JP2024101622A - Blood Purification Device - Google Patents

Abstract

To recover prescribed liquid remaining in a liquid supply channel as much as possible while suppressing reduction in an inflow amount of the prescribed liquid to a blood circuit.SOLUTION: In a blood purification device 1 based on the present disclosure, a sensor 71 is provided in a detection object part located on the upstream side with respect to a first valve 40V in a liquid supply channel 40. A control unit 90 executes first step S10 of receiving from a sensor 71 an input of a signal that indicates that the liquid in the liquid supply channel 40 virtually becomes empty in the detection object part when the first valve 40V is open and a liquid supply pump 40P is running, second step S20 of determining whether or not the liquid supply pump 40P dispenses a prescribed amount of the prescribed liquid after the first step S10, and third step S30 of stopping the operation of the liquid supply pump 40P when it is determined that the liquid supply pump 40P has dispensed the prescribed amount of the prescribed liquid in the second step S20.SELECTED DRAWING: Figure 6

Description

This disclosure relates to a blood purification device.

JP 2020-000803 A (Patent Document 1) discloses a conventional blood purification device. This blood purification device includes a blood purifier, an upstream blood pipeline, a downstream blood pipeline, a replacement fluid pipeline, a drainage pipeline, a blood pump, a second pump that pumps the replacement fluid, a third pump that pumps the drainage fluid, and a first valve that opens and closes the replacement fluid pipeline. The upstream end of the replacement fluid pipeline is connected to a first supply source that supplies the replacement fluid and the first fluid, which is a dialysis fluid.

JP 2020-000803 A

When performing plasma exchange (PE) using a blood purification device, for example, fresh frozen plasma (FFP) or albumin preparations are used as the liquid to be introduced into the blood circuit. Such liquids are relatively expensive. For this reason, it is desirable to use up as much of the specified liquid to be introduced into the blood circuit as possible. However, if the liquid supply pump continues to operate even after the amount of liquid remaining in the liquid supply line becomes small in order to fully use up (recover) this liquid, the amount of the liquid flowing into the blood circuit will decrease compared to the flow rate set by the liquid supply pump that was previously set.

The present disclosure has been made in consideration of the above problems, and aims to provide a blood purification device that can recover as much of the specified liquid remaining in the liquid supply pipeline as possible while suppressing a decrease in the amount of the specified liquid flowing into the blood circuit.

The blood purification device according to the present disclosure includes a blood purifier, an arterial blood circuit, a venous blood circuit, a liquid supply line, a drain line, a blood pump, a liquid supply pump, a drain pump, a first valve, a sensor, and a control unit. The arterial blood circuit is connected to the blood purifier. The arterial blood circuit is a circuit for making blood flow into the blood purifier. The venous blood circuit is connected to the blood purifier. The venous blood circuit is a circuit for making blood flow out of the blood purifier. The liquid supply line is connected to the blood purifier, the arterial blood circuit, or the venous blood circuit, and supplies a predetermined liquid. The drain line flows the drained liquid discharged from the blood purifier. The blood pump is provided in the arterial blood circuit and pumps out blood. The liquid supply pump is provided in the liquid supply line and pumps out the predetermined liquid. The drain pump is provided in the drain line and pumps out the drained liquid. The first valve is provided in the liquid supply line and opens and closes the liquid supply line. The sensor is provided in a detection target portion located upstream of the first valve in the liquid supply pipe. The sensor can detect that the liquid supply pipe is substantially empty at the detection target portion. The control unit controls at least the liquid supply pump and the first valve in response to an input from the sensor. The control unit performs a first step of receiving an input of a signal indicating that the liquid supply pipe is substantially empty at the detection target portion when the first valve is open and the liquid supply pump is operating, a second step of determining whether the liquid supply pump has flowed a predetermined amount of the predetermined liquid after the first step, and a third step of stopping the operation of the liquid supply pump when it is determined in the second step that the liquid supply pump has flowed the predetermined amount of the predetermined liquid.

