reduced.

JP 2008-150305 A International Publication No. 2006/067967 Pamphlet JP 2006-124315 A JP 2006-69909 A JP 2007-161613 A JP 2008-143825 A Japanese Patent Publication No. 6-27058 Japanese Patent Laid-Open No. 7-10726 Japanese Patent Laid-Open No. 9-12438 JP 2002-68947 A

  As described above, in the dentifrice composition containing isopropylmethylphenol, the bactericidal action on the intraoral biofilm derived from isopropylmethylphenol is more highly demonstrated, and there is less irritation to oral mucosal irritation and the taste is suppressed. While it is required to have excellent usability and good foaming during toothbrushing, the conventional techniques have various problems and it has been difficult to satisfy all of them.

  The present invention was made in order to solve the above-mentioned problems, has a higher bactericidal effect on oral biofilms derived from isopropylmethylphenol, has a reduced peculiar taste, has less irritation to the oral mucosa, and is used An object of the present invention is to provide a dentifrice composition that is excellent in feeling and also has good foaming during dentifrice.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) isopropylmethylphenol and (B) 3-octanol, 3-octyl acetate, or 1-octane selected from 3-octanone. The above perfume ingredients, (C) fatty acid amidopropyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine having 12 to 14 carbon atoms of fatty acid, and (D) pyrophosphate And / or tripolyphosphate and (E) lauryl sulfate are used in combination, and by blending the component (D) in a specific amount, the bactericidal effect on the oral biofilm is enhanced, and the taste taste unique to isopropylmethylphenol Reduced taste, almost no taste, little irritation to the oral mucosa, good usability, and good foaming during dentifrice Found that a dentifrice composition is obtained such, the present invention has been completed.

  That is, according to the present invention, by blending the specific fragrance of the component (B) with the dentifrice composition containing (A) isopropylmethylphenol and using the components (C) to (E) in combination, Various problems are solved, sterilization effect derived from isopropylmethylphenol is enhanced, peculiar taste is reduced, there is little irritation to the oral mucosa, it is excellent in use feeling, and foaming at the time of dentifrice is also good. Thus, it is possible to obtain a dentifrice composition effective for preventing or ameliorating oral diseases such as periodontal disease.

  In addition, since the fragrance | flavor component of said (B) component has characteristic fragrance | flavor and is used for trace amounts of some compound flavors, such as cheese, since it is unpleasant fragrance itself, the dentifrice composition The use as a fragrance was limited. The present inventors have unexpectedly found that when the specific flavor of the above component (B) is used in combination with isopropylmethylphenol in a dentifrice composition, the tasting taste derived from isopropylmethylphenol can be sufficiently suppressed.

  Furthermore, in this invention, (D) component / (A) component is 10-50 by mass ratio, and (C) component / (E) component is 0.4-2 by mass ratio. Preferably, the sterilization effect with respect to a biofilm can be heightened more by setting it as such a mixture ratio.

  Further, in the present invention, by adding (F) anisaldehyde to the dentifrice composition containing the above components (A) to (E), the special taste can be further reduced and the feeling in use can be further improved.

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
(A) isopropylmethylphenol,
(B) 1 type, or 2 or more types of fragrance | flavor components chosen from 3-octanol, 3-octyl acetate, and 3-octanone,
(C) Fatty acid amide propyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine whose fatty acid has 12 to 14 carbon atoms,
(D) pyrophosphate and / or tripolyphosphate,
(E) A dentifrice composition comprising lauryl sulfate, wherein the blending amount of component (D) is 0.1 to 2.0% by mass.
Claim 2:
The dentifrice composition according to claim 1, wherein the blending ratio of component (D) / component (A) is 2 to 100 in terms of mass ratio.
Claim 3:
The dentifrice composition according to claim 1 or 2, wherein the mixing ratio of component (C) / component (E) is 0.1 to 5 in terms of mass ratio.
Claim 4:
(A) 0.01-0.2 mass% of component, (B) component 0.0001-0.1 mass%, (C) component 0.1-2.0 mass%, (E) component The dentifrice composition of any one of Claims 1 thru | or 3 containing 0.2-2.5 mass%.
Claim 5:
The dentifrice composition according to any one of claims 1 to 4, further comprising (F) anisaldehyde.
Claim 6:
The dentifrice composition of Claim 5 which contains 0.0001-0.1 mass% of (F) component.

