JP2553906B2 - Hair nourishment - Google Patents

Description

TECHNICAL FIELD The present invention relates to a new hair nourishing agent effective for normalizing the human scalp and hair (including a medicated hair nourishing agent which is a quasi drug and an external skin agent which is a drug). The same shall apply hereinafter), and its purpose is to provide a hair nourishing agent effective for the prevention or treatment of scalp and hair dandruff, itching or hair loss.

(Prior art and its problems) Conventionally, it has been proposed to mix various drugs for the prevention or treatment of dandruff, kayumi, or hair loss on the scalp and hair, but the efficacy, safety or stability of the drug has been suggested. From the aspect, there are few things that can be sufficiently satisfied.

Traditionally, female hormone agents, cembly extract, hinokitiol, capsicum tincture, cantharitin tincture, cepharanthin, carpronium chloride, etc. have been used for this purpose, but they are not yet satisfactory and their effects have been questioned academically. There are many things that have been done.

(Progress of Invention) The present inventor has conducted earnest research to develop a truly effective hair nourishing agent.

Neurospora sitophila
The fermentation product of was found to have a very effective action against stains, freckles, hadare, etc., leading to the completion of excellent skin cosmetics, but in the course of this research, this fermentation product At the same time, they have found the fact that they have an extremely effective action against dandruff, kayumi, etc., and thus are effective in preventing or treating hair loss.

That is, Neurospora sitop
As a fermentation product using hila), there is Ontjom, which is a traditional Indonesian fermented food.
This uses peanuts or soybeans as a raw material, and is a fermented food as excellent as natto in Japan.

However, they are used exclusively for food,
There are no examples used as hair restorer.

This fermentation product has a very effective action on spots, freckles, hadare, etc., and at the same time, it was found that it is effective for dandruff, Kayumi, hair loss, etc. by including it in a hair restorer. And this invention was completed.

(Means for Solving the Problem) In the present invention, Neurospora
sitophila) fermented product containing a fermented product, the fermented product is a fermented product, a fermented liquor or an extract thereof, a hair nourishing product, a fermented product, an onchome (Ontjom ) Is a hair nourishing agent,
Fermentation product is a fermentation product obtained by allowing Neurospora sitophila to act on a medium containing peanuts and / or soybeans, a hair nourishment, peanuts and / or soybeans, Processed goods,
The above problems are solved by providing a hair nourishing agent characterized by being a cooked product or a composition separated therefrom.

(Constitution of the Invention) Neurospora sitophila
The medium used in the action of is not particularly limited, but the bacteria used in the practice of the invention can be satisfactorily propagated, and the fermentation product has a composition that effectively acts on dandruff, itchiness, hair loss, etc. Any medium may be used as long as it contains the components.

Any nitrogen source may be used as long as it can assimilate Neurospora sitophila, for example, casein peptone, whey protein, skim milk, malt extract, yeast extract, defatted soybean, potato extract, corn extract, various kinds. Protein degradation products,
Organic nitrogen sources such as amino acids and inorganic nitrogen sources such as ammonium salts and nitrates can be used alone or in combination.

As a carbon source, Neurospora sitophila (Neuros
As long as pora sitophila) can be assimilated, glucose, galactose, raffinose, sucrose, lactose, dextrin, glycerin and the like can be used.

If necessary, depending on the medium, inorganic salts such as phosphates, hydrochlorides, magnesium salts, potassium salts, vitamins, amino acids, lipids or proliferative factors rich in these are added. be able to.

However, as is clear from the course of the invention, more preferably, heat-treated peanut meal or soybean is used.

That is, a method of producing onjom is sufficient.

Usually, steamed peanut, peanut meal or soybean is used as it is, but if necessary, the above-mentioned nitrogen source, carbon source, growth factor and the like can be added thereto.

Neurospora sitophila
The method for fermenting lactic acid depends on the type of bacterium to be used and the type of medium, but as a practically convenient and advantageous method, the following method can be mentioned.

The peanuts are carefully selected, washed, and then immersed in water overnight to absorb water sufficiently.

The peanuts that have absorbed water are removed from the seed coat and steamed.

Steamed peanuts, after draining well, corn,
Add starch such as rice and cassava to form a kamaboko mold.

Pre-cultured Neurospora sitophila (Neur
ospora sitophila) spores at a temperature of 27-30 ° C
The fermented product can be obtained by culturing in the fermentation chamber for ~ 72 hours.

Neurospora sitophila used in the fermentation of the present invention may be used any strain, the fermentation product obtained, for dandruff, Kayumi, hair loss, etc., having a preventive or therapeutic effect If so, the strain is not particularly limited.

Those isolated from the natural world, or artificial or natural mutants thereof can be used.

In actually using these fermentation products,
It is also possible to use the fermented product as it is, but since it contains a large amount of insoluble solids such as peanuts, a fermented liquid obtained by squeezing the fermented product or a solvent extract or a concentrate thereof is used more effectively. Can be done.

