JP2021107345A - Disinfectant - Google Patents

Abstract

To provide a disinfectant that exhibits excellent disinfecting effect even if diluted with tap water into a low concentration when in use.SOLUTION: Benzyl alkyl (C16-18) dimethyl ammonium salt makes it possible to exhibit excellent disinfecting effect even if diluted with tap water into a low concentration level of about several ppm.SELECTED DRAWING: None

Description

The present invention relates to a sterilizing agent that exhibits an excellent sterilizing effect even when diluted with tap water and used at a low concentration. The present invention also relates to a detergent composition using the disinfectant.

Generally, in an environment where water flows temporarily, such as inside a toilet bowl, minerals and organic substances form insoluble salts, and dark stains derived from microorganisms such as bacteria and molds are likely to occur using them as substrates. It is common practice to impart a sterilizing action to a detergent composition used for a water-related product in which such microorganisms are likely to adhere or propagate.

On the other hand, benzalkonium chloride is a component containing benzyldodecyldimethylammonium chloride and / or benzyltetradecyldimethylammonium chloride as a main component, and is known to be a compound capable of exerting a bactericidal action by a quaternary ammonium cation. There is. Conventionally, various cleaning agent compositions containing benzalkonium chloride and imparting a bactericidal action have been reported (see, for example, Patent Document 1).

However, the conventional cleaning agent composition containing benzalkonium chloride has a drawback that it cannot exert a sufficient sterilizing effect in an actual usage environment such as cleaning a toilet.

Special Table 2012-515726A

The present inventor has conducted various studies on the sterilizing performance of benzalkonium chloride. As a result, when the main component of ordinary benzalkonium chloride is used at a low concentration of several ppm, the sterilizing effect becomes insufficient. I found the drawback. Furthermore, some of the main components of ordinary benzalkonium chloride have a sterilizing effect even when diluted with purified water to a low concentration of several ppm, but they have such characteristics. However, it was found that when diluted with tap water to a low concentration of several ppm, the sterilization effect is significantly reduced. Due to these drawbacks, ordinary benzalkonium chloride has the problem that even if it is used as a disinfectant, it cannot achieve the desired disinfectant effect in an actual usage environment such as cleaning a toilet. I understand.

Therefore, an object of the present invention is to provide a sterilizing agent that exhibits an excellent sterilizing effect even when diluted with tap water to a low concentration and used.

The present inventors have conducted diligent studies to solve the above problems, and found that the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt is excellent even when diluted with tap water to a low concentration of several ppm level. It was found that it can produce a sterilizing effect. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. A disinfectant containing a benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt as an active ingredient.
Item 2. Item 2. The disinfectant according to Item 1, wherein the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt is benzylcetyldimethylammonium chloride and / or benzylstearyldimethylammonium chloride.
Item 3. Item 2. The disinfectant according to Item 1 or 2, which is diluted with tap water and used.
Item 4. A detergent composition containing the disinfectant according to any one of Items 1 to 3 and a surfactant.
Item 5. Item 2. The detergent composition according to Item 4, which is diluted with tap water and used.
Item 6. Item 4. The cleaning agent composition according to Item 4 or 5, which is a cleaning agent for toilet bowls.

The disinfectant of the present invention has an excellent disinfecting effect even when diluted with tap water to a low concentration and used. Even if it is blended with the composition and used, an excellent sterilizing effect can be obtained.

1. 1. Disinfectant The disinfectant of the present invention is characterized by containing a benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt as an active ingredient. Hereinafter, the disinfectant of the present invention will be described in detail.

[Benzyl alkyl (16 to 18 carbon atoms) dimethylammonium salt]
Benzylalkyl (16-18 carbon atoms) dimethylammonium salt is a salt of a compound in which an alkyl group having 16-18 carbon atoms (hereinafter referred to as a long-chain alkyl group) and two methyl groups are bonded to an amino group of benzylammonium. Yes, it is a compound whose sterilizing effect is not known conventionally. Benzalkonium chloride salt is known as a sterilizing component, but benzalkonium chloride salt contains benzyldodecyldimethylammonium chloride and / or benzyltetradecyldimethylammonium chloride as a main component, and is used in the present invention. The alkyl (16 to 18 carbon atoms) dimethylammonium salt itself is not used as an active ingredient for eradication.

The long-chain alkyl group in the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt may be linear or branched, but is preferably linear. Further, examples of the long-chain alkyl group in the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt include an alkyl group having 16 or 18 carbon atoms, and more preferably an alkyl group having 18 carbon atoms.