  The dentifrice composition of the present invention reduces the peculiar taste that the composition containing isopropylmethylphenol has, has a high bactericidal effect on the biofilm, has little irritation to the oral mucosa, and has foaming during dentifrice. Good dentifrice composition.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is suitably prepared as a dentifrice such as a toothpaste, a liquid dentifrice, and a toothpaste, especially a toothpaste, and comprises (A) isopropylmethylphenol, (B) 3-octanol, 3-octyl acetate, 1 or 2 or more types of perfume ingredients selected from 3-octanone, (C) fatty acid amidopropyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazole having 12 to 14 carbon atoms Nitrobetaine, (D) pyrophosphate and / or tripolyphosphate, and (E) lauryl sulfate.

  (A) Isopropylmethylphenol used in the present invention is 4-isopropyl-3-methylphenol, and for example, commercially available products such as isopropylmethylphenol manufactured by Osaka Kasei Co., Ltd. can be used.

  (A) The blending amount of isopropylmethylphenol is preferably 0.01 to 0.2% (mass%, the same applies hereinafter), particularly 0.02 to 0.1% of the whole composition, and less than 0.01%. In some cases, the sufficient bactericidal effect may not be exhibited, and if it exceeds 0.2%, an unpleasant taste may occur and the taste may deteriorate.

The component (B) is a fragrance component effective for masking the unpleasant taste derived from isopropylmethylphenol and expressing a good flavor. Among 3-octanol, 3-octyl acetate, 3-octanone, and Fencon , 3- It is one or more perfume ingredients selected from octanol, 3-octyl acetate, and 3-octanone .
When combining 2 or more types of the said fragrance | flavor components, the combination of 3-octanol, 3-octyl acetate, and / or Fencon is suitable.
In addition, even if it is octanol, 1-octanol common as a fragrance | flavor of a dentifrice composition does not have an effect which masks the taste which originates in isopropylmethylphenol, and is not suitable as a fragrance | flavor component concerning this invention.

The component (B) may be a commercial product, for example, 3-octanol product Shiono perfume Ltd., 3-octyl acetate, 3-octanone be used as each Ltd. Inoue perfume Mill Products Can do. Fencon can use products from Koei Kogyo Co., Ltd.

  (B) Although the total compounding quantity of a component is not specifically limited, 0.0001-0.1% with respect to the composition whole quantity, Especially 0.0005-0.05%, Especially 0.001-0.02% desirable. If the blending amount is less than 0.0001%, it may not be possible to mask the tasting taste derived from isopropylmethylphenol, and the feeling of use may be worsened. If it exceeds 0.1%, the flavoring of the fragrance ingredient itself is too strong, resulting in tasting. There is a case.

The component (C) is a betaine-type surfactant selected from fatty acid amidopropyl betaine having a fatty acid having 12 to 14 carbon atoms and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
As fatty acid amidopropyl betaine, fatty acid having 12 to 14 carbon atoms is used, and examples thereof include lauric acid amidopropyl betaine and coconut oil fatty acid amidopropyl betaine. Is preferable. Moreover, as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, N-lauroyl-N-carboxymethyl- Examples thereof include sodium N-hydroxyethylethylenediamine, and particularly, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium is preferable in terms of foaming.