In the case of a squeezed fermentation liquid, the active ingredient may remain in a large amount in the residue, so it is more preferably extracted with a suitable solvent before use.

The solvent used is not particularly limited as long as it can effectively extract a component having a preventive or therapeutic effect against dandruff, itchiness, hair loss, etc. from the fermented product.

More preferably, water or ethanol or a mixture thereof can be used.

The resulting Neurospora Citophila (Neuros
The fermented solution or fermented extract obtained by the action of pora sitophila) can be used alone as a hair nourishing agent as it is, but as a raw material for hair nourishing agents, it is usually used as a lotion, hair oil, hair liquid, hair. It can be used by blending it with cream, shampoo, conditioner and the like.

In this case, it is more preferable to use a concentrate or a dried product.

In addition, a hair nourishing agent can be produced by simultaneously blending other hair-producing agents such as female hormone, assembly extract, cantharisin tincture, cepharantin, and calipronium chloride.

The fermentation product thus obtained acts extremely effectively for the prevention or treatment of dandruff, itchiness, hair loss, etc., but the active ingredient in the fermentation product and its mechanism of action are not yet clear.

In the fermentation products, various amino acids, peptides, various sugars, various organic acids such as citric acid, vitamins
It contains various vitamins such as B ₆ , vitamin B ₁₂ and nicotinic acid, and various inorganic salts, and imparts preferable properties as a hair nourishing agent.

In particular, Neurospora sitopira
As a feature of hila), it produces a large amount of carotenoid pigment having a vitamin A effect and is extremely effective for hair growth.

Furthermore, the fermentation product contains a large number of other unknown compounds, and it is considered that these compounds exert an additive or synergistic effect to exert the effect.

Therefore, it is not always necessary to identify and isolate the active ingredient for use in a hair nourishment.

In addition, as a characteristic point of the fermentation product,
This product emits a sweet fruit-like ester scent, and does not require the addition of synthetic fragrances which have been regarded as problems in terms of safety.

(Effect of the invention) This invention is Neurospora s
Since it relates to a hair nourishing agent containing a fermentation product of itophila), it is effective in preventing or treating dandruff, itching or hair loss of the scalp and hair.

Next, the effects will be made more clear by describing Examples and Experimental Examples.

(Examples and Experimental Examples) Example 1 (Neurospora sitophila (Neuros
Preparation of the extract of the fermented product obtained by the action of pora sitophila) 100 g of the carefully selected peanuts are thoroughly washed with water and then soaked in water overnight for sufficient water absorption.

 The peanuts that have absorbed water are steamed after removing the seed coat.

The steamed peanuts are spread quickly in a container and cooled while removing moisture as much as possible.

When the temperature drops to 90 ° C, add about 10% of starch and mix well to gelatinize a part of the mixture to form a binder.

When the temperature further dropped to 30 ° C., the corn was molded into a kamaboko mold, placed on a plastic tray, and preheat-sterilized corn was inoculated with Neurospora sitophila by slope culture, and then inoculated at 27 ° C. for 3 days. After cultivation, inoculate the cells that have been dried at low temperature.

Put it in the fermentation room and incubate it at a temperature of 27 ℃ for 48 hours.
A lump-shaped fermentation product of

This fermented product was quickly mixed well with 600 cc of a mixed liquid of water and ethanol (1 part of water and 9 parts of ethanol) with a mixer and then suction filtered, and the residue was washed well with the same mixed liquid to obtain a fermented product extract solution of 1.

Further, this filtrate was subjected to sterilization filtration with a membrane filter.

Example 2 (Preparation of Aqueous Extract of Fermented Material Obtained in Example 1) 120 g of the fermented material obtained in Example 1 was thoroughly mixed with 600 cc of water and then suction filtered, and the residue was washed well with water, and A fermented product extract was obtained.

Further, this liquid was subjected to sterilization filtration with a membrane filter.

Example 3 (Preparation of Extract of Fermented Product Obtained by Acting Neurospora sitophila on Peanut Meal) 60 g of defatted peanut meal and 60 g of hot water were added, and steamed at 100 ° C. for 1 hour.

This was treated in the same manner as in Example 1 to obtain a fermented product extract.

Example 4 (Preparation of Extract of Fermentation Product Obtained by Acting Neurospora sitophila on Soybean) 100 g of carefully selected soybean is thoroughly washed with water and then immersed in 0.1% lactic acid aqueous solution overnight to absorb water sufficiently.

The soybean that has absorbed water is removed from the seed coat and steamed at 100 ° C. for 1 hour.

This was treated in the same manner as in Example 1 to obtain a fermented product extract.

Example 5 (Preparation of Extract of Fermentation Product Obtained by Acting Neurospora cytophylla) 30 g of corn extract, 5 g of skim milk, 1 g of glucose, and 0.5 g of yeast extract are added with water to prepare a total liquid medium of 1.

