JP3251908B2 - Bath composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention is excellent in heat retention effect,
The present invention relates to a bath composition that is excellent in improving skin pruritus and excellent in beautiful skin effect (gloss, texture, and moist feeling).

[0002]

2. Description of the Related Art Conventional bath compositions mainly contain so-called inorganic salts such as sodium sulfate, sodium hydrogen carbonate, sodium chloride and the like, and further contain fragrances, oils, pigments and the like. Auxiliary components are appropriately blended to refresh the mood during bathing, promote blood circulation,
A wide variety of products are on the market to increase metabolism. However, the main purpose of the current bath composition is to promote blood circulation and increase metabolism, and to have a sweating effect and a warming effect.

[0003] On the other hand, skin diseases such as atopic dermatitis and senile pruritus are intense itching, and exhibit symptoms such as inflammation, keratin failure, reduced barrier ability, and dry skin. The number of people suffering from skin diseases is rapidly increasing due to bacteria, changes in living environment, and increased stress. Currently, in topical medical treatment, treatment with steroids, mainly corticosteroids, is common. However, long-term use of steroids has side effects, and their use requires careful attention under the guidance of a physician. Then, a safe skin application agent with few side effects is desired.

[0004] Conventionally, skin diseases such as eczema and other atopic dermatitis and senile pruritus tend to be prohibited from taking a bath because they have no effect of improving the symptoms. However, the effects of bath salts on skin disease patients such as atopic dermatitis and senile pruritus have also been reviewed. For example, Japanese Unexamined Patent Publication No.
285131, JP-A-8-73367, JP-A-8-99889, JP-A-9-124460 and the like. However, these bath compositions are inadequate and more desirable for improving skin pruritus while having a beautiful skin effect.

In view of such circumstances, as a result of diligent studies on bath compositions having an excellent heat retaining effect, an improvement in skin pruritus, and an excellent skin effect, a bath composition containing diisopropylamine dichloroacetate and a neem extract was found. , Diisopropylamine dichloroacetate and neem extract, and a bath composition containing 10 to 90% by weight of dried seawater and 0.1 to 5% by weight of anhydrous silicic acid are effective for heat retention, improvement of skin pruritus and skin effect (Gloss, texture and moist feeling), which has led to the completion of the present invention. The object of the present invention is to provide an excellent heat retaining effect, an excellent skin pruritus, and An object of the present invention is to provide a bath composition excellent in beautiful skin effect (skin shine, texture and moist feeling).

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide a bath composition characterized by incorporating diisopropylamine dichloroacetate and neem extract, and diisopropylamine dichloroacetate and neem extract;
And a bath composition characterized by containing 10 to 90% by weight of dried seawater and 0.1 to 5% by weight of silicic anhydride.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The details of the structure of the present invention will be described below.

[0008] The diisopropylamine dichloroacetate used in the present invention is represented by the following formula, is in the form of a white crystalline powder, has almost no smell, has a bitter taste,
Easy to dissolve in water, ethanol, etc. Its melting point is 1
The pH of a 5% aqueous solution at 18-122 ° C is 5.6-6.8.

[0009]

Embedded image

The amount of diisopropylamine dichloroacetate (hereinafter abbreviated as DADA) used in the present invention is determined based on the total amount of the bath composition.
0.1 to 20% by weight is suitable, and particularly preferably 0.5 to 10% by weight. If the amount is less than 0.1% by weight, the effect is not sufficiently developed, and if it is more than 20% by weight, the cost may not be appropriate.

The neem used in the present invention is:
It is a neem (Azadiracta indica) of a plant of the family Meliaceae.

The neem extract used in the present invention is obtained by extracting neem with an organic solvent such as methanol, ethanol, 1,3-butylene glycol, acetone, ethyl acetate, ethyl ether, chloroform, etc., and filtering or centrifuging the extract. These include those prepared by removing the residue by separation, etc., those obtained by further purifying the extract by treatment with activated carbon, synthetic polymer adsorbent, etc., and those obtained by removing these solvents and concentrating to dryness. And commercially available extractables and powders.

[0013]

The amount of the neem extract used in the present invention is suitably from 0.01 to 10% by weight, especially from 0.1 to 10% by weight, based on the total amount of the bath composition.
05-2 by weight% is preferred.

The dried seawater used in the present invention includes:
Natural salt with reduced water content using seawater as the raw material or hot water-dried or freeze-dried seawater as it is, but if necessary, salts that cause stickiness from the viewpoint of maintaining the quality stability of the bath composition To reduce
A seawater dried product which has been desalted by a so-called reverse osmosis membrane or the like, freeze-dried and pulverized is particularly preferred.

The desalted seawater dried product is rich in so-called trace elements such as magnesium, potassium, phosphorus and the like, in addition to a decrease in chlorine and sodium as compared with a product obtained by freeze-drying seawater as it is. I have. In addition, since the desalted seawater dried product has a reduced amount of salts that cause stickiness as described above, the desalted seawater dried product is required to maintain the workability when blended into the bath composition or the quality stability of the bath composition. Particularly preferred.

