JP2644285B2 - Surface treatment method of Ni-Ti-based shape memory alloy implant for bioimplantation - Google Patents
Surface treatment method of Ni-Ti-based shape memory alloy implant for bioimplantationInfo
- Publication number
- JP2644285B2 JP2644285B2 JP63141503A JP14150388A JP2644285B2 JP 2644285 B2 JP2644285 B2 JP 2644285B2 JP 63141503 A JP63141503 A JP 63141503A JP 14150388 A JP14150388 A JP 14150388A JP 2644285 B2 JP2644285 B2 JP 2644285B2
- Authority
- JP
- Japan
- Prior art keywords
- shape memory
- memory alloy
- implant
- based shape
- bioimplantation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
- A61C2008/0046—Textured surface, e.g. roughness, microstructure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C2201/00—Material properties
- A61C2201/007—Material properties using shape memory effect
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ceramic Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Dental Prosthetics (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明はNi−Ti系形状記憶合金からなる生体埋入用イ
ンプラントの表面処理方法に関するもので、特にインプ
ラントとして生体との適合性を改善するものである。Description: FIELD OF THE INVENTION The present invention relates to a method for treating a surface of an implant for living body implantation made of a Ni-Ti based shape memory alloy, and in particular, to improve compatibility with a living body as an implant. Things.
Ni−Ti系形状記憶合金とは、NiとTiを原子比で1:1と
した金属間化合物にごく近い組成からなる合金で、室温
付近で熱弾性型マルテンサイト変態を起し、この変態を
境に特異な現象の一つである形状記憶効果を示す。即ち
変態点以上の温度において所望形状に成形し、これを変
態点以下の温度で変形しても、変態点以上の温度に昇温
すると、所望の形状に回復する。Ni−Ti系形状記憶合金
はこのような形状記憶効果を利用し、種々の分野に応用
され、医療分野においても1970年代の後半から米国を中
心に始められた。適用分野としては整形外科、外科につ
いで歯科が多い。歯科分野においては歯科矯正ワイヤー
としての応用、歯列鋳造による補綴物への応用、人工歯
根としてのインプラントへの応用が期待されている。A Ni-Ti shape memory alloy is an alloy that has a composition very close to an intermetallic compound in which the atomic ratio of Ni and Ti is 1: 1.It causes a thermoelastic martensitic transformation near room temperature and causes this transformation. It shows the shape memory effect, one of the phenomena peculiar to the boundary. That is, even if a desired shape is formed at a temperature equal to or higher than the transformation point and is deformed at a temperature equal to or lower than the transformation point, when the temperature is increased to a temperature equal to or higher than the transformation point, the shape is restored. Utilizing such shape memory effect, Ni-Ti based shape memory alloys have been applied to various fields, and the medical field was started mainly in the United States from the latter half of the 1970s. As an application field, there are many dentistry after orthopedic surgery and surgery. In the field of dentistry, applications as orthodontic wires, applications to prostheses by dentition casting, and applications to implants as artificial dental roots are expected.
抜歯などによって喪失した歯を補うため、歯槽部に人
工的な歯根を埋込む骨内インプラントは、義歯に比較し
て咬合性がよく、装着感に優れている。Ni−Ti系形状記
憶合金インプラントはブレードの先端を加熱による形状
記憶効果によって形状を変化させ、骨内保持力を高める
と同時に、咬合力を分散して沈下を減少した人工歯根で
ある。実用化されている人工歯根はブレード先端部が交
互に曲げられており、手術前にまっすぐにのばして歯槽
部の骨に形成した溝に挿入する。埋入後加熱して形状記
憶効果により先端部を骨内に張り出させて固定する。An intraosseous implant in which an artificial root is implanted in the alveolar portion to make up for a tooth lost due to tooth extraction or the like has better occlusalness than a denture and is excellent in wearing feeling. The Ni-Ti-based shape memory alloy implant is an artificial tooth root in which the shape of the tip of the blade is changed by a shape memory effect by heating to increase the intraosseous retention force, and at the same time, disperse the occlusal force to reduce the subsidence. Practical artificial dental roots have alternately bent blade tips, and are straightened before surgery and inserted into grooves formed in the alveolar bone. After implantation, it is heated and the tip is extended into the bone by the shape memory effect and fixed.