According to the present disclosure, even after the sensor detects that the detection target portion is empty of the specified liquid, the liquid supply pump continues to operate, so that as much of the specified liquid remaining in the liquid supply pipeline as possible can be recovered. In addition, by setting the device to allow only a specified amount of the specified liquid to flow after the sensor detects, a decrease in the inflow rate of the specified liquid into the blood circuit can be suppressed.

1 is a circuit diagram showing a configuration of a blood purification device according to an embodiment of the present disclosure. 4 is a block diagram showing the electrical connection relationship between a control unit and each component of the blood purification device according to one embodiment of the present disclosure. FIG. FIG. 11 is a flow diagram showing the flow of a first liquid recovery process in an embodiment of the present disclosure. 11 is a circuit diagram showing a state of the blood purification device when it is determined that the weight of the first weighing bag is not equal to or less than a threshold in one embodiment of the present disclosure. FIG. 10 is a circuit diagram showing a state of the blood purification device when it is determined that the weight of the first weighing bag is equal to or less than a threshold in an embodiment of the present disclosure. FIG. 11 is a flow diagram showing the flow of a second liquid recovery process in an embodiment of the present disclosure. FIG. FIG. 2 is a circuit diagram showing a state of a blood purification device when detected by a sensor in one embodiment of the present disclosure. 1 is a circuit diagram showing an example of a state of a blood purification apparatus when the operation of a liquid supply pump is stopped in an embodiment of the present disclosure. FIG.

A blood purification device according to one embodiment of the present disclosure will be described below with reference to the drawings. In the following description of the embodiment, the same or corresponding parts in the drawings will be given the same reference numerals, and their description will not be repeated.

In the following description of the embodiment, a blood purification device used for plasma exchange (PE) will be described as a blood purification device. However, the blood purification device may be a blood purification device used for any of continuous blood purification therapy (CBP), continuous renal replacement therapy (CRRT), continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), continuous hemodialysis (CHD), and slow continuous ultrafiltration (SCUF).

Figure 1 is a circuit diagram showing the configuration of a blood purification device according to one embodiment of the present disclosure. Figure 2 is a block diagram showing the electrical connection relationship between the control unit of a blood purification device according to one embodiment of the present disclosure and each component.

As shown in Figures 1 and 2, the blood purification device 1 according to one embodiment of the present disclosure includes a blood purifier 10, an arterial blood circuit 20, a blood pump 20P, a venous blood circuit 30, a liquid supply line 40, a liquid supply pump 40P, a first valve 40V, a drainage line 50, a fourth valve 50V, a drainage pump 50P, a first connection line 60, a second valve 60V, a first measuring bag 61, a second connection line 62, a third valve 62V, a second measuring bag 63, an attachment unit 64, a scale 65, a sensor 71, an alarm unit 80, and a control unit 90.

The blood purifier 10 includes a semipermeable membrane, for example a hollow fiber membrane, inside. The blood purifier 10 has a blood inlet 11, a blood outlet 12, and a drainage outlet 13. The blood inlet 11 is connected to an arterial blood circuit 20. The blood outlet 12 is connected to a venous blood circuit 30. The drainage outlet 13 is connected to a drainage pipeline 50.

The arterial blood circuit 20 is connected to the blood purifier 10 and is a circuit for feeding blood into the blood purifier 10. The blood pump 20P is provided in the arterial blood circuit 20 and pumps out blood. In the arterial blood circuit 20, an arterial air trap chamber 21 is provided between the blood pump 20P and the blood purifier 10.

The blood collected from the patient's artery flows through the arterial blood circuit 20, and the pressure is measured by a pressure gauge as it passes through the arterial air trap chamber 21. The arterial air trap chamber 21 is provided to prevent air from mixing with the blood in the arterial blood circuit 20.

