JP2775482B2 - Indoor acaricide - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to an acaricide for indoor use, comprising a selected aromatic aldehyde or aromatic carboxylic acid ester derivative as an active ingredient.

[Conventional technology]

An extremely large variety of mites inhabit the earth. For example, citrus spider mites and spider mites, which are parasitic on plants, cause great damage to agricultural crops. These acaricides for agricultural use have been developed for a long time, and new promising compounds have recently been discovered one after another.

On the other hand, due to changes in the living environment in recent years, household mites,
Dust mites, dust mites, and the like are generated, causing not only discomfort but also problems such as causing allergic asthma and rash. It has been known that organophosphorus agents such as sumithion and diazinon are effective for these indoor mites, but there is an obstacle to practical use due to safety and resistance to humans and livestock.

Recently, the application of highly safe pyrethroids and acaricides using terpene compounds have been disclosed in JP-A-63-104905 and JP-A-1-163104, but the control effect is not necessarily. Unsatisfactory, and attempts to use acaricides instead of acaricides are not a fundamental extermination method because they only move the habitat, and the development of an accurate acaricide is desired. That is the current situation.

[Problems to be solved by the invention]

The present invention solves the problem of toxicity to humans and animals having the conventional indoor acaricide, disadvantages such as insufficient control effect,
An object of the present invention is to provide an indoor acaricide that is excellent in safety and effectiveness, and is inexpensive and easy to use.

[Means for solving the problem]

To achieve the above object, the present inventors have made intensive studies and found that p-anisaldehyde, m-anisaldehyde, heliotropin, methyl p-anisate, methyl m-anisate, methyl o-anisate and phenyl An indoor acaricide containing one or more selected from the group consisting of ethyl acetate as an active ingredient exhibits a high acaricidal effect on mites, such as house dust mites, mites, dust mites, which live in houses. In addition, they have found that they have low toxicity and completed the present invention.

The compound group used in the present invention is widely used as a fragrance, but is known to exhibit no insecticidal properties,
This discovery of acaricidal effect was completely unexpected.

 The structural formula of the compound group is as follows.

(1) p-anisaldehyde (2) m-anisaldehyde (5) Heliotropin (6) Methyl p-anisate (7) methyl m-anisate (8) O-Methyl anisate (9) Ethyl phenylacetate The active ingredient of the indoor acaricide of the present invention is usually a liquid or a solid, and the active ingredient can be applied as it is. However, it is usually preferable to use an appropriate carrier or other compounding agents. Depending on the purpose, it is used in various forms, for example, emulsions, wettable powders, powders, oils, aerosols, coatings, tablets and the like.

In addition, the above-mentioned active ingredient has a higher volatility than a conventional acaricide, and is so-called heat-evaporated by a suitable heat-evaporator after being impregnated in a room-temperature sustained-release preparation or an appropriate support such as a pulp plate. It is also possible to apply as a heating transpiration agent or a smoke agent. As a liquid carrier, for example,
Water, alcohols (methyl alcohol, ethyl alcohol, ethylene glycol, etc.), ketones (acetone,
Methyl ethyl ketone, cyclohexanone, etc.), ethers (ethyl ether, dioxane, cellosolves, etc.),
Aliphatic hydrocarbons (gasoline, kerosene, kerosene, etc.),
Aromatic hydrocarbons (benzene, toluene, xylene, methylnaphthalene, etc.), halogenated hydrocarbons (dichloromethane, trichlorobenzene, Freon 113, Freon 114B
Etc.), esters, acid amides, nitriles and the like are suitable, and one or a mixture of two or more thereof is used. Suitable solid carriers include, for example, clays (kaolin, bentonite, etc.), talc, silicas, calcium carbonate, alumina powder, activated carbons, wood flour, starch, plant powders such as flour, cyclodextrin and the like. And mixtures of one or more of these are used. Further, as the compounding agent, an emulsifier, a dispersant, a spreading agent, a propellant, a penetrant, a surfactant, a stabilizer, a film forming agent, a volatilization modifier, and the like are appropriate, and one or more of these may be used. Is used.