This was placed in a 2 volume jar and sterilized at 120 ° C. for 15 minutes, and the inoculum of Neurospora cytophyra obtained in Example 1 was inoculated into this medium and shake-cultured at 30 ° C. for 1 hour.

After this culture was suction-filtered, the filtrate was further sterilized by filtration through a membrane filter to obtain a fermentation solution of about 950 cc.

Experimental Example 1 (Effect of Fermented Product Extract or Fermented Solution Obtained in Examples 1, 2, 3, 4 and 5) Fermented Product Extract or Fermentation Obtained in Examples 1, 2, 3, 4 and 5 A 20% liquor was prepared for each liquor and the hair growth effect on rabbits was tested as follows. (However, the concentration of ethanol was adjusted to about 60%.) Twenty-five rabbit (12-week-old) males were divided into 5 groups, and their back hairs were trimmed with electric clippers, and 2 times a day on the right side. The control solution was applied to the left side of the test solution, and after 2 weeks, the length of the extended hair was measured.

 The results are shown in Table 1.

Experimental Example 2 (Effect of hair nourishing agent containing the fermented product extract obtained in Example 1) With respect to four types of hair nourishing agents shown in Table 2 below, the hair growth effect on rabbits was tested as follows. .

20 male rabbits (12 weeks old) were divided into 4 groups, the hair on the back was cut with an electric clipper, the test hair nourishing agent was applied to the right side twice a day, and the control solution was applied to the left side. Two weeks later The length of the extended hair was measured.

 The results are shown in Table 3.

Experimental Example 3 (Effect of hair nourishing agent obtained in Experimental Example 2 No. 4 in Table 2 on dandruff and itch) The following tests were carried out.

(1) Subjects: 24 males (21 to 54 years old) who complain of dandruff and kayumi violently (2) Test method The subjects were asked to apply 2 to 4 cc of hair nourishment twice a day every morning and evening, and self-evaluate the improvement effect one month later. Let

(3) Evaluation The effects of self-evaluation are classified as follows.

Effective: Almost all dandruff and kayumi disappeared.

Slightly effective: Dandruff and Kayumi still existed, but worked well.

Ineffective: Little or no effect on dandruff and kayumi.

 The evaluation results are shown in Table 4.

Experimental Example 4 (Effect of the hair nourishing agent obtained in No. 4 of Table 2 of Experimental Example 2 on alopecia areata) The effects on alopecia areata were tested as follows.

(1) Test subject Nine male patients diagnosed with alopecia areata (19 to 51 years old) (2) Test method A test subject was applied to the entire head twice daily in the morning and evening, and lightly massaged, and then on the affected area. 2 to 4 cc was applied and massaged well, and the improvement effect was evaluated 3 months later.

(3) Evaluation This symptom was evaluated as follows.

Effective: The hair loss part disappears, or the hair loss part is macroscopically contracted, or the hair loss part has black hair although the density is not high.

Somewhat effective: the hair loss area is slightly reduced visually,
Thin hair-like hairs are scattered around the hair loss area.

Invalid: The symptom has little change or has worsened.

 The evaluation results are shown in Table 5.

Example 6 (Preparation of shampoo containing fermented product extract obtained in Example 5) Formulation wt% Fermented product extract obtained in Example 5 10.0 Polyoxyethylene lauryl ether sodium sulfate (2E.O) 8.5 lauryl Dimethylaminoacetate betaine 5.0 1,3-butylene glycol 4.0 Lauric acid diethanolamide 2.0 Edetate disodium 0.1 Preservative proper amount Fragrance proper amount Purified water balance The shampoo prepared by the above formulation was used three times a week for three months, and dandruff, Kayumi disappeared almost completely, leaving her shiny and supple hair.

Example 7 (Preparation of rinse containing fermented product extract obtained in Example 2) Formulation wt% Fermented product extract obtained in Example 2 10.0 Polyoxyethylene oleyl ether (7E.O.) 2.0 Chlorinated chloride Ruconium 3.0 Distearyldimethylammonium chloride 2.0 1,3-butylene glycol 4.0 Fragrance Suitable amount Purified water balance The rinse prepared by the above formulation was used after shampooing three times a week for three months after shampooing.
Kayumi almost disappeared.

Further, it was more effective to use the shampoo prepared in Example 6 at the same time.

Claims (5)

(57) [Claims] 1. A neurospora s.
A hair nourishing agent containing a fermentation product of (itophila). 2. The hair nourishing agent according to claim 1, wherein the fermentation product is a fermentation product, a fermentation liquid or an extract thereof. 3. The hair nourishing agent according to claim 1 or 2, wherein the fermentation product is Ontjom. 4. The fermentation product is a fermentation product obtained by allowing Neurospora sitophila to act on peanut and / or soybean or a medium containing them. 1 to claim 3
Stated hair nourishment. 5. The hair nourishing agent according to claim 4, wherein the peanut and / or soybean is a processed product, a cooked product, or a composition separated from them.