The venous blood circuit 30 is connected to the blood purifier 10 and is a circuit for discharging blood from the blood purifier 10. The venous blood circuit 30 is provided with a venous air trap chamber 31.

The blood purified by the blood purifier 10 flows through the venous blood circuit 30, has its pressure measured by a pressure gauge as it passes through the venous air trap chamber 31, and is then returned to the patient's veins. The venous air trap chamber 31 is provided to prevent air from mixing with the blood in the venous blood circuit 30.

The liquid supply line 40 is connected to the blood purifier 10, the arterial blood circuit 20, or the venous blood circuit 30, and supplies a specified liquid to the blood circuit.

In this embodiment, the liquid supply line 40 is connected to the venous blood circuit 30. More specifically, the liquid supply line 40 is connected upstream of the venous air trap chamber 31 in the venous blood circuit 30. In other words, the liquid supply line 40 is connected between the blood purifier 10 and the venous air trap chamber 31 in the venous blood circuit 30. The blood purification device 1 employs the so-called post-dilution method.

In this embodiment, the specified liquid is specifically a replacement fluid. The liquid supply line 40 is specifically a replacement fluid line, and the liquid supply pump 40P described later is specifically a replacement fluid pump. Note that the specified liquid is not limited to replacement fluid, and may be a treatment fluid. When the specified liquid is a treatment fluid, the liquid supply line 40 is connected to the blood purifier 10, the liquid supply line 40 is specifically a treatment fluid line, and the liquid supply pump 40P described later is a treatment fluid pump.

The liquid supply pump 40P is provided in the liquid supply line 40 and pumps out the above-mentioned specified liquid. The liquid supply pump 40P is a peristaltic finger type pump, but may also be a roller type pump.

The first valve 40V is provided in the liquid supply line 40 and opens and closes the liquid supply line 40. The first valve 40V is provided in the liquid supply line 40 upstream of the liquid supply pump 40P.

The liquid supply pipeline 40 has a detection target 41 in which a sensor 71 is provided. The detection target 41 is located upstream of the first valve 40V in the liquid supply pipeline 40.

The liquid supply pipe 40 has an upstream end 42 and a downstream end 43. The upstream end 42 is provided with a supply source 44 in which the above-mentioned specified liquid is stored. The upstream end 42 is located approximately above the detection target portion 41. The downstream end 43 is connected to the arterial blood circuit 20 or the venous blood circuit 30, and in this embodiment, is connected to the venous blood circuit 30.

The liquid supply line 40 is further provided with a plurality of liquid heaters 45 for heating the above-mentioned specified liquid. The liquid heaters 45 are provided downstream of the liquid supply pump 40P. In other words, the liquid heaters 45 are provided in the liquid supply line 40 between the liquid supply pump 40P and the venous blood circuit 30.

The drainage line 50 carries the drainage liquid discharged from the blood purifier 10. The drainage pump 50P is provided in the drainage line 50 and pumps out the drainage liquid. The drainage pump 50P is a peristaltic finger pump, but may also be a roller pump.

The fourth valve 50V is provided in the drainage line 50 and opens and closes the drainage line 50. The fourth valve 50V is provided downstream of the drainage pump 50P.

A drain tank 51 is connected to the downstream end of the drain line 50. The drain tank 51 stores the drainage discharged from the blood purifier 10.

The first connection line 60 is connected between the liquid supply pump 40P and the first valve 40V in the liquid supply line 40. The second valve 60V is provided in the first connection line 60.

The first measuring bag 61 is provided at the end of the first connection line 60 opposite the liquid supply line 40. The first measuring bag 61 is configured to temporarily store the specified liquid that has flowed in from the liquid supply line 40 and to be able to send the stored specified liquid to the liquid supply line 40. The first measuring bag 61 is a soft bag that does not have any holes for venting air.