  As lauric acid amidopropyl betaine, for example, Amphithol 20AB (30% aqueous solution, Kao Corporation), Softazoline LPB (30% aqueous solution, Kawaken Fine Chemical Co., Ltd.) and the like are used. Further, as palm oil fatty acid amidopropyl betaine, Amphithol 55AB (30% aqueous solution, Kao Corporation), TEGO BETAIN CK (30% aqueous solution, Goldschmidt), NIKKOL AM-3130N (30% aqueous solution, Nikko Chemicals Corporation) ) Etc. are used.

  Examples of N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium include enadicol C-40H (40% aqueous solution (solid content), Lion Co., Ltd.), Amphital 20Y-B (Kao Co., Ltd.) )), Softazolin CH (30% aqueous solution, Kawaken Fine Chemical Co., Ltd.), softazoline CL-R (30% aqueous solution, Kawaken Fine Chemical Co., Ltd.) and the like, and N-lauroyl-N-carboxymethyl-N- As hydroxyethylethylenediamine sodium, for example, softazolin LHL (27% aqueous solution, Kawaken Fine Chemical Co., Ltd.) is used, but in any case, the above is not restrictive.

  The blending amount of the component (C) betaine type surfactant is 0.1 to 2.0%, particularly 0.3 to 1.5% of the whole composition. If it is less than 0.1%, irritation to the oral mucosa may become strong, and if it exceeds 2.0%, an unpleasant taste may occur due to the inherent bitterness derived from the component (C).

  The component (D) is pyrophosphate and / or tripolyphosphate, and is effective for improving the osmotic sterilization power derived from isopropylmethylphenol. Pyrophosphate and tripolyphosphate are condensed phosphates formed by dehydration condensation of phosphoric acid, pyrophosphate is a dimer, tripolyphosphate is a trimer, and linear polyphosphoric acid. Salt. Examples of these salts include alkali metal salts such as sodium and potassium, and alkaline earth metal salts such as magnesium salt. Sodium salts are preferred from the viewpoint of water solubility. Furthermore, in order to make pH at the time of dissolution into a neutral range, tetrasodium salt is preferable for pyrophosphate and pentasodium salt is preferable for tripolyphosphate. As these sodium pyrophosphate and sodium tripolyphosphate, for example, Taihei Chemical Industry Co., Ltd. is used.

(D) The compounding quantity of the condensed phosphate of a component is 0.1 to 2.0% of the whole composition, and 0.5 to 1.5% is especially preferable. The amount can not be obtained a high sterilization effect is less than 0.1%, greater than 2.0% when the oral mucosal irritation may turn strongly.

  (E) The lauryl sulfate of a component is widely used as a foaming agent component of a dentifrice composition, As the salt, alkali metal salts, such as sodium salt and potassium salt, are mentioned. As lauryl sulfate, sodium lauryl sulfate is particularly preferably used.

  The blending amount of lauryl sulfate is preferably 0.2 to 2.5%, particularly 0.5 to 1.5% of the entire composition. If it is less than 0.2%, sufficient foaming may not be obtained at the time of dentifrice, and the bactericidal effect may be inferior, and if it exceeds 2.5%, mucous membrane irritation may become strong.

  The blending ratio of the (D) component condensed phosphate and the (A) component isopropylmethylphenol is preferably 2 to 100 (particularly 10 to 50) of (D) component / (A) component in mass ratio. When the blending ratio is less than 2 or more than 100, there are cases where a high bactericidal effect cannot be obtained for the biofilm.

  In addition, the blending ratio of the (C) component betaine surfactant and the (E) component lauryl sulfate is such that (C) component / ( E) The component is preferably 0.1 to 5, particularly preferably 0.4 to 2. If the blending ratio of component (C) / component (E) is less than 0.1, reduction of oral mucosal irritation may not be sufficient, and if it exceeds 5, a high bactericidal effect may not be obtained for biofilms. is there.

  Furthermore, in this invention, it is preferable to mix | blend anisaldehyde as (F) component, and by adding anisaldehyde in addition to the fragrance | flavor component of (B) component, the masking effect with respect to an odor derived from isopropylmethylphenol is improved more. And a better flavor can be obtained.

