JP2019149978A - Composition having alcohol metabolism promotion effect and food containing the same - Google Patents

Abstract

To provide a composition capable of exhibiting its physiological active functions while minimizing content of a component derived from Antrodia camphorata.SOLUTION: An exemplary composition of the present invention has an alcohol metabolism promotion effect. The composition contains a component derived from Antrodia camphorata (for example Antrodia camphorata mycelium extract), L-cystine and oligochitosan as active components. By containing L-cystine and oligochitosan in addition to the component derived from Antrodia camphorata, content of the component derived from Antrodia camphorata is minimized, and the alcohol metabolism promotion effect can be exhibited. Since thereby flavor specific to the Antrodia camphorata component is suppressed, it can be suitably used as a containing component for food such as beverage.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a composition having an effect of promoting alcohol metabolism, and a food containing the same.

  Benix nokitake (scientific name: Antrodia Cinnamomea) is a kind of mushroom belonging to the family Sarnococcidae. Benix nokitake grows only in the beetle of the camphor family that grows in Taiwan. Benix octopus is known as a traditional Chinese medicine in Taiwan and has been used as a therapeutic food to treat, for example, addiction, diarrhea, abdominal pain, high blood pressure, itching of the skin, and liver cancer.

  Patent Document 1 discloses a pharmaceutical composition containing, as an active ingredient, an ethanol extract of the mycelium of Antrodia Cinnamomea. Patent Document 1 describes that the pharmaceutical composition can reduce systolic blood pressure or increase high-density lipoprotein. Patent Document 1 describes that this pharmaceutical composition has an anti-inflammatory action.

  Benix nokitake has a characteristic flavor (bitterness, astringency, etc.). Therefore, at present, supplements and health foods containing components derived from Benicus mushrooms are often taken in the form of tablets or capsules.

JP 2005-247724 A

  Nowadays, consumer preferences for food are diversifying. Therefore, to improve the flavor of foods containing functional ingredients that have a useful effect on the physiological functions of the body (for example, health foods, supplements, foods for specified health use, functional indication foods, etc.) Is desired.

  However, since the component derived from Benicus mushroom has a strong unique flavor as described above, if the content is increased in order to improve its pharmacological function, it is very difficult for the eater to take it. There is a problem of becoming. For example, when it is in the form of a beverage, the unique flavor becomes conspicuous and it may be difficult for some people to eat. In addition, since Benix nokitake is very expensive, it is desired to exhibit a pharmacological effect in a state in which the content is kept as small as possible.

  Therefore, an object of one aspect of the present invention is to provide a composition capable of exerting its physiologically active function (for example, alcohol metabolism promoting action) while suppressing the content of the component derived from Benicus mushrooms low. .

  As a result of intensive studies in view of the above problems, the inventors of the present application have included L-cystine and oligochitosan in the composition as active ingredients other than the component derived from Benix nocturnus, thereby It has been found that even if the content is kept lower than before, the alcohol metabolism promoting action can be exhibited, and the present invention has been completed.

  That is, the composition according to one aspect of the present invention contains a component derived from Benicus mushroom, L-cystine, and oligochitosan, and has an alcohol metabolism promoting effect.

  In the composition according to one aspect of the present invention, it is preferable that the component derived from Benicus mushroom is an extract of mycelial fungus.

  The composition according to one aspect of the present invention may further contain a component derived from at least one of soybean, wheat, and sesame. These components may be used as a mixture. As such a component, the grain fermented extract demonstrated in embodiment mentioned later is mentioned, for example.

  Another aspect of the present invention relates to a food containing any of the above compositions. This food may be a beverage, for example. Thereby, the functional drink which has an alcohol metabolism promotion effect can be provided.

  The food product according to one aspect of the present invention may contain the above-mentioned Benix nokitake-derived component within a range of 0.10 wt% or more and 0.22 wt% or less.

  Moreover, the foodstuff concerning 1 aspect of said this invention can contain the said L-cystine within 0.025 weight% or more and 0.035 weight% or less.

  Moreover, the food according to one aspect of the present invention described above can contain the oligochitosan within a range of 0.20 wt% to 0.25 wt%.

  The food according to one aspect of the present invention may further contain fruit juice. Thereby, the flavor of a foodstuff can be improved more.

  As described above, the composition according to one aspect of the present invention contains L-cystine and oligochitosan in addition to the component derived from Benix nokitake. Thereby, the alcohol metabolism promoting action can be exhibited in a state where the content of the component derived from Benicus mushroom is kept relatively low. Therefore, in the food / beverage products containing the said composition, the peculiar flavor which the component derived from a Benicus mushroom has can be made not conspicuous.