Specific examples of the salt form in the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt include halide salts such as chlorides, bromides, and iodides. Among these, chloride is preferably mentioned.

Specific examples of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt include benzylcetyldimethylammonium chloride and benzylstearyldimethylammonium chloride.

In the disinfectant of the present invention, one type of benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt may be used alone, or two or more types may be used in combination. For example, a benzylcetyl dimethylammonium salt and a benzylstearyldimethylammonium salt may be used in combination.

[Other sterilizing ingredients]
The disinfectant of the present invention may contain other disinfectant components in addition to the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt.

Examples of the sterilizing component include a benzylalkyl (8 to 14 carbon atoms) dimethylammonium salt (a chloride salt of a compound in which an alkyl group having 8 to 14 carbon atoms and two methyl groups are bonded to an amino group of benzylammonium. Etc.); benzethonium salt such as benzethonium chloride; cetylpyridinium salt such as cetylpyridinium chloride; chlorhexidine salt such as chlorhexidine gluconate and chlorhexidine hydrochloride; paraoxybenzoic acid ester, chlorine dioxide and the like. These sterilizing components may be used alone or in combination of two or more.

One aspect of the disinfectant of the present invention is that the disinfectant component does not contain or contains a small amount of benzylalkyl (8 to 14 carbon atoms) dimethylammonium salt. 5 parts by weight or more, preferably 5 parts by weight or more, of benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt per 100 parts by weight of the total amount of dimethylammonium salt (16 to 18 carbon atoms) and benzylalkyl (8 to 14 carbon atoms) dimethylammonium salt. 20 parts by weight or more, more preferably 30 parts by weight or more, still more preferably 50 parts by weight or more, still more preferably 70 parts by weight or more, particularly preferably 90 parts by weight or more or 100 parts by weight (that is, benzylalkyl (8 carbon atoms). ~ 14) Dimethylammonium salt is not contained).

[Usage / Usage]
The sterilizing agent of the present invention is used by adding it to various products for which a sterilizing action is required. Products that are required to have a sterilizing effect include, for example, detergent compositions, bleaching agents, fabric softener compositions, clothing finishing agent compositions, deodorant compositions, pharmaceutical compositions, and cosmetics. Examples include compositions. Among these, a detergent composition is preferably mentioned as a target for adding the disinfectant of the present invention. Specific aspects of the detergent composition will be described in detail in "2. Detergent Composition".

The form of various products to which the disinfectant of the present invention is added is not particularly limited, and is, for example, liquid, solid (powder, tablet, etc.), semi-solid (paste, gel, etc.), etc. It may be any of.

The amount of the disinfectant of the present invention added to the various products is such that the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt satisfies the concentration described later at the time of use, depending on the type and mode of use of the various products. It may be set appropriately.

The concentration of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt when the disinfectant of the present invention is used is, for example, 0.1 to 5.0 ppm, preferably 0.1 to 3.0 ppm, more preferably 0.1 to 3.0 ppm. 0.1 to 2.0 ppm, more preferably 0.1 to 1.5 ppm, and particularly preferably 0.25 to 1.5 ppm. Here, the "concentration of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt at the time of use" is the concentration of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt at the time of contact with the object to be sterilized. Concentration. That is, when various products to which the sterilizing agent of the present invention is added are used after being diluted with water at the time of use and then brought into contact with the sterilizing object, the sterilization of the present invention in the various products is carried out. The concentration of the bactericidal agent may be appropriately set according to the set dilution ratio so that the concentration of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt after dilution is within the above range.

Further, when various products to which the disinfectant of the present invention is added are used after being diluted with water, the water to be diluted may be purified water, but tap water is preferable. Benzalkonium chloride has a drawback that it cannot exert a sufficient sterilizing effect when diluted to several ppm with tap water, but the sterilizing agent of the present invention overcomes this drawback and tap water. Even if it is diluted to several ppm, an excellent sterilization effect can be obtained.

2. Detergent composition As described above, a detergent composition can be mentioned as a suitable example of the addition target of the disinfectant. Therefore, the present invention further provides a detergent composition containing the disinfectant and the surfactant. Hereinafter, the detergent composition of the present invention will be described in detail.

[Bactericidal agent]
The detergent composition of the present invention contains a benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt as a disinfectant. The types of benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt and the like are as described in the above-mentioned "1. Disinfectant" column.