  As anisaldehyde, commercially available products such as products of Taiyo Perfume Co., Ltd. can be used. The blending amount is preferably 0.0001 to 0.1%, particularly 0.001 to 0.02%, based on the total amount of the composition. If the blending amount is less than 0.0001%, the masking effect of the tastelessness may not be sufficiently enhanced. If the amount exceeds 0.1%, the flavor of the anisaldehyde itself is too strong as in the case of the component (B). May occur.

When (F) anisaldehyde is blended, the total blending amount of the (B) component and the (F) component is 0.0002 to 0.15%, particularly 0, in order to further enhance the masking effect of the taste that is derived from isopropylmethylphenol. It is desirable to be 0.002 to 0.03%. If the total blending amount is less than 0.0002%, the masking effect of disgusting may not be sufficiently enhanced, and if it exceeds 0.15%, the flavors of the components (B) and (F) themselves are too strong to cause discomfort. May occur.
As the combination of the component (B) and the component (F), a combination of 3-octanol and anisaldehyde is particularly preferable, and an especially excellent masking effect is exerted with respect to an odor derived from isopropylmethylphenol. The

  In the dentifrice composition of the present invention, in addition to the above-described constituent components, other optional components that are usually blended in the dentifrice composition can be blended as necessary within a range not impeding the effects of the present invention. For example, appropriate components such as abrasives, surfactants, thickeners, binders, sweeteners, fragrances, colorants, preservatives, pH adjusters, medicinal ingredients, and the like are blended within a range not impairing the effects of the present invention. Can do.

  As abrasives, abrasive silica, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy Examples include calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, tetracalcium phosphate, and eighth calcium phosphate. The blending amount of the abrasive is usually preferably 10 to 60%, particularly preferably 15 to 40% of the whole composition.

  As the surfactant, in addition to the (C) component betaine type surfactant and the (E) component lauryl sulfate, other anionic surfactants, nonionic surfactants, amphoteric surfactants and the like are added. May be. For example, examples of the anionic surfactant include alkyl sulfates other than lauryl sulfate, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, lauroyl sarcosine salt, and α-olefin sulfonate. Nonionic surfactants include, for example, polyoxyethylene alkyl ether, alkyl glycoside, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, fatty acid polyglyceryl, polyoxyethylene hardened castor Oil etc. are mentioned. Examples of amphoteric surfactants include N-acyl glutamate. In addition, it is preferable that the compounding quantity of these other surfactant is about 0 to 3% of the whole composition, and especially 0 to 2%.

  As a thickener, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, erythritol and other sugar alcohols, polyhydric alcohols, and the like may be blended. . The blending amount of the thickener is usually 10 to 50%, particularly 20 to 40%.

  As the binder, sodium polyacrylate, carrageenan, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose and the like can be blended. The amount of binder is usually 0.5-2%.

  As the sweetener, saccharin sodium, stevioside, neohesperidyl dihydrochalcone, perilartin, p-methoxycinnamic aldehyde, aspartame and the like can be blended.