  Another aspect of the invention relates to a food or beverage. This food or beverage contains any of the above compositions. According to this food or beverage, the alcohol metabolism promoting action can be exerted in a state where the content of the component derived from Benicus mushroom is kept relatively low. Therefore, it is possible to provide a functional food or a functional beverage that can cope with diversified palatability.

It is a graph which shows the result of the test 1 of a present Example. It is a graph which shows the result of the test subject a of the test 2 of a present Example. It is a graph which shows the result of the test subject b of the test 2 of a present Example. It is a graph which shows the result of the test subject c of the test 2 of a present Example. It is a graph which shows the result of the test subject d of the test 2 of a present Example.

  Hereinafter, the present invention will be described more specifically. However, the present invention is not limited to this.

[First Embodiment]
(Composition having alcohol metabolism promoting effect)
The composition according to the first embodiment has an alcohol metabolism promoting action. This composition contains a component derived from Benicus mushroom, L-cystine, and oligochitosan as active ingredients.

  The component derived from Benix nocturnus is a component derived from Benixnochitake (scientific name: Antrodia Cinnamomea) which is a kind of mushroom. The component derived from Benicus mushroom may be a material obtained by pulverizing a part of the tissue (such as fruit body or mycelium) of Benicus mushroom or powdered after drying.

  Alternatively, the Benix nocturnus-derived component may be a Benix noctum extract. For example, Benix nokitake extract is obtained by bringing a part or all of a tissue (fruit body, mycelium, etc.) of Benix nokitake into contact with a solvent and insoluble components soluble in the solvent contained in the tissue. It is obtained by selectively separating from poorly soluble components. Benicus mushroom includes physiologically active components such as hepasin, polysaccharides, and GABA.

In the present embodiment, water or organic solvent extract of Benix nocturnus mycelium (hereinafter referred to as “Bennix nokitake mycelium extract”) is suitably used as the component derived from Benixo nocturnis. Organic solvents include alcohols (eg, CH ₃ OH, C ₂ H ₅ OH, C ₃ H ₇ OH, etc.), esters (eg, acetyl acetate, etc.), alkanes (eg, hexane, etc.), and halogenated alkanes (eg, , CH ₃ Cl, C ₂ H ₂ Cl _2, etc.). Preferred organic solvents are ethanol or alcoholic solvents that do not cause any side effects in humans. Compared with fruit bodies, Benix nokitake mycelium is inexpensive and can be obtained relatively easily.

  In the composition according to the present embodiment, the component derived from Benicus mushroom can be contained, for example, in the range of 50 mg to 500 mg, preferably in the range of 80 mg to 300 mg. It can be contained within the range of 100 mg or more and 220 mg or less. Alcohol metabolism after ingestion of alcohol can be promoted by ingesting 80 mg or more of a component derived from Benicus mushroom in a single intake. Moreover, peculiar flavor can be restrained to some extent low by content of the component derived from Benicus mushrooms contained in a composition being 300 mg or less.

  L-cystine has a structure in which two cysteine molecules are connected via a disulfide bond (SS bond). L-cystine is converted into L-cysteine in vivo. L-cysteine is a kind of amino acid and produces glutathione, which is important for liver detoxification. L-cysteine also has a function of maintaining the health of hair and nails, and a skin beautifying and whitening effect by suppressing the production of melanin.

  In the composition according to the present embodiment, L-cystine can be contained, for example, within a range of 5 mg to 100 mg, preferably within a range of 10 mg to 50 mg as a single intake. More preferably, it can be contained in the range of 25 mg or more and 35 mg or less. By ingesting 10 mg or more of L-cystine together with a component derived from Benicus mushrooms in a single intake, the effect of promoting alcohol metabolism after alcohol intake can be further increased.

  Oligochitosan is a polymer of 2 or more and 8 or less oligoglucosamine, for example. Oligochitosan is also called “oligoglucosamine” or “chitosan oligosaccharide”. Oligochitosan has physiological activities such as liver function improving effect and immunostimulatory action.

  In the composition according to this embodiment, oligochitosan can be contained within a range of, for example, 100 mg or more and 500 mg or less, preferably 150 mg or more and 300 mg or less. More preferably, it can be contained in the range of 200 mg to 250 mg. By ingesting 150 mg or more of oligo chitosan together with a component derived from Benix nokitake in a single intake, the effect of promoting alcohol metabolism after alcohol intake can be further increased.

  Moreover, the composition concerning this embodiment can be made to contain a cereal fermented extract as components other than the above.