The second connection line 62 is connected between the drainage pump 50P and the fourth valve 50V in the drainage line 50. The third valve 62V is provided in the second connection line 62.

The second weighing bag 63 is provided at the end of the second connection line 62 opposite the drainage line 50. The second weighing bag 63 is configured to temporarily store the drainage liquid flowing in from the drainage line 50 and to be able to send the stored drainage liquid to the drainage line 50. The second weighing bag 63 is a soft bag that does not have any holes for venting air.

A first weighing bag 61 and a second weighing bag 63 are attached to the mounting portion 64. The weight measuring portion of the scale 65 is connected to the mounting portion 64. In this embodiment, the scale 65 is a load cell, but it may also be a spring scale or the like.

The scale 65 is configured to measure the total weight of the items attached to the attachment portion 64 (in this embodiment, the first weighing bag 61 and the second weighing bag 63) and output the measured weight value to the control unit 90. Therefore, for example, when the third valve 62V is closed, the control unit 90 can measure the change over time in the weight of the first weighing bag 61.

The sensor 71 is provided in the detection target 41 located upstream of the first valve 40V in the liquid supply pipe 40. The sensor 71 is configured to be able to detect when the liquid in the liquid supply pipe 40 has been substantially emptied in the detection target 41. The sensor 71 is a so-called ultrasonic transmission type empty detector, and more specifically, is an ultrasonic sensor that can detect when air bubbles are present in the specified liquid flowing in the detection target 41 of the liquid supply pipe 40.

The blood purification device 1 further includes a setting input unit 72 connected to the control unit 90. The setting input unit 72 accepts input from the user. Specifically, it accepts input of various treatment conditions, such as input of flow rate settings for each pump, such as the blood pump 20P, the liquid supply pump 40P, and the drainage pump 50P. The setting input unit 72 can also accept input of the value of the "predetermined amount" after detection by the sensor 71, and input of a specific value of the "threshold value" in the liquid recovery process described below.

The specific device of the setting input unit 72 is not particularly limited, but examples include a touch screen in which a touch panel that accepts touch input from the user and a display are superimposed.

When the control unit 90 receives an input from the sensor 71, the alarm unit 80 is caused to issue an alarm by the control unit 90. The alarm unit 80 may be, for example, an alarm lamp, or a display connected to the control unit 90. When the alarm unit 80 is a display, the alarm is issued, for example, by displaying a warning screen.

The control unit 90 is electrically connected to the gravity measuring unit of the scale 65, the sensor 71, the setting input unit 72, the blood pump 20P, the liquid supply pump 40P, the drainage pump 50P, the first valve 40V, the second valve 60V, the third valve 62V, the fourth valve 50V, the alarm unit 80, and each of the various pressure gauges. The control unit 90 is also configured to be able to control the blood pump 20P, the liquid supply pump 40P, the drainage pump 50P, the first valve 40V, the second valve 60V, the third valve 62V, the fourth valve 50V, and the alarm unit 80 in response to inputs from the scale 65, the sensor 71, the setting input unit 72, and each of the various pressure gauges.

The following describes the liquid recovery process, which is a process executed by the control unit 90 when recovering the above-mentioned specified liquid in the first measuring bag 61 and the liquid supply line 40 in the blood purification device 1.

In the liquid recovery process, the control unit 90 executes a first liquid recovery process to recover the specified liquid in the first measuring bag 61, and then executes a second liquid recovery process to recover the specified liquid in the liquid supply line 40. First, the flow of the first liquid recovery process will be described.

Figure 3 is a flow diagram showing the flow of the first liquid recovery process in one embodiment of the present disclosure. As shown in Figure 3, the control unit 90 first determines whether the weight of the first weighing bag 61 is equal to or less than a predetermined threshold value based on the weight value input from the scale 65 (S01). The threshold value may be a set value stored in the control unit 90 by a user input from the setting input unit 72, or it may be a value previously stored in the control unit 90 regardless of user input. The threshold value is, for example, 5 g.