  In addition to the component (B) and (F), other fragrances include, for example, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, Peppermint oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, Celery oil, bay oil, origanum oil, pine needle oil, neroli oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchoulia absolute, ginger Natural fragrances such as leoresin, pepper oleoresin, capsicum oleoresin, pepper extract, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powder flavor Perfume and limonene, pinene, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linalool, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol, anethole, Thymol, methylchavicol, eugenol, carvone, menthone, pregon, 1,8-cineole, yonon, caron, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl buty Rate, isoamyl acetate, hexyl acetate, ethyl 2-methylbutyrate, allyl hexanoate, allyl cyclohexane propionate, linalyl acetate, menthyl acetate, menthyl lactate, carbyl acetate, phenoxyethyl isobutyrate, methyl jasmonate, Methyl salicylate, ethyl salicylate, methyl cinnamate, methyl anthranilate, phenyl ethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, ambretlide, dimethyl sulfide, trimethylpyrazine, ethyl β -Methylthiopropionate, furaneol, ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propionic acid, p Single fragrances such as methoxycinnamic aldehyde, 3-l-menthoxypropane-1,2-diol, menthone glycerin acetal, spiranthol, monomenthyl succinate, linalool oxide, vanillyl butyl ether, isopulegol, strawberry flavor, apple flavor , Melon flavor, banana flavor, peach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor, ume flavor, orange flavor, lemon flavor, grapefruit flavor, tea flavor, butter flavor, milk flavor, etc. , And ethyl alcohol, propylene glycol, triacetin, glycerin fat Known perfume materials used in dentifrice compositions, such as perfume solvents such as acid esters, can be used in combination. Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for perfume using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a composition.

  As coloring agents, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, mica titanium, titanium oxide and the like.

  Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

  Examples of the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, glycerophosphoric acid, various salts thereof, sodium hydroxide, and the like. It is preferable that the dentifrice composition of this invention is adjusted to pH 6-10, especially 7-9.

  Medicinal ingredients include isopropylmethylphenol, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, chlorhexidine, triclosan, cetylpyridinium chloride, benzaza chloride Antibacterial substances such as luconium, benzethonium chloride, chlorhexidine salts, sorbate, hinokitiol, azulene sulfonate, proteases such as protease, glucanase, lysozyme, tranexamic acid, epsilon aminocaproic acid, allantoin, glycyrrhizic acid, glycyrrhetinic acid, etc. Anti-inflammatory substances, sodium chloride, potassium nitrate, aluminum lactate, zinc chloride, zinc citrate, strontium chloride and other inorganic salts, zeolite, copper chlorophyllin sodium, chloro And chelating compounds such as glyceryl phosphate, various vitamins such as ascorbic acid, tocopherol acetate, and pyridoxine, and natural extracts such as camphor, soft extract, duckweed extract, chamomile, clove, rosemary, ugone, safflower, etc. . The compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  The material in particular of the container which accommodates the dentifrice composition of this invention is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% is mass% unless otherwise specified.

Examples and comparative examples
A dentifrice composition having the composition shown in Tables 1 to 3 was prepared by the following production method and evaluated as follows. The results are shown in Tables 1-3.
(Production method)
(1) A phase A was prepared by mixing and dissolving the component (D) and water-soluble components (excluding the binder and propylene glycol) in purified water at room temperature.
(2) Component (A) in propylene glycol: After dissolving isopropylmethylphenol, a phase B in which a binder was dispersed at room temperature was prepared.
(3) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(4) In phase C, component (B), if necessary, component (F) and components other than water-soluble components such as fragrance components and abrasives shown in Tables 4 and 5, and (C) component, (E ) Component surfactant was mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Factory), defoamed under reduced pressure (4 kPa) to obtain 1.2 kg of a dentifrice composition.

  Each component used for the preparation of these dentifrice compositions was abrasive silica (Tixosil 73, Rhodia Nikka Co., Ltd., median diameter 14 μm), sodium lauryl sulfate (Toho Chemical Co., Ltd.), Sorbit (70% aqueous solution product, Towa Kasei Kogyo Co., Ltd.), glycerin (85% aqueous solution, Lion Chemical Co., Ltd.), isopropylmethylphenol (Osaka Kasei Co., Ltd.), coconut oil fatty acid amidopropyl betaine solution (30% aqueous solution TEGO BETAIN CK, Goldschmidt Co., Ltd.), amidopropyl betaine laurate (30% aqueous solution, Amhitoal 20AB, Kao Corporation), N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium (40% aqueous solution (solid content) , Enigol C-40H, Lion ( )), Anhydrous sodium pyrophosphate (Taihei Chemical Industrial Co., Ltd.), sodium tripolyphosphate (Taihei Chemical Industrial Co., Ltd.), 3-octanol (Shiono Fragrance Co., Ltd.), 3-octyl acetate (Inoue Fragrance Co., Ltd.) ), 3-Octanone (Inoue Fragrance Co., Ltd.), Fencon (Koei Kogyo Co., Ltd.), Anisaldehyde (Taiyo Fragrance Co., Ltd.), 1-octanol (Takasago Fragrance Co., Ltd.), other components As for sodium alginate, propylene glycol, sodium saccharin, sodium fluoride, and water, those conforming to the Quasi-drug raw material standard 2006 were used. About the component whose form is aqueous solution, all showed the compounding quantity of pure part conversion also including the table | surface. As optional fragrance components, fragrance compositions A to I were prepared and blended using the fragrance compositions shown in Tables 4 and 5.