  The cereal fermented extract means a composition obtained by using a cereal as a base material (culture medium) and utilizing a fermentation action by microorganisms. Examples of cereals include wheat, rice, legumes, sesame, and potatoes. Examples of the microorganism include lactic acid bacteria, yeast, and acetic acid bacteria.

  Among the above-mentioned various cereals, it is preferable to use cereals such as soybeans, pigeons, and sesame as the raw material for the fermented cereal extract. Moreover, it is preferable to use lactic acid bacteria among the above-mentioned various microorganisms as the microorganisms used in the cereal fermented extract.

  “Lactic acid bacteria” as used herein is a general term for microorganisms that assimilate glucose and produce lactic acid with a yield of sugar of 50% or more. The physiological properties are gram-positive bacteria, cocci or bacilli, no motility, and spore formation. It has characteristics such as inability and catalase negative. Lactic acid bacteria have been eaten throughout the world through fermented milk since ancient times, and can be said to be extremely safe microorganisms.

  Thus, the composition according to this embodiment includes rice, corn, beans (soybeans, red beans, peas, etc.), millet grains (millet, millet, millet, etc.) buckwheat, wheat (barley, wheat, pigeons, etc.). And a component derived from at least one of sesame seeds. More specifically, the composition according to the present embodiment contains a fermented cereal extract obtained by fermenting soybeans, pigeons, and sesame as raw materials (fermentation medium) and adding lactic acid bacteria thereto. It is preferable to do. By using the fermented extract, an improvement in the absorption rate of the components derived from grains can be expected.

  It is known that each grain-derived component contained in the above-described fermented grain extract has an action of promoting alcohol metabolism. Therefore, it is thought that the composition concerning this embodiment can improve the alcohol metabolism promotion effect of the said composition more by containing a cereal fermentation extract.

  In the composition according to this embodiment, the fermented cereal extract can be contained within a range of, for example, 100 mg or more and 800 mg or less, preferably 200 mg or more and 700 mg or less. More preferably, it can be contained in the range of 250 mg or more and 550 mg or less.

  When manufacturing the composition concerning this embodiment, the blend extract in which the component (for example, Benix nokita mycelium extract) derived from Benix nokitake and the fermented cereal extract can also be used. As such a blend extract, a component containing Benix nokitake and a cereal fermented extract is contained in a weight ratio of 1: 2 to 3 (= Benix nokitake derived component: cereal fermented extract). Can be used.

  Moreover, when manufacturing the composition concerning this embodiment using this blend extract, the three components of a Benix nokitake origin component, an oligo chitosan, and L-cystine are the following compounding ratios (weight ratio). It is desirable to mix so that it becomes.

  That is, the blending ratio of the three components is Benix nokitake-derived component: oligoglucosamine: L-cystine = 2-9: 5-10: 1, and more preferably, Benixnochatake-derived component: oligoglucosamine: L-cystine. = 4.5: 7.5: 1. This blending ratio can also be applied to the composition according to the second embodiment described later and the food according to the third embodiment.

  The composition according to the present embodiment has a physiologically active function of promoting alcohol metabolism. Therefore, it can be used as an active ingredient such as food (excluding animals and plants itself), health food, functional food, functional beverage, and medicine. That is, foods (excluding animals and plants themselves), health foods, functional foods, functional beverages, and pharmaceuticals containing the composition according to this embodiment as an active ingredient are also included in the technical scope of the present invention.

  In addition, the composition itself according to the present embodiment may be realized as food (excluding animals and plants itself), health food, functional food, functional drink, medicine, and the like. That is, the food, health food, functional food, functional beverage, and pharmaceutical product according to another aspect of the present invention contain, as active ingredients, a component derived from Benicus mushroom, L-cystine, and oligochitosan. .

  When the composition itself according to the present embodiment is realized as a food (excluding animals and plants itself), health food, functional food, functional beverage, pharmaceutical product, etc., a component derived from Benicus mushroom, L-cystine, and oligo In addition to chitosan, well-known additives that can be contained in foods or pharmaceuticals can be contained.

  When using the composition concerning this embodiment for a pharmaceutical, you may contain the known additive which can be contained in a pharmaceutical other than the said composition. Such additives include excipients, disintegrants, binders, fluidizing agents, flavoring agents, flavoring agents, coloring agents, sweetening agents, solvents, fats and oils, thickeners, surfactants, gelling agents, stability agents. Agents, preservatives, buffers, suspending agents, thickeners and the like.