Figure 4 is a circuit diagram showing the state of the blood purification device when it is determined that the weight of the first weighing bag is not equal to or less than the threshold in one embodiment of the present disclosure. As shown in Figures 3 and 4, when the control unit 90 determines that the weight of the first weighing bag 61 is not equal to or less than the threshold (NO in S01), it closes the first valve 40V and opens the second valve 60V, and operates the liquid supply pump 40P (S02). This stops the supply of the specified liquid from the supply source 44 provided at the upstream end 42 of the liquid supply line 40, and allows as much of the specified liquid remaining in the first weighing bag 61 as possible to be recovered.

In addition, in this embodiment, the control unit 90 opens the fourth valve 50V during step S02 or before step S02, and also operates the blood pump 20P and the drainage pump 50P. This allows the patient to continue being treated during the liquid recovery operation. Furthermore, during step S02, the control unit 90 closes the third valve 62V. This makes it possible to measure the change in weight of the first weighing bag 61 over time.

After step S02, the control unit 90 again determines whether the weight of the first weighing bag 61 is equal to or less than the threshold (S03). FIG. 5 is a circuit diagram showing the state of the blood purification device when it is determined that the weight of the first weighing bag is equal to or less than the threshold in one embodiment of the present disclosure. As shown in FIGS. 3 and 5, when it is determined that the weight of the first weighing bag 61 is equal to or less than the threshold (YES in S03), the first valve 40V is opened and the second valve 60V is closed (S04). This makes it possible to recover as much of the above-mentioned predetermined liquid remaining in the first weighing bag 61 as possible and then move to the second liquid recovery process (a process of recovering the predetermined liquid in the liquid supply pipe 40). When it is determined in step S02 that the weight of the first weighing bag 61 is not equal to or less than the threshold (NO in S03), step S03 is executed again.

If it is determined in step S01 that the weight of the first weighing bag 61 is equal to or less than the threshold value (YES in S01), the first valve 40V is opened, the second valve 60V is closed, and the liquid supply pump 40P is operated (S05). This allows the process to proceed to the second liquid recovery process (the recovery process of the specified liquid in the liquid supply line 40) after confirming that the amount of the specified liquid remaining in the first weighing bag 61 is already small. In step S05, as in step S02, the control unit 90 closes the third valve 62V and opens the fourth valve 50V during or before step S05, and operates the blood pump 20P and the drainage pump 50P.

After the first liquid recovery process described above, the blood purification device 1 proceeds to the second liquid recovery process. Next, the second liquid recovery process will be described.

Figure 6 is a flow diagram showing the flow of the second liquid recovery process in one embodiment of the present disclosure. Figure 7 is a circuit diagram showing the state of the blood purification device when detected by the sensor in one embodiment of the present disclosure. As shown in Figures 6 and 7, when the first valve 40V is open, the second valve 60V is closed, and the liquid supply pump 40P is operating, the control unit 90 receives an input of a signal from the sensor 71 indicating that the liquid supply line 40 at the detection target portion 41 has been substantially emptied of liquid (first step S10). In other words, the input of this signal indicates that the above-mentioned specified liquid in the supply source 44 connected to the upstream end 42 of the liquid supply line 40 has been used up.

After the first step S10, the control unit 90 stops the alarm unit 80 from issuing an alarm (S11). This makes it possible to suppress unnecessary alarms from being issued by the alarm unit 80 during the second liquid recovery process, specifically, during the recovery of the above-mentioned specified liquid in the liquid supply line 40.

After the first step, the control unit 90 determines whether the liquid supply pump 40P has flowed a predetermined amount of the predetermined liquid (second step S20). The predetermined amount may be a set value stored in the control unit 90 by a user input from the setting input unit 72, or may be a value that is stored in advance in the control unit 90 regardless of user input.