Regarding the content of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt in the detergent composition of the present invention, the concentration after dilution with water at the time of use is shown in the column of "1. Disinfectant". It may be appropriately set so that the concentration at the time of use is obtained. Specifically, the content of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt in the detergent composition of the present invention is 0.5 to 15% by weight, preferably 0.5 to 10% by weight, more preferably. Is 1.5 to 10% by weight.

Further, the detergent composition of the present invention may contain other disinfectant components, if necessary, in addition to the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt. The types of other disinfectant components are as described in the column of "1. Disinfectant" above.

Further, one aspect of the cleaning agent composition of the present invention is that the benzylalkyl (8 to 14 carbon atoms) dimethylammonium salt is not contained or is contained in a small amount, and specifically, benzylalkyl (carbon number of carbon atoms). 16-18) benzylalkyl (16-18 carbon atoms) dimethylammonium salt is 5 parts by weight or more, preferably 20 parts by weight, per 100 parts by weight of the total amount of dimethylammonium salt and benzylalkyl (8-14 carbon atoms) dimethylammonium salt. More than parts, more preferably 30 parts by weight or more, still more preferably 50 parts by weight or more, even more preferably 70 parts by weight or more, particularly preferably 90 parts by weight or more or 100 parts by weight (that is, benzylalkyl (8 to 14 carbon atoms). ) It does not contain dimethylammonium salt).

[Surfactant]
The detergent composition of the present invention contains a surfactant as a cleaning component. The type of surfactant used in the present invention is not particularly limited, and may be any of nonionic surfactant, cationic surfactant, anionic surfactant, and amphoteric surfactant.

Examples of the nonionic surfactant include polyoxyalkylene alkyl ether (polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether), polyoxyethylene glycerin fatty acid ester, and polyoxyethylene sorbitan. Fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyglycerin fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, polyethylene glycol fatty acid ester, propylene glycol monofatty acid ester, alkyl polyhydric alcohol ether, polyoxyalkylene block polymer, polyoxyethylene alkyl Phenyle, polyoxyethylene alkylamine, fatty acid alkanolamide, acylmethylglucamide, polyoxyethylene acetylene glycol, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene granite oil, polyoxyethylene hydrogenated castor oil, polyoxy Examples thereof include ethylene phytosterol, polyoxyethylene cholestanol, polyoxyethylene nonylphenylformaldehyde condensate, and alkyl glucoside.

Examples of the cationic surfactant include amide amine salt-type surfactants such as diethylaminoethylamide glutamate stearate and diethylaminoethylamide glutamate lanolin fatty acid; and amide guanidine salt-type surfactants such as laurate amide guanidine hydrochloride. Can be mentioned.

Examples of the anionic surfactant include alkylbenzene sulfonate, alkenyl sulfonate (α-olefin sulfonate), alkyl sulfoacetate, alkyl sulfate, alkane sulfonate, higher fatty acid salt, and alkyl ether carboxylate. , N-acylamine salt, higher fatty acid amide sulfonate, polyoxyethylene fatty acid phosphate ester salt and the like.

Examples of the amphoteric tenside include a betaine-type amphoteric tenside such as alkyldimethylaminoacetic acid betaine; an amino acid-type amphoteric tenside; and an amine oxide-type amphoteric tenside.

These surfactants may be used alone or in combination of two or more.

Among the surfactants, preferably nonionic surfactants, more preferably polyoxyalkylene alkyl ethers, polyoxyalkylene block polymers, and even more preferably polyoxyethylene polyoxypropylene alkyl ethers.

The content of the surfactant in the detergent composition of the present invention may be appropriately set according to the type of the surfactant used, the dilution ratio at the time of use, etc., and is preferably 10 to 60% by weight, for example. 20 to 55% by weight, more preferably 30 to 50% by weight.

[Other ingredients / forms, etc.]
The detergent composition of the present invention may contain other additives and bases in addition to the above-mentioned components. Examples of such additives and bases include water, monohydric lower alcohols, polyhydric alcohols, bleaching agents, fragrances, deodorants, colorants, solubilizers, chelating agents, bulking agents, and solubility adjusting agents. , Fillers, pH adjusters, thickeners, inorganic builders, organic builders, enzymes and the like.

The form of the detergent composition of the present invention is not particularly limited, and may be liquid, solid (powder, tablet, etc.), semi-solid (paste, gel, etc.) or the like. good.