  Next, the physiological activity of the composition according to this embodiment will be described. The composition according to the present embodiment has an alcohol metabolism promoting action. Here, the alcohol metabolism promoting action means a function of promoting the decomposition (metabolism) of alcohol taken into the body as compared with the case of no treatment.

  The alcohol metabolism promoting effect also includes an effect of promoting a decrease in blood alcohol concentration that rises after drinking. The alcohol metabolism promoting action also includes an action of promoting a decrease in the breath alcohol concentration that rises after drinking. Such an effect can be confirmed by measuring the concentration of alcohol contained in the blood or exhaled breath of a human after drinking. In addition, the alcohol metabolism promoting action includes an action of suppressing or preventing an increase in blood alcohol concentration or breath alcohol concentration caused by drinking compared to the case of no treatment.

  Therefore, the composition according to this embodiment can be used for preventing or ameliorating various symptoms caused by alcohol consumption. Specifically, the composition according to the present embodiment has the following effects: leaning after alcohol ingestion, tingling (hangover, nausea, nausea, upset stomach, nausea, nausea), vomiting, hangover, stomach / abdominal fullness It is effective for the prevention or improvement of gastric hyperacidity, stomach discomfort, indigestion, heartburn, chest grip, loss of appetite, stomach weight, stomach weakness, stomach pain, etc.

  As described above, the composition according to this embodiment has an alcohol metabolism promoting action. In order to exhibit this function more effectively, it is preferable to ingest the composition before ingesting (drinking alcohol). More specifically, the composition may be ingested between about 1 hour before ingesting alcohol and immediately before. In order to further promote alcohol metabolism, it is preferable to ingest the composition between about 30 minutes and about 5 minutes before ingesting alcohol. In addition, when ingesting the composition for the main purpose of improving various symptoms caused by alcohol consumption, the composition may be ingested during or after drinking.

[Second Embodiment]
(Composition having liver function protecting action and / or liver function improving action)
The composition according to the first embodiment described above contains a Benix nokitake-derived component, L-cystine, and oligochitosan as active ingredients, and has an alcohol metabolism promoting effect. As described above, each active ingredient contained in this composition has an action of protecting liver function and / or improving liver function. Therefore, it can be expected that the liver function is protected or the liver function is improved by ingesting the composition according to the first embodiment. Therefore, in the second embodiment, use of the composition according to the first embodiment for the purpose of protecting liver function and / or improving liver function will be described.

  About each component contained in the composition concerning this embodiment, the component similar to the composition concerning 1st Embodiment is applicable. Therefore, specific description is omitted.

  The composition according to this embodiment has a liver function protecting action and / or a liver function improving action. Here, the liver function protecting action and / or the liver function improving action include (1) protein synthesis and nutrient storage, (2) detoxification and decomposition of harmful substances, and (3) bile synthesis and secretion. It means to contribute to the protection or improvement of liver function. In addition, the liver function protecting action and / or the liver function improving action includes an action of suppressing the possibility that the liver function is lowered by ingestion of alcohol.

  As described above, the composition according to this embodiment has a liver function protecting action and / or a liver function improving action. When the composition is ingested for this purpose, for example, a composition containing each of the components derived from Benix nokitake, L-cystine, and oligochitosan at the preferred contents described in the first embodiment. In order to exhibit the liver function protecting action and / or the liver function improving action more effectively, it is preferable to take the above composition at a frequency of about once a day within a predetermined dose range.

  By daily intake of the composition according to this embodiment, liver function is improved, and various symptoms that can occur when alcohol is ingested (for example, so-called hangover symptoms such as leaning and nausea resulting from alcohol intake) Can be expected to prevent or improve.

[Third Embodiment]
(Food containing the above composition)
Subsequently, a third embodiment will be described. The third embodiment relates to a food containing the composition according to the first or second embodiment described above. The foodstuff concerning this embodiment has an alcohol metabolism promotion effect | action by containing the composition concerning 1st Embodiment. Moreover, the foodstuff concerning this embodiment has a liver function protection effect and / or a liver function improvement effect by containing the composition concerning 2nd Embodiment.

  In addition to the composition according to the first or second embodiment, the food according to this embodiment may contain a known additive that can be contained in food (for example, functional food). . Such additives include water, sugars, sugar alcohols, starch and processed starch, dietary fiber, milk, processed milk, soy milk, fruit juice, vegetable juice, alcohols, fruits / vegetables and processed products thereof, proteins, peptides , Amino acids, lipids (eg lecithin), animal and plant crude drug extracts, naturally derived polymers (collagen, hyaluronic acid, chondroitin, etc.), vitamins, minerals, thickeners, emulsifiers, preservatives, sweeteners, sour taste , Coloring agents, fragrances and the like.