The amount of the dried seawater used in the present invention is 10 to 10% based on the total amount of the bath composition.
It is preferably 90% by weight, particularly preferably 10 to 60% by weight. If the amount is less than 10% by weight, the effect is not sufficiently expressed, and if it is more than 90% by weight, cost and stability are not suitable.

Dried seawater is highly hygroscopic in terms of physical properties. When flavors, other plant extracts, oils and the like which are usually added to these are added, the composition is solidified at the time of production and the fluidity is poor.
There are drawbacks in operation such as difficulty in handling during manufacture, and the appearance of the product is poor and it is difficult to come out of the container smoothly. However, these problems can be solved by adding silicic anhydride.

The silicic anhydride used in the present invention includes:
It may be a known compound produced by reacting an acid with a sodium silicate solution and decomposing it. Examples of commercially available products include commercial products such as Silopure (manufactured by Fuji Divison Chemical Co., Ltd.). In addition, the average particle diameter of 2 to 4 microns, which is generally known for these particle diameters, is preferable.

The amount of the silicic anhydride used in the present invention is 0.1 to 0.1% based on the total amount of the bath composition.
It is preferably 5% by weight, particularly preferably 0.2 to 3% by weight. When the amount is less than 0.1% by weight, the composition cannot sufficiently exhibit the anti-caking effect, and when the amount is more than 5% by weight, the appearance of the composition upon dissolution is not suitable.

In the present invention, DADA, neem extract,
The components of the bath composition that can be added to the dried seawater and the silicic acid anhydride can be appropriately selected from those commonly used in the following bath compositions.

1) Inorganic salts Sodium bicarbonate, sodium carbonate, boric acid, borax, sodium sulfate, sodium sulfide, potassium sulfide,
Sodium nitrate, calcium nitrate, ammonium sulfate,
Sodium thiosulfate, calcium hydrogen phosphate, potassium chloride, ammonium chloride, sodium phosphate, sodium hyposulfite, calcium thiosulfate, sulfur, urea, sodium sesquicarbonate, magnesium sulfate and the like.

2) Inorganic acids Metasilicic acid, boric acid, etc.

3) Organic acids Benzoic acid, citric acid, fumaric acid, tartaric acid, malic acid, salicylic acid and the like.

4) Fats and oils Olive oil, soybean oil, almond oil, castor oil, coconut oil, palm oil, turtle oil, nuka oil, jojoba oil, mink oil, egg yolk oil, squalane, avocado oil, lanolin, liquid paraffin, white Vaseline, DHA, EPA and the like.

5) Binders Sodium carboxymethylcellulose, sodium methylcellulose, casein, pectin, starch, sodium alginate, polyvinyl alcohol, polyvinylpyrrolidone, locust bean gum, carrageenan, agar, carbopol and the like.

6) Polyhydric alcohols Glycerin, propylene glycol, sorbitol, polyethylene glycol, 1,3-butylene glycol and the like.

7) Flavors Lavender oil, jasmine oil, rose oil, lemon oil, orange oil, peppermint oil, thyme oil, shobu oil, fennel oil, cedar oil, hiba oil, hinoki oil, rose oil, eucalyptus oil, camphor And natural and synthetic flavors such as peppermint oil, spearmint oil, geraniol, tangerine oil, spruce, citronellol.

8) Plant powders and herbal medicines (extracts, powders) Lemon skin, seaweed, cypress, hiba, rice bran, shrub,
Ginger, liquorice, cockroach, spruce, touki, carrot, peppermint, cabbage, squirrel, mugwort, dokudami,
Pulverized products such as peach moth, chamomile, aloe, jasmine, rose hip, lavender, guava, ogon, wolfberry, litchi, elderberry, ashitaba, okogi, burdock, licorice, and water-soluble or oil-soluble extracts thereof.

Further, the bath agent composition of the present invention may further contain, if necessary, other components, such as a bactericide, a surfactant, a vitamin, a high molecular compound, an anti-inflammatory agent and a cosmetic. A tar dye or the like can be appropriately compounded.

The amount of the bath composition of the present invention is usually 25 to 30 g per 200 l of a general bathtub.

[0031]

The present invention will be described in detail below based on examples and comparative examples.

(Production of Neem Extract) 10 l of ethanol was added to 600 g of neem leaves and stems, and the mixture was heated under reflux for 2 hours. This was repeated three times, and filtered with a filter cloth to obtain a filtrate. The filtrate was dried under reduced pressure using an evaporator to obtain about 65 g of a neem extract.

(Preparation method of seawater dried product)
After heating for a few hours, adding a small amount of bleach, stirring for 15 minutes and filtering to remove impurities, then reducing the salt of the solution using a reverse osmosis method,
After that, it is cooled, freeze-dried, and desalted seawater dried product about 30 g
I got Table 1 shows the component content of dried seawater after desalination (reverse osmosis). In addition, the desalted seawater dried product was shown in the range of the content because some variation in the component content occurred due to the collected seawater.