[Washing target]
The cleaning target of the detergent composition of the present invention is not particularly limited as long as sterilization and dirt removal are required, but for example, toilets (toilet bowls, toilet floors), bathrooms, kitchens, kitchens, etc. Examples include hard surfaces that can come into contact with water, such as drain pipes and water storage facilities (pools, artificial ponds, etc.). Among these, the toilet bowl of a flush toilet is easily adhered with feces, and the action of disinfecting and removing stains is strongly required. Therefore, the detergent composition of the present invention is suitable as a detergent for a flush toilet toilet bowl. ..

[how to use]
In order to clean a hard surface using the detergent composition of the present invention, it may be diluted with water so as to have a predetermined dilution ratio and brought into contact with the hard surface by spraying, coating, running water or the like. Further, when the cleaning agent composition of the present invention is brought into contact with a hard surface, brushing may be performed with a brush if necessary.

In the detergent composition of the present invention, the dilution ratio when diluted with water at the time of use is such that the concentration of the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt at the time of use (after dilution) is within the above-mentioned range. However, for example, it may be about 10,000 to 1,000,000 times, preferably about 20,000 to 500,000 times, and more preferably about 30,000 to 250,000 times.

The water for diluting the detergent composition of the present invention may be purified water, but tap water is preferable from the viewpoint of convenience and the like. Benzalkonium chloride has a drawback that the sterilizing effect is diminished when diluted to several ppm with tap water, but in the cleaning composition of the present invention, benzylalkyl (16 to 18 carbon atoms) dimethyl is used in tap water. Even if the ammonium salt is diluted to several ppm, an excellent sterilizing effect can be obtained.

When the detergent composition of the present invention is a detergent for toilet bowls, it is preferable to dilute it with flush water of the toilet (tap water flowing through the toilet bowl). In such a case, the detergent composition of the present invention can be used for an on-tank of a flush toilet, for a rim portion, for adhering to the surface of a toilet bowl, and the like. The on-tank type is used by installing it on the hand-washing part of the flush toilet, and the container containing the cleaning agent composition comes into contact with the flush water for washing supplied to the hand-washing part. As a result, the cleaning agent composition is discharged from the container, and the flush water in which the cleaning agent composition is dissolved is discharged into the toilet bowl to clean the surface of the toilet bowl. Further, for the rim portion, the cleaning agent composition is used by being attached to the rim portion of the flush toilet, and the cleaning agent composition is put into a container by contacting the flush water discharged to the toilet bowl with the container containing the cleaning agent composition. The surface of the toilet bowl is cleaned by discharging the flush water, which is discharged from the toilet bowl and in which the cleaning agent composition is dissolved, into the toilet bowl. For attachment to the surface of the toilet bowl, the cleaning agent composition of the present invention, which has been made into a gel or solid, is directly adhered to the surface of the toilet bowl and comes into contact with the flush water on the surface of the toilet bowl during flushing, and the cleaning agent composition is eluted into the flush water. By doing so, the surface of the toilet bowl is cleaned.

Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

Information on raw material products of the ingredients used in the following test examples and prescription examples is as follows. Further, the content of each component shown in the following test examples and formulation examples is not the content of the raw material product but the content of each component itself.
-Benzylcetyldimethylammonium chloride : trade name "benzylcetyldimethylammonium chloride hydrate" (containing 97% by weight or more of benzylcetyldimethylammonium chloride), manufactured by Tokyo Chemical Industry Co., Ltd.
-Benzylstearyldimethylammonium chloride : trade name "Cation S" (containing 91% by weight of benzylstearyldimethylammonium chloride), manufactured by Sanyo Chemical Industries, Ltd.
Benzalkonium chloride : Contains 50% by weight of quaternary ammonium salt; Composition analysis results: Most of the quaternary ammonium salts contained are benzyldodecyldimethylammonium chloride and benzyltetradecyldimethylammonium chloride, and benzylstearyl. Does not contain dimethylammonium chloride.
-Benzyl octyl dimethyl ammonium chloride : trade name "benzyl dimethyl octyl ammonium chloride" (containing 96% by weight or more of benzyl octyl dimethyl ammonium chloride), manufactured by Sigma-Aldrich.
-Benzyldecyldimethylammonium chloride : trade name "benzyldimethyldecylammonium chloride" (containing 97% by weight or more of benzyldecyldimethylammonium chloride), manufactured by Sigma-Aldrich.
-Benzyldodecyldimethylammonium chloride : trade name "benzyldodecyldimethylammonium chloride dihydrate" (containing 98% by weight or more of benzyldodecyldimethylammonium chloride), manufactured by Tokyo Chemical Industry Co., Ltd.
-Benzyltetradecyldimethylammonium chloride : trade name "benzyldimethyltetradecylammonium chloride hydrate" (containing 98% by weight or more of benzyltetradecyldimethylammonium chloride), manufactured by Tokyo Chemical Industry Co., Ltd.
Polyoxyalkylene alkyl ether: structural formula R- (EO) of about ₁₇ - compound of (PO) approximately ₃ -H (R is a linear alkyl group of 10 carbon atoms, EO is ethylene oxide, PO is propylene oxide)