  The food according to this embodiment is preferably realized in the form of a beverage. When the food according to the present embodiment is a beverage, for example, it becomes easier for a person before drinking to take it. When realized in the form of a beverage, the content of various components (benix nokitake-derived component, L-cystine, oligochitosan, cereal fermented extract) contained in the composition according to the first or second embodiment is It can be within the range described in the first and second embodiments. Thereby, the physiologically active function (for example, an alcohol metabolism promotion effect, a liver function protection effect, and / or a liver function improvement effect) can be exhibited, suppressing the peculiar flavor resulting from a component derived from Benicus mushroom.

  Specifically, in the beverage according to the present embodiment, the component derived from Benicus mushroom is included in the range of 0.10 wt% to 0.22 wt% with respect to the total weight (total mass) of the beverage. It is preferable.

  Moreover, it is preferable that the drink concerning this embodiment contains L-cystine within 0.025 weight% or more and 0.035 weight% or less with respect to the total weight (total mass) of a drink. . Moreover, it is preferable that the oligochitosan is contained in the drink concerning this embodiment within the range of 0.20 weight% or more and 0.25 weight% or less with respect to the total weight (total mass) of a drink. Moreover, it is preferable that the cereal fermentation extract is contained in the drink concerning this embodiment within the range of 0.25 weight% or more and 0.55 weight% or less with respect to the total weight (total mass) of a drink. .

  Moreover, the drink concerning this embodiment may contain the well-known additive which can be contained in a drink (for example, functional drink). Such additives include water, sugars, sugar alcohols, starches and processed starch, dietary fiber, milk, processed milk, soy milk, fruit juice, vegetable juice, alcohols, carbon dioxide, fruits and vegetables and processed products thereof. , Proteins, peptides, amino acids, lipids (eg, lecithin), animal and plant crude drug extracts, naturally derived polymers (collagen, hyaluronic acid, chondroitin, etc.), vitamins (eg, vitamin C, vitamin B), minerals , Thickeners, emulsifiers, preservatives, sweeteners, acidulants, colorants, fragrances and the like.

  Among these additives, it is particularly preferable to include fruit juice and saccharides. By including fruit juice and saccharides in the beverage according to the present embodiment, it is possible to mask the peculiar flavor of the component derived from Benix nokitake.

  Examples of the fruit juice contained in the beverage include lemon, grapefruit, lychee, orange, mandarin orange, citron, peach, apple, pineapple, mango, passion fruit, grape, cassis, and plum. Among these, grapefruit, lemon, lychee, grape, peach, pineapple and other fruit juices are preferable. This is because the peculiar flavor of the component derived from Benicus mushroom can be relieved by the acidity or sweetness contained in these fruit juices.

  In the drink concerning this embodiment, fruit juice can be contained in the range of 1.0 weight% or more and 50.0 weight% or less with respect to the total weight (total mass) of a drink, for example. Moreover, it is preferable to contain fruit juice within the range of 3.0 weight% or more and 30.0 weight% or less with respect to the total weight (total mass) of a drink. By containing fruit juice at such a ratio, the flavor of the beverage can be made better.

  Examples of the saccharide contained in the beverage include sugar, brown sugar, fructose, honey, and cyclic oligosaccharide. In the drink concerning this embodiment, saccharides can be contained in the range of 1.0 weight% or more and 15.0 weight% or less with respect to the total weight (total mass) of a drink, for example. Moreover, it is preferable to contain saccharides within the range of 2.0 weight% or more and 10.0 weight% or less with respect to the total weight (total mass) of a drink. Thereby, moderate sweetness can be added to a drink and the flavor of a drink can be made more favorable.

  Moreover, in the drink concerning this embodiment, corn starch may be added as starches, for example. Moreover, in the drink concerning this embodiment, stevia may be added as a sweetener, for example.

  Moreover, you may add luxury goods, such as green tea, black tea, coffee, cocoa, herbal tea, in the drink concerning this embodiment. Thereby, the flavor of a drink can be made more favorable. More preferably, the coffee is sweetened. Moreover, you may add a carbon dioxide gas, a mint extract, etc. in the drink concerning this embodiment. Thereby, a refreshing mouth can be given to a drink.