Ni−Ti系形状記憶合金からなる生体埋入用インプラン
トを生体に埋め込んで使用する場合、最も重要な問題は
生体との適合性である。Ni−Ti系形状記憶合金について
生体適合性に関する研究は、新材料であるためと、手間
と時間のかかる実験であるため、それほど多くない。従
ってこれ等の研究を進めると共に、良好な生体適合性を
得るため、最適な表面処理方法の開発が望まれている。When implanting a living body implant made of a Ni-Ti based shape memory alloy into a living body, the most important problem is compatibility with the living body. Studies on biocompatibility of Ni-Ti based shape memory alloys are not so many because they are new materials and because they are laborious and time-consuming experiments. Therefore, development of an optimal surface treatment method is desired in order to advance these studies and obtain good biocompatibility.
本発明はこれに鑑み種々検討の結果、生体埋入用Ni−
Ti系形状記憶合金インプラントの生体適合性を向上する
表面処理方式を開発したものである。In view of this, the present invention has been subjected to various studies, and as a result, Ni-
We developed a surface treatment method to improve the biocompatibility of Ti-based shape memory alloy implants.
即ち本発明は、Ni−Ti系形状記憶合金からなる生体埋
入用インプラントにおいて、生体との適合性を良好にす
るため、インプラントをフッ硝酸水溶液中で洗浄処理す
ることを特徴とするもので、フッ硝酸水溶液にフッ酸1,
硝酸4,水５の水溶液を用い、２〜10分間洗浄処理する。That is, the present invention provides a bioimplantable implant made of a Ni-Ti-based shape memory alloy, in which the implant is washed in an aqueous solution of hydrofluoric nitric acid in order to improve compatibility with the living body. Hydrofluoric acid 1,
Washing treatment is performed for 2 to 10 minutes using an aqueous solution of nitric acid 4 and water 5.
本発明において、フッ硝酸水溶液による洗浄処理とい
う化学的な方法を選択した理由は、機械的な研摩では表
面の凹凸を激しく、良好な生体への適合性が得られない
ためである。また洗浄液にフッ酸1,硝酸4,水５のフッ硝
酸水設液を用い、洗浄時間を２〜10分間と限定したの
は、この範囲内において、Ni−Ti系形状記憶合金インプ
ラントは表面状態が良好で、生体との適合性が優れてお
り、洗浄時間が２分未満では洗浄が不十分でインプラン
ト表面に酸化膜が残留し、10分を越えるとインプラント
表面にエッチピットが形成され、表面の平坦度が悪くな
る。In the present invention, the reason for selecting the chemical method of cleaning treatment with an aqueous solution of hydrofluoric-nitric acid is that mechanical polishing produces severe irregularities on the surface, and good compatibility with living organisms cannot be obtained. The reason why the cleaning solution used was a hydrofluoric acid solution of hydrofluoric acid 1, nitric acid 4, and water 5 and the cleaning time was limited to 2 to 10 minutes. If the cleaning time is less than 2 minutes, the cleaning is insufficient and the oxide film remains on the implant surface. The flatness of the film becomes worse.
Ni51.0at％,Ti49.0at％のNi−Ti系形状記憶合金を黒
鉛ルツボを用いて溶解し、金型に鋳造した。このインゴ
ットを熱間で鍛造した後、熱間圧廷と冷却圧延を加え、
厚さ1.3mm、幅5mm、長さ7mmの試験片を作製し、大気中5
50℃において形状記憶処理を行なった。これについて表
面に付着している酸化皮膜を取除くため、第１表に示す
洗浄処理を行ない更に蒸溜水で超音波洗浄を行なって動
物実験を行ない生体との適合性を評価した。その結果を
第１表に併記した。A Ni-Ti based shape memory alloy of 51.0 at% Ni and 49.0 at% Ti was melted using a graphite crucible and cast into a mold. After hot forging this ingot, hot pressing and cold rolling are added,
1.3mm thick, 5mm wide, 7mm long test specimens were prepared.
Shape memory treatment was performed at 50 ° C. In order to remove the oxide film adhering to the surface, cleaning treatment shown in Table 1 was performed, and ultrasonic cleaning was performed with distilled water, and an animal experiment was performed to evaluate compatibility with a living body. The results are shown in Table 1.
尚フッ硝酸水溶液としては、フッ酸1,硝酸4,水５の水
溶液を用いた。また生体との適合性が良好なものを○
印、やや劣るものをΔ印、悪いものを×印で表わした。As the aqueous solution of hydrofluoric acid, an aqueous solution of hydrofluoric acid, nitric acid 4, and water 5 was used. Good compatibility with living organisms
A mark, a slightly inferior one was represented by a Δ, and a poor one was represented by an X.