Test Example 1
Staphylococcus aureus (NBRC12732) was used as the test strain, and the eradication efficacy test was carried out by the following method.

The pre-cultured test strain was suspended in SCD medium (Soybean-Casein Digist Broth "DAIGO", manufactured by Nihon Pharmaceutical Co., Ltd.) so as to have a ^{concentration of 1.0 × 10 8 to} 5.0 × 10 ⁸ cfu / ml, and the bacteria were cultivated. The liquid was prepared. 10 ml of each sterilizing component diluted solution having the composition shown in Tables 1 to 4 was dispensed into a 50 ml sterilized centrifuge tube (manufactured by Nippon Becton Dickinson Co., Ltd.). Then, each centrifuge tube was inoculated with 0.1 ml of the bacterial solution and statically cultured at 25 ° C. for 5 hours. After culturing, 0.1 ml was collected, and a dilution series was prepared using phosphate buffered saline (Wako Pure Chemical Industries, Ltd.) as appropriate, and then 0.1 ml of the stock solution and each diluted solution were added to the SCDLP agar medium (Soybean-Casein). Dilution Agar with Recithin & Polysorbate 80 (Nippon Pharmaceutical Co., Ltd.) was smeared and cultured at 35 ° C. for 18 to 24 hours to measure the viable cell count. Further, as a blank, a sterilized physiological saline solution (Otsuka Pharmaceutical Co., Ltd.) was used instead of the diluted solution of the disinfectant component, and the test was conducted under the same conditions as described above. The antibacterial activity value was calculated according to the following formula.

The results are shown in Tables 1 to 4. Benzalkonium chloride, which is a mixture of long-chain alkyl chains with 8 to 14 carbon atoms, and benzylalkyldimethylammonium chloride, which has 8 to 12 carbon atoms in long-chain alkyl chains, are diluted with either purified water or tap water. Even in this case, almost no sterilizing effect was observed at a concentration of 1 ppm (Comparative Examples 1 to 8 and 11 to 18). In addition, benzylalkyldimethylammonium chloride (benzyltetradecyldimethylammonium chloride), which has 14 carbon atoms in a long-chain alkyl chain, was found to have a sterilizing effect when diluted to 1 ppm with purified water, but was reduced to 1 ppm with tap water. When diluted, the sterilizing effect was significantly attenuated (Comparative Examples 9 and 10).

In contrast, benzylalkyldimethylammonium chlorides (benzylcetyldimethylammonium chloride and benzylstearyldimethylammonium chloride), which have 16 and 18 carbon atoms in long-chain alkyl chains, can be diluted with either purified water or tap water. It had an excellent sterilizing effect at a concentration of 1 ppm. In particular, benzylstearyldimethylammonium chloride had a sufficient sterilizing effect even when diluted to 0.25 ppm with tap water.

From the above results, a disinfectant using a benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt as an active ingredient may be sufficiently diluted with flush water of a toilet and allowed to flow into a toilet bowl at a low concentration, for example. It was clarified that it can have a sterilizing effect.

Claims (6)

A disinfectant containing a benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt as an active ingredient. The disinfectant according to claim 1, wherein the benzylalkyl (16 to 18 carbon atoms) dimethylammonium salt is benzylcetyldimethylammonium chloride and / or benzylstearyldimethylammonium chloride. The disinfectant according to claim 1 or 2, which is diluted with tap water and used. A detergent composition containing the disinfectant according to any one of claims 1 to 3 and a surfactant. The cleaning composition according to claim 4, which is diluted with tap water and used. The cleaning agent composition according to claim 4 or 5, which is a cleaning agent for a toilet bowl.