  Moreover, it is preferable that the thickener is added in the drink concerning this embodiment. Examples of the thickener include welan gum, xanthan gum, pectin and the like. A thickener can be contained in the range of 0.005 weight% or more and 0.300 weight% or less with respect to the total weight (total mass) of a drink, for example. Moreover, it is preferable to contain a thickener within the range of 0.010 weight% or more and 0.200 weight% or less with respect to the total weight (total mass) of a drink. By adding a thickener in the beverage, precipitation of L-cystine can be suppressed. Moreover, the roughening of food texture can be suppressed by adding a thickener in a drink.

  In addition, the composition concerning this embodiment can also be implement | achieved as food / beverage products of forms other than a drink. Specific examples of such foods and beverages include gums, gummi, jelly, biscuits and the like.

  The food according to this embodiment is composed of the various components as described above. Therefore, the physiologically active function (for example, alcohol metabolism promoting action, liver function protecting action and / or liver function improving action) can be exerted in a state where the content of the component derived from Benicus mushroom is suppressed to a relatively low amount. it can. Therefore, in the food containing the composition, the unique flavor of the component derived from Benicus mushroom can be made inconspicuous. Therefore, it is possible to provide a food that can cope with more diverse palatability.

  For example, in a food in the form of a capsule or a tablet containing a conventional component derived from Benicus mushroom, about 800 mg of the component derived from Benicus mushroom is required in a single intake in order to exert an alcohol metabolism promoting effect. It was.

  On the other hand, in the food according to the present embodiment, the content of the component derived from Benicus mushroom at the time of ingestion can be, for example, in the range of 50 mg to 500 mg, and preferably 80 mg to 300 mg. It can be within the following range, and more preferably within the range of 100 mg to 220 mg. Alcohol metabolism after ingestion of alcohol can be promoted by ingesting 80 mg or more of a component derived from Benicus mushroom in a single intake. Moreover, peculiar flavor can be restrained to some extent low by content of the component derived from Benicus mushrooms contained in a composition being 300 mg or less. Moreover, there is also an effect of reducing the cost by setting the content of the component derived from Benicus mushroom to 300 mg or less.

  For example, when the food according to the present embodiment is ingested in the form of a beverage, the total amount of the 100-ml beverage can contain the component derived from Benicus mushroom within the above numerical range. And by ingesting 100 ml of the said drink before drinking, as shown also in the below-mentioned Example, alcohol metabolism promotion effect | action can fully be exhibited. Moreover, if a component derived from Benicus mushroom is contained in the 100 ml beverage within the above numerical range, it is possible to suppress a strong sense of a peculiar flavor by the eater. Therefore, even before drinking, an appropriate amount of 100 ml can be taken while feeling a good flavor without feeling an excessive characteristic flavor.

  As described above, the food according to the present embodiment has an alcohol metabolism promoting action. In order to exhibit this function more effectively, it is preferable to ingest the composition at a timing before ingesting (drinking alcohol). More specifically, the food may be ingested between about 1 hour before ingesting alcohol and immediately before. In order to further promote alcohol metabolism, it is preferable to ingest the food product about 5 minutes before ingesting alcohol.

  In addition, when the food according to this embodiment is a beverage, the amount of each intake can be in the range of about 50 ml to about 500 ml, and can be in the range of about 75 ml to about 350 ml. Is preferred. By making the amount of one intake about 75 ml or more, it becomes easy to suppress the specific flavor. Moreover, it can be set as a reasonable intake by setting a single intake to about 150 ml or less.

  In addition, the food according to this embodiment has a liver function protecting action and / or a liver function improving action. In order to exhibit this function more effectively, the food may be taken once every few days. In order to more effectively exert the liver function protecting action and / or the liver function improving action, it is preferable to take the food once a day.

  The beverage according to the present embodiment is analyzed by high performance liquid chromatography (HPLC method) to determine whether or not various components (Benix nokitake-derived component, L-cystine, oligochitosan, cereal fermentation extract) are contained. It can implement by the well-known analysis methods, such as. When performing component analysis by the HPLC method, a precision balance, a test tube shaker, a quantitative bottle, a test tube, a centrifuge, a filter paper, a filtration device, an HPLC device, etc. are used as equipment. Further, acetonitrile, ion-exchanged water, phosphoric acid, absolute ethanol, or the like may be used as a reagent.

  The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is defined by the terms of the claims, rather than the description above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  Hereinafter, the present invention will be described in more detail with reference to examples. In addition, the Example shown below is only an illustration and does not limit this invention.