The obtained dentifrice composition was a laminate tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, thickness 257 μm (Dai Nippon Printing Co., Ltd.) whose innermost layer was composed of linear low density polyethylene. 50 g) was filled.
The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene white LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum PET: Polyethylene terephthalate EMAA: Ethylene / methacrylic acid copolymer resin

  (1) Model biofilm bactericidal effect of dentifrice composition, (2) No taste, (3) Evaluation of foaming at the time of dentifrice, (4) Evaluation of no irritation was evaluated by the following methods.

(1) Evaluation method of model biofilm bactericidal effect Triptychase soy broth treated with human unstimulated saliva filtered through a 0.45 μm filter with a 7 mm diameter hydroxyapatite (HA) plate and added with hemin and menadione Among them, Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nuclatum, Fusobacterium nucleatum A model biofilm is formed on the HA plate by continuous culture for a week. Made. Once a day after culturing for two weeks, artificial saliva (50 mmol / L KCl + 1 mmol / L KH ₂ PO ₄ +1 mmol / L CaCl ₂ +0.1 mmol / L MgCl ₂ (pH 7.0) was added to the dentifrice formulations shown in Tables 1 to 3 below. )) Was added twice as much and dispersed, and the centrifuged supernatant was used as a test drug solution. The model biofilm was immersed in the solution for 3 minutes and further cultured for 3 days. At the end of the culture, the model biofilm was taken out, dispersed, and cultured on an agar plate to determine the number of viable bacteria of each bacterial species in the model biofilm. Although the number of viable bacteria fluctuated somewhat depending on the culture conditions, it was about 8.5 log cfu (colony forming units / HA plate) when artificial saliva was used instead of the test drug solution. The improvement effect of the model biofilm sterilization effect according to the present invention was judged according to the following evaluation criteria, and in the case of less than 5.0 log cfu / HA plate, the biofilm sterilization power was judged to be high.
A: Less than 4.5 log cfu / HA plate B: More than 4.5 log cfu / HA plate to less than 5.0 log cfu / HA plate Δ: More than 5.0 log cfu / HA plate to less than 6.0 log cfu / HA plate ×: More than 6.0 log cfu / HA board

(2) Lack of taste A sensory test was conducted using 10 expert panelists. About 1 g of the test dentifrice composition filled in an 8 mm diameter laminated tube was placed on a commercially available toothbrush and brushed for 3 minutes by the usual brushing method, and the unpleasant taste felt during use was evaluated according to the following ratings: . An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ○ were ensured on the basis of the following criteria were judged to be toothpaste compositions without taste.
(Score)
4 points: no disgusting 3 points: little disgusting 2 points: slightly disgusting 1 point: disgusting (judgment criteria for the average of the evaluation results of 10 professional panelists)
◎: 3.7 points to 4.0 points ◎ to ○: 3.3 points to less than 3.7 points ○: 3.0 points to less than 3.3 points Δ: 2.0 points to 3 points Less than 0 point x: Less than 2.0 point