If the control unit 90 determines in the second step S20 that the liquid supply pump 40P has not flowed the predetermined amount of the specified liquid after detection by the sensor 71 (NO in the second step S20), it performs the processes of step S11 and the second step S20 again. That is, after the first step S10, the control unit 90 stops the alarm unit 80 from issuing an alarm until it determines that the liquid supply pump 40P has flowed the predetermined amount of the specified liquid.

When the control unit 90 determines in the second step S20 that the liquid supply pump 40P has flowed a predetermined amount of the predetermined liquid (YES in the second step S20), it stops the operation of the liquid supply pump 40P (third step S30). FIG. 8 is a circuit diagram showing an example of the state of the blood purification device when the liquid supply pump is stopped in one embodiment of the present disclosure. As shown in FIG. 8, by stopping the operation of the liquid supply pump 40P after the liquid supply pump 40P has flowed a predetermined amount of the predetermined liquid, it is possible to recover (use) as much of the predetermined liquid remaining in the liquid supply pipe 40 as possible while suppressing a decrease in the inflow amount of the predetermined liquid in the liquid supply pipe 40 to the blood circuit (venous blood circuit 30).

In addition, in this embodiment, in the third step S30, the drainage pump 50P is stopped in conjunction with the stopping of the operation of the liquid supply pump 40P. This stops the inflow of the specified liquid and the outflow of the drainage liquid. Furthermore, in the third step S30, the first valve 40V and the fourth valve 50V are closed to more reliably stop the inflow of the specified liquid and the outflow of the drainage liquid.

The "predetermined amount" of the above-mentioned predetermined liquid is the volume of the above-mentioned predetermined liquid estimated based on the set flow rate value of the liquid supply pump 40P in the second liquid recovery process (i.e., the set value of the volume of the above-mentioned predetermined liquid to be moved per unit time), and may differ from the net cumulative flow rate of the above-mentioned predetermined liquid. Specifically, the "predetermined amount" is calculated by multiplying the set flow rate value of the liquid supply pump 40P by the operation time of the liquid supply pump 40P. The "predetermined amount" is preferably set to a predetermined volume corresponding to the volume of the liquid supply pipe 40. This makes it possible to recover the above-mentioned predetermined liquid in the liquid supply pipe 40 by the amount of the predetermined volume corresponding to the volume of the liquid supply pipe 40. The "predetermined volume" corresponding to the volume of the liquid supply pipe 40 may be, for example, the total volume of the liquid supply pipe 40 from the upstream end 42 to the downstream end 43, or may be the volume from the detection target portion 41 to the downstream end 43. The "predetermined volume" is, for example, about 70 mL.

Then, as shown in FIG. 6, the control unit 90 stops the operation of the liquid supply pump 40P in the third step S30 and causes the alarm unit 80 to sound (step S31). This allows the user to easily recognize that the recovery process of the specified liquid has been completed.

As described above, in one embodiment of the present disclosure, the sensor 71 is provided in a detection target portion located upstream of the first valve 40V in the liquid supply pipe 40. The sensor 71 can detect that the liquid in the liquid supply pipe 40 has become substantially empty at the detection target portion. The control unit 90 controls at least the liquid supply pump 40P and the first valve 40V in response to the input from the sensor 71. When the first valve 40V is open and the liquid supply pump 40P is operating, the control unit 90 performs a first step S10 of receiving an input of a signal indicating that the liquid in the liquid supply pipe 40 has become substantially empty at the detection target portion from the sensor 71, a second step S20 of determining whether the liquid supply pump 40P has flowed a predetermined amount of the predetermined liquid after the first step S10, and a third step S30 of stopping the operation of the liquid supply pump 40P when it is determined in the second step S20 that the liquid supply pump 40P has flowed the predetermined amount of the predetermined liquid.