[Test 1]
In Test 1, a test beverage (an example of a beverage according to this embodiment) was ingested before drinking, and the change in the blood alcohol level of the subject after drinking was measured. In addition, as beverages to be compared, two types of commercially available drinks (comparative beverage A: trade name Turmeric Power (registered trademark) Turmeric extract drink (manufactured by House Wellness Foods Co., Ltd.)), comparative beverage B: trade name Heparise W ( The same test was performed using a registered trademark (made by Zeria Shinyaku Kogyo Co., Ltd.) and a placebo beverage.

The specific test method was as follows.
(subject)
Sixteen healthy Japanese adult men and women (average age: 47.3 years, 1: 2 ratio). As subjects, those who felt relatively intoxicated by alcohol were selected.

(Test drink)
(1) Test Beverage As a test beverage, a drink agent (manufactured by I-ne Inc.), which is an example of a beverage according to the present embodiment, was used. In this drink, 0.13 wt% (134 mg / 100 ml) of Benix nokitake-derived components, 0.030 wt% (30 mg / 100 ml) of L-cystine, 0.225 wt% (225 mg / 100 ml) of oligochitosan ), And a fermented cereal extract at a concentration of 0.33% by weight (335 mg / 100 ml). In addition, this drink contains grapefruit juice at a concentration of about 18% by weight and fructose at a concentration of about 3% by weight. In addition, this drink contains various vitamins, thickeners, sweeteners and the like as trace components. Other than these various components, it is composed of water.
(2) Beverage for comparison A: Brand name Turmeric Power (registered trademark) Turmeric extract drink (manufactured by House Wellness Foods (registered trademark))
(3) Beverage for comparison B: Product name Heparise W (registered trademark) (Zeria (registered trademark) Shinyaku Kogyo Co., Ltd.)
(4) Placebo Beverage As a placebo beverage, a drink was prepared from the components of the test beverage of the above (1) except for the component derived from Benicus mushroom, L-cystine, oligochitosan, and the fermented cereal extract.

(Test method)
30 minutes before the alcohol load, any of the test beverage, the two types of comparative beverages, and the placebo beverage was orally ingested. All intakes were 100 ml and the number of intakes was once.

  As a test method, a randomized placebo food control double-blind crossover comparative test was used. Specifically, 16 subjects are divided into four groups, and for each group of subjects, one of four types of beverages (ie, test beverages, two types of comparative beverages, and placebo beverages) Beverage information was provided without disclosure. A total of four tests were conducted on different dates so that subjects in each group could conduct tests on all four types of beverages.

  Each subject drank 30 minutes after drinking any of the above four types of beverages. Specifically, about 0.5 g of alcohol (ethanol) per kg body weight of each subject was diluted with the same amount of water and ingested over about 15 minutes. In addition, over the course of 3 hours from alcohol intake to 180 minutes after blood collection, whiskey to be ingested under alcohol load was divided into water and the same amount of water was ingested.

  Blood was collected from the subjects before drinking and at 30 minutes, 60 minutes, 120 minutes, and 180 minutes after drinking. And the blood alcohol concentration (mg / dL) of each test subject was measured.

  The result is shown in the graph of FIG. In addition, the result shown in FIG. 1 is represented by the estimated peripheral average value of each subject.

Moreover, although the measured value of (4) placebo drink is not shown in the graph of FIG. 1, the following results were obtained.
(Estimated peripheral average value of blood alcohol concentration measurements of placebo beverages)
Before drinking: 0.0 (mg / dL)
After 30 minutes: 86.5 (mg / dL)
After 60 minutes: 72.8 (mg / dL)
After 120 minutes: 53.3 (mg / dL)
After 180 minutes: 37.5 (mg / dL)

  From the above results, in the test beverage, a significant decrease in the amount of blood alcohol was observed after 60 minutes after drinking, compared with the comparative beverages A and B. Moreover, in the test beverage, a significant decrease in the amount of blood alcohol was observed 30 minutes after drinking and 120 minutes after drinking, compared to the placebo beverage. From this result, it was confirmed that the test beverage has an alcohol metabolism promoting effect.

In the test beverage, it was considered that each component contained in the test beverage acts as follows as a factor that suppresses the increase in the blood alcohol level after drinking.
About the component derived from Benicus mushroom, the activity of the enzyme that decomposes alcohol is increased.
For L-cystine, a coenzyme is supplied to the liver to promote primary metabolism of alcohol. L-cysteine, which is a degradation product of L-cystine, has a function of protecting the liver from acetaldehyde.
Oligochitosan promotes transport of proteins and the like to the liver and repairs liver tissue.

  From the above, it is considered that the test beverage contains Benix nokitake-derived components, L-cystine, and oligochitosan, and these components can act in a complex manner to promote alcohol metabolism.