第１表から明らかなように、サンドブラストやバレル
研摩の機械的方法で表面処理を行なったものは、表面の
起伏が激しく、生体の適合性が悪い。これに対しフッ硝
酸水溶液で洗浄処理する化学的な方法では生体との適合
性が良く、特に２〜10分の洗浄処理によるものは、滑ら
かな表面状態を示し、生体との適合性が良好である。 As is clear from Table 1, those subjected to surface treatment by mechanical methods such as sand blasting and barrel polishing have severe surface undulations and poor biocompatibility. On the other hand, the chemical method of washing with an aqueous solution of hydrofluoric-nitric acid has good compatibility with the living body, and particularly, the one obtained by the washing treatment for 2 to 10 minutes shows a smooth surface state and has good compatibility with the living body. is there.
このようにNi−Ti系形状記憶合金を生体埋入用インプ
ラントとして用いる場合、フッ硝酸水溶液にて表面処理
することにより、生体適合性を著しく向上し、歯科領域
に留まらず、整形外科、外科、その他各科の医療分野に
おけるNi−Ti系形状記憶合金の応用において極めて多大
な効果を奏するものである。In the case where the Ni-Ti shape memory alloy is used as a bioimplant as described above, biocompatibility is significantly improved by surface treatment with a hydrofluoric nitric acid aqueous solution, and not only in the dental area, but also in orthopedic surgery, surgery, and the like. In addition, the present invention has an extremely great effect in the application of the Ni-Ti based shape memory alloy in the medical fields of various departments.
Claims (2)
インプラントにおいて、生体との適合性を良好にするた
め、インプラントをフッ硝酸水溶液中で洗浄処理するこ
とを特徴とする生体埋入用Ni−Ti系形状記憶合金インプ
ラントの表面処理。1. An implant for implanting a living body comprising a Ni-Ti based shape memory alloy, wherein the implant is washed in an aqueous solution of hydrofluoric nitric acid in order to improve compatibility with the living body. Treatment of Ni-Ti shape memory alloy implant for dental use.
溶液を用い、２〜10分間洗浄する請求項（１）記載の生
体埋入用Ni−Ti系形状記憶合金インプラントの表面処理
方法。2. The surface of a Ni-Ti-based shape memory alloy implant for bioimplantation according to claim 1, wherein the aqueous solution of hydrofluoric acid, nitric acid and water is used for washing for 2 to 10 minutes. Processing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63141503A JP2644285B2 (en) | 1988-06-10 | 1988-06-10 | Surface treatment method of Ni-Ti-based shape memory alloy implant for bioimplantation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63141503A JP2644285B2 (en) | 1988-06-10 | 1988-06-10 | Surface treatment method of Ni-Ti-based shape memory alloy implant for bioimplantation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01310664A JPH01310664A (en) | 1989-12-14 |
| JP2644285B2 true JP2644285B2 (en) | 1997-08-25 |
Family
ID=15293467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63141503A Expired - Fee Related JP2644285B2 (en) | 1988-06-10 | 1988-06-10 | Surface treatment method of Ni-Ti-based shape memory alloy implant for bioimplantation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2644285B2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2141056B1 (en) * | 1998-05-21 | 2000-10-16 | Univ Catalunya Politecnica | NEW MATERIALS FOR YUXTAOSEO IMPLANTS. |
| US6447664B1 (en) * | 1999-01-08 | 2002-09-10 | Scimed Life Systems, Inc. | Methods for coating metallic articles |
| US7695471B2 (en) | 2003-04-18 | 2010-04-13 | The University Of Hong Kong | Fixation device |
| CN100432257C (en) | 2003-04-18 | 2008-11-12 | 香港大学 | Shape memory material and its preparation method |
| WO2008064517A1 (en) * | 2006-11-27 | 2008-06-05 | Lifetech Scientific (Shenzhen) Co., Ltd. | Method for preparing a coating on the surface of medical devices made of nickel-titanium alloy |
| CN103271761B (en) | 2008-01-14 | 2015-10-28 | 康文图斯整形外科公司 | For the apparatus and method of fracture repair |
| ES2733729T3 (en) | 2010-01-20 | 2019-12-02 | Conventus Orthopaedics Inc | Bone access device and cavity preparation |
| JP6539652B2 (en) | 2013-12-12 | 2019-07-03 | コンベンタス オーソピディックス， インコーポレイテッド | Tissue displacement tools and methods |
| US10918426B2 (en) | 2017-07-04 | 2021-02-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for treatment of a bone |
| CN115155090B (en) * | 2022-06-29 | 2023-09-05 | 天津众业建设工程有限公司 | Energy-saving and environment-friendly distillation system for fine chemical engineering |
-
1988
- 1988-06-10 JP JP63141503A patent/JP2644285B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01310664A (en) | 1989-12-14 |
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