Examples of the coating film forming agent include cellulose derivatives, vinyl resins, alkyd resins, urea resins, silicone resins, urethane resins, epoxy resins, and the like. Decane, cyclododecane, 2,4,6-triisopropyl-1,3,5
-Trioxane, sublimable carriers such as trimethylene norbornene, and as a retention agent, for example, butyl stearate,
Examples include higher fatty acid esters such as isopropyl myristate, piperonyl butoxide, and sinepirin 500.

Further, the indoor acaricide of the present invention may contain various insecticides, synergists, antioxidants, fungicides, fungicides, repellents, fragrances, coloring agents, and the like. As pesticides that can be blended,
Aresulin, d-T80-aresulin, praletrin, d
-T80-Flamethrin, d-T80-phthalsulin, d-T8
0-resmethrin, phenothrin, permethrin, cyphenothrin, cypermethrin, fenvalerate,
Examples include pyrethroid compounds such as etofenprox, organic phosphorus compounds such as fenitrothion, diazinon and pyridafenthion, and carbamate compounds such as NAC, MTMC, and PHC. Further, the indoor acaricide of the present invention may be combined with a volatile insecticide such as empentrin, DDVP, or paradichlorobenzene, naphthalene, or camphor, or a repellent such as diet, N-butylacetanilide, or N, N-diethylsuccinate. Can be mixed as appropriate to obtain a multipurpose acaricide having an excellent effect.

The amount of the active ingredient and the amount used in the indoor acaricide of the present invention are appropriately determined according to the dosage form, the application target, the application method, the application place, and the like. For example, for the control of mites that inhabit the mites such as mites, 0.1 mg or more, preferably 1 mg to 2 g of the above-mentioned active ingredient per tatami, and for the control of Dermatophagoides mite that inhabits carpets, 0.5 mg to ² g per 1 m2 are used. It is desirable to process the active ingredients.

The present invention also provides a miticide obtained by holding the above-mentioned acaricide on a substrate. The mite control material is used as a film, a sheet, a cushion, a filler for bedding, a building material, and a construction material having mite control properties by utilizing the properties of the base material. Here, as the substrate, for example,
Synthetic resin sheets such as polyethylene, polypropylene, polyester, ethylene-vinyl acetate, animal and plant or inorganic fibrous sheets, and natural cotton, synthetic fiber cotton, feathers, buckwheat hulls, foam plastic, etc. as cushioning and bedding fillers Is raised.

As a preferred embodiment of the tick control material provided by the present invention, a tick control carpet can be exemplified. The mite control carpet is an indoor carpet of the present invention having a liquid form in which, for example, a normal carpet including a pile, a first base cloth, a packing agent, and a second base cloth is prepared, and then a film forming agent is added as necessary. Spray-applying the acaricide or prior to the preparation of the carpet, at least one of a pile, a first base fabric and a second base fabric is treated with the indoor acaricide of the present invention, and the carpet is used using these. Is obtained. The mite control carpet created as described above,
It is preferable to about 0.1~10g hold the active ingredient per carpet area 1 m ^2.

The acaricide for indoor use of the present invention thus obtained or a mite control material obtained by retaining the same exhibits a high extermination effect on various mites, and particularly exhibits bronchial asthma, atopic dermatitis, nasal allergy and the like. For the control of Dermatophagoides, Dermatophagoides and Dermatophagoides pteronyssinus, which are said to cause, Dermatophagoides farinae and Dermatophagoides, such as Dermatophagoides farinae and Dermatophagoides farinae, which are regarded as pathogens of allergic diseases and mite mites in humans. It is extremely useful.

Hereinafter, the present invention will be described in more detail with reference to Test Examples and Examples, but the present invention is not limited to the following Examples as long as the gist is not exceeded.

Test Example 1 0.5 ml of a 10 mM acetone solution of the test compound was dropped on a 5 cm × 10 cm rectangular filter paper, air-dried, and 50 to 150 Dermatophagoides farinae were released between two folds.