  Therefore, it is considered that the test beverage has an effect on hangover after drinking. Moreover, it is thought that a test drink also has a liver function protection effect and / or a liver function improvement effect by interaction of said each component.

[Test 2]
In Test 2, a test beverage (an example of a beverage according to this embodiment) was ingested before drinking, and the breath alcohol concentration of the subject after drinking was measured. In addition, as comparative beverages, Comparative Example A containing only Benix nokitake-derived components as active ingredients, Comparative Example B containing only oligochitosan (oligoglucosamine) as active ingredients, and Comparative Examples containing only L-cystine as active ingredients A similar test was conducted using C.

The specific test method was as follows.
(subject)
Four healthy Japanese adult men and women (subjects a, b, c, d) were used.

(Test drink)
(1) Test drink The same drink as the above-mentioned test 1 was used as a test drink.
(2) As Comparative Example A, a drink containing only L-cystine and oligochitosan from the components contained in the test beverage of (1) above (ie, a drink containing only the component derived from Benix nokitake as an active ingredient) Agent).
(3) As Comparative Example B, a drink agent (that is, only oligo chitosan is effective in a component excluding the component derived from Benix nokitake, L-cystine, and the fermented cereal extract from the component of the test beverage of (1) above. Prepared as a component).
(4) As Comparative Example C, a drink agent (that is, only L-cystine is effective in a component excluding the component derived from Benix nokitake, oligo chitosan, and cereal fermented extract from the component of the test beverage of (1) above. Prepared as a component).

(Test method)
Five minutes before alcohol intake, any of the test beverages and Comparative Examples A to C was orally ingested. All intakes were 100 ml and the number of intakes was once.

  Each subject a to d is a state after 90 minutes or more have passed since each subject has taken a comparable lunch, and after 5 minutes have passed, the alcoholic beverage 15 Ingested over a minute. The amount of alcohol to be ingested was 0.6 ml / kg per body weight of each subject. Moreover, the alcoholic beverage of frequency 11 was used as an alcoholic beverage to ingest. Moreover, during the test, food and drink other than the test beverage (or the beverage of the comparative example) and the alcoholic beverage were restricted.

  The breath alcohol concentration (mg / L) was measured before drinking, and at each timing after 30 minutes, 60 minutes, 120 minutes, and 180 minutes after drinking.

  Each test subject a to d performed the above test on each of the above four types of beverages. The results are shown in the graphs of FIGS. 2 shows the result of the subject a, FIG. 3 shows the result of the subject b, FIG. 4 shows the result of the subject c, and FIG. 5 shows the result of the subject d.

  As shown in FIG. 2, in subject a, the breath alcohol concentration of the test beverage decreases at a peak of 60 minutes after drinking, while the breath alcohol concentration of Comparative Examples A to C increases or continues until 120 minutes after drinking. It was confirmed that As shown in FIG. 3, in the subject b, the test alcohol had the lowest breath alcohol concentration until 120 minutes after drinking. As shown in FIG. 4, in the subject c, the test alcohol had the lowest breath alcohol concentration until 180 minutes after drinking. As shown in FIG. 5, in the subject d, the result was that the breath alcohol concentration of Comparative Example C was the lowest.

  From the above, it was confirmed that the test beverage was effective in promoting alcohol metabolism after drinking for 3 subjects (subjects a, b, c) out of 4 subjects. From this, although there are differences in efficacy depending on the subject, for a relatively large number of people, the test beverage containing Benix nokitake-derived components, L-cystine, and oligochitosan is a beverage containing each component alone. In comparison, it was confirmed to be effective in promoting alcohol metabolism.

Claims (9)

Benix nokitake-derived ingredients,
L-cystine,
A composition containing oligochitosan and having an action of promoting alcohol metabolism.   The composition according to claim 1, wherein the component derived from Benicus mushroom is an extract of mycelial fungus.   The composition according to claim 1 or 2, further comprising a component derived from at least one of soybeans, pigeons, and sesame.   The foodstuff containing the composition of any one of Claim 1 to 3.   The food according to claim 4, which is a beverage.   The foodstuff of Claim 4 or 5 which contains the said venix mushroom origin component in the range of 0.10 weight% or more and 0.22 weight% or less.   The food according to any one of claims 4 to 6, wherein the L-cystine is contained within a range of 0.025 wt% or more and 0.035 wt% or less.   The foodstuff according to any one of claims 4 to 7, wherein the oligochitosan is contained within a range of 0.20 wt% or more and 0.25 wt% or less.   The food according to any one of claims 4 to 8, further comprising fruit juice.

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