With the above configuration, even after the sensor 71 detects that the specified liquid has been depleted in the detection target portion 41, the liquid supply pump 40P can be kept running to recover as much of the specified liquid remaining in the liquid supply pipeline 40 as possible. In addition, by setting the specified liquid to flow only at a specified amount after the sensor 71 detects, a decrease in the inflow rate of the specified liquid into the blood circuit can be suppressed.

The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims, not by the above description, and is intended to include all modifications within the meaning and scope of the claims.

1 Blood purification device, 10 Blood purifier, 11 Blood inlet, 12 Blood outlet, 13 Drain outlet, 20 Arterial blood circuit, 20P Blood pump, 21 Arterial air trap chamber, 30 Venous blood circuit, 31 Venous air trap chamber, 40 Liquid supply line, 40P Liquid supply pump, 40V First valve, 41 Detection target, 42 Upstream end, 43 Downstream end, 44 Supply source, 45 Liquid heater, 50 Drain line, 50P Drain pump, 50V Fourth valve, 51 Drain tank, 60 First connection line, 60V Second valve, 61 First measuring bag, 62 Second connecting line, 62V Third valve, 63 Second measuring bag, 64 Mounting section, 65 Scale, 71 Sensor, 72 Setting input section, 80 Alarm section, 90 Control section.

Claims (3)

Blood purifier,
an arterial blood circuit connected to the blood purifier for allowing blood to flow into the blood purifier;
a venous blood circuit connected to the blood purifier for allowing blood to flow out of the blood purifier;
a liquid supply line connected to the blood purifier, the arterial blood circuit, or the venous blood circuit, for supplying a predetermined liquid;
a drainage pipe through which the drainage liquid discharged from the blood purifier flows;
a blood pump provided in the arterial blood circuit for pumping blood;
a liquid supply pump provided in the liquid supply line for pumping out the predetermined liquid;
a drainage pump provided in the drainage pipeline for pumping out the drainage liquid;
a first valve provided in the liquid supply line for opening and closing the liquid supply line;
a sensor provided in a detection target portion located upstream of the first valve in the liquid supply pipeline, the sensor being capable of detecting that the liquid in the liquid supply pipeline has been substantially depleted in the detection target portion;
a control unit that controls at least the liquid supply pump and the first valve in response to an input from the sensor,
The control unit is
a first step of receiving an input of a signal from the sensor indicating that the liquid supply line has become substantially empty of liquid at the detection target portion when the first valve is open and the liquid supply pump is operating;
a second step of determining whether or not the liquid supply pump has flowed a predetermined amount of the predetermined liquid after the first step;
and a third step of stopping operation of the liquid supply pump when it is determined in the second step that the liquid supply pump has flowed the predetermined amount of the predetermined liquid. The control unit further includes an alarm unit that issues an alarm when the control unit receives an input from the sensor,
2. The blood purification apparatus according to claim 1, wherein the control unit stops the alarm from issuing an alarm until the liquid supply pump flows the predetermined amount of the predetermined liquid after the first step. a first connection line connected between the liquid supply pump and the first valve in the liquid supply line;
a first measuring bag provided at an end of the first connecting pipeline opposite to the liquid supply pipeline, the first measuring bag being capable of temporarily storing the predetermined liquid flowing in from the liquid supply pipeline and discharging the stored predetermined liquid;
a second valve provided in the first connecting line;
a mounting portion to which the first weighing bag is attached;
a scale connected to the mounting portion, capable of measuring a weight of an article attached to the mounting portion including the first weighing bag, and outputting the measured weight value to the control portion;
The control unit is
3. The blood purification apparatus according to claim 1, further comprising: a step of determining, before the first step, whether or not the weight of the first weighing bag is equal to or less than a predetermined threshold based on a weight value input from the scale; and, if it is determined that the weight is not equal to or less than the threshold, closing the first valve and opening the second valve to operate the liquid supply pump; and, if it is determined that the weight is equal to or less than the threshold, opening the first valve and closing the second valve to operate the liquid supply pump.

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