[0034]

[Table 1]

Examples 1 and 2 and Comparative Examples 1 to 3 Examples 1 and 2 for bath compositions having the compositions shown in Table 2
And Comparative Examples 1, 2 and 3 were evaluated. The production method followed the method of the usual bath composition. In addition, the amount of composition is shown by weight%.

[0036]

[Table 2]

(1) Skin beautiful effect evaluation method is as follows.
For 0 subjects, the feeling during bathing, the feeling after bathing, the reduction of skin pruritus, and the condition of the skin after continuous use for one week were evaluated. About 200 l of hot water at 40 ° C. was put into the bath, 30 g of the bath composition composed of each of Examples 1-2 and Comparative Examples 1-3 was charged, and the bath was bathed for 10 minutes. Very good 5
The points of 4 points, good 4 points, ordinary 3 points, no change 2 points, and bad 1 point were entered and averaged. Table 3 shows the results.

[0038]

[Table 3]

From Table 3, it is apparent that Examples 1 and 2
Compared to Comparative Examples 1, 2, and 3, the skin feels better during bathing, is less irritating, gives the bathed skin a glossy, moisturizing, moisturizing (moisturizing) effect, is superior in skin-beautifying effect, and has more skin pruritus. Alleviated.

(2) Sweating effect and warming effect (temporal changes in water evaporation and skin surface temperature) No active ingredient was added to Examples 1 and 2 and Comparative Examples 1, 2 and 3 shown in Table 4 and the bathtub. A comparison was made for a freshwater bath.
About 200 liters of hot water at 40 ° C. was put into the bathtub, and 30 g of each of Examples 1-2 and Comparative Examples 1-3 was put in the freshwater bath as it was, and the bath was bathed for 15 minutes. Bathing bath temperature is 40 ° C, bathing time is 5 minutes bathing, 5 minutes rest, 10 minutes repeating bathing, 25 ° C, 60% constant temperature and humidity room, (1) sweating effect The amount of transpiration was defined as the amount of perspiration, and the amount was measured using a ventilation capsule having an area of 1 cm ² using a hydrograph manufactured by Forshon Co., Ltd. (2) For evaluation of the heat retention effect, the temperature of the chest was measured by a thermograph manufactured by NEC Corporation.

[0041]

[Table 4]

[0042]

[Table 5]

From the results in Tables 4 and 5, it can be seen that Examples 1 and 2 have a greater amount of water transpiration even after 60 minutes of bathing than Comparative Examples 1 to 3 and a freshwater bath, and therefore have a sweating effect. The skin temperature is higher and the skin surface temperature is higher than that of the comparative example and the fresh water bath, so that the skin is more excellent in heat retention.

Example 3 and Comparative Examples 4 and 5 Example 3 was compared with Comparative Examples 4 and 5 for the bath composition having the composition shown in Table 6. The preparation method of the sample was the same as that of the usual bath composition. In addition, the amount of composition is shown by weight%.

[0045]

[Table 6]

(1) Beautiful skin effect and skin irritation evaluation method is as follows.
For 0 subjects, the feeling during bathing, the feeling after bathing, the reduction of skin pruritus, and the condition of the skin after continuous use for one week were evaluated. It carried out according to the method and evaluation described in Example 1. Table 7 shows the results.

[0047]

[Table 7]

From Table 7, it is apparent that Example 3 has a better feeling to the skin during bathing than Comparative Examples 4 and 5, has no irritation, and gives a gloss, texture, and moist feeling (moisturizing property) to the skin after bathing.
And it was recognized that the skin pruritic effect was improved and the skin pruritus was also improved.

(2) Sweating effect and heat retention effect (temporal change of water evaporation and skin surface temperature) The sweating effect (water evaporation) described in Example 1 for Example 3, Comparative Example 4 and Comparative Example 5 shown in Table 6 Amount) and the heat retention effect (skin surface temperature) were measured according to the respective tests.

[0050]

[Table 8]

[0051]

[Table 9]

From the results shown in Tables 8 and 9, Example 3 shows that
Compared to Comparative Examples 4 and 5, even at 60 minutes after bathing, the amount of water transpiration was large, so the sweating action was higher, and the skin surface temperature was higher than that of Comparative Example and freshwater bath. Excellent heat retention.

[0053]

As described above, the present invention is superior to conventional bath compositions in terms of heat retention, skin pruritus, and skin beautification (smoothness, texture and moist feeling). It is clear to provide an improved bath composition.

──────────────────────────────────────────────────の Continued on the front page Examiner Ikuharu Oya (56) References JP-A-2000-86495 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/50 CA (STN )

Claims (2)

(57) [Claims] 1. A bath composition comprising diisopropylamine dichloroacetate and neem extract. 2. A bath composition comprising the diisopropylamine dichloroacetate and neem extract according to claim 1, 10 to 90% by weight of dried seawater and 0.1 to 5% by weight of silicic anhydride. object.