This two-fold filter paper is put into two acrylic cylinders (inner diameter 4.1cm,
After fixing it with a rubber band, place it in a container with a cap of 1 (27-28 ° C, 65% RH), leave it for 24 hours, count the number of live mites and dead mites, and test each sample The acaricidal efficacy of the compounds was investigated. In addition, as a control compound, pyrethroid compound d-T80-resmethrin and JP-A-1-163
Citral and carvone disclosed in Japanese Patent Publication No. 104 were used.

As a result of the test, the selected aromatic aldehyde or aromatic carboxylic acid ester derivative used in the present invention shows high contact acaricidal activity against Dermatophagoides farinae, and the control compound d-T80-resmethrin and JP-A-1-163104 are disclosed. The disclosed citral and carvone were much better.

Test Example 2 A test was conducted using the same apparatus as in Test Example 1 in order to examine the acaricide efficacy of the test compound on volatile compounds.

A 100 mM acetone solution 10 of the test compound was applied to about 1 cm square fabric.
After dropping 0 μl (200 μl in the case of Acarina mites), air-drying and placing it on the bottom of the lower acrylic cylinder, 100-200 Dermatophagoides farinae or Acarina mites were placed between two untreated folded papers and placed in one container. After leaving for 24 hours,
The number of live mites and the number of dead mites were counted, and the lethal efficacy of each test compound volatilized was determined. The results are as shown in the table below.

In addition, empentrin which is a volatile volatile pyrethroid, citral, and citronellal were used as control compounds.

As a result of the test, it was confirmed that the selected aromatic aldehyde or aromatic carboxylate derivative used in the present invention has extremely high acaricidal effect on volatile molecules, and is useful for application to sustained-release preparations and heat evaporation preparations. Was done.

On the other hand, it was also revealed that empentrin, which is widely used as an insect repellent, and citral and citronellal disclosed in JP-A-1-163104 have very weak acaricidal efficacy.

Example 1 To 10 g of each of the above compound Nos. (1), (2), (5), (6) and (9), a very small amount of a fragrance and kerosene were added to make a total of 120 ml, which was mixed with liquefied petroleum gas and dimethyl ether. After filling 180 ml of the mixture (1: 1 volume ratio) into a pressure-resistant can for aerosol, an injection device was attached to obtain an acaricide for indoor use of the present invention in the form of an aerosol.

20ml per 1m ² in the carpet house dust mite has occurred
One day after the injection, the number of mites in the carpet was observed. The ratio of the number of dead mites to the number of collected mites was 90% or more.

Example 2 A carpet treated with the indoor acaricide of the present invention according to the specifications shown in the following table was produced.

The compound numbers are the same as those of the above compound examples.

The carpet treated with the acaricide of the present invention is cut into a size of 20 × 20 cm, a tick culture medium containing about 5,000 Dermatophagoides farinae is placed in the center, stored at 25 ° C. and 60% RH for 2 days, and then carpeted with a vacuum cleaner. Suck the mites on the front or back, count the number of live mites according to the prescribed method, X: The number of surviving mites in the carpet untreated Y drug; The mortality was determined by the number of surviving mites in the carpet treated with the acaricide.

In addition, these carpets confirmed the usefulness of the indoor acaricide of the present invention without any problem in terms of odor and irritation.

Example 3 8 g of a gelling agent was added to 2 g of each of the above compound Nos. (2), (5) and (8) to prepare a tablet-form acaricide for indoor use of the present invention in a conventional manner.

When two tablets (packaged with Japanese paper) were stored in a cloth bag storing the futon, no mites were found on the futon.

〔The invention's effect〕

INDUSTRIAL APPLICABILITY The indoor acaricide of the present invention is excellent in safety and usability and exhibits high acaricidal efficacy based on containing an aromatic aldehyde or an aromatic carboxylic acid ester derivative selected as an active ingredient. .

Claims (1)

(57) [Claims] 1. One or two members selected from the group consisting of p-anisaldehyde, m-anisaldehyde, heliotropin, methyl p-anisate, methyl m-anisate, methyl o-anisate and ethyl phenylacetate. An acaricide for indoor use, comprising at least one species as an active ingredient.