(3) Evaluation of foaming at the time of dentifrice It evaluated by the sensory test using ten expert panelists. About 1.5 cm of the test dentifrice composition was placed on a toothbrush and used in a normal brushing method. The foaming of the dentifrice composition in the oral cavity during use was evaluated according to the following criteria.
4 points: The amount of foaming is sufficient and the feeling of use is excellent.
3 points: The amount of foaming is moderate and the feeling of use is satisfactory.
2 points: The amount of foaming is small and the feeling of use is slightly inferior.
1 point: There is almost no foaming and the feeling of use is bad.
The evaluation results of 10 people were averaged and indicated by the following criteria, and ◎ and ○ were judged to be a dentifrice composition that ensured foaming during dentifrice and gave a satisfactory feeling of use.
◎: Bubbling in the oral cavity is 3.5 points to 4.0 points or less ○: Bubbling in the oral cavity is 3.0 points to less than 3.5 points △: Bubbling in the oral cavity is 2.0 points Or more to less than 3.0 points x: foaming in the oral cavity is less than 2.0 points

(4) Evaluation of non-stimulation Evaluation was made by a sensory test using 10 expert panelists. About 1 g of the dentifrice was placed on a commercially available toothbrush and brushed for 3 minutes. The tongue and oral mucosal irritation felt during use was evaluated according to the following criteria.
Evaluation criteria;
4 points: no stimulation at all 3 points: little stimulation 2 points: some stimulation 1 point: there is stimulation Average evaluation results of 10 people, and ◎ and ○ evaluations are secured according to the following criteria Was determined to be an unstimulated dentifrice composition.
◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

＊：配合量は、純分換算の配合量（以下、同様。）。

*: The compounding amount is the compounding amount in terms of pure content (hereinafter the same).

  From the results shown in Table 1, the dentifrice composition containing isopropylmethylphenol of the present invention has a reduced taste taste specific to isopropylmethylphenol, exhibits a high bactericidal effect on biofilms, has little irritation to the oral mucosa, and dentifrice It was confirmed that the foaming at the time was also good.

  From the results of Table 2, if any of the essential requirements of the present invention is lacking, it is inferior to any of the tasting effects peculiar to isopropylmethylphenol, penetrating bactericidal power, irritation to oral mucosa, and foaming during dentifrice. The object of the invention could not be achieved.

  From the results in Table 3, it was found that when (F) anisaldehyde was further added in addition to the components (A) to (E), the taste was further reduced and the flavor development without taste was further enhanced.

＊＊：なお、上記香料組成中に３−オクタノール、３−オクチルアセテート、３−オクタ
ノン、フェンコン、アニスアルデヒドは含まれない。

**: In addition, 3-octanol, 3-octyl acetate, 3-octanone, Fencon, and anisaldehyde are not included in the above fragrance composition.

Claims (6)

(A) isopropylmethylphenol,
(B) 1 type, or 2 or more types of fragrance | flavor components chosen from 3-octanol, 3-octyl acetate, and 3-octanone,
(C) Fatty acid amide propyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine whose fatty acid has 12 to 14 carbon atoms,
(D) pyrophosphate and / or tripolyphosphate,
(E) A dentifrice composition comprising lauryl sulfate, wherein the blending amount of component (D) is 0.1 to 2.0% by mass. The dentifrice composition according to claim 1, wherein the blending ratio of component (D) / component (A) is 2 to 100 in terms of mass ratio. The dentifrice composition according to claim 1 or 2, wherein the mixing ratio of component (C) / component (E) is 0.1 to 5 in terms of mass ratio.   (A) 0.01-0.2 mass% of component, (B) component 0.0001-0.1 mass%, (C) component 0.1-2.0 mass%, (E) component The dentifrice composition of any one of Claims 1 thru | or 3 containing 0.2-2.5 mass%.   The dentifrice composition according to any one of claims 1 to 4, further comprising (F) anisaldehyde.   The dentifrice composition of Claim 5 which contains 0.0001-0.1 mass